WO2000063403A3 - Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein - Google Patents
Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein Download PDFInfo
- Publication number
- WO2000063403A3 WO2000063403A3 PCT/NL2000/000247 NL0000247W WO0063403A3 WO 2000063403 A3 WO2000063403 A3 WO 2000063403A3 NL 0000247 W NL0000247 W NL 0000247W WO 0063403 A3 WO0063403 A3 WO 0063403A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- protein
- sequences encoding
- human cell
- human
- encoding adenovirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MXPA01010360A MXPA01010360A (en) | 1999-04-15 | 2000-04-17 | Recombinant protein production in a human cell. |
| DE60018171T DE60018171T3 (en) | 1999-04-15 | 2000-04-17 | USE OF ADENOVIRUS E1 PROTEIN ENCODING SEQUENCES FOR THE PREPARATION OF RECOMBINANT PROTEINS IN HUMAN CELLS. |
| NZ514951A NZ514951A (en) | 1999-04-15 | 2000-04-17 | Recombinant protein production in a cultured human cell |
| AT00921175T ATE289354T1 (en) | 1999-04-15 | 2000-04-17 | USE OF ADENOVIRUS E1 PROTEIN ENCODING SEQUENCES TO PRODUCE RECOMBINANT PROTEINS IN HUMAN CELLS. |
| SI200030662T SI1161548T2 (en) | 1999-04-15 | 2000-04-17 | Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein |
| AU41520/00A AU772352B2 (en) | 1999-04-15 | 2000-04-17 | Recombinant protein production in a human cell |
| DK00921175.6T DK1161548T4 (en) | 1999-04-15 | 2000-04-17 | Recombinant protein production in a human cell using sequences encoding adenovirus E1 protein |
| PT00921175T PT1161548E (en) | 1999-04-15 | 2000-04-17 | PRODUCTION OF RECOMBINANT PROTEINS IN A HUMAN CELL USING SEQUENCES BY CODING ADENOVIRUS E1 PROTEIN |
| CA2370477A CA2370477C (en) | 1999-04-15 | 2000-04-17 | Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein |
| HK03100323.5A HK1048138B (en) | 1999-04-15 | 2000-04-17 | Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein |
| JP2000612481A JP4210036B2 (en) | 1999-04-15 | 2000-04-17 | Production of recombinant proteins in human cells |
| EP00921175A EP1161548B2 (en) | 1999-04-15 | 2000-04-17 | Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein |
| IL14584900A IL145849A0 (en) | 1999-04-15 | 2000-04-17 | Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein |
| IL145849A IL145849A (en) | 1999-04-15 | 2001-10-10 | Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein |
| NO20014977A NO328951B1 (en) | 1999-04-15 | 2001-10-12 | Method of Recombinant Production of Proteins in a Human Cell |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99201176 | 1999-04-15 | ||
| EP99201176.7 | 1999-04-15 | ||
| EP99204434.7 | 1999-12-21 | ||
| EP99204434 | 1999-12-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2000063403A2 WO2000063403A2 (en) | 2000-10-26 |
| WO2000063403A3 true WO2000063403A3 (en) | 2001-02-15 |
Family
ID=26153302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/NL2000/000247 Ceased WO2000063403A2 (en) | 1999-04-15 | 2000-04-17 | Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein |
Country Status (18)
| Country | Link |
|---|---|
| EP (3) | EP1533380B1 (en) |
| JP (1) | JP4210036B2 (en) |
| CN (1) | CN100457914C (en) |
| AT (3) | ATE536417T1 (en) |
| AU (1) | AU772352B2 (en) |
| CA (1) | CA2370477C (en) |
| CY (1) | CY1109759T1 (en) |
| DE (2) | DE60018171T3 (en) |
| DK (3) | DK1161548T4 (en) |
| ES (3) | ES2378272T3 (en) |
| HK (1) | HK1048138B (en) |
| IL (2) | IL145849A0 (en) |
| MX (1) | MXPA01010360A (en) |
| NO (1) | NO328951B1 (en) |
| NZ (1) | NZ514951A (en) |
| PT (2) | PT1161548E (en) |
| SI (2) | SI1161548T2 (en) |
| WO (1) | WO2000063403A2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8871216B2 (en) | 2005-04-06 | 2014-10-28 | Ibc Pharmaceuticals, Inc. | Multiple signaling pathways induced by hexvalent, monospecific and bispecific antibodies for enhanced toxicity to B-cell lymphomas and other diseases |
| US8906378B2 (en) | 2005-04-06 | 2014-12-09 | Ibc Pharmaceuticals, Inc. | Combination therapy with anti-CD74 antibodies provides enhanced toxicity to malignancies, autoimmune disease and other diseases |
| WO2024043227A1 (en) | 2022-08-23 | 2024-02-29 | 小野薬品工業株式会社 | Bispecific antibody |
Families Citing this family (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6855544B1 (en) | 1999-04-15 | 2005-02-15 | Crucell Holland B.V. | Recombinant protein production in a human cell |
| US7297680B2 (en) | 1999-04-15 | 2007-11-20 | Crucell Holland B.V. | Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content |
| WO2003048197A1 (en) * | 2001-12-07 | 2003-06-12 | Crucell Holland B.V. | Production and of viruses, viral isolates and vaccines |
| US8236561B2 (en) | 1999-04-15 | 2012-08-07 | Crucell Holland B.V. | Efficient production of IgA in recombinant mammalian cells |
| US7604960B2 (en) | 1999-04-15 | 2009-10-20 | Crucell Holland B.V. | Transient protein expression methods |
| US7425437B2 (en) * | 1999-11-26 | 2008-09-16 | Crucell Holland B.V. | Vaccines against West Nile Virus |
| US7192759B1 (en) | 1999-11-26 | 2007-03-20 | Crucell Holland B.V. | Production of vaccines |
| US7521220B2 (en) | 1999-11-26 | 2009-04-21 | Crucell Holland B.V. | Production of vaccines |
| US7527961B2 (en) | 1999-11-26 | 2009-05-05 | Crucell Holland B.V. | Production of vaccines |
| EP1256803A1 (en) | 2001-05-07 | 2002-11-13 | Crucell Holland B.V. | Methods for the identification of antiviral compounds |
| AU2002224199A1 (en) * | 2001-10-29 | 2003-06-23 | Crucell Holland B.V. | Methods and means for producing proteins with predetermined post-translational modifications |
| EA008220B1 (en) | 2001-10-29 | 2007-04-27 | Круселл Холланд Б.В. | Composition containing erythropoitin-like molecules and method of their use |
| ATE384785T1 (en) * | 2001-12-07 | 2008-02-15 | Crucell Holland Bv | PRODUCTION OF VIRUSES, VIRUS ISOLATES, AND VACCINES |
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| KR101017732B1 (en) | 2002-03-01 | 2011-02-28 | 이뮤노메딕스, 인코오포레이티드 | Internalized anti-CD74 antibodies and methods of using the same |
| AU2002307635A1 (en) * | 2002-04-19 | 2003-11-03 | Crucell Holland B.V. | Methods and means for producing proteins with predetermined post-translational modifications |
| ES2524767T3 (en) | 2002-06-14 | 2014-12-12 | Immunomedics, Inc. | HPAM4 humanized monoclonal antibody |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| NZ537277A (en) | 2002-07-18 | 2008-04-30 | Crucell Holland Bv | Recombinant production of mixtures of antibodies |
| KR101115797B1 (en) | 2002-08-01 | 2012-07-27 | 이뮤노메딕스, 인코오포레이티드 | Alpha-fetoprotein Immu31 antibodies and fusion proteins and methods of use thereof |
| US7541440B2 (en) | 2002-09-30 | 2009-06-02 | Immunomedics, Inc. | Chimeric, human and humanized anti-granulocyte antibodies and methods of use |
| US8524477B2 (en) | 2002-10-29 | 2013-09-03 | Crucell Holland B.V. | Methods to obtain recombinant proteins with increased sialylation from cells that express adenovirus E1A protein, and proteins obtained thereby |
| US7534427B2 (en) | 2002-12-31 | 2009-05-19 | Immunomedics, Inc. | Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins |
| NZ542585A (en) | 2003-05-09 | 2007-11-30 | Crucell Holland Bv | Cultures of PER.C6-immortalized cells and processes for culturing the same to increase product yields therefrom |
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| US8871216B2 (en) | 2005-04-06 | 2014-10-28 | Ibc Pharmaceuticals, Inc. | Multiple signaling pathways induced by hexvalent, monospecific and bispecific antibodies for enhanced toxicity to B-cell lymphomas and other diseases |
| US8906378B2 (en) | 2005-04-06 | 2014-12-09 | Ibc Pharmaceuticals, Inc. | Combination therapy with anti-CD74 antibodies provides enhanced toxicity to malignancies, autoimmune disease and other diseases |
| US9359443B2 (en) | 2005-04-06 | 2016-06-07 | Ibc Pharmaceuticals, Inc. | Combination therapy with anti-CD74 and anti-CD20 antibodies provides enhanced toxicity to B-cell diseases |
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