WO2000064921A3 - Process of purifying phytosterols from wood or plant-derived sources by means of metal salt complexes and compositions resulting therefrom - Google Patents

Process of purifying phytosterols from wood or plant-derived sources by means of metal salt complexes and compositions resulting therefrom Download PDF

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Publication number
WO2000064921A3
WO2000064921A3 PCT/CA2000/000455 CA0000455W WO0064921A3 WO 2000064921 A3 WO2000064921 A3 WO 2000064921A3 CA 0000455 W CA0000455 W CA 0000455W WO 0064921 A3 WO0064921 A3 WO 0064921A3
Authority
WO
WIPO (PCT)
Prior art keywords
metal salt
phytosterols
wood
plant
resulting therefrom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2000/000455
Other languages
French (fr)
Other versions
WO2000064921A2 (en
Inventor
James L Coss
James P Kutney
Radka K Milanova
Paul Jollez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forbes Medi-Tech Inc
Original Assignee
Forbes Medi-Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK00922365T priority Critical patent/DK1173464T3/en
Application filed by Forbes Medi-Tech Inc filed Critical Forbes Medi-Tech Inc
Priority to SI200031006T priority patent/SI1173464T1/en
Priority to CA 2372154 priority patent/CA2372154A1/en
Priority to JP2000614270A priority patent/JP2002543088A/en
Priority to AU42794/00A priority patent/AU4279400A/en
Priority to EP20000922365 priority patent/EP1173464B1/en
Priority to DE60039232T priority patent/DE60039232D1/en
Priority to BR0010062A priority patent/BR0010062A/en
Publication of WO2000064921A2 publication Critical patent/WO2000064921A2/en
Publication of WO2000064921A3 publication Critical patent/WO2000064921A3/en
Anticipated expiration legal-status Critical
Priority to CY20081100754T priority patent/CY1110390T1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B13/00—Recovery of fats, fatty oils or fatty acids from waste materials
    • C11B13/02—Recovery of fats, fatty oils or fatty acids from waste materials from soap stock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B13/00—Recovery of fats, fatty oils or fatty acids from waste materials
    • C11B13/005—Recovery of fats, fatty oils or fatty acids from waste materials of residues of the fabrication of wood-cellulose (in particular tall-oil)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
    • Y02W30/00—Technologies for solid waste management
    • Y02W30/50—Reuse, recycling or recovery technologies
    • Y02W30/74—Recovery of fats, fatty oils, fatty acids or other fatty substances, e.g. lanolin or waxes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A universal process for purifying phytosterols from a wood or plant derived source comprises extracting from the source a concentrated extract comprising phytosterols and a hydrocarbon; complexing the extract so formed with a metal salt; separating the phytosterol/metal salt complex from the hydrocarbon; washing the complex with a solvent mixture comprising one or both of a hydrocarbon and a ketone; hydrolysing the washed complex so formed and finally separating the phytosterols therefrom. A novel composition comprises beta-sitosterol, campesterol, campestanol, sitostanol and optionally brassicasterol and brassicastanol.
PCT/CA2000/000455 1999-04-27 2000-04-27 Process of purifying phytosterols from wood or plant-derived sources by means of metal salt complexes and compositions resulting therefrom Ceased WO2000064921A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
BR0010062A BR0010062A (en) 1999-04-27 2000-04-27 Purification process of phytosterols from sources derived from plant or wood and compositions resulting from this
SI200031006T SI1173464T1 (en) 1999-04-27 2000-04-27 Process for preparing a phytosterol composition
CA 2372154 CA2372154A1 (en) 1999-04-27 2000-04-27 Process of purifying phytosterols from wood or plant-derived sources and compositions resulting therefrom
JP2000614270A JP2002543088A (en) 1999-04-27 2000-04-27 Process for purifying phytosterols from wood or plant-derived sources and compositions resulting therefrom
AU42794/00A AU4279400A (en) 1999-04-27 2000-04-27 Process of purifying phytosterols from wood or plant-derived sources and compositions resulting therefrom
DK00922365T DK1173464T3 (en) 1999-04-27 2000-04-27 Process for Preparing a Phytosterol Composition
DE60039232T DE60039232D1 (en) 1999-04-27 2000-04-27 Process for the preparation of a phytosterol composition
EP20000922365 EP1173464B1 (en) 1999-04-27 2000-04-27 Process for preparing a phytosterol composition
CY20081100754T CY1110390T1 (en) 1999-04-27 2008-07-21 METHOD FOR THE PREPARATION OF A COMPOSITION OF PHYTOSTEROLS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30013599A 1999-04-27 1999-04-27
US09/300,135 1999-04-27

Publications (2)

Publication Number Publication Date
WO2000064921A2 WO2000064921A2 (en) 2000-11-02
WO2000064921A3 true WO2000064921A3 (en) 2001-07-12

Family

ID=23157859

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/000455 Ceased WO2000064921A2 (en) 1999-04-27 2000-04-27 Process of purifying phytosterols from wood or plant-derived sources by means of metal salt complexes and compositions resulting therefrom

Country Status (13)

Country Link
EP (1) EP1173464B1 (en)
JP (1) JP2002543088A (en)
AT (1) ATE398629T1 (en)
AU (1) AU4279400A (en)
BR (1) BR0010062A (en)
CA (1) CA2372154A1 (en)
CY (1) CY1110390T1 (en)
DE (1) DE60039232D1 (en)
DK (1) DK1173464T3 (en)
ES (1) ES2308979T3 (en)
PT (1) PT1173464E (en)
SI (1) SI1173464T1 (en)
WO (1) WO2000064921A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1250350T3 (en) * 2000-01-21 2006-08-21 Forbes Medi Tech Inc New crystalline composites comprising phytosterols and phytostanols or derivatives thereof
JP4707862B2 (en) * 2001-04-16 2011-06-22 花王株式会社 Production of plant sterols
EP1648238A1 (en) * 2003-07-29 2006-04-26 Unilever N.V. Food product comprising phytosterols
EP1568760A1 (en) * 2004-02-06 2005-08-31 Härting Glade, Thomas Francis Process for refinig a raw material comprising black liquor soap, crude tall oil or tall oil pitch
JP6057313B2 (en) 2008-03-10 2017-01-11 サンパイン アーベーＳｕｎｐｉｎｅ Ａｂ Regeneration of plant sterols from residual vegetable oil streams
JP5378001B2 (en) * 2009-02-17 2013-12-25 花王株式会社 Method for purifying fatty acid alkyl ester
JP5412301B2 (en) * 2009-02-17 2014-02-12 花王株式会社 Vegetable oil refining and manufacturing method
US10383886B2 (en) 2010-01-11 2019-08-20 Phoenix Biotechnology, Inc. Method of treating neurological conditions with oleandrin
US10307450B2 (en) 2010-01-11 2019-06-04 Phoenix Biotechnology, Inc. Method of treating neurological conditions with extract of Nerium species or Thevetia species
US9011937B2 (en) 2010-11-22 2015-04-21 Phoenix Biotechnology, Inc. Method of treating neurological conditions with extract of Nerium species or Thevetia species
US8039025B1 (en) 2010-10-15 2011-10-18 Life Plus, LLC Methods and dosage forms for the treatment of human cancers
US10596186B2 (en) 2016-09-14 2020-03-24 Phoenix Biotechnology, Inc. Method and compositions for treating viral infections
US10702567B2 (en) 2016-09-14 2020-07-07 Phoenix Biotechnology, Inc. Method and compositions for treating viral infection
US10729735B1 (en) 2016-09-14 2020-08-04 Phoenix Biotechnology, Inc. Method and compostitions for treating coronavirus infection
EP3625241A4 (en) 2017-09-14 2020-10-21 Fermenta Biotech Limited SOLVENT-FREE PROCESS FOR THE EXTRACTION OF CHOLESTEROL FROM MILK FAT
JP7370966B2 (en) 2017-09-14 2023-10-30 フェニックス・バイオテクノロジー・インコーポレイテッド Methods and improved neuroprotective compositions for treating neurological conditions
US11331291B2 (en) 2017-09-14 2022-05-17 Phoenix Biotechnology, Inc. Method of and improved composition for treating triterpene-responsive conditions, diseases or disorders
US20220340615A1 (en) * 2019-09-27 2022-10-27 Basf Se Process for the purification of phytosterol
US11806359B2 (en) 2020-03-31 2023-11-07 Phoenix Biotechnology, Inc. Method and compositions for treating Coronavirus infection

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE827199C (en) * 1948-02-09 1952-01-07 Konink Veenendaalsche Sajeten Process for the production of sterols
GB1164769A (en) * 1967-05-11 1969-09-24 Konink Veenendaalsche Sajet En A Process for extracting Sterols
US4148810A (en) * 1976-12-11 1979-04-10 Henkel Kommanditgesellschaft Auf Aktien Process for isolating sterols from fat processing residues
US4425275A (en) * 1982-07-12 1984-01-10 Eastman Kodak Company Process for separating 3-hydroxy steroids or sterols from mixtures such as lipids
WO1996010033A1 (en) * 1994-09-29 1996-04-04 The University Of British Columbia Sterol compositions from pulping soap

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3840570A (en) * 1970-12-07 1974-10-08 Procter & Gamble Process for preparing sterols from tall oil pitch
US4044031A (en) * 1976-07-02 1977-08-23 Ake Allan Johansson Process for the separation of sterols

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE827199C (en) * 1948-02-09 1952-01-07 Konink Veenendaalsche Sajeten Process for the production of sterols
GB1164769A (en) * 1967-05-11 1969-09-24 Konink Veenendaalsche Sajet En A Process for extracting Sterols
US4148810A (en) * 1976-12-11 1979-04-10 Henkel Kommanditgesellschaft Auf Aktien Process for isolating sterols from fat processing residues
US4425275A (en) * 1982-07-12 1984-01-10 Eastman Kodak Company Process for separating 3-hydroxy steroids or sterols from mixtures such as lipids
WO1996010033A1 (en) * 1994-09-29 1996-04-04 The University Of British Columbia Sterol compositions from pulping soap

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
(JUNE 28-29, 1989) PP. 242-256. [CZECH]. MEETING INFO.: INTERPROGRESS '89 CONF. (ZILINA, CZECHOSL.) PROC.. *
DATABASE PAPERCHEM2 [online] Institute of Paper Science and Technology (IPST); SEIFERT, R. ET AL: "Obtaining Phytosterols from Sulfate Soap", XP002147628, retrieved from STN Database accession no. 93:4902 *
STRUVE, A. ET AL: "Production of sterols from residues of fat cleavage", FETTE, SEIFEN, ANSTRICHM. (1985), 87(3), 103-6, XP002147627 *

Also Published As

Publication number Publication date
DK1173464T3 (en) 2008-10-06
CA2372154A1 (en) 2000-11-02
ES2308979T3 (en) 2008-12-16
ATE398629T1 (en) 2008-07-15
EP1173464A2 (en) 2002-01-23
DE60039232D1 (en) 2008-07-31
BR0010062A (en) 2002-05-21
SI1173464T1 (en) 2009-02-28
AU4279400A (en) 2000-11-10
PT1173464E (en) 2008-08-05
EP1173464B1 (en) 2008-06-18
CY1110390T1 (en) 2012-05-23
WO2000064921A2 (en) 2000-11-02
JP2002543088A (en) 2002-12-17

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