WO2000056808A3 - Surface and its manufacture and uses - Google Patents

Surface and its manufacture and uses Download PDF

Info

Publication number
WO2000056808A3
WO2000056808A3 PCT/EP2000/002632 EP0002632W WO0056808A3 WO 2000056808 A3 WO2000056808 A3 WO 2000056808A3 EP 0002632 W EP0002632 W EP 0002632W WO 0056808 A3 WO0056808 A3 WO 0056808A3
Authority
WO
WIPO (PCT)
Prior art keywords
plastics
polymer material
substance
plasma
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/002632
Other languages
French (fr)
Other versions
WO2000056808A2 (en
Inventor
Anders Larsson
Anette Ocklind
Helene Derand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Sweden AB
Original Assignee
Amersham Pharmacia Biotech AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Pharmacia Biotech AB filed Critical Amersham Pharmacia Biotech AB
Priority to DE60003642T priority Critical patent/DE60003642T2/en
Priority to DK00920571T priority patent/DK1163103T3/en
Priority to JP2000606668A priority patent/JP5025043B2/en
Priority to EP00920571A priority patent/EP1163103B1/en
Priority to AT00920571T priority patent/ATE244130T1/en
Priority to US09/937,533 priority patent/US6967101B1/en
Priority to AU41100/00A priority patent/AU4110000A/en
Priority to CA002367736A priority patent/CA2367736A1/en
Publication of WO2000056808A2 publication Critical patent/WO2000056808A2/en
Publication of WO2000056808A3 publication Critical patent/WO2000056808A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
    • B29C59/14—Surface shaping of articles, e.g. embossing; Apparatus therefor by plasma treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037—Other properties
    • B29K2995/0092—Other properties hydrophilic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Optical Measuring Cells (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

A method for rendering a surface covered by a polymer material (plastics) more hydrophilic by treatment in a gas plasma of a non-polymerizable gas. The method is characterized in that the intensity of the plasma is selected so that the surface becomes permanently more hydrophilic. A naked plasma treated surface of plastics having an immediate water-contact angle ≤ 30°, such as ≤ 20°, said water-contact angle being changed less than ± 20 % and/or less than ± 5° upon washing with ethanol/water mixture (70 % w/w). A kit comprising (a) a microfabricated device comprising a surface (i) which is manufactured from a synthetic polymer material (plastics) and (ii) on which there are at least one chamber and/or at least one channel, and (b) a fluorescent substance to be detected in the device. The kit is characterized in that the plastics has a fluorescence that is non-significant with respect to the fluorescence of the substance at the wavelength at which the substance fluoresces. A microfabricated device having a liquid transportation system which is formed in/on a polymer material (plastics) that is a polymerised aliphatic monomer containing unsaturation.
PCT/EP2000/002632 1999-03-24 2000-03-24 Surface and its manufacture and uses Ceased WO2000056808A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE60003642T DE60003642T2 (en) 1999-03-24 2000-03-24 USE OF A SURFACE HYDROPHILIZED IN GASPLASMA AS A LIQUID CONTACT SURFACE AND A DEVICE PRODUCED BY A MICROPROCESS WITH A SURFACE HYDROPHILIZED IN GASPLASMA
DK00920571T DK1163103T3 (en) 1999-03-24 2000-03-24 Use of gas plasma hydrophilized surface as a liquid contact surface and microfabricated device containing a gas plasma hydrophilized surface
JP2000606668A JP5025043B2 (en) 1999-03-24 2000-03-24 Surface and its manufacture and use
EP00920571A EP1163103B1 (en) 1999-03-24 2000-03-24 Use of gas plasma hydrophilised surface as a liquid contact surface and microfabricated device containing a gas plasma hydrophilised surface
AT00920571T ATE244130T1 (en) 1999-03-24 2000-03-24 USE OF A GAS PLASMA HYDROPHILIZED SURFACE AS A LIQUID CONTACT SURFACE AND DEVICE PRODUCED BY A MICROPROCESS HAVING A GAS PLASMA HYDROPHILIZED SURFACE
US09/937,533 US6967101B1 (en) 1999-03-24 2000-03-24 Surface and its manufacture and uses
AU41100/00A AU4110000A (en) 1999-03-24 2000-03-24 Surface and its manufacture and uses
CA002367736A CA2367736A1 (en) 1999-03-24 2000-03-24 Surface and its manufacture and uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9901100A SE9901100D0 (en) 1999-03-24 1999-03-24 Surface and tis manufacture and uses
SE9901100-9 1999-03-24

Publications (2)

Publication Number Publication Date
WO2000056808A2 WO2000056808A2 (en) 2000-09-28
WO2000056808A3 true WO2000056808A3 (en) 2001-03-22

Family

ID=20415008

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/002632 Ceased WO2000056808A2 (en) 1999-03-24 2000-03-24 Surface and its manufacture and uses

Country Status (11)

Country Link
US (1) US6967101B1 (en)
EP (2) EP1163103B1 (en)
JP (1) JP5025043B2 (en)
AT (1) ATE244130T1 (en)
AU (1) AU4110000A (en)
CA (1) CA2367736A1 (en)
DE (1) DE60003642T2 (en)
DK (1) DK1163103T3 (en)
ES (1) ES2200861T3 (en)
SE (1) SE9901100D0 (en)
WO (1) WO2000056808A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9993819B2 (en) 2014-12-30 2018-06-12 Stmicroelectronics S.R.L. Apparatus for actuating and reading a centrifugal microfluidic disk for biological and biochemical analyses, and use of the apparatus

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9808836D0 (en) 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
GB9809943D0 (en) * 1998-05-08 1998-07-08 Amersham Pharm Biotech Ab Microfluidic device
SE9902474D0 (en) 1999-06-30 1999-06-30 Amersham Pharm Biotech Ab Polymer valves
SE0001790D0 (en) * 2000-05-12 2000-05-12 Aamic Ab Hydrophobic barrier
WO2002029397A2 (en) * 2000-10-05 2002-04-11 E.I. Du Pont De Nemours And Company Polymeric microfabricated fluidic device suitable for ultraviolet detection
SE0004296D0 (en) 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
US7429354B2 (en) 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
US7759067B2 (en) 2001-03-19 2010-07-20 Gyros Patent Ab Method for determining the amount of an analyte with a disc-shaped microfluidic device
CA2442342A1 (en) * 2001-03-19 2002-09-26 Gyros Ab A microfluidic system (edi)
DE10132091A1 (en) * 2001-07-05 2003-01-16 Td Verwaltungs Gmbh Micro-moulding, comprises placing the mould in an oxygen containing atmosphere at reduced pressure, adjusting the temperature and creating a gas discharge
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
EP2269736B1 (en) 2001-08-28 2013-04-24 Gyros Patent Ab Retaining microfluidic microcavity and other microfluidic structures
WO2003018198A1 (en) 2001-08-28 2003-03-06 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US6617152B2 (en) * 2001-09-04 2003-09-09 Corning Inc Method for creating a cell growth surface on a polymeric substrate
US7189368B2 (en) 2001-09-17 2007-03-13 Gyros Patent Ab Functional unit enabling controlled flow in a microfluidic device
GB2394477B (en) * 2002-08-22 2005-03-30 Celltran Ltd Cell culture
GB2381535A (en) * 2001-10-30 2003-05-07 Qinetiq Ltd Device for forming a cellular network
JP2003149252A (en) * 2001-11-16 2003-05-21 Starlite Co Ltd Chemical microdevice
US20050214442A1 (en) * 2001-11-27 2005-09-29 Anders Larsson Surface and its manufacture and uses
WO2003082730A1 (en) * 2002-03-31 2003-10-09 Gyros Ab Efficient mmicrofluidic devices
EP1492724A1 (en) * 2002-04-09 2005-01-05 Gyros AB Microfluidic devices with new inner surfaces
US6955738B2 (en) * 2002-04-09 2005-10-18 Gyros Ab Microfluidic devices with new inner surfaces
JP4009683B2 (en) * 2002-09-26 2007-11-21 アークレイ株式会社 Method for manufacturing analytical tool
JP4519124B2 (en) 2003-01-30 2010-08-04 ユィロス・パテント・アクチボラグ Wall inside the microfluidic device
US20060172085A1 (en) * 2003-03-12 2006-08-03 Toyo Seikan Kaisha, Ltd Method and apparatus for chemical plasma processing of plastic container
SE0300822D0 (en) * 2003-03-23 2003-03-23 Gyros Ab A collection of Micro Scale Devices
SE0300823D0 (en) 2003-03-23 2003-03-23 Gyros Ab Preloaded Microscale Devices
US8758974B2 (en) 2003-03-27 2014-06-24 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Photoresist-free micropatterning on polymer surfaces
JP2007502218A (en) 2003-05-23 2007-02-08 ユィロス・パテント・アクチボラグ Hydrophilic / hydrophobic surface
SE0400007D0 (en) * 2004-01-02 2004-01-02 Gyros Ab Large scale surface modifivation of microfluidic devices
JP2007524849A (en) * 2004-01-06 2007-08-30 ユィロス・パテント・アクチボラグ Contact heating arrangement
US20090010819A1 (en) * 2004-01-17 2009-01-08 Gyros Patent Ab Versatile flow path
SE0400181D0 (en) * 2004-01-29 2004-01-29 Gyros Ab Segmented porous and preloaded microscale devices
ATE385572T1 (en) 2004-03-05 2008-02-15 Egomedical Swiss Ag ANALYTE TEST SYSTEM FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A PHYSIOLOGICAL LIQUID
PT1776464E (en) 2004-08-13 2010-01-06 Egomedical Technologies Ag Analyte test system for determining the concentration of an analyte in a physiological or aqueous fluid
EP1843849A2 (en) * 2005-01-12 2007-10-17 Inverness Medical Switzerland GmbH A method of producing a microfluidic device and microfluidic devices
WO2006105622A1 (en) * 2005-04-04 2006-10-12 Universite De Liege Novel supports, in particular for immunodetection of molecules of interest
WO2006110095A1 (en) 2005-04-14 2006-10-19 Gyros Patent Ab A microfluidic device with finger valves
AU2005336058A1 (en) * 2005-08-31 2007-03-08 Egomedical Technologies Ag Coagulation test system
EP2237037A1 (en) 2005-12-12 2010-10-06 Gyros Patent Ab Microfluidic device and use thereof
US20070134739A1 (en) * 2005-12-12 2007-06-14 Gyros Patent Ab Microfluidic assays and microfluidic devices
US7651869B2 (en) 2006-03-14 2010-01-26 Research International, Inc. Optical assay apparatus and methods
JP2008031511A (en) * 2006-07-27 2008-02-14 Asahi Glass Co Ltd Method for producing hydrophilic oil-repellent article
US20080132598A1 (en) * 2006-12-04 2008-06-05 Electronics & Telecommunications Research Institute Surface modification of cycloolefin copolymer substrates
EP2101917A1 (en) 2007-01-10 2009-09-23 Scandinavian Micro Biodevices A/S A microfluidic device and a microfluidic system and a method of performing a test
SE0700424L (en) 2007-02-21 2008-05-20 Gyros Patent Ab Process for mixing aliquots in a microchannel structure
CN101579957A (en) * 2008-05-14 2009-11-18 拜耳材料科技贸易(上海)有限公司 Composite material as well as preparation method and application thereof
JP5723767B2 (en) * 2008-05-27 2015-05-27 エーオー テクノロジー アーゲー Surface modification of polymers
US20100056652A1 (en) * 2008-08-28 2010-03-04 General Electric Company Processes for forming hydrophilic membranes and porous membranes thereof
US20110294677A1 (en) * 2009-02-20 2011-12-01 Koninklijke Philips Electronics N.V. Microfluidic systems comprising a rubber material substrate
WO2010138486A1 (en) * 2009-05-29 2010-12-02 Corning Incorporated Substrates for adhering, culturing and assaying cells
EP2404867A1 (en) * 2010-07-09 2012-01-11 Trinean NV Method for preparing microfluidic devices
US9492952B2 (en) 2010-08-30 2016-11-15 Endo-Surgery, Inc. Super-hydrophilic structures
US20120143228A1 (en) 2010-08-30 2012-06-07 Agency For Science Technology And Research Adhesive structure with stiff protrusions on adhesive surface
US20120156433A1 (en) * 2010-12-21 2012-06-21 Natarajan Sriram N Silicone polymer substrates having improved biological response from hkdcs
US20120302465A1 (en) * 2011-05-26 2012-11-29 Agency For Science Technology And Research Polymeric structures for adsorbing biological material and their method of preparation
KR101528396B1 (en) 2011-07-01 2015-06-11 아반스트레이트 가부시키가이샤 Glass substrate for flat pannel display
JP6153945B2 (en) 2011-12-29 2017-06-28 エシコン・インコーポレイテッドＥｔｈｉｃｏｎ， Ｉｎｃｏｒｐｏｒａｔｅｄ Adhesive structure having tissue penetrating protrusions on the surface
US8969648B2 (en) 2012-04-06 2015-03-03 Ethicon, Inc. Blood clotting substrate and medical device
US8926881B2 (en) 2012-04-06 2015-01-06 DePuy Synthes Products, LLC Super-hydrophobic hierarchical structures, method of forming them and medical devices incorporating them
US9604209B2 (en) 2015-03-19 2017-03-28 International Business Machines Corporation Microfluidic device with anti-wetting, venting areas
KR20200060559A (en) * 2018-11-20 2020-06-01 세메스 주식회사 Bonding apparatus and bonding method
JP2022103121A (en) * 2020-12-25 2022-07-07 国立大学法人信州大学 Cell culture member and method for modifying surface thereof
CN218385464U (en) * 2022-10-24 2023-01-24 宁德时代新能源科技股份有限公司 Welding fixture

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2061969A (en) * 1979-10-23 1981-05-20 Shinetsu Chemical Co Method for preparing shaped articles of vinyl chloride resins with a hydrophilic surface
EP0106662A2 (en) * 1982-10-12 1984-04-25 Dynatech Laboratories, Incorporated Non-fluorescent vessels for holding test samples in fluorescent assays
EP0111795A2 (en) * 1982-12-03 1984-06-27 Shin-Etsu Chemical Co., Ltd. A method for increasing hydrophilicity of a fabric material of synthetic fibers
DE3712491A1 (en) * 1986-04-11 1987-10-15 Applied Membrane Tech Microfiltration membrane, process for the production thereof and use thereof
US4741619A (en) * 1987-05-05 1988-05-03 Molecular Devices Corporation Hydrophilic microplates for vertical beam photometry
EP0467639A2 (en) * 1990-07-17 1992-01-22 E.C. Chemical Co. Ltd. Atmospheric pressure plasma surface treatment process
US5399316A (en) * 1992-03-13 1995-03-21 Olympus Optical Co., Ltd. Reaction vessel for conducting an immunological assay
WO1997021090A1 (en) * 1995-12-05 1997-06-12 Gamera Bioscience Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
DE19739119A1 (en) * 1997-09-06 1999-03-11 Univ Schiller Jena Microtitration plate for wide application
WO1999058245A1 (en) * 1998-05-08 1999-11-18 Gyros Ab Microfluidic device
US6027695A (en) * 1998-04-01 2000-02-22 Dupont Pharmaceuticals Company Apparatus for holding small volumes of liquids

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1489470A (en) 1974-07-04 1977-10-19 Showa Denko Kk Norbornene polymers
JPS5930832A (en) 1982-08-13 1984-02-18 Shin Etsu Chem Co Ltd Molded fluororesin article having modified surface characteristic
JPS6091983A (en) * 1983-10-25 1985-05-23 Susumu Kogyo Kk Membrane carrier for immobilizing protein and its preparation
GB2238791A (en) 1989-12-06 1991-06-12 Shell Int Research Process for polymerizing oxanorbornenes and polymers obtainable by the process
SE470347B (en) 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Microstructure for fluid flow systems and process for manufacturing such a system
GB2244276A (en) * 1990-05-21 1991-11-27 Ici Plc Amorphous polyolefins
JPH0564579A (en) * 1991-09-06 1993-03-19 Sumitomo Bakelite Co Ltd Tool for culturing cell and method for processing its surface
JP2755880B2 (en) * 1992-09-11 1998-05-25 住友ベークライト株式会社 Culture device and method for producing the same
SE508435C2 (en) 1993-02-23 1998-10-05 Erik Stemme Diaphragm pump type pump
SE501380C2 (en) 1993-06-15 1995-01-30 Pharmacia Lkb Biotech Ways to manufacture microchannel / microcavity structures
SE9304145D0 (en) 1993-12-10 1993-12-10 Pharmacia Lkb Biotech Ways to manufacture cavity structures
SE9401327D0 (en) 1994-04-20 1994-04-20 Pharmacia Lkb Biotech Hydrophilization of hydrophobic polymer
US5700559A (en) 1994-12-16 1997-12-23 Advanced Surface Technology Durable hydrophilic surface coatings
EP0823054A1 (en) 1995-04-27 1998-02-11 Pharmacia Biotech AB Apparatus for continuously measuring physical and chemical parameters in a fluid flow
SE9502258D0 (en) 1995-06-21 1995-06-21 Pharmacia Biotech Ab Method for the manufacture of a membrane-containing microstructure
SE9502251D0 (en) 1995-06-21 1995-06-21 Pharmacia Ab Flow-through sampling cell and use thereof
US6143247A (en) * 1996-12-20 2000-11-07 Gamera Bioscience Inc. Affinity binding-based system for detecting particulates in a fluid
US6144447A (en) 1996-04-25 2000-11-07 Pharmacia Biotech Ab Apparatus for continuously measuring physical and chemical parameters in a fluid flow
SE9602638D0 (en) 1996-07-03 1996-07-03 Pharmacia Biotech Ab An improved method for the capillary electrophoresis of nucleic acids, proteins and low molecular charged compounds
WO1998002743A1 (en) 1996-07-15 1998-01-22 Sensors Technology Company B.V. Sensors
AT404099B (en) 1996-12-18 1998-08-25 Buchmeiser Michael Rudolf Mag POLYMER SEPARATING MATERIAL
DE19716606A1 (en) * 1997-04-21 1998-10-22 Huels Chemische Werke Ag Bacteria-repellent and blood-compatible modified surfaces
AU7709198A (en) 1997-06-02 1998-12-21 Aurora Biosciences Corporation Low background multi-well plates for fluorescence measurements of biological andbiochemical samples
JP3527830B2 (en) * 1997-06-13 2004-05-17 俊秀 原口 Bioreactor element, method for producing the element, and bioreactor using the element
AU1517999A (en) * 1997-10-15 1999-05-03 Aclara Biosciences, Inc. Laminate microstructure device and method for making same
GB9808836D0 (en) 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
US20040202579A1 (en) 1998-05-08 2004-10-14 Anders Larsson Microfluidic device
EP1358987A3 (en) 1998-10-14 2004-03-03 Gyros AB A replication matrix
WO2000032248A1 (en) * 1998-11-30 2000-06-08 The Regents Of The University Of California Plasma-assisted surface modification of polymers for medical device applications
SE9903011D0 (en) 1999-08-26 1999-08-26 Aamic Ab Methods of manufacturing a plastic product and a plastic product forming arrangement utilized for this purpose
US6653625B2 (en) 2001-03-19 2003-11-25 Gyros Ab Microfluidic system (MS)
US20040099310A1 (en) 2001-01-05 2004-05-27 Per Andersson Microfluidic device
US7429354B2 (en) 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
CA2442342A1 (en) 2001-03-19 2002-09-26 Gyros Ab A microfluidic system (edi)
US6717136B2 (en) 2001-03-19 2004-04-06 Gyros Ab Microfludic system (EDI)
US7759067B2 (en) 2001-03-19 2010-07-20 Gyros Patent Ab Method for determining the amount of an analyte with a disc-shaped microfluidic device
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
SE0104077D0 (en) 2001-10-21 2001-12-05 Gyros Ab A method and instrumentation for micro dispensation of droplets
US20030054563A1 (en) 2001-09-17 2003-03-20 Gyros Ab Detector arrangement for microfluidic devices
SE0103109D0 (en) 2001-09-17 2001-09-17 Gyros Microlabs Ab Detector arrangement with rotary drive in an instrument for analysis of microscale liquid sample volumes
US6728644B2 (en) 2001-09-17 2004-04-27 Gyros Ab Method editor
US7189368B2 (en) 2001-09-17 2007-03-13 Gyros Patent Ab Functional unit enabling controlled flow in a microfluidic device
US7238255B2 (en) 2001-12-31 2007-07-03 Gyros Patent Ab Microfluidic device and its manufacture
US7221783B2 (en) 2001-12-31 2007-05-22 Gyros Patent Ab Method and arrangement for reducing noise
WO2003082730A1 (en) 2002-03-31 2003-10-09 Gyros Ab Efficient mmicrofluidic devices
JP4338529B2 (en) 2002-04-08 2009-10-07 ユロス・パテント・アクチボラゲット Homing process
US6955738B2 (en) 2002-04-09 2005-10-18 Gyros Ab Microfluidic devices with new inner surfaces

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2061969A (en) * 1979-10-23 1981-05-20 Shinetsu Chemical Co Method for preparing shaped articles of vinyl chloride resins with a hydrophilic surface
EP0106662A2 (en) * 1982-10-12 1984-04-25 Dynatech Laboratories, Incorporated Non-fluorescent vessels for holding test samples in fluorescent assays
EP0111795A2 (en) * 1982-12-03 1984-06-27 Shin-Etsu Chemical Co., Ltd. A method for increasing hydrophilicity of a fabric material of synthetic fibers
DE3712491A1 (en) * 1986-04-11 1987-10-15 Applied Membrane Tech Microfiltration membrane, process for the production thereof and use thereof
US4741619A (en) * 1987-05-05 1988-05-03 Molecular Devices Corporation Hydrophilic microplates for vertical beam photometry
EP0467639A2 (en) * 1990-07-17 1992-01-22 E.C. Chemical Co. Ltd. Atmospheric pressure plasma surface treatment process
US5399316A (en) * 1992-03-13 1995-03-21 Olympus Optical Co., Ltd. Reaction vessel for conducting an immunological assay
WO1997021090A1 (en) * 1995-12-05 1997-06-12 Gamera Bioscience Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
DE19739119A1 (en) * 1997-09-06 1999-03-11 Univ Schiller Jena Microtitration plate for wide application
US6027695A (en) * 1998-04-01 2000-02-22 Dupont Pharmaceuticals Company Apparatus for holding small volumes of liquids
WO1999058245A1 (en) * 1998-05-08 1999-11-18 Gyros Ab Microfluidic device

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9993819B2 (en) 2014-12-30 2018-06-12 Stmicroelectronics S.R.L. Apparatus for actuating and reading a centrifugal microfluidic disk for biological and biochemical analyses, and use of the apparatus

Also Published As

Publication number Publication date
DE60003642T2 (en) 2004-05-13
US6967101B1 (en) 2005-11-22
ES2200861T3 (en) 2004-03-16
EP1163103A2 (en) 2001-12-19
ATE244130T1 (en) 2003-07-15
SE9901100D0 (en) 1999-03-24
EP1163103B1 (en) 2003-07-02
CA2367736A1 (en) 2000-09-28
EP1323475A3 (en) 2005-02-09
AU4110000A (en) 2000-10-09
JP2003526702A (en) 2003-09-09
WO2000056808A2 (en) 2000-09-28
JP5025043B2 (en) 2012-09-12
DK1163103T3 (en) 2003-10-20
EP1323475A2 (en) 2003-07-02
DE60003642D1 (en) 2003-08-07

Similar Documents

Publication Publication Date Title
WO2000056808A3 (en) Surface and its manufacture and uses
AU4646397A (en) Polymeric membranes and polymer articles having hydrophilic surface and method for their preparation
DE502004010170D1 (en) SPRÜPOLYMERISATIONSVERFAHREN
WO2002017801A3 (en) Systems and methods for treating vertebral bodies
CA2417421A1 (en) Water-soluble or water-swellable, associatively thickening copolymers containing sulfo groups, method for producing the same and use thereof
WO2002012402A3 (en) Colorant compounds containing copolymerizable vinyl groups
ATE501740T1 (en) ABSORBENT ARTICLE WITH A COATED WATER-Swollen MATERIAL
DE60023160T2 (en) PROCESS FOR PREPARING COMPOSITE POLYMERS
WO2002015865A3 (en) Skin cosmetic formulations
GR3036234T3 (en) Water-swelling polymers cross-linked with unsaturated amino alcohols, the production and use of same
JO2358B1 (en) Treatment of mineral materials
DK0991701T3 (en) Hydrophilic coatings and processes for their preparation
NO920303L (en) FLUORESCING COATING
ATE69823T1 (en) PROCESS FOR THE PRODUCTION OF WATER-SOLUBLE COPOLYMERISATS OF MALEIC ACID AND THEIR USE AS WATER TREATMENT AGENTS.
DE50105082D1 (en) NETWORKED WATER-SOURCE POLYMERISATE AND METHOD FOR THE PRODUCTION THEREOF
DE602005016291D1 (en) COMPOSITIONS OF OPTICAL LIGHTER
DE60025374D1 (en) DYNAMIC COATING
ATE259381T1 (en) METHOD FOR PRODUCING WATER-SOLUBLE OR WATER-SULLABLE POLYMERS WITH VERY LOW RESIDUAL MONOMER CONTENT, PRODUCTS PRODUCED THEREFROM AND THEIR USE
CA2501974A1 (en) Process for mixing treatment additives to contaminated liquids
DE59807763D1 (en) METHOD FOR PRODUCING CATIONIC POLYELECTROLYTE
GB2083052A (en) Preparation of water-soluble polymers having a low residual monomer content
KR950011651A (en) Water treatment polymer containing water treatment agent and manufacturing method of the polymer
ES2131610T3 (en) PROCEDURE FOR THE ELIMINATION OF ALUMINUM IONS FROM BEVERAGES.
WO1999022020A3 (en) Labelling of polymers and sequencing of nucleic acids
SE0300373D0 (en) Pressure polymerization process

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2000920571

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2367736

Country of ref document: CA

Ref country code: CA

Ref document number: 2367736

Kind code of ref document: A

Format of ref document f/p: F

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 606668

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 09937533

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2000920571

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 2000920571

Country of ref document: EP