WO2000072880A3 - Prevention and treatment of amyloidogenic disease - Google Patents

Prevention and treatment of amyloidogenic disease Download PDF

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Publication number
WO2000072880A3
WO2000072880A3 PCT/US2000/014810 US0014810W WO0072880A3 WO 2000072880 A3 WO2000072880 A3 WO 2000072880A3 US 0014810 W US0014810 W US 0014810W WO 0072880 A3 WO0072880 A3 WO 0072880A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
methods
prevention
agents
amyloidogenic disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/014810
Other languages
French (fr)
Other versions
WO2000072880A2 (en
Inventor
Dale B Schenk
Frederique Bard
Nicki J Vasquez
Ted Yednock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neuralab Ltd
Original Assignee
Neuralab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23254226&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2000072880(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EEP200100626A priority Critical patent/EE05671B1/en
Application filed by Neuralab Ltd filed Critical Neuralab Ltd
Priority to HR20010877A priority patent/HRP20010877B1/en
Priority to CN008081174A priority patent/CN1359301B/en
Priority to NZ515403A priority patent/NZ515403A/en
Priority to IL14643500A priority patent/IL146435A0/en
Priority to DE60042451T priority patent/DE60042451D1/en
Priority to PL357182A priority patent/PL200458B1/en
Priority to CA2370311A priority patent/CA2370311C/en
Priority to GB0130969A priority patent/GB2368794B/en
Priority to EP00937919A priority patent/EP1185298B1/en
Priority to KR1020017015232A priority patent/KR101058482B1/en
Priority to DE10084643T priority patent/DE10084643T1/en
Priority to UA2001118146A priority patent/UA81215C2/en
Priority to HU0201250A priority patent/HU230550B1/en
Priority to JP2001511319A priority patent/JP5580504B2/en
Priority to HK02106696.2A priority patent/HK1045116B/en
Priority to AT00937919T priority patent/ATE434444T1/en
Priority to HR20090510A priority patent/HRP20090510A2/en
Priority to AU53031/00A priority patent/AU5303100A/en
Priority to MXPA01011621A priority patent/MXPA01011621A/en
Priority to BR0011000-0A priority patent/BR0011000A/en
Priority to EA200101251A priority patent/EA006630B1/en
Priority to SK1698-2001A priority patent/SK287513B6/en
Publication of WO2000072880A2 publication Critical patent/WO2000072880A2/en
Publication of WO2000072880A3 publication Critical patent/WO2000072880A3/en
Priority to IS6154A priority patent/IS6154A/en
Priority to NO20015773A priority patent/NO337301B1/en
Anticipated expiration legal-status Critical
Priority to BG106241A priority patent/BG65882B1/en
Priority to IL187526A priority patent/IL187526A/en
Priority to BG10110407A priority patent/BG66083B1/en
Priority to NO20100264A priority patent/NO20100264L/en
Priority to NO20160043A priority patent/NO340768B1/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/605—MHC molecules or ligands thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the amyloid deposit. The methods are useful for prophylactic and therapeutic treatment of Alzheimer's disease. Preferred agents including N-terminal fragments of Aβ and antibodies binding to the same.
PCT/US2000/014810 1999-05-28 2000-05-26 Prevention and treatment of amyloidogenic disease Ceased WO2000072880A2 (en)

Priority Applications (30)

Application Number Priority Date Filing Date Title
SK1698-2001A SK287513B6 (en) 1999-05-28 2000-05-26 Method, a pharmaceutical agent and a diagnostic kit
HK02106696.2A HK1045116B (en) 1999-05-28 2000-05-26 Prevention and treatment of amyloidogenic disease
HR20010877A HRP20010877B1 (en) 1999-05-28 2000-05-26 PREPARATIONS FOR THE PREVENTION AND TREATMENT OF AMYLOIDOGEN DISEASES
CN008081174A CN1359301B (en) 1999-05-28 2000-05-26 Pharmaceutical compositions containing antibodies specifically binding to epitopes within Aβ1-10 residues and uses thereof
NZ515403A NZ515403A (en) 1999-05-28 2000-05-26 Prevention and treatment of amyloidogenic disease
IL14643500A IL146435A0 (en) 1999-05-28 2000-05-26 Pharmaceutical compositions containing antibodies that bind to β-amyloid peptide
DE60042451T DE60042451D1 (en) 1999-05-28 2000-05-26 PREVENTIVE AND TREATMENT OF AMYLOIDOGENIC DISEASES
PL357182A PL200458B1 (en) 1999-05-28 2000-05-26 Prevention and treatment of amyloidogenic disease
CA2370311A CA2370311C (en) 1999-05-28 2000-05-26 Prevention and treatment of amyloidogenic disease
GB0130969A GB2368794B (en) 1999-05-28 2000-05-26 Prevention and treatment of amyloidogenic disease
EP00937919A EP1185298B1 (en) 1999-05-28 2000-05-26 Prevention and treatment of amyloidogenic disease
KR1020017015232A KR101058482B1 (en) 1999-05-28 2000-05-26 Prevention and Treatment of Amyloidosis Disease
DE10084643T DE10084643T1 (en) 1999-05-28 2000-05-26 Prevention and treatment of an amyloidogenic disease
UA2001118146A UA81215C2 (en) 1999-05-28 2000-05-26 Method of prevention and treatment of amyloid-induced diseases
HU0201250A HU230550B1 (en) 1999-05-28 2000-05-26 Prevention and treatment of amyloidogenic disease
JP2001511319A JP5580504B2 (en) 1999-05-28 2000-05-26 Prevention and treatment of amyloidogenic diseases
AT00937919T ATE434444T1 (en) 1999-05-28 2000-05-26 PREVENTION AND TREATMENT OF AMYLOIDOGENIC DISEASES
EEP200100626A EE05671B1 (en) 1999-05-28 2000-05-26 Supporting peptide Aβ fragment, its use, a pharmaceutical composition comprising a support peptide Aβ fragment and its use
HR20090510A HRP20090510A2 (en) 1999-05-28 2000-05-26 Prevention and treatment of amyloidogenic disease
AU53031/00A AU5303100A (en) 1999-05-28 2000-05-26 Prevention and treatment of amyloidogenic disease
MXPA01011621A MXPA01011621A (en) 1999-05-28 2000-05-26 Prevention and treatment of amyloidogenic disease.
BR0011000-0A BR0011000A (en) 1999-05-28 2000-05-26 Methods to prevent or treat a disease associated with ab amyloid deposits in a patient's brain, to evaluate an antibody for the removal activity of a biological entity physically associated with an antigen and to detect an amyloid deposit in a patient, pharmaceutical composition, and, diagnostic set
EA200101251A EA006630B1 (en) 1999-05-28 2000-05-26 Methods of prevention and treatment of amyloidogenic disease and pharmaceutical compositions used therein
IS6154A IS6154A (en) 1999-05-28 2001-11-09 Substances for bereavement and treatment of amniotic fluid
NO20015773A NO337301B1 (en) 1999-05-28 2001-11-27 Aβ fragment, pharmaceutical composition, and use
BG106241A BG65882B1 (en) 1999-05-28 2001-12-19 Abeta FRAGMENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR PREVENTION AND TREATMENT OF AMYLOIDOGENIC DISEASE
IL187526A IL187526A (en) 1999-05-28 2007-11-20 Aß fragment, compositions comprising the same and uses thereof
BG10110407A BG66083B1 (en) 1999-05-28 2009-06-17 Pharmaceutical compositions containing antibodies, and antibodies for prevention andf treatment of amyloidogenic disease
NO20100264A NO20100264L (en) 1999-05-28 2010-02-23 Prevention and treatment of amyloidogenic disease
NO20160043A NO340768B1 (en) 1999-05-28 2016-01-08 Pharmaceutical composition and antibody to Aβ fragment

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/322,289 US7964192B1 (en) 1997-12-02 1999-05-28 Prevention and treatment of amyloidgenic disease
US09/322,289 1999-05-28

Publications (2)

Publication Number Publication Date
WO2000072880A2 WO2000072880A2 (en) 2000-12-07
WO2000072880A3 true WO2000072880A3 (en) 2001-05-31

Family

ID=23254226

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/014810 Ceased WO2000072880A2 (en) 1999-05-28 2000-05-26 Prevention and treatment of amyloidogenic disease

Country Status (38)

Country Link
US (6) US7964192B1 (en)
EP (3) EP2305302B1 (en)
JP (2) JP5580504B2 (en)
KR (2) KR101058482B1 (en)
CN (2) CN1814287A (en)
AR (1) AR024074A1 (en)
AT (1) ATE434444T1 (en)
AU (1) AU5303100A (en)
BG (2) BG65882B1 (en)
BR (1) BR0011000A (en)
CA (1) CA2370311C (en)
CL (1) CL2010000018A1 (en)
CO (1) CO5170495A1 (en)
CZ (1) CZ304876B6 (en)
DE (2) DE10084643T1 (en)
EA (2) EA006630B1 (en)
EE (1) EE05671B1 (en)
ES (1) ES2624908T3 (en)
GB (2) GB2368794B (en)
HK (1) HK1045116B (en)
HR (2) HRP20090510A2 (en)
HU (1) HU230550B1 (en)
IL (2) IL146435A0 (en)
IS (1) IS6154A (en)
MX (1) MXPA01011621A (en)
MY (1) MY132784A (en)
NO (3) NO337301B1 (en)
NZ (1) NZ515403A (en)
PE (1) PE20010191A1 (en)
PL (1) PL200458B1 (en)
SG (3) SG147273A1 (en)
SK (1) SK287513B6 (en)
TR (2) TR200202231T2 (en)
TW (1) TWI263503B (en)
UA (1) UA81215C2 (en)
UY (1) UY26182A1 (en)
WO (1) WO2000072880A2 (en)
ZA (1) ZA200109487B (en)

Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6787637B1 (en) 1999-05-28 2004-09-07 Neuralab Limited N-Terminal amyloid-β antibodies
US6787138B1 (en) 1997-12-02 2004-09-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
US6808712B2 (en) 1997-12-02 2004-10-26 Neuralab Limited Prevention and treatment of amyloidogenic disease
US6890535B1 (en) 1997-12-02 2005-05-10 Neuralab Limited Pharmaceutical compositions and methods for treatment of amyloid diseases
US6905686B1 (en) 1997-12-02 2005-06-14 Neuralab Limited Active immunization for treatment of alzheimer's disease
US7179892B2 (en) 2000-12-06 2007-02-20 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
US7189819B2 (en) 2000-12-06 2007-03-13 Wyeth Humanized antibodies that recognize beta amyloid peptide
US7256273B2 (en) 2002-03-12 2007-08-14 Elan Pharma International Limited Humanized antibodies that recognize beta amyloid peptide
US7575880B1 (en) 2000-05-26 2009-08-18 Elan Pharma International Limited Method of screening an antibody for activity in clearing an amyloid deposit
US7588766B1 (en) 2000-05-26 2009-09-15 Elan Pharma International Limited Treatment of amyloidogenic disease
US7625560B2 (en) 2004-12-15 2009-12-01 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7635473B2 (en) 2005-01-28 2009-12-22 Janssen Alzheimer Immunotherapy Anti Aβ antibody formulation
US7674599B2 (en) 2003-11-08 2010-03-09 Elan Pharmaceuticals, Inc. Methods of using antibodies to detect alpha-synuclein in fluid samples
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
US7727957B2 (en) 2002-11-01 2010-06-01 Janssen Alzheimer Immunotherapy Treatment and delay of outset of Parkinson's disease
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7871615B2 (en) 2003-05-30 2011-01-18 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7893214B2 (en) 1997-12-02 2011-02-22 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7919088B2 (en) 2003-10-31 2011-04-05 Elan Pharmaceuticals, Inc. Treatment and delay of onset of synucleinopathic and amyloidogenic disease
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US7977316B2 (en) 1999-06-01 2011-07-12 Elan Pharmaceuticals, Inc. Prevention and treatment of amyloidogenic diseases
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
US8092801B2 (en) 2007-02-23 2012-01-10 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
US8147833B2 (en) 2007-02-23 2012-04-03 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
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US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
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