WO2001014546A3 - Replication protein a binding transcriptional factor (rbt1) and uses thereof - Google Patents

Replication protein a binding transcriptional factor (rbt1) and uses thereof Download PDF

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Publication number
WO2001014546A3
WO2001014546A3 PCT/CA2000/000948 CA0000948W WO0114546A3 WO 2001014546 A3 WO2001014546 A3 WO 2001014546A3 CA 0000948 W CA0000948 W CA 0000948W WO 0114546 A3 WO0114546 A3 WO 0114546A3
Authority
WO
WIPO (PCT)
Prior art keywords
rbt1
replication protein
binding transcriptional
transcriptional factor
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2000/000948
Other languages
French (fr)
Other versions
WO2001014546A2 (en
Inventor
Moulay A Alaoui-Jamali
John Myung-Jae Cho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CENTRE FOR TRANSLATIONAL RESEARCH IN CANCER
ALAOUI JAMALI MOULAY A
CHO JOHN MYUNG JAE
CT FOR TRANSLATIONAL RES IN CA
Original Assignee
CENTRE FOR TRANSLATIONAL RESEARCH IN CANCER
ALAOUI JAMALI MOULAY A
CHO JOHN MYUNG JAE
CT FOR TRANSLATIONAL RES IN CA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CENTRE FOR TRANSLATIONAL RESEARCH IN CANCER, ALAOUI JAMALI MOULAY A, CHO JOHN MYUNG JAE, CT FOR TRANSLATIONAL RES IN CA filed Critical CENTRE FOR TRANSLATIONAL RESEARCH IN CANCER
Priority to EP00954207A priority Critical patent/EP1206542B1/en
Priority to AT00954207T priority patent/ATE309354T1/en
Priority to DE60023915T priority patent/DE60023915T2/en
Priority to AU66759/00A priority patent/AU6675900A/en
Priority to CA002377730A priority patent/CA2377730A1/en
Priority to US10/069,386 priority patent/US7094891B1/en
Publication of WO2001014546A2 publication Critical patent/WO2001014546A2/en
Publication of WO2001014546A3 publication Critical patent/WO2001014546A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to replication protein A (RPA) transcriptional factors. There is provided a nucleotide sequence encoding a replication protein A binding transcriptional activator 1 (RBT1) and a protein encoded by such a nucleotide sequence. RBT1 has a high activity and is highly transactivated in cancer cells. The sequence may be used to treat neoplastic disorders and in gene therapy.
PCT/CA2000/000948 1999-08-19 2000-08-17 Replication protein a binding transcriptional factor (rbt1) and uses thereof Ceased WO2001014546A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP00954207A EP1206542B1 (en) 1999-08-19 2000-08-17 Replication protein a binding transcriptional factor (rbt1) and uses thereof
AT00954207T ATE309354T1 (en) 1999-08-19 2000-08-17 REPLICATION PROTEIN A BINDING TRANSCRIPTION FACTOR (RBT1) AND USES THEREOF
DE60023915T DE60023915T2 (en) 1999-08-19 2000-08-17 REPLICATION PROTEIN A BINDING TRANSCRIPTION FACTOR (RBT1) AND ITS USES
AU66759/00A AU6675900A (en) 1999-08-19 2000-08-17 Replication protein a binding transcriptional factor (rbt1) and uses thereof
CA002377730A CA2377730A1 (en) 1999-08-19 2000-08-17 Replication protein a binding transcriptional factor (rbt1) and uses thereof
US10/069,386 US7094891B1 (en) 1999-08-19 2000-08-17 Replication protein a binding transcriptional factor (RBT1) and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14947299P 1999-08-19 1999-08-19
US60/149,472 1999-08-19

Publications (2)

Publication Number Publication Date
WO2001014546A2 WO2001014546A2 (en) 2001-03-01
WO2001014546A3 true WO2001014546A3 (en) 2001-11-29

Family

ID=22530436

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/000948 Ceased WO2001014546A2 (en) 1999-08-19 2000-08-17 Replication protein a binding transcriptional factor (rbt1) and uses thereof

Country Status (6)

Country Link
EP (1) EP1206542B1 (en)
AT (1) ATE309354T1 (en)
AU (1) AU6675900A (en)
CA (1) CA2377730A1 (en)
DE (1) DE60023915T2 (en)
WO (1) WO2001014546A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000013A1 (en) * 1996-06-28 1998-01-08 The Regents Of The University Of California Enhancement of cancer cell death
WO1998037901A1 (en) * 1997-02-28 1998-09-03 Boehringer Ingelheim Pharmaceuticals, Inc. Self-regulated apoptosis of inflammatory cells by gene therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000013A1 (en) * 1996-06-28 1998-01-08 The Regents Of The University Of California Enhancement of cancer cell death
WO1998037901A1 (en) * 1997-02-28 1998-09-03 Boehringer Ingelheim Pharmaceuticals, Inc. Self-regulated apoptosis of inflammatory cells by gene therapy

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CHO J M ET AL.: "RBT1, a novel transcriptional co-activator, binds the second subunit of Replication Protein A", NUCLEIC ACIDS RESEARCH, vol. 28, no. 18, 15 September 2000 (2000-09-15), pages 3478 - 3485, XP002167204 *
DATABASE EM_EST EMBL; 19 December 1997 (1997-12-19), MARRA M ET AL.: "vt32d01.r1 Barstead mouse proximal colon MPLRB6 Mus musculus cDNA clone IMAGE:1164769 5', mRNA sequence", XP002167206 *
DATABASE EM_EST EMBL; 24 June 1997 (1997-06-24), HILLIER L ET AL.: "zt34d02.r1 Soares ovary tumor NbHOT Homo sapiens cDNA clone IMAGE:724227 5', mRNA sequence", XP002167205 *
DATABASE EM_HUM EMBL; 17 September 1999 (1999-09-17), DOE JOINT GENOME INSTITUTE STANFORD HUMAN GENOME CENTER: "Homo sapines chromosome 19 CTC-492K19, complete sequence", XP002167207 *
IFTODE C ET AL.: "Replication protein A (RPA): the eukaryotic SSB", CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 34, no. 3, 1999, pages 141 - 180, XP001002021 *
NAGELHUS TA ET AL.: "A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 10, 7 March 1997 (1997-03-07), pages 6561 - 6566, XP002167201 *
WOLD MS: "Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism", ANNUAL REVIEW OF BIOCHEMISTRY, vol. 66, 1997, pages 61 - 92, XP001002023 *

Also Published As

Publication number Publication date
DE60023915T2 (en) 2006-08-10
WO2001014546A2 (en) 2001-03-01
AU6675900A (en) 2001-03-19
EP1206542A2 (en) 2002-05-22
DE60023915D1 (en) 2005-12-15
ATE309354T1 (en) 2005-11-15
EP1206542B1 (en) 2005-11-09
CA2377730A1 (en) 2001-03-01

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