WO2001000241A3 - Neue vektorkomplexe und deren verwendung für die gentherapie - Google Patents

Neue vektorkomplexe und deren verwendung für die gentherapie Download PDF

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Publication number
WO2001000241A3
WO2001000241A3 PCT/EP2000/005371 EP0005371W WO0100241A3 WO 2001000241 A3 WO2001000241 A3 WO 2001000241A3 EP 0005371 W EP0005371 W EP 0005371W WO 0100241 A3 WO0100241 A3 WO 0100241A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene therapy
component
novel vector
vector complexes
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/005371
Other languages
English (en)
French (fr)
Other versions
WO2001000241A2 (de
Inventor
Hans-Harald Sedlacek
Sabine Bruesselbach
Thomas Kissel
Rolf Mueller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to AU61496/00A priority Critical patent/AU6149600A/en
Priority to EP00947840A priority patent/EP1196618A2/de
Priority to JP2001505948A priority patent/JP2003503362A/ja
Publication of WO2001000241A2 publication Critical patent/WO2001000241A2/de
Publication of WO2001000241A3 publication Critical patent/WO2001000241A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Die Erfindung bezieht sich auf einen Vektorkomplex, enthaltend folgende Komponenten: a) eine Nukleinsäuresequenz beliebiger Länge; b) einen kationischen Träger; c) ein Polymer, welches mehr als 3 kationische und mehr als 3 anionische Ladungen besitzt; und d) optional einen Liganden, welcher an die Komponente a) oder die Komponente b) oder die Komponente c) bindet und zugleich eine Bindungsstelle für eine Zielzelle hat; seine Herstellung und Verwendung zur Prophylaxe und Therapie von Erkrankungen.
PCT/EP2000/005371 1999-06-24 2000-06-10 Neue vektorkomplexe und deren verwendung für die gentherapie Ceased WO2001000241A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU61496/00A AU6149600A (en) 1999-06-24 2000-06-10 Novel vector complexes and their use in gene therapy
EP00947840A EP1196618A2 (de) 1999-06-24 2000-06-10 Neue vektorkomplexe und deren verwendung für die gentherapie
JP2001505948A JP2003503362A (ja) 1999-06-24 2000-06-10 新規なベクター複合体および遺伝子治療のためのその使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1999129104 DE19929104A1 (de) 1999-06-24 1999-06-24 Neue Vektorkomplexe und deren Verwendung für die Gentherapie
DE19929104.7 1999-06-24

Publications (2)

Publication Number Publication Date
WO2001000241A2 WO2001000241A2 (de) 2001-01-04
WO2001000241A3 true WO2001000241A3 (de) 2001-08-09

Family

ID=7912489

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/005371 Ceased WO2001000241A2 (de) 1999-06-24 2000-06-10 Neue vektorkomplexe und deren verwendung für die gentherapie

Country Status (5)

Country Link
EP (1) EP1196618A2 (de)
JP (1) JP2003503362A (de)
AU (1) AU6149600A (de)
DE (1) DE19929104A1 (de)
WO (1) WO2001000241A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004045583A1 (ja) * 2002-11-15 2004-06-03 Nipro Corporation リポソーム
JP2005298486A (ja) * 2004-03-15 2005-10-27 Nipro Corp リポソームを含む癌治療用医薬組成物

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847240A (en) * 1978-01-16 1989-07-11 The Trustees Of Boston University Method of effecting cellular uptake of molecules
US5354844A (en) * 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates
US5574142A (en) * 1992-12-15 1996-11-12 Microprobe Corporation Peptide linkers for improved oligonucleotide delivery
WO1997012051A1 (fr) * 1995-09-28 1997-04-03 Rhone-Poulenc Rorer S.A. Composition pharmaceutique utile pour la transfection d'acides nucleiques et ses utilisations
WO1998006869A1 (en) * 1996-08-14 1998-02-19 The Children's Hospital Of Philadelphia Non-viral vehicles for use in gene transfer
EP0846772A1 (de) * 1996-11-29 1998-06-10 Hoechst Aktiengesellschaft Multifunktionneles Ligand-System zum Zell-spezifischen Gentransfer von Nukleinsäure
US5972707A (en) * 1994-06-27 1999-10-26 The Johns Hopkins University Gene delivery system

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4119590A (en) * 1975-05-22 1978-10-10 Toyo Soda Manufacturing Co., Ltd. Process for producing a polyion complex having a nucleic acid base
US5908777A (en) * 1995-06-23 1999-06-01 University Of Pittsburgh Lipidic vector for nucleic acid delivery
DE19605279A1 (de) * 1996-02-13 1997-08-14 Hoechst Ag Zielzellspezifische Vektoren für die Einschleusung von Genen in Zellen, Arzneimittel enthaltend derartige Vektoren und deren Verwendung
GB9623051D0 (en) * 1996-11-06 1997-01-08 Schacht Etienne H Delivery of DNA to target cells in biological systems

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847240A (en) * 1978-01-16 1989-07-11 The Trustees Of Boston University Method of effecting cellular uptake of molecules
US5354844A (en) * 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates
US5792645A (en) * 1989-03-16 1998-08-11 Boehringer Ingelheim International Gmbh Protein-polycation nucleic acid complexes and methods of use
US5574142A (en) * 1992-12-15 1996-11-12 Microprobe Corporation Peptide linkers for improved oligonucleotide delivery
US5972707A (en) * 1994-06-27 1999-10-26 The Johns Hopkins University Gene delivery system
WO1997012051A1 (fr) * 1995-09-28 1997-04-03 Rhone-Poulenc Rorer S.A. Composition pharmaceutique utile pour la transfection d'acides nucleiques et ses utilisations
WO1998006869A1 (en) * 1996-08-14 1998-02-19 The Children's Hospital Of Philadelphia Non-viral vehicles for use in gene transfer
EP0846772A1 (de) * 1996-11-29 1998-06-10 Hoechst Aktiengesellschaft Multifunktionneles Ligand-System zum Zell-spezifischen Gentransfer von Nukleinsäure

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BONFILS E ET AL: "DRUG TARGETING: SYNTHESIS AND ENDOCYTOSIS OF OLIGONUCLEOTIDE- NEOGLYCOPROTEIN CONJUGATES", NUCLEIC ACIDS RESEARCH,GB,OXFORD UNIVERSITY PRESS, SURREY, vol. 20, no. 17, 11 September 1992 (1992-09-11), pages 4621 - 4629, XP000461068, ISSN: 0305-1048 *
DASH P R ET AL: "Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery.", GENE THERAPY, vol. 6, no. 4, April 1999 (1999-04-01), pages 643 - 650, XP000982444, ISSN: 0969-7128 *
GOTTSCHALK S ET AL: "A NOVEL DNA-PEPTIDE COMPLEX FOR EFFICIENT GENE TRANSFER AND EXPRESSION IN MAMMALIAN CELLS", GENE THERAPY,GB,MACMILLAN PRESS LTD., BASINGSTOKE, vol. 3, no. 5, 1 May 1996 (1996-05-01), pages 448 - 457, XP000577712, ISSN: 0969-7128 *
GUPTA P K ET AL: "ALBUMIN MICROSPHERES II: APPLICATIONS IN DRUG DELIVERY", JOURNAL OF MICROENCAPSULATION,GB,TAYLOR AND FRANCIS INC. LONDON, vol. 6, no. 4, 1 October 1989 (1989-10-01), pages 463 - 472, XP000086853, ISSN: 0265-2048 *
HAN JUNGHEE ET AL: "Receptor-mediated gene transfer to cells of hepatic origin by galactosylated albumin-polylysine complexes.", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 22, no. 8, August 1999 (1999-08-01), pages 836 - 840, XP000979353, ISSN: 0918-6158 *
HAN JUNGHEE ET AL: "Receptor-mediated gene transfer to cells of hepatic origin by galactosylated albumin-polylysine conjugates.", PHARMACEUTICAL RESEARCH (NEW YORK), vol. 14, no. 11 SUPPL., November 1997 (1997-11-01), & Annual Meeting of the American Association of Pharmaceutical Scientists; Boston, US; November 2-6, 1997, pages S55, Zusammenfassung Nummer 1171,, XP000982439, ISSN: 0724-8741 *
INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE BIOACTIVE MATERIALS, 20 June 1999 (1999-06-20) - 25 June 1999 (1999-06-25), BOSTON, US *
KINSEY B. ET AL: "Polmethyleneimine conjugated to macroaggregated albumin mediates high level transfection in vitro and in vivo", PROCEEDINGS OF THE CONTROLLED RELEASE SOCIETY, 1999, NO. 26, PAGE(S) 619-620, XP000982539 *
SANDIG M ET AL: "The homophilic binding site of the neural cell adhesion molecule NCAM is directly involved in promoting neurite outgrowth from cultured neural retinal cells", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 269, no. 20, 20 May 1994 (1994-05-20), pages 14841 - 14848, XP002104481, ISSN: 0021-9258 *
SHEN W -C ET AL: "CONJUGATION OF POLY-L-LYSINE TO ALBUMIN AND HORSERADISH PEROXIDASE:A NOVEL METHOD OF ENHANCING THE CELLULAR UPTAKE OF PROTEINS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES,NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC,US, vol. 75, no. 4, April 1978 (1978-04-01), pages 1872 - 1876, XP000953474, ISSN: 0027-8424 *
WU C H ET AL: "TARGETING GENES: DELIVERY AND PERSISTENT EXPRESSION OF A FOREIGN GENE DRIVEN BY MAMMALIAN REGULATORY ELEMENTS IN VIVO", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 264, no. 29, 15 October 1989 (1989-10-15), pages 16985 - 16987, XP002030967, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
EP1196618A2 (de) 2002-04-17
DE19929104A1 (de) 2000-12-28
AU6149600A (en) 2001-01-31
JP2003503362A (ja) 2003-01-28
WO2001000241A2 (de) 2001-01-04

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