WO2000075324A3 - Recombinant prion-like genes and proteins and materials and methods comprising same - Google Patents

Recombinant prion-like genes and proteins and materials and methods comprising same Download PDF

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Publication number
WO2000075324A3
WO2000075324A3 PCT/US2000/015876 US0015876W WO0075324A3 WO 2000075324 A3 WO2000075324 A3 WO 2000075324A3 US 0015876 W US0015876 W US 0015876W WO 0075324 A3 WO0075324 A3 WO 0075324A3
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WO
WIPO (PCT)
Prior art keywords
methods
genes
proteins
materials
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/015876
Other languages
French (fr)
Other versions
WO2000075324A2 (en
WO2000075324A9 (en
Inventor
Susan Lindquist
Liming Li
Jiyan Ma
Jia-Jia Liu
Neil Sondheimer
Thomas Scheibel
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Arch Development Corp
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Arch Development Corp
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Filing date
Publication date
Application filed by Arch Development Corp filed Critical Arch Development Corp
Priority to EP00941299A priority Critical patent/EP1187920A2/en
Priority to AU56021/00A priority patent/AU5602100A/en
Publication of WO2000075324A2 publication Critical patent/WO2000075324A2/en
Publication of WO2000075324A3 publication Critical patent/WO2000075324A3/en
Publication of WO2000075324A9 publication Critical patent/WO2000075324A9/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention provides polypeptides comprising a prion-aggregation domain and a second domain; polynucleotides encoding such polypeptides; host cells transformed or transfected with such polynucleotides; and methods of making and using the foregoing.
PCT/US2000/015876 1999-06-09 2000-06-09 Recombinant prion-like genes and proteins and materials and methods comprising same Ceased WO2000075324A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00941299A EP1187920A2 (en) 1999-06-09 2000-06-09 Recombinant prion-like genes and proteins and materials and methods comprising same
AU56021/00A AU5602100A (en) 1999-06-09 2000-06-09 Recombinant prion-like genes and proteins and materials and methods comprising same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13883399P 1999-06-09 1999-06-09
US60/138,833 1999-06-09

Publications (3)

Publication Number Publication Date
WO2000075324A2 WO2000075324A2 (en) 2000-12-14
WO2000075324A3 true WO2000075324A3 (en) 2001-06-28
WO2000075324A9 WO2000075324A9 (en) 2001-07-26

Family

ID=22483877

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/015876 Ceased WO2000075324A2 (en) 1999-06-09 2000-06-09 Recombinant prion-like genes and proteins and materials and methods comprising same

Country Status (4)

Country Link
US (2) US7569660B1 (en)
EP (1) EP1187920A2 (en)
AU (1) AU5602100A (en)
WO (1) WO2000075324A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5602100A (en) 1999-06-09 2000-12-28 Arch Development Corporation Recombinant prion-like genes and proteins and materials and methods comprising same
US7939641B2 (en) 2002-04-09 2011-05-10 The Scripps Research Institute Motif-grafted hybrid polypeptides and uses thereof
US20050266242A1 (en) * 2004-03-31 2005-12-01 Susan Lindquist Electrical conductors and devices from prion-like proteins
WO2005118633A2 (en) * 2004-05-20 2005-12-15 The Whitehead Institute For Biomedical Research Electrical conductors and devices from prion-like proteins
US20090280480A1 (en) * 2005-06-09 2009-11-12 Susan Lindquist Devices from Prion-Like Proteins
WO2007103788A2 (en) * 2006-03-02 2007-09-13 The Board Of Trustees Of The University Of Illinois Yeast reporter system based on fusion proteins of sup35p
WO2008033451A2 (en) * 2006-09-13 2008-03-20 Whitehead Institute For Biomedical Research Protein aggregation domains from prions and methods of use thereof
EP2121726A4 (en) * 2006-12-04 2010-10-20 Innovative Purification Techno Protein particles
EP2524040B1 (en) 2010-01-12 2017-03-15 The Whitehead Institute for Biomedical Research Yeast cells expressing amyloid beta and uses therefor
EP3155003B9 (en) 2014-06-13 2020-12-30 Whitehead Institute for Biomedical Research Amyloid beta expression constructs and uses therefor
SE541260C2 (en) * 2016-05-17 2019-05-21 Benjamin Schmuck Antibody binding nanofibrils
US12060398B2 (en) 2018-06-21 2024-08-13 Northeastern University Fibrous proteinaceous networks and methods of use thereof
WO2020072491A1 (en) * 2018-10-01 2020-04-09 The Brigham And Women's Hospital, Inc. Brevican-binding peptides for brain tumor imaging
WO2020125707A1 (en) * 2018-12-19 2020-06-25 Tsinghua University Mtu δi-cm intein variant and the use thereof

Citations (5)

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WO1993010227A1 (en) * 1991-11-14 1993-05-27 Charles Weissmann Transgenic animals lacking prion proteins
WO1996028471A1 (en) * 1995-03-14 1996-09-19 Praecis Pharmaceuticals Incorporated Modulators of amyloid aggregation
US5770697A (en) * 1986-11-04 1998-06-23 Protein Polymer Technologies, Inc. Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
US5789655A (en) * 1994-05-13 1998-08-04 The Regents Of The University Of California Transgenic animals expressing artificial epitope-tagged proteins
WO1999006545A2 (en) * 1997-08-01 1999-02-11 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Composition and method for the detection of diseases associated with amyloid-like fibril or protein aggregate formation

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US5434050A (en) 1991-08-13 1995-07-18 Regents Of The University Of Minnesota Labelled β-amyloid peptide and methods of screening for Alzheimer's disease
NL9102009A (en) 1991-11-29 1993-06-16 Stichting Katholieke Univ PRODUCTION OF BIOACTIVE PEPTIDES WITH RECOMBINANT CELLS.
ATE177754T1 (en) 1991-12-03 1999-04-15 Proteus Molecular Design FRAGMENTS OF PRION PROTEINS.
AU671093B2 (en) 1992-01-07 1996-08-15 Elan Pharmaceuticals, Inc. Transgenic animal models for alzheimer's disease
US5670483A (en) 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
WO1994028412A1 (en) 1993-05-28 1994-12-08 The Miriam Hospital Composition and method for in vivo imaging of amyloid deposits
CA2125467C (en) 1993-07-06 2001-02-06 Heinz Dobeli Process for producing hydrophobic polypeptides, proteins or peptides
US5744368A (en) 1993-11-04 1998-04-28 Research Foundation Of State University Of New York Methods for the detection of soluble amyloid β-protein (βAP) or soluble transthyretin (TTR)
JPH07132033A (en) 1993-11-12 1995-05-23 Hoechst Japan Ltd Alzheimer's disease model transgenic animal
AU692237B2 (en) 1994-02-03 1998-06-04 Picower Institute For Medical Research, The Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis
US5565186A (en) 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US5792901A (en) 1994-05-13 1998-08-11 The Regents Of The University Of California Detecting prions in a sample and prion preparation and transgenic animal used for same
US5679530A (en) 1995-04-12 1997-10-21 Ludwig Institute For Cancer Research Isolated protein having molecular weight of from about 55 kilodaltons to about 65 kilodaltons (SDS-page) which binds to prion protein
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
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WO1993010227A1 (en) * 1991-11-14 1993-05-27 Charles Weissmann Transgenic animals lacking prion proteins
US5789655A (en) * 1994-05-13 1998-08-04 The Regents Of The University Of California Transgenic animals expressing artificial epitope-tagged proteins
WO1996028471A1 (en) * 1995-03-14 1996-09-19 Praecis Pharmaceuticals Incorporated Modulators of amyloid aggregation
US5854204A (en) * 1995-03-14 1998-12-29 Praecis Pharmaceuticals, Inc. Aβ peptides that modulate β-amyloid aggregation
WO1999006545A2 (en) * 1997-08-01 1999-02-11 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Composition and method for the detection of diseases associated with amyloid-like fibril or protein aggregate formation

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CHIH-YEN KING ET AL.: "Prion-inducing domain 2-114 of yeast Sup35 protein transforms in vitro into amyloid-like filaments", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 94, June 1997 (1997-06-01), WASHINGTON US, pages 6618 - 6622, XP000915118 *
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Also Published As

Publication number Publication date
EP1187920A2 (en) 2002-03-20
WO2000075324A2 (en) 2000-12-14
AU5602100A (en) 2000-12-28
WO2000075324A9 (en) 2001-07-26
US7569660B1 (en) 2009-08-04
US20050227322A1 (en) 2005-10-13

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