WO2000077518A3 - Methods and compositions for opsonophagocytic assays - Google Patents

Methods and compositions for opsonophagocytic assays Download PDF

Info

Publication number
WO2000077518A3
WO2000077518A3 PCT/US2000/015858 US0015858W WO0077518A3 WO 2000077518 A3 WO2000077518 A3 WO 2000077518A3 US 0015858 W US0015858 W US 0015858W WO 0077518 A3 WO0077518 A3 WO 0077518A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
assays
methods
opsonophagocytic
opsonophagocytic assays
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/015858
Other languages
French (fr)
Other versions
WO2000077518A2 (en
WO2000077518A9 (en
Inventor
Joseph E Martinez
George M Carlone
Michael H Hickey
Sandra Steiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Flow Applications Inc
US Department of Health and Human Services
Original Assignee
Flow Applications Inc
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flow Applications Inc, US Department of Health and Human Services filed Critical Flow Applications Inc
Priority to DE60034363T priority Critical patent/DE60034363T2/en
Priority to US10/009,660 priority patent/US6815172B1/en
Priority to AU54768/00A priority patent/AU768051B2/en
Priority to EP00939724A priority patent/EP1226440B1/en
Publication of WO2000077518A2 publication Critical patent/WO2000077518A2/en
Anticipated expiration legal-status Critical
Publication of WO2000077518A3 publication Critical patent/WO2000077518A3/en
Publication of WO2000077518A9 publication Critical patent/WO2000077518A9/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/22—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Neisseriaceae (F), e.g. Acinetobacter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/315—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Streptococcus (G), e.g. Enterococci
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

Methods and compositions comprising immunoassays for the detection of functional antibodies and the analysis of vaccine efficacy are described. In particular, the present invention provides opsonophagocytic assays. The assays are useful for the rapid and simultaneous detection of multiple different functional antibodies. In preferred embodiments, the assays include fluorescent labels of multiple colors and/or intensities.
PCT/US2000/015858 1999-06-11 2000-06-09 Methods and compositions for opsonophagocytic assays Ceased WO2000077518A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE60034363T DE60034363T2 (en) 1999-06-11 2000-06-09 PROCESS AND COMPOSITIONS FOR OPSONOPHAGOZYTTESTS
US10/009,660 US6815172B1 (en) 1999-06-11 2000-06-09 Methods and compositions for opsonophagocytic assays
AU54768/00A AU768051B2 (en) 1999-06-11 2000-06-09 Methods and compositions for opsonophagocytic assays
EP00939724A EP1226440B1 (en) 1999-06-11 2000-06-09 Methods and compositions for opsonophagocytic assays

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13891199P 1999-06-11 1999-06-11
US60/138,911 1999-06-11
CA002274207A CA2274207C (en) 1999-06-11 1999-06-11 Methods and compositions for opsonophagocytic assays

Publications (3)

Publication Number Publication Date
WO2000077518A2 WO2000077518A2 (en) 2000-12-21
WO2000077518A3 true WO2000077518A3 (en) 2002-05-30
WO2000077518A9 WO2000077518A9 (en) 2002-08-29

Family

ID=40255148

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/015858 Ceased WO2000077518A2 (en) 1999-06-11 2000-06-09 Methods and compositions for opsonophagocytic assays

Country Status (4)

Country Link
EP (1) EP1226440B1 (en)
AU (1) AU768051B2 (en)
CA (2) CA2643355C (en)
WO (1) WO2000077518A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003069342A1 (en) * 2002-02-11 2003-08-21 The Walter And Eliza Hall Institute Of Medical Research A method of screening
FR2874093B1 (en) * 2004-08-03 2006-12-01 Inodiag Sa METHOD AND KIT FOR DETERMINING VACCINE STATUS OF PEOPLE
US7642068B2 (en) 2006-04-21 2010-01-05 The United States Of America As Represented By The Department Of Health And Human Services, Center For Disease Control And Prevention Multiple-valent opsonophagocytic assay selection panel arrays and uses therefor
WO2009143168A2 (en) * 2008-05-19 2009-11-26 Novartis Ag Vaccine assays
EP2612148B1 (en) 2010-09-04 2019-06-12 GlaxoSmithKline Biologicals SA Bactericidal antibody assays to assess immunogenicity and potency of meningococcal capsular saccharide vaccines
ES2750366T3 (en) 2012-03-08 2020-03-25 Glaxosmithkline Biologicals Sa In vitro potency assay for protein-based meningococcal vaccines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE MEDLINE American Medical Association; 1986, R.J. SVEUM ET AL.: "A quantitative fluorescent method for measurement of bacterial adherence and phagocytosis.", XP002188000 *

Also Published As

Publication number Publication date
WO2000077518A2 (en) 2000-12-21
EP1226440A2 (en) 2002-07-31
WO2000077518A9 (en) 2002-08-29
AU5476800A (en) 2001-01-02
CA2643355A1 (en) 2000-12-11
CA2274207A1 (en) 2000-12-11
EP1226440B1 (en) 2007-04-11
CA2643355C (en) 2011-09-13
AU768051B2 (en) 2003-11-27
CA2274207C (en) 2009-04-07

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