WO2000063351A3 - Carbohydrate-modifying enzymes - Google Patents

Carbohydrate-modifying enzymes Download PDF

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Publication number
WO2000063351A3
WO2000063351A3 PCT/US2000/010882 US0010882W WO0063351A3 WO 2000063351 A3 WO2000063351 A3 WO 2000063351A3 US 0010882 W US0010882 W US 0010882W WO 0063351 A3 WO0063351 A3 WO 0063351A3
Authority
WO
WIPO (PCT)
Prior art keywords
cme
carbohydrate
modifying enzymes
provides
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/010882
Other languages
French (fr)
Other versions
WO2000063351A2 (en
Inventor
Preeti Lal
Henry Yue
Y Tom Tang
Jennifer L Hillman
Mariah R Baughn
Junming Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc filed Critical Incyte Genomics Inc
Priority to CA002369342A priority Critical patent/CA2369342A1/en
Priority to EP00923579A priority patent/EP1173552A2/en
Priority to JP2000612430A priority patent/JP2002541836A/en
Priority to AU43679/00A priority patent/AU4367900A/en
Publication of WO2000063351A2 publication Critical patent/WO2000063351A2/en
Publication of WO2000063351A3 publication Critical patent/WO2000063351A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01113—Mannosyl-oligosaccharide 1,2-alpha-mannosidase (3.2.1.113), i.e. alpha-1,2-mannosidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01017—Glucuronosyltransferase (2.4.1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07043—N-Acylneuraminate cytidylyltransferase (2.7.7.43)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01021—Beta-glucosidase (3.2.1.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The invention provides human carbohydrate-modifying enzymes (CME) and polynucleotides which identify and encode CME. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of CME.
PCT/US2000/010882 1999-04-21 2000-04-20 Carbohydrate-modifying enzymes Ceased WO2000063351A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002369342A CA2369342A1 (en) 1999-04-21 2000-04-20 Carbohydrate-modifying enzymes
EP00923579A EP1173552A2 (en) 1999-04-21 2000-04-20 Carbohydrate-modifying enzymes
JP2000612430A JP2002541836A (en) 1999-04-21 2000-04-20 Carbohydrate modifying enzymes
AU43679/00A AU4367900A (en) 1999-04-21 2000-04-20 Carbohydrate-modifying enzymes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13038399P 1999-04-21 1999-04-21
US60/130,383 1999-04-21

Publications (2)

Publication Number Publication Date
WO2000063351A2 WO2000063351A2 (en) 2000-10-26
WO2000063351A3 true WO2000063351A3 (en) 2001-08-09

Family

ID=22444456

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/010882 Ceased WO2000063351A2 (en) 1999-04-21 2000-04-20 Carbohydrate-modifying enzymes

Country Status (5)

Country Link
EP (1) EP1173552A2 (en)
JP (1) JP2002541836A (en)
AU (1) AU4367900A (en)
CA (1) CA2369342A1 (en)
WO (1) WO2000063351A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6987014B2 (en) * 2000-08-30 2006-01-17 Applera Corporation Isolated nucleic acid molecules encoding human drug metabolizing proteins
EP1366162A2 (en) * 2000-12-06 2003-12-03 Curagen Corporation Putative proteins and nucleic acids encoding same
WO2002061059A2 (en) * 2000-12-20 2002-08-08 Incyte Genomics, Inc. Carbohydrate metabolism enzymes
US7033790B2 (en) 2001-04-03 2006-04-25 Curagen Corporation Proteins and nucleic acids encoding same

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007573A1 (en) * 1988-12-23 1990-07-12 Genzyme Corporation Enzymatically active recombinant glucocerebrosidase
WO1994014472A1 (en) * 1992-12-22 1994-07-07 The Regents Of The University Of California Method for inhibition of cell adhesion to receptors containing selectins
WO1994023070A1 (en) * 1993-03-26 1994-10-13 New York Blood Center, Inc. RECOMBINANT α-N-ACETYLGALACTOSAMINIDASE ENZYME AND cDNA ENCODING SAID ENZYME
WO1994025061A1 (en) * 1993-04-23 1994-11-10 Glyko, Inc. Methods and compositions for treating diseases with carbohydrate modifying enzymes
EP0737745A1 (en) * 1993-12-24 1996-10-16 The Institute Of Physical & Chemical Research Novel sugar-chain synthetase and process for producing the same
EP0893506A1 (en) * 1996-04-05 1999-01-27 Seikagaku Corporation Polypeptide of human-origin hyaluronate synthetase and dna encoding the same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007573A1 (en) * 1988-12-23 1990-07-12 Genzyme Corporation Enzymatically active recombinant glucocerebrosidase
WO1994014472A1 (en) * 1992-12-22 1994-07-07 The Regents Of The University Of California Method for inhibition of cell adhesion to receptors containing selectins
WO1994023070A1 (en) * 1993-03-26 1994-10-13 New York Blood Center, Inc. RECOMBINANT α-N-ACETYLGALACTOSAMINIDASE ENZYME AND cDNA ENCODING SAID ENZYME
WO1994025061A1 (en) * 1993-04-23 1994-11-10 Glyko, Inc. Methods and compositions for treating diseases with carbohydrate modifying enzymes
EP0737745A1 (en) * 1993-12-24 1996-10-16 The Institute Of Physical & Chemical Research Novel sugar-chain synthetase and process for producing the same
EP0893506A1 (en) * 1996-04-05 1999-01-27 Seikagaku Corporation Polypeptide of human-origin hyaluronate synthetase and dna encoding the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MÜNSTER ANJA-K ET AL: "Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: A nuclear protein with evolutionarily conserved structural motifs.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 95, no. 16, 4 August 1998 (1998-08-04), pages 9140 - 9145, XP002153786, ISSN: 0027-8424 *
NEHES V L ET AL: "HUMAN LYSOSOMAL ALPHA-MANNOSIDASE: ISOLATION AND NUCLEOTIDE SEQUENCE OF THE FULL-LENGTH CDNA1", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,US,ACADEMIC PRESS INC. ORLANDO, FL, vol. 200, no. 1, 15 April 1994 (1994-04-15), pages 239 - 245, XP000647751, ISSN: 0006-291X *

Also Published As

Publication number Publication date
WO2000063351A2 (en) 2000-10-26
EP1173552A2 (en) 2002-01-23
AU4367900A (en) 2000-11-02
CA2369342A1 (en) 2000-10-26
JP2002541836A (en) 2002-12-10

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