WO2001011038A3 - Medicament for the prevention and/or the treatment of ischemic heart and peripheral vascular diseases, tumour and wounds - Google Patents

Medicament for the prevention and/or the treatment of ischemic heart and peripheral vascular diseases, tumour and wounds Download PDF

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Publication number
WO2001011038A3
WO2001011038A3 PCT/EP2000/007731 EP0007731W WO0111038A3 WO 2001011038 A3 WO2001011038 A3 WO 2001011038A3 EP 0007731 W EP0007731 W EP 0007731W WO 0111038 A3 WO0111038 A3 WO 0111038A3
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WO
WIPO (PCT)
Prior art keywords
medicament
peripheral vascular
ischemic heart
vascular diseases
tumour
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/007731
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German (de)
French (fr)
Other versions
WO2001011038A2 (en
Inventor
Jean-Luc Balligand
Olivier Feron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Université Catholique de Louvain
Original Assignee
Université Catholique de Louvain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Université Catholique de Louvain filed Critical Université Catholique de Louvain
Priority to DE60021583T priority Critical patent/DE60021583D1/en
Priority to AT00951488T priority patent/ATE300614T1/en
Priority to EP00951488A priority patent/EP1206539B1/en
Priority to AU64408/00A priority patent/AU6440800A/en
Publication of WO2001011038A2 publication Critical patent/WO2001011038A2/en
Publication of WO2001011038A3 publication Critical patent/WO2001011038A3/en
Anticipated expiration legal-status Critical
Priority to US10/068,965 priority patent/US20020156123A1/en
Priority to US10/651,024 priority patent/US20040110684A1/en
Priority to US12/338,062 priority patent/US20090226427A1/en
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5064—Endothelial cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention is related to a compound or a pharmaceutical composition thereof for the use of a medicament in the modulation of angiogenesis through the tackling of the intracellular free cholesterol-caveolin1-eNOS-NO pathway. The present invention also provides a method of study, testing, screening and manufacturing of new compounds or compositions which influences the angiogenesis via said pathway with the aim of identifying a compound or composition having possible therapeutic or prophylactic properties upon ischemic heart and peripheral vascular diseases including cerebral diseases, tumour development and wound healing.
PCT/EP2000/007731 1999-08-02 2000-08-09 Medicament for the prevention and/or the treatment of ischemic heart and peripheral vascular diseases, tumour and wounds Ceased WO2001011038A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE60021583T DE60021583D1 (en) 1999-08-09 2000-08-09 MEDICINAL PRODUCTS FOR THE PREVENTION AND / OR TREATMENT OF CARDIAL BLEACHING DISEASES, PERIPHERAL VASCULAR DISEASES, TUMORS AND WOUNDS
AT00951488T ATE300614T1 (en) 1999-08-09 2000-08-09 MEDICINAL PRODUCTS FOR THE PREVENTION AND/OR TREATMENT OF CARDIAL CIRCULATION DISORDERS, PERIPHERAL VASCULAR DISEASES, TUMORS AND WOUNDS
EP00951488A EP1206539B1 (en) 1999-08-09 2000-08-09 Medicament for the prevention and/or the treatment of ischemic heart and peripheral vascular diseases, tumour and wounds
AU64408/00A AU6440800A (en) 1999-08-09 2000-08-09 Use of compound or pharmaceutical composition for the prevention and/or the treatment of ischemic heart and peripheral vascular diseases, tumour development andfor wound healing
US10/068,965 US20020156123A1 (en) 1999-08-09 2002-02-11 Novel pharmaceutical compositions for modulating angiogenesis
US10/651,024 US20040110684A1 (en) 1999-08-02 2003-08-29 Novel pharmaceutical compositions for modulating angiogenesis
US12/338,062 US20090226427A1 (en) 1999-08-09 2008-12-18 Novel pharmaceutical compositions for modulating angiogenesis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99870171A EP1076091A1 (en) 1999-08-09 1999-08-09 Medicament for the prevention and/or the treatment of ischemic heart and peripheral vascular diseases, tumour and wounds
EP99870171.8 1999-08-09

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/068,965 Continuation-In-Part US20020156123A1 (en) 1999-08-02 2002-02-11 Novel pharmaceutical compositions for modulating angiogenesis

Publications (2)

Publication Number Publication Date
WO2001011038A2 WO2001011038A2 (en) 2001-02-15
WO2001011038A3 true WO2001011038A3 (en) 2001-12-13

Family

ID=8243881

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/007731 Ceased WO2001011038A2 (en) 1999-08-02 2000-08-09 Medicament for the prevention and/or the treatment of ischemic heart and peripheral vascular diseases, tumour and wounds

Country Status (6)

Country Link
US (1) US20020156123A1 (en)
EP (3) EP1076091A1 (en)
AT (1) ATE300614T1 (en)
AU (1) AU6440800A (en)
DE (1) DE60021583D1 (en)
WO (1) WO2001011038A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1216038T3 (en) 1999-08-30 2005-12-27 Sanofi Aventis Deutschland Use of inhibitors of the renin angiotensin system in the prevention of cardiovascular events
WO2001024826A2 (en) * 1999-10-06 2001-04-12 The Brigham And Women's Hospital, Inc. Inrease of enos activity through activation of the pi3-kinase/akt pathway by estrogens
GB2360453B (en) * 2000-01-05 2004-09-01 Univ Cardiff Treatment of skin conditions
US20020077283A1 (en) 2000-09-08 2002-06-20 Sessa William C. Caveolin peptides and their use as therapeutics
RU2201239C1 (en) * 2001-07-31 2003-03-27 Научно-исследовательский институт фармакологии Томского научного центра РАМН Agent eliciting antihyperlipoproteinemic activity, food supplement based on thereof and method of treatment of lipid metabolism disturbance in patients with cardiovascular diseases
AU2002951611A0 (en) * 2002-09-24 2002-10-10 The Baker Medical Research Institute Cholesterol efflux and uses thereof
KR20110008022A (en) * 2008-03-21 2011-01-25 재단법인서울대학교산학협력재단 A composition for treating and improving diabetes containing caveolin as an active ingredient and a method for treating diabetes using the same
WO2013184482A1 (en) * 2012-06-04 2013-12-12 Yale University Method of treating and preventing ocular angiogenesis
KR20230148263A (en) 2013-03-15 2023-10-24 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 Inhibition of Pulmonary Fibrosis with Nutlin-3a and Peptides
KR102958241B1 (en) * 2018-09-10 2026-04-30 레인 테라퓨틱스, 인크. Modified peptide fragment of CAV-1 protein and its use in the treatment of fibrosis

Citations (4)

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Publication number Priority date Publication date Assignee Title
EP0471236A1 (en) * 1990-07-30 1992-02-19 Takeda Chemical Industries, Ltd. Imidazopyridine derivatives and their use
WO1999018801A1 (en) * 1997-10-16 1999-04-22 Fordham University Methods and compositions for the treatment of autoimmune disease using heat shock proteins
WO1999022773A2 (en) * 1997-11-05 1999-05-14 Baylor College Of Medicine Sequences for targeting metastatic cells
WO2000067737A2 (en) * 1999-05-07 2000-11-16 The Brigham And Women's Hospital, Inc. USE OF HMGCoA REDUCTASE INHIBITORS IN THE PREVENTION OF DISEASES WHOSE PATHOGENESIS IS DEPENDENT ON NEOVASCULARIZATION

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FR2722507B1 (en) * 1994-07-12 1996-08-14 Rhone Poulenc Rorer Sa ADENOVIRUS COMPRISING A GENE ENCODING NO SYNTHASE
JPH1087698A (en) * 1996-07-09 1998-04-07 Takeda Chem Ind Ltd Novel protein and its DNA
WO1998048826A1 (en) * 1997-04-30 1998-11-05 Northwestern University Inhibition of nitric oxide synthase by amino acids and dipeptides
YU2700A (en) * 1997-08-29 2002-06-19 Pfizer Products Inc. Pharmaceutical combinacion of amlodipine and statine compounds
CA2299397A1 (en) * 1997-12-12 1999-06-24 Warner-Lambert Company Antihyperlipidemic statin-lp(a) inhibitor combinations
AU2993599A (en) * 1998-03-09 1999-09-27 Regents Of The University Of California, The Regulation of the cell cycle by sterols

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0471236A1 (en) * 1990-07-30 1992-02-19 Takeda Chemical Industries, Ltd. Imidazopyridine derivatives and their use
WO1999018801A1 (en) * 1997-10-16 1999-04-22 Fordham University Methods and compositions for the treatment of autoimmune disease using heat shock proteins
WO1999022773A2 (en) * 1997-11-05 1999-05-14 Baylor College Of Medicine Sequences for targeting metastatic cells
WO2000067737A2 (en) * 1999-05-07 2000-11-16 The Brigham And Women's Hospital, Inc. USE OF HMGCoA REDUCTASE INHIBITORS IN THE PREVENTION OF DISEASES WHOSE PATHOGENESIS IS DEPENDENT ON NEOVASCULARIZATION

Non-Patent Citations (15)

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CANADIAN JOURNAL OF CARDIOLOGY, vol. 14, no. 3, March 1998 (1998-03-01), pages 355 - 361, ISSN: 0828-282X *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1995, HANNAH J S ET AL: "Effects of acipimox on the metabolism of free fatty acids and very low density lipoprotein triglyceride.", XP002156499, Database accession no. PREV199698650769 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; July 1999 (1999-07-01), BURNETT JOHN R ET AL: "Inhibition of ACAT by avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs.", XP002156497, Database accession no. PREV199900374754 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; March 1998 (1998-03-01), LACOUR ANNE ET AL: "Comparison of efficacy and cost among lipid-lowering agents in patients with primary hypercholesterolemia.", XP002156498, Database accession no. PREV199800232626 *
FERON O ET AL: "High LDL-cholesterol decreases NO production through enhanced caveolin abundance in endothelial cells: Correction by atorvastatin.", ANNUAL MEETING OF THE PROFESSIONAL RESEARCH SCIENTISTS FOR EXPERIMENTAL BIOLOGY 99;WASHINGTON, D.C., USA; APRIL 17-21, 1999, vol. 13, no. 4 PART 1, 12 March 1999 (1999-03-12), FASEB Journal March 12, 1999, pages A201, XP002136666, ISSN: 0892-6638 *
GARCIA-CARDENA GUILLERMO ET AL: "Dynamic activation of endothelial nitric oxide synthase by Hsp90.", NATURE (LONDON), vol. 392, no. 6678, 23 April 1998 (1998-04-23), pages 821 - 824, XP002163482, ISSN: 0028-0836 *
JOURNAL OF LIPID RESEARCH, vol. 40, no. 7, July 1999 (1999-07-01), pages 1317 - 1327, ISSN: 0022-2275 *
KERWIN ET AL: "the arginine-nitric oxide pathway : a target for new drugs", MEDICINAL RESEARCH REVIEWS, vol. 14, no. 1, 1994, pages 23 - 74, XP000906832 *
KONG D ET AL: "THE ANTI-ANGIOGENIC EFFECTS OF HMGCOA REDUCTASE INHIBITORS: A NEW ROLE FOR RHOA GTPASE IN THE REGULATION OF ANGIOGENESIS", CIRCULATION,AMERICAN HEART ASSOCIATION, DALLAS, TX,US, vol. 110, no. 18, SUPPL, 2 November 1999 (1999-11-02), pages I39, XP000938028, ISSN: 0009-7322 *
LIU JUN ET AL: "Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells: Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 22, 28 May 1999 (1999-05-28), pages 15781 - 15785, XP002156496, ISSN: 0021-9258 *
MICHEL JEFFREY B ET AL: "Caveolin versus calmodulin. Counterbalancing allosteric modulators of endothelial nitric oxide synthase.", JOURNAL OF BIOLOGICAL CHEMISTRY 1997, vol. 272, no. 41, 1997, pages 25907 - 25912, XP002136661, ISSN: 0021-9258 *
MICHEL JEFFREY B ET AL: "Reciprocal regulation of endothelial NO synthase by Ca2+ calmodulin and caveolin", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 25, 1997, pages 15583 - 15586, XP002136665, ISSN: 0009-7322 *
MUROHARA TOYOAKI ET AL: "Nitric oxide synthase modulates angiogenesis in response to tissue ischemia", JOURNAL OF CLINICAL INVESTIGATION,US,NEW YORK, NY, vol. 11, no. 101, 1 June 1998 (1998-06-01), pages 2567 - 2578, XP002138210, ISSN: 0021-9738 *
OKAMOTO ET AL: "caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 10, 1998, pages 5419 - 5422, XP002136663 *

Also Published As

Publication number Publication date
EP1586644A3 (en) 2008-06-25
EP1076091A1 (en) 2001-02-14
WO2001011038A2 (en) 2001-02-15
AU6440800A (en) 2001-03-05
EP1586644A2 (en) 2005-10-19
ATE300614T1 (en) 2005-08-15
US20020156123A1 (en) 2002-10-24
EP1206539A2 (en) 2002-05-22
EP1206539B1 (en) 2005-07-27
DE60021583D1 (en) 2005-09-01

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