WO2001000245A3 - HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES - Google Patents

HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES Download PDF

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Publication number
WO2001000245A3
WO2001000245A3 PCT/US2000/017366 US0017366W WO0100245A3 WO 2001000245 A3 WO2001000245 A3 WO 2001000245A3 US 0017366 W US0017366 W US 0017366W WO 0100245 A3 WO0100245 A3 WO 0100245A3
Authority
WO
WIPO (PCT)
Prior art keywords
erbb2 antibodies
treatment
humanized anti
erbb2
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/017366
Other languages
French (fr)
Other versions
WO2001000245A2 (en
Inventor
Camellia W Adams
Leonard G Presta
Mark Sliwkowsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22495168&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2001000245(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to BRPI0012198A priority Critical patent/BRPI0012198B8/en
Priority to IL14695400A priority patent/IL146954A0/en
Priority to NZ516830A priority patent/NZ516830A/en
Priority to BR122014028365A priority patent/BR122014028365B8/en
Priority to AT0911000A priority patent/AT500848B1/en
Priority to DE60042648T priority patent/DE60042648D1/en
Priority to GB0200506A priority patent/GB2368796B/en
Priority to CA002376596A priority patent/CA2376596C/en
Priority to DE10084743T priority patent/DE10084743T1/en
Priority to JP2001505952A priority patent/JP4283474B2/en
Priority to AT00943115T priority patent/ATE437655T1/en
Priority to PL352321A priority patent/PL204629B1/en
Priority to HK02105805.2A priority patent/HK1044888B/en
Priority to AU57632/00A priority patent/AU784045B2/en
Priority to HU0201695A priority patent/HU226742B1/en
Priority to DK00943115.6T priority patent/DK1189641T5/en
Priority to SI200031040T priority patent/SI1189641T1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Priority to MXPA01013458A priority patent/MXPA01013458A/en
Priority to EP00943115A priority patent/EP1189641B1/en
Publication of WO2001000245A2 publication Critical patent/WO2001000245A2/en
Publication of WO2001000245A3 publication Critical patent/WO2001000245A3/en
Priority to IL146954A priority patent/IL146954A/en
Priority to NO20016329A priority patent/NO328377B1/en
Anticipated expiration legal-status Critical
Priority to IL197359A priority patent/IL197359A0/en
Priority to NO20091792A priority patent/NO336040B1/en
Priority to BE2013C020C priority patent/BE2013C020I2/fr
Priority to FR13C0016C priority patent/FR13C0016I2/en
Priority to CY2013010C priority patent/CY2013010I2/en
Priority to NO2013005C priority patent/NO2013005I1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Packages (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present application describes humanized anti-ErbB2 antibodies and methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies.
PCT/US2000/017366 1999-06-25 2000-06-23 HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES Ceased WO2001000245A2 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
EP00943115A EP1189641B1 (en) 1999-06-25 2000-06-23 HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES
HU0201695A HU226742B1 (en) 1999-06-25 2000-06-23 Humanized anti-erbb2 antibodies and treatment with anti-erbb2 antibodies
NZ516830A NZ516830A (en) 1999-06-25 2000-06-23 Humanized anti-ErbB2 antibodies conjugated with a cytotoxic or chemotherapeutic agent for treating cancer
BR122014028365A BR122014028365B8 (en) 1999-06-25 2000-06-23 manufactured article comprising a first container comprising a composition of humab4d5-8 contained therein and a second container comprising a composition of rhumab 2c4 contained therein
AT0911000A AT500848B1 (en) 1999-06-25 2000-06-23 HUMANIZED ANTI-ERBB2 ANTIBODIES
DE60042648T DE60042648D1 (en) 1999-06-25 2000-06-23 HUMANIZED ANTI-ERBB2 ANTIBODIES AND TREATMENT WITH ANTI-ERBB2 ANTIBODIES
GB0200506A GB2368796B (en) 1999-06-25 2000-06-23 Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
CA002376596A CA2376596C (en) 1999-06-25 2000-06-23 Humanized anti-erbb2 antibodies and treatment with anti-erbb2 antibodies
SI200031040T SI1189641T1 (en) 1999-06-25 2000-06-23 HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES
JP2001505952A JP4283474B2 (en) 1999-06-25 2000-06-23 Treatment with humanized anti-ErbB2 antibody and anti-ErbB2 antibody
AT00943115T ATE437655T1 (en) 1999-06-25 2000-06-23 HUMANIZED ANTI-ERBB2 ANTIBODIES AND TREATMENT WITH ANTI-ERBB2 ANTIBODIES
PL352321A PL204629B1 (en) 1999-06-25 2000-06-23 Humanized antibodies of anti-ERBB2 and treatment with antibodies of anti-ERBB2
HK02105805.2A HK1044888B (en) 1999-06-25 2000-06-23 Humanized anti-erbb2 antibodies and treatment with anti-erbb2 antibodies
AU57632/00A AU784045B2 (en) 1999-06-25 2000-06-23 Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
DK00943115.6T DK1189641T5 (en) 1999-06-25 2000-06-23 Humanized ANTI-ErbB2 antibodies and treatment with ANTI-ErbB2 antibodies
BRPI0012198A BRPI0012198B8 (en) 1999-06-25 2000-06-23 humanized antibodies, composition and immunoconjugate
DE10084743T DE10084743T1 (en) 1999-06-25 2000-06-23 Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
IL14695400A IL146954A0 (en) 1999-06-25 2000-06-23 HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES
MXPA01013458A MXPA01013458A (en) 1999-06-25 2000-06-23 HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES.
IL146954A IL146954A (en) 1999-06-25 2001-12-06 HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES
NO20016329A NO328377B1 (en) 1999-06-25 2001-12-21 Humanized monoclonal antibody that binds ErbB2 / HER2, pharmaceutical formulation, immunoconjugate, isolated nucleic acid, vector, host cell and antibody preparation method.
IL197359A IL197359A0 (en) 1999-06-25 2009-03-03 HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES
NO20091792A NO336040B1 (en) 1999-06-25 2009-05-05 Use of antibody that binds to ErbB2 and blocks ligand activation of an ErbB2 receptor, for the manufacture of a drug for the treatment of human cancer, use of rhuMAb 2C4 for the preparation of a drug for the treatment of cancer, humanized antibody, immune conjugate, affinity matured antibody
BE2013C020C BE2013C020I2 (en) 1999-06-25 2013-03-08
FR13C0016C FR13C0016I2 (en) 1999-06-25 2013-03-08 HUMANIZED ANTI-ERBB2 ANTIBODIES AND TREATMENT USING THESE ANTIBODIES
CY2013010C CY2013010I2 (en) 1999-06-25 2013-03-11 HUMANIZED ANTI-ErbB2 ANTIBODIES AND THERAPEUTIC TREATMENT WITH ANTI-ErbB2 ANTIBODIES
NO2013005C NO2013005I1 (en) 1999-06-25 2013-03-12 Pertuzumab

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60/141,316 1999-05-26
US14131699P 1999-06-25 1999-06-25

Publications (2)

Publication Number Publication Date
WO2001000245A2 WO2001000245A2 (en) 2001-01-04
WO2001000245A3 true WO2001000245A3 (en) 2001-10-25

Family

ID=22495168

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/017366 Ceased WO2001000245A2 (en) 1999-06-25 2000-06-23 HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES

Country Status (32)

Country Link
EP (2) EP1189641B1 (en)
JP (2) JP4283474B2 (en)
KR (2) KR100797308B1 (en)
CN (4) CN100340575C (en)
AR (1) AR024464A1 (en)
AT (2) AT500848B1 (en)
AU (2) AU784045B2 (en)
BE (1) BE2013C020I2 (en)
BR (2) BRPI0012198B8 (en)
CA (2) CA2376596C (en)
CH (1) CH694589A5 (en)
CY (2) CY1109525T1 (en)
CZ (1) CZ299702B6 (en)
DE (2) DE10084743T1 (en)
DK (1) DK1189641T5 (en)
ES (1) ES2329437T3 (en)
FR (1) FR13C0016I2 (en)
GB (1) GB2368796B (en)
GE (1) GEP20104998B (en)
HU (1) HU226742B1 (en)
IL (3) IL146954A0 (en)
LU (1) LU92164I2 (en)
MX (1) MXPA01013458A (en)
NO (3) NO328377B1 (en)
NZ (2) NZ531426A (en)
PL (2) PL203326B1 (en)
PT (1) PT1189641E (en)
RU (2) RU2270029C2 (en)
SI (3) SI2283866T1 (en)
TR (1) TR200103756T2 (en)
WO (1) WO2001000245A2 (en)
ZA (2) ZA200109786B (en)

Cited By (18)

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US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
US7371379B2 (en) 1999-08-27 2008-05-13 Genentech, Inc. Dosages for treatment with anti-ErbB2 antibodies
USRE43899E1 (en) 1999-10-01 2013-01-01 Immunogen Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US8771966B2 (en) 2010-06-03 2014-07-08 Genentech, Inc. Immuno-PET imaging of antibodies and immunoconjugates and uses therefor
US9017671B2 (en) 2004-10-20 2015-04-28 Genentech, Inc. Method of treating cancer with a pharmaceutical formulation comprising a HER2 antibody
US9096877B2 (en) 2009-10-07 2015-08-04 Macrogenics, Inc. Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use
US9327023B2 (en) 2011-10-25 2016-05-03 The Regents Of The University Of Michigan HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells
US9428548B2 (en) 2009-09-01 2016-08-30 Genentech, Inc. Enhanced protein purification through a modified protein A elution
US9487809B2 (en) 2010-05-28 2016-11-08 Genentech, Inc. Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
US9662395B2 (en) 2010-03-22 2017-05-30 Genentech, Inc. Compositions and methods useful for stabilizing protein-containing formulations
US10280227B2 (en) 2009-09-11 2019-05-07 Genentech, Inc. Highly concentrated pharmaceutical formulations
US10385405B2 (en) 2007-06-08 2019-08-20 Genentech, Inc. Gene expression markers of tumor resistance to HER2 inhibitor treatment
US11077189B2 (en) 2017-03-02 2021-08-03 Genentech Inc. Adjuvant treatment of HER2-positive breast cancer
US11414498B2 (en) 2008-01-30 2022-08-16 Genentech, Inc. Composition comprising antibody that binds to domain II of HER2 and acidic variants thereof
US11618790B2 (en) 2010-12-23 2023-04-04 Hoffmann-La Roche Inc. Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
US11945837B2 (en) 2011-12-22 2024-04-02 Genentech, Inc. Ion exchange membrane chromatography
US12427193B2 (en) 2009-07-31 2025-09-30 Genentech, Inc. Subcutaneous anti-HER2 antibody formulations and uses thereof
US12527867B2 (en) 2011-10-14 2026-01-20 Genentech, Inc. Uses for and article of manufacture including HER2 dimerization inhibitor Pertuzumab

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BR0012196A (en) * 1999-06-25 2002-03-19 Genentech Inc Method of treating a tumor in mammals using maytansinoid conjugates and anti-erbb receptor antibody and industrialized article
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US6825333B1 (en) 1999-08-20 2004-11-30 Chiron Corporation EGFH2 genes and gene products
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ITTO20020340A1 (en) * 2002-04-19 2003-10-20 Biother Di Contardi Gabriella LOCATION OF THE HER2 RECEPTOR BY HUMANIZED BIOTINYLATE ANTIBODY.
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WO2004008099A2 (en) * 2002-07-15 2004-01-22 Genentech, Inc. METHODS FOR IDENTIFYING TUMORS THAT ARE RESPONSIVE TO TREATMENT WITH ANTI-ErbB2 ANTIBODIES
NO340576B1 (en) * 2002-07-11 2017-05-15 Hoffmann La Roche Recombinant humanized antibody 2C4 (rhuMab 2C4) for use with a second, various growth inhibitory anti-ErbB2 antibody in a method of treating cancer in a patient and use thereof for the manufacture of a drug
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JP5138867B2 (en) 2002-08-01 2013-02-06 イミューノメディクス、インコーポレイテッド α-fetoprotein Immu31 antibody and fusion protein and method of use thereof
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