WO2000071096A3 - Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases - Google Patents

Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases Download PDF

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Publication number
WO2000071096A3
WO2000071096A3 PCT/US2000/014350 US0014350W WO0071096A3 WO 2000071096 A3 WO2000071096 A3 WO 2000071096A3 US 0014350 W US0014350 W US 0014350W WO 0071096 A3 WO0071096 A3 WO 0071096A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
transfer
treatment
gene therapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/014350
Other languages
French (fr)
Other versions
WO2000071096A2 (en
Inventor
Rajagopal Ramesh
Jack A Roth
Tomoyuki Saeki
Deborah Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Introgen Therapeutics Inc
University of Texas System
University of Texas at Austin
Original Assignee
Introgen Therapeutics Inc
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Introgen Therapeutics Inc, University of Texas System, University of Texas at Austin filed Critical Introgen Therapeutics Inc
Priority to DE60030970T priority Critical patent/DE60030970T2/en
Priority to AU51618/00A priority patent/AU5161800A/en
Priority to EP00936279A priority patent/EP1180016B1/en
Priority to CA2371922A priority patent/CA2371922C/en
Publication of WO2000071096A2 publication Critical patent/WO2000071096A2/en
Publication of WO2000071096A3 publication Critical patent/WO2000071096A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention relates to non-viral gene therapy methods and compositions for treatment of hyperproliferative disease in humans. More specifically, the invention is directed, in one embodiment, to lipid formulations which form stable liposome structures, capable of efficient in vivo nucleic acid transfer. In other embodiments, methods and compositions are directed to liposome transfer of anti-proliferative nucleic acids, wherein the transfer of the nucleic acids is cell specific via cell specific targeting moieties. The present invention, thus provides non-viral, liposome compositions and methods of gene transfer particularly useful for targeting and treating hyperproliferative disease.
PCT/US2000/014350 1999-05-24 2000-05-24 Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases Ceased WO2000071096A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE60030970T DE60030970T2 (en) 1999-05-24 2000-05-24 METHOD AND COMPOSITIONS FOR NONVIRAL GENE THERAPY FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES
AU51618/00A AU5161800A (en) 1999-05-24 2000-05-24 Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases
EP00936279A EP1180016B1 (en) 1999-05-24 2000-05-24 Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases
CA2371922A CA2371922C (en) 1999-05-24 2000-05-24 Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13581899P 1999-05-24 1999-05-24
US60/135,818 1999-05-24

Publications (2)

Publication Number Publication Date
WO2000071096A2 WO2000071096A2 (en) 2000-11-30
WO2000071096A3 true WO2000071096A3 (en) 2001-05-03

Family

ID=22469835

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/014350 Ceased WO2000071096A2 (en) 1999-05-24 2000-05-24 Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases

Country Status (7)

Country Link
EP (1) EP1180016B1 (en)
AT (1) ATE340560T1 (en)
AU (1) AU5161800A (en)
CA (1) CA2371922C (en)
DE (1) DE60030970T2 (en)
ES (1) ES2273699T3 (en)
WO (1) WO2000071096A2 (en)

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EP1854488A1 (en) * 1999-07-15 2007-11-14 Introgen Therapeutics, Inc. Methods for treatment of hyperproliferative diseases using human MDA-7
US20080038274A1 (en) * 1999-09-23 2008-02-14 Foster Keith A Inhibition of secretion from non-neuronal cells
WO2002045737A2 (en) * 2000-12-07 2002-06-13 Board Of Regents, The University Of Texas System Methods of treatment involving human mda-7
US6656732B1 (en) 2001-05-18 2003-12-02 Isis Pharmaceuticals, Inc. Antisense inhibition of src-c expression
WO2003097805A2 (en) 2002-05-15 2003-11-27 California Pacific Medical Center Delivery of nucleic acid-like compounds
WO2005082396A2 (en) 2003-12-01 2005-09-09 Introgen Therapeutics, Inc. Use of mda-7 to inhibit infection by pathogenic organisms
CN1318591C (en) * 2004-07-08 2007-05-30 杨安钢 Immune tbid gene and its coded protein and application
EP2302055B1 (en) 2004-11-12 2014-08-27 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
AU2007281261B2 (en) 2006-08-01 2013-03-21 Board Of Regents Of The University Of Texas System Identification of a micro-RNA that activates expression of beta-myosin heavy chain
DK2118123T3 (en) 2007-01-31 2016-01-25 Dana Farber Cancer Inst Inc Stabilized p53 peptides and uses thereof
US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
WO2009003211A1 (en) * 2007-06-29 2009-01-08 Newsouth Innovations Pty Limited Treatment of rheumatoid arthritis
CN111808084A (en) 2008-11-10 2020-10-23 阿布特斯生物制药公司 Novel lipids and compositions for delivery of therapeutic agents
WO2010120814A1 (en) 2009-04-14 2010-10-21 Prometheus Laboratories Inc. Inflammatory bowel disease prognostics
WO2011060098A1 (en) 2009-11-10 2011-05-19 Prometheus Laboratories Inc. Methods for predicting post-surgery risk associated with ileal pouch-anal anastomosis
EP2542678B1 (en) 2010-03-04 2017-04-12 InteRNA Technologies B.V. A MiRNA MOLECULE DEFINED BY ITS SOURCE AND ITS THERAPEUTIC USES IN CANCER ASSOCIATED WITH EMT
EP2591106A1 (en) 2010-07-06 2013-05-15 InteRNA Technologies B.V. Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
ES2711526T3 (en) 2010-08-13 2019-05-06 Aileron Therapeutics Inc Peptidomimetic macrocycles
EP2474617A1 (en) 2011-01-11 2012-07-11 InteRNA Technologies BV Mir for treating neo-angiogenesis
TW201806968A (en) 2011-10-18 2018-03-01 艾利倫治療公司 Peptidomimetic macrocycles
JP2015502740A (en) 2011-10-21 2015-01-29 ネステク ソシエテ アノニム Methods for improving the diagnosis of inflammatory bowel disease
EP3369818B1 (en) 2011-12-22 2021-06-09 InteRNA Technologies B.V. Mirna for treating head and neck cancer
BR112014020103A2 (en) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. peptidomimetic macrocycles
EP2819688A4 (en) 2012-02-15 2015-10-28 Aileron Therapeutics Inc PEPTIDOMIMETIC MACROCYCLES CROSS-LINKED WITH TRIAZOLE AND THIOETHER
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
EP2917348A1 (en) 2012-11-06 2015-09-16 InteRNA Technologies B.V. Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated b-raf pathway
EP2935627A4 (en) 2012-12-21 2016-09-28 Univ Columbia BIOMARKERS FOR CHRONIC TRAUMATIC ENCEPHALOPATHY
US9758835B2 (en) 2013-03-15 2017-09-12 Baylor Research Institute Ulcerative colitis (UC)-associated colorectal neoplasia markers
CA2930693A1 (en) 2013-11-15 2015-05-21 The Board Of Trustees Of The Leland Stanford Junior Unversity Methods of treating heart failure with agonists of hypocretin receptor 2
US10772974B2 (en) 2013-11-18 2020-09-15 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for cardiac regeneration
CN105316380B (en) * 2014-06-20 2021-03-09 浙江海洋学院 Application of mud snail polypeptide in resisting lung cancer
EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
AU2015320545C1 (en) 2014-09-24 2020-05-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
GB201503967D0 (en) 2015-03-09 2015-04-22 Univ Glasgow Biocompatible implants for use in tendon therapy
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2017044633A1 (en) 2015-09-10 2017-03-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of mcl-1
WO2017096326A1 (en) 2015-12-02 2017-06-08 Massachusetts Institute Of Technology Method for efficient generation of neurons from non-neuronal cells
EP3609519B1 (en) 2017-04-11 2025-11-26 University of Maryland, Baltimore Compositions and methods for treating inflammation and cancer
CN111344403B (en) 2017-09-15 2025-05-06 利兰斯坦福初级大学董事会 Multiplexed generation and barcoding of genetically engineered cells
IL273759B2 (en) 2017-10-03 2024-08-01 Aptahem Ab A nucleic acid molecule with anti-inflammatory and anti-coagulant and organ-protective properties
CN111566212A (en) 2017-11-03 2020-08-21 因特尔纳技术有限公司 miRNA molecules, equivalents, antanemia or sources thereof for use in the treatment and/or diagnosis of disorders and/or diseases associated with neuronal defects or for use in neuronal generation and/or regeneration
CA3115240A1 (en) * 2018-10-05 2020-04-09 International Institute Of Cancer Immunology, Inc. Composition for preventing or treating benign tumor
US20250011787A1 (en) 2021-10-21 2025-01-09 The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads Retroelement-generated transcription factor decoys
CA3237482A1 (en) 2021-11-03 2023-05-11 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Precise genome editing using retrons
EP4499839A1 (en) 2022-03-25 2025-02-05 The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone Methods of assessing engineered retron activity, and uses thereof
EP4499822A1 (en) 2022-03-25 2025-02-05 The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone Rt-dna fidelity and retron genome editing
WO2023183627A1 (en) 2022-03-25 2023-09-28 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Production of reverse transcribed dna (rt-dna) using a retron reverse transcriptase from exogenous rna
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Citations (3)

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Publication number Priority date Publication date Assignee Title
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WO1998007408A1 (en) * 1996-08-19 1998-02-26 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Novel liposome complexes for increased systemic delivery
WO1998020857A1 (en) * 1996-11-12 1998-05-22 The Regents Of The University Of California Preparation of stable formulations of lipid-nucleic acid complexes for efficient in vivo delivery

Patent Citations (3)

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WO1998007408A1 (en) * 1996-08-19 1998-02-26 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Novel liposome complexes for increased systemic delivery
WO1998020857A1 (en) * 1996-11-12 1998-05-22 The Regents Of The University Of California Preparation of stable formulations of lipid-nucleic acid complexes for efficient in vivo delivery

Non-Patent Citations (2)

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Title
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Also Published As

Publication number Publication date
ATE340560T1 (en) 2006-10-15
CA2371922A1 (en) 2000-11-30
CA2371922C (en) 2012-03-27
EP1180016B1 (en) 2006-09-27
ES2273699T3 (en) 2007-05-16
DE60030970T2 (en) 2007-09-06
WO2000071096A2 (en) 2000-11-30
AU5161800A (en) 2000-12-12
EP1180016A2 (en) 2002-02-20
DE60030970D1 (en) 2006-11-09

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