WO2001004150A3 - Neisseria meningitidis compounds and anti-infection applications thereof - Google Patents

Neisseria meningitidis compounds and anti-infection applications thereof Download PDF

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Publication number
WO2001004150A3
WO2001004150A3 PCT/EP2000/006943 EP0006943W WO0104150A3 WO 2001004150 A3 WO2001004150 A3 WO 2001004150A3 EP 0006943 W EP0006943 W EP 0006943W WO 0104150 A3 WO0104150 A3 WO 0104150A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
neisseria meningitidis
infection
applications
infection applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/006943
Other languages
French (fr)
Other versions
WO2001004150A2 (en
Inventor
Xavier Nassif
Colin Tinsley
Silke Klee
Mark Achtman
Petra Merker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV, Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority to AU68254/00A priority Critical patent/AU6825400A/en
Priority to EP00956222A priority patent/EP1194446A2/en
Priority to CA002378875A priority patent/CA2378875A1/en
Publication of WO2001004150A2 publication Critical patent/WO2001004150A2/en
Publication of WO2001004150A3 publication Critical patent/WO2001004150A3/en
Anticipated expiration legal-status Critical
Priority to US10/845,424 priority patent/US7422754B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1217—Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides novel Neisseria meningitidis (Nm) polypeptides and polynucleotides which cover the Nm genetic diversity, and which correspond to polypeptide of Nm outer membrane and/or periplasma, and to methods for producing such Nm compounds. Also provided are anti-Nm infection, and particularly diagnostic, prophylactic and therapeutic uses thereof.
PCT/EP2000/006943 1999-07-13 2000-07-05 Neisseria meningitidis compounds and anti-infection applications thereof Ceased WO2001004150A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU68254/00A AU6825400A (en) 1999-07-13 2000-07-05 Novel neisseria meningitidis compounds and anti-infection applications thereof
EP00956222A EP1194446A2 (en) 1999-07-13 2000-07-05 Neisseria meningitidis compounds and anti-infection applications thereof
CA002378875A CA2378875A1 (en) 1999-07-13 2000-07-05 Novel neisseria meningitidis compounds and anti-infection applications thereof
US10/845,424 US7422754B2 (en) 1999-07-13 2004-05-14 Neisseria meningitidis compounds and anti-infection applications thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99401764A EP1069133A1 (en) 1999-07-13 1999-07-13 Neisseria meningitidis compounds and anti-infection applications thereof
EP99401764.8 1999-07-13

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10030740 A-371-Of-International 2000-07-05
US10/845,424 Division US7422754B2 (en) 1999-07-13 2004-05-14 Neisseria meningitidis compounds and anti-infection applications thereof

Publications (2)

Publication Number Publication Date
WO2001004150A2 WO2001004150A2 (en) 2001-01-18
WO2001004150A3 true WO2001004150A3 (en) 2001-12-13

Family

ID=8242056

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/006943 Ceased WO2001004150A2 (en) 1999-07-13 2000-07-05 Neisseria meningitidis compounds and anti-infection applications thereof

Country Status (5)

Country Link
US (1) US7422754B2 (en)
EP (2) EP1069133A1 (en)
AU (1) AU6825400A (en)
CA (1) CA2378875A1 (en)
WO (1) WO2001004150A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990004641A1 (en) * 1988-10-27 1990-05-03 The Board Of Trustees Of The Leland Stanford Junior University FILAMENTOUS HEMAGGLUTININ OF $i(B. PERTUSSIS)
WO1990006696A2 (en) * 1988-12-19 1990-06-28 Praxis Biologics, Inc. Meningococcal class 1 outer-membrane protein vaccine
WO1992003467A1 (en) * 1990-08-23 1992-03-05 The University Of North Carolina Of Chapel Hill Transferrin binding proteins from neisseria gonorrhoeae and neisseria meningitidis
WO1994005326A1 (en) * 1992-09-04 1994-03-17 University Of Saskatchewan Novel bacterial vaccines using vaccine strains of pathogenic bacteria
WO1997028273A1 (en) * 1996-02-01 1997-08-07 North American Vaccine, Inc. Expression of group b neisseria meningitidis outer membrane (mb3) protein from yeast and vaccines

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990004641A1 (en) * 1988-10-27 1990-05-03 The Board Of Trustees Of The Leland Stanford Junior University FILAMENTOUS HEMAGGLUTININ OF $i(B. PERTUSSIS)
WO1990006696A2 (en) * 1988-12-19 1990-06-28 Praxis Biologics, Inc. Meningococcal class 1 outer-membrane protein vaccine
WO1992003467A1 (en) * 1990-08-23 1992-03-05 The University Of North Carolina Of Chapel Hill Transferrin binding proteins from neisseria gonorrhoeae and neisseria meningitidis
WO1994005326A1 (en) * 1992-09-04 1994-03-17 University Of Saskatchewan Novel bacterial vaccines using vaccine strains of pathogenic bacteria
WO1997028273A1 (en) * 1996-02-01 1997-08-07 North American Vaccine, Inc. Expression of group b neisseria meningitidis outer membrane (mb3) protein from yeast and vaccines

Non-Patent Citations (17)

* Cited by examiner, † Cited by third party
Title
ALA'ALDEEN D A A: "VACCINES AGAINST NEISSERIA MENINGITIDIS: PAST, PRESENT AND FUTURE", BIOTECNOLOGIA APLICADA, vol. 13, no. 1, 1996, pages 1-7, XP002052679, ISSN: 1027-2852 *
BARENKAMP S J ET AL: "CLONING, EXPRESSION, AND DNA SEQUENCE ANALYSIS OF GENES ENCODING NONTYPEABLE HAEMOPHILUS INFLUENZAE HIGH-MOLECULAR-WEIGHT SURFACE-EXPOSED PROTEINS RELATED TO FILAMENTOUS HEMAGGLUTININ OF BORDETELLA PERTUSSIS", INFECTION AND IMMUNITY,US,AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, vol. 60, no. 4, 1 April 1992 (1992-04-01), pages 1302-1313, XP000578343, ISSN: 0019-9567 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), STOJILJKOVIC I.: "NEISSERIA MENINGITIDIS NATD (NATD) AND NATC (NATC) GENES, COMPLETE CDS", XP002156086, Database accession no. AF121772 *
GOMEZ J A ET AL: "Antigenicity, cross-reactivity and surface exposure of the Neisseria meningitidis 37 kDa protein (Fbp)", VACCINE, vol. 14, no. 14, 1996, pages 1340-1346, XP004070969, ISSN: 0264-410X *
JONSON G ET AL.,: "Cloning an sequencing of Vibrio cholera mannose-sensitive haemagglutinin pilin gene: localization of mshA within a cluster oftype 4 pilin genes", MOLECULAR MICROBIOLOGY, vol. 13, no. 1, 1994, pages 109 - 118, XP000884514 *
MAIDEN M.C.J. ET AL.,: "Multilocus sequence typing: a portable approach to the identification of clones within populations of patogenic microorganisms", PROC. NATL. ACAD. SCI. USA, vol. 95, March 1998 (1998-03-01), pages 3140 - 3145, XP002125131 *
NASSIF X ET AL: "What do we know about the entry of Neisseria meningitidis into the meninges?", BULL. INS.PASTEUR, vol. 95, no. 4, 1997, pages 219-235, XP004108359, ISSN: 0223-5234 *
PEEK J.A. AND TAYLOR R.K.: "Characterization of a periplasmic thiol:disulfide interchange protein required for the functional maturation of secreted virulence factors of Vibrio cholerae", PROC. NATL. ACAD. SCI. U.S.A, vol. 89, 1992, pages 6210-6214, XP000857644 *
SALIT IE AND MORTON G: "Adherence of Neisseria meningitidis to human epithelial cells", INFECTION AND IMMUNITY, vol. 31, no. 1, January 1981 (1981-01-01), pages 430 - 435, XP000877193 *
SARKARI J. ET AL.,: "Variable expression of the Opc outer membrane protein in Neisseria meningitidis is caused by size variation of a promoter containing poly-citidine", MOLECULAR MICROBIOLOGY, vol. 13, no. 2, 1994, pages 207 - 217, XP000863030 *
SCHEUERPFLUG I ET AL.,: "Roles of PilC and PilE proteins in pilus-mediated adherence of Neisseria gonorrhoea and Neisseria meningitidis to human erythrocytes and endothelial and epithelial cells", INFECTION AND IMMUNITY, vol. 67, no. 2, February 1999 (1999-02-01), pages 834 - 843, XP000877194 *
STIBITZ S ET AL.,: "Genetic analysis of a region of the Bordetella pertussis chromosome encoding filamentous hemagglutinin and the pleiotropic regulatory locus vir", JOURNAL OF BACTERIOLOGY, vol. 170, no. 7, July 1988 (1988-07-01), pages 2904 - 2913, XP000884520 *
STONE BARBARA J ET AL: "Salmonella enteritidis has a homologue of tolC that is required for virulence in BALB/c mice.", MOLECULAR MICROBIOLOGY, vol. 17, no. 4, 1995, pages 701 - 712, XP000978140, ISSN: 0950-382X *
VAN DER LEY P ET AL: "Construction of Neisseria meningitidis strains carrying multiple chromosomal copies of the porA gene for use in the production of a multivalent outer membrane vesicle vaccine", VACCINE, vol. 13, no. 4, 1995, pages 401-407, XP004057740, ISSN: 0264-410X *
VIRJI M ET AL: "VARIATIONS IN THE EXPRESSION OF PILI: THE EFFECT ON ADHERENCE OF NEISSERIA MENINGITIDIS TO HUMAN EPITHELIAL AND ENDOTHELIAL CELLS", MOLECULAR MICROBIOLOGY,GB,OXFORD, vol. 6, no. 10, 1992, pages 1271-1279, XP000560443 *
WATARAI M. ET AL.,: "Disulfide oxidoreductase activity of Shigella flexneri is required for release of Ipa proteins and invasion of epithelial cells.", PROC. NATL. ACAD. SCI. U.S.A., vol. 92, 1995, pages 4927-4931, XP000857645 *
ZHOU J ET AL: "SEQUENCE DIVERSITY WITHIN THE ARGF, FBP AND RECA GENES OF NATURAL ISOLATES OF NEISSERIA MENINGITIDIS: INTERSPECIES RECOMBINATION WITHIN THE ARGF GENE", MOLECULAR MICROBIOLOGY, vol. 6, no. 15, 1992, pages 2135-2146, XP000645119 *

Also Published As

Publication number Publication date
WO2001004150A2 (en) 2001-01-18
US7422754B2 (en) 2008-09-09
US20050089527A1 (en) 2005-04-28
EP1194446A2 (en) 2002-04-10
CA2378875A1 (en) 2001-01-18
AU6825400A (en) 2001-01-30
EP1069133A1 (en) 2001-01-17

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