WO2000061141A3 - Methods and compositions for enhancing delivery of therapeutic agents to tissues - Google Patents

Methods and compositions for enhancing delivery of therapeutic agents to tissues Download PDF

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Publication number
WO2000061141A3
WO2000061141A3 PCT/US2000/009329 US0009329W WO0061141A3 WO 2000061141 A3 WO2000061141 A3 WO 2000061141A3 US 0009329 W US0009329 W US 0009329W WO 0061141 A3 WO0061141 A3 WO 0061141A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissues
therapeutic agents
methods
compositions
interior
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/009329
Other languages
French (fr)
Other versions
WO2000061141A2 (en
Inventor
Jessie L-S Au
Guillaume Wientjes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU42142/00A priority Critical patent/AU777620B2/en
Priority to CA002369263A priority patent/CA2369263A1/en
Priority to JP2000610474A priority patent/JP2003524624A/en
Priority to EP00921881A priority patent/EP1171118A2/en
Publication of WO2000061141A2 publication Critical patent/WO2000061141A2/en
Publication of WO2000061141A3 publication Critical patent/WO2000061141A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention, at least in part, is directed to methods for enhancing delivery of therapeutic agents, such as macromolecules and drugs, into the interior of tissues, such as solid tissues or tumors. The method initially uses an apoptosis inducing agent, such as paclitaxel, in doses which create channels within the tissues, and enhance the penetration of therapeutic agents to the interior of the tissue. Current methods of treating tissues are often not effective because the therapeutic agents are not delivered to the interior of the tissue. By using the methods and the compositions of the current invention, therapeutic agents can be delivered to the interior of the tissue.
PCT/US2000/009329 1999-04-09 2000-04-07 Methods and compositions for enhancing delivery of therapeutic agents to tissues Ceased WO2000061141A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU42142/00A AU777620B2 (en) 1999-04-09 2000-04-07 Methods and compositions for enhancing delivery of therapeutic agents to tissues
CA002369263A CA2369263A1 (en) 1999-04-09 2000-04-07 Methods and compositions for enhancing delivery of therapeutic agents to tissues
JP2000610474A JP2003524624A (en) 1999-04-09 2000-04-07 Methods and compositions for enhancing delivery of therapeutic agents to tissues
EP00921881A EP1171118A2 (en) 1999-04-09 2000-04-07 Methods and compositions for enhancing delivery of therapeutic agents to tissues

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12867499P 1999-04-09 1999-04-09
US60/128,674 1999-04-09

Publications (2)

Publication Number Publication Date
WO2000061141A2 WO2000061141A2 (en) 2000-10-19
WO2000061141A3 true WO2000061141A3 (en) 2001-03-01

Family

ID=22436437

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/009329 Ceased WO2000061141A2 (en) 1999-04-09 2000-04-07 Methods and compositions for enhancing delivery of therapeutic agents to tissues

Country Status (5)

Country Link
EP (1) EP1171118A2 (en)
JP (1) JP2003524624A (en)
AU (1) AU777620B2 (en)
CA (1) CA2369263A1 (en)
WO (1) WO2000061141A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7850990B2 (en) 2001-10-03 2010-12-14 Celator Pharmaceuticals, Inc. Compositions for delivery of drug combinations
ES2272768T3 (en) * 2001-10-03 2007-05-01 Celator Pharmaceuticals Inc COMPOSITIONS FOR THE ADMINISTRATION OF COMBINATIONS OF PHARMACOS.
CA2383259A1 (en) 2002-04-23 2003-10-23 Celator Technologies Inc. Synergistic compositions
CA2469623C (en) 2001-12-12 2012-05-29 F H Faulding & Co Limited Composition for the preservation of viruses
JP2004277379A (en) * 2003-03-18 2004-10-07 Medicos Hirata:Kk Drug delivery system for inducing apoptosis
JP4927535B2 (en) * 2003-04-03 2012-05-09 ジェシー エル エス オウ Particles encapsulating drugs that target tumors
US8043631B2 (en) * 2004-04-02 2011-10-25 Au Jessie L S Tumor targeting drug-loaded particles
BRPI0502497A (en) * 2005-06-28 2007-02-06 Univ Minas Gerais use of protein-coupled receptor agonists and antagonists, but as modulators of apoptotic activity for the study, prevention and treatment of diseases
WO2009116556A1 (en) * 2008-03-19 2009-09-24 富士フイルム株式会社 Pharmaceutical composition for injection
KR101208587B1 (en) * 2009-06-24 2012-12-06 여오영 Anticancer composition for local injection comprising hydroxychloroquine
US9775819B2 (en) 2009-09-16 2017-10-03 R.P. Scherer Technologies, Llc Oral solid dosage form containing nanoparticles and process of formulating the same using fish gelatin
IN2012DN02576A (en) * 2009-09-21 2015-08-28 Jw Pharmaceutical Corportion

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710134A (en) * 1994-05-20 1998-01-20 Behringwerke Aktiengesellschaft Combination of necrosis-inducing substances with substances which are activated by necroses for the selective therapy of tumors and inflammatory disorders
WO1998032440A1 (en) * 1997-01-28 1998-07-30 The Procter & Gamble Company Kit for inhibiting the growth of cancers, comprising a chemotherapeutic agent and a benzimidazole, and optionally a potentiator
JPH11269065A (en) * 1998-03-19 1999-10-05 Microbial Chem Res Found Agent for overcoming apoptosis resistance of cancer cells
JPH11322602A (en) * 1998-05-13 1999-11-24 Kazuo Umezawa Inhibitor of transcription factor nfkappab activation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023014A1 (en) * 1992-05-20 1993-11-25 Martin Daniel S Chemotherapeutic drug combinations
DE69432867T2 (en) * 1993-11-18 2004-04-22 Sirtex Medical Ltd., Burswood PREPARATION WITH CONTROLLED RELEASE
WO1998043618A2 (en) * 1997-03-31 1998-10-08 Neorx Corporation Use of cytoskeletal inhibitors for the prevention of restenosis
JP2002505682A (en) * 1997-06-20 2002-02-19 ベーカー ノートン ファーマシューティカルズ インコーポレイテッド Soluble prodrug of paclitaxel

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710134A (en) * 1994-05-20 1998-01-20 Behringwerke Aktiengesellschaft Combination of necrosis-inducing substances with substances which are activated by necroses for the selective therapy of tumors and inflammatory disorders
WO1998032440A1 (en) * 1997-01-28 1998-07-30 The Procter & Gamble Company Kit for inhibiting the growth of cancers, comprising a chemotherapeutic agent and a benzimidazole, and optionally a potentiator
JPH11269065A (en) * 1998-03-19 1999-10-05 Microbial Chem Res Found Agent for overcoming apoptosis resistance of cancer cells
JPH11322602A (en) * 1998-05-13 1999-11-24 Kazuo Umezawa Inhibitor of transcription factor nfkappab activation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 200008, Derwent World Patents Index; Class B02, AN 2000-090993, XP002150249 *
PATENT ABSTRACTS OF JAPAN vol. 2000, no. 01 31 January 2000 (2000-01-31) *
See also references of EP1171118A2 *

Also Published As

Publication number Publication date
EP1171118A2 (en) 2002-01-16
WO2000061141A2 (en) 2000-10-19
AU4214200A (en) 2000-11-14
CA2369263A1 (en) 2000-10-19
AU777620B2 (en) 2004-10-21
JP2003524624A (en) 2003-08-19

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