WO2001029217A3 - Novel polypeptides and polynucleotides encoding same - Google Patents

Novel polypeptides and polynucleotides encoding same Download PDF

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Publication number
WO2001029217A3
WO2001029217A3 PCT/US2000/028474 US0028474W WO0129217A3 WO 2001029217 A3 WO2001029217 A3 WO 2001029217A3 US 0028474 W US0028474 W US 0028474W WO 0129217 A3 WO0129217 A3 WO 0129217A3
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotides encoding
novel polypeptides
encoding same
disclosed
acid sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/028474
Other languages
French (fr)
Other versions
WO2001029217A2 (en
Inventor
Sudhirdas K Prayaga
Raymond J Taupier Jr
Raj Bandaru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CuraGen Corp
Original Assignee
CuraGen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CuraGen Corp filed Critical CuraGen Corp
Priority to JP2001532200A priority Critical patent/JP2004500046A/en
Priority to EP00973541A priority patent/EP1222272A2/en
Priority to CA002386922A priority patent/CA2386922A1/en
Priority to AU12043/01A priority patent/AU1204301A/en
Publication of WO2001029217A2 publication Critical patent/WO2001029217A2/en
Publication of WO2001029217A3 publication Critical patent/WO2001029217A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Disclosed herein are novel human nucleic acid sequences. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving these novel nucleic acids and proteins.
PCT/US2000/028474 1999-10-15 2000-10-13 Novel polypeptides and polynucleotides encoding same Ceased WO2001029217A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001532200A JP2004500046A (en) 1999-10-15 2000-10-13 Novel polypeptide and polynucleotide encoding the same
EP00973541A EP1222272A2 (en) 1999-10-15 2000-10-13 Polypeptides and polynucleotides encoding same
CA002386922A CA2386922A1 (en) 1999-10-15 2000-10-13 Novel polypeptides and polynucleotides encoding same
AU12043/01A AU1204301A (en) 1999-10-15 2000-10-13 Novel polypeptides and polynucleotides encoding same

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US15980599P 1999-10-15 1999-10-15
US60/159,805 1999-10-15
US15999299P 1999-10-18 1999-10-18
US60/159,992 1999-10-18
US16095299P 1999-10-22 1999-10-22
US60/160,952 1999-10-22

Publications (2)

Publication Number Publication Date
WO2001029217A2 WO2001029217A2 (en) 2001-04-26
WO2001029217A3 true WO2001029217A3 (en) 2002-01-10

Family

ID=27388360

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/028474 Ceased WO2001029217A2 (en) 1999-10-15 2000-10-13 Novel polypeptides and polynucleotides encoding same

Country Status (3)

Country Link
EP (1) EP1222272A2 (en)
AU (1) AU1204301A (en)
WO (1) WO2001029217A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9688987B2 (en) 2008-08-25 2017-06-27 Excaliard Pharmaceuticals, Inc. Antisense oligonucleotides directed against connective tissue growth factor and uses thereof

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6974684B2 (en) * 2001-08-08 2005-12-13 Curagen Corporation Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US20030224982A1 (en) * 2001-07-05 2003-12-04 Li Li Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US6992170B2 (en) 1999-10-15 2006-01-31 Curagen Corporation Polypeptides and polynucleotides homologous to thymosin, ephrin a receptors, and fibromodulin
US6855806B1 (en) 1999-10-15 2005-02-15 Curagen Corporation Thymosin beta 10-like proteins and nucleic acids encoding same
EP1492807A4 (en) * 2001-08-02 2006-05-17 Curagen Corp Novel proteins and nucleic acids encoding same
US20040038230A1 (en) * 2001-11-05 2004-02-26 Alsobrook John P. Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US6965025B2 (en) 2001-12-10 2005-11-15 Isis Pharmaceuticals, Inc. Antisense modulation of connective tissue growth factor expression
EP1513864A4 (en) * 2002-02-08 2006-04-05 Curagen Corp Therapeutic polypeptides, nucleic acids encoding same, and methods of use
EP1687410A4 (en) 2003-10-07 2008-04-09 Isis Pharmaceuticals Inc ANTISENSE OLIGONUCLEOTIDES OPTIMIZED TO TARGET THE KIDNEY
US20050191653A1 (en) 2003-11-03 2005-09-01 Freier Susan M. Modulation of SGLT2 expression
US8946172B2 (en) 2008-08-25 2015-02-03 Excaliard Pharmaceuticals, Inc. Method for reducing scarring during wound healing using antisense compounds directed to CTGF
IT1395255B1 (en) * 2009-07-09 2012-09-05 Mastelli S R L COMPOSITION FOR MALE INFERTILITY TREATMENT
KR101697396B1 (en) 2011-02-02 2017-01-17 엑스칼리아드 파마슈티컬즈, 인코포레이티드 Method of treating keloids or hypertrophic scars using antisense compounds targeting connective tissue growth factor (ctgf)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047674A2 (en) * 1998-03-18 1999-09-23 Corixa Corporation Compounds and methods for therapy and diagnosis of lung cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047674A2 (en) * 1998-03-18 1999-09-23 Corixa Corporation Compounds and methods for therapy and diagnosis of lung cancer

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 12 March 1999 (1999-03-12), WILSON S: "Human DNA sequence from clone RP1-61A9 on chromosome 1p35.2-36.13 Contains part of the EPHB2 gene for tyrosine-protein kinase, the gene KIAA0478 for a C2H2 type zinc finger gene, ESTs, STSs, GSSs and three putative CpG Islands.", XP002169952 *
DATABASE EMBL 15 October 1999 (1999-10-15), HATTORI M ET AL: "Homo sapiens genomic DNA, chromosome 11q13 clone:RP11-45M18, WORKING DRAFT SEQUENCE, 14 unordered pieces.", XP002169957 *
DATABASE EMBL 19 March 1997 (1997-03-19), WRAY P: "Homo sapiens DNA sequence from PAC 958B3 on chromosome Xp22.11-Xp22.22. Contains ESTs STS and CpG island", XP002163902 *
DATABASE EMBL 23 May 2000 (2000-05-23), OHARA O ET AL: "Homo sapiens mRNA KIAA1459 protein, partial cds.", XP002169954 *
DATABASE EMBL 25 December 1996 (1996-12-25), PARK S: "Mus musculus Eph-and Elk-related kinase (eek) mRNA, complete cds.", XP002169953 *
DATABASE EMBL 26 January 1998 (1998-01-26), NCI-CGAP: "ah66c02.s1 Soares_testis_NHT Homo sapiens cDNA clone 1320578 3' similar to gb:S54005 THYMOSIN BETA-10 (HUMAN);, mRNA sequence.", XP002163903 *
DATABASE EMBL 31 January 2000 (2000-01-31), LACY S E ET AL: "Homo sapiens leucine-rich repeat transmembrane protein FLRT1 (FLRT1) mRNA, complete cds.", XP002169956 *
DATABASE EMBL 9 February 1998 (1998-02-09), ANDERSSON B ET AL: "Homo sapiens clone 23898 unknown mRNA, partial cds.", XP002169955 *
LACY SUSAN E ET AL: "Identification of FLRT1, FLRT2, and FLRT3: A novel family of transmembrane leucine-rich repeat proteins.", GENOMICS, vol. 62, no. 3, 15 December 1999 (1999-12-15), pages 417 - 426, XP002169951 *
NAGASE T ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. XVII. THE COMPLETE SEQUENCES OF 100 NEW SDNA CLONES FROM BRAIN WHICH CODE FOR LARGE PROTEINS IN VITRO", DNA RESEARCH,UNIVERSAL ACADEMY PRESS,JP, vol. 7, pages 143 - 150, XP000983090 *
PARK SOOCHUL ET AL: "The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands.", ONCOGENE, vol. 14, no. 5, 1997, pages 533 - 542, XP001009718 *
TUERECI OE ET AL: "HUMAN CARBONIC ANHYDRASE XII: CDNA CLONING,EXPRESSION, AND CHROMOSOMAL LOCALIZATION OF A CARBONIC ANHYDRASE GENE THAT IS OVEREXPRESSED IN SOME RENAL CELL CANCERS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,NATIONAL ACADEMY OF SCIENCE. WASHINGTON,US, vol. 95, no. 13, 23 June 1998 (1998-06-23), pages 7608 - 7613, XP000941354, ISSN: 0027-8424 *
WETERMAN M A J ET AL: "THYMOSIN BETA-10 EXPRESSION IN MELANOMA CELL LINES AND MELANOCYTIC LESIONS: A NEW PROGRESSION MARKER FOR HUMAN CUTANEOUS MELANOMA", INTERNATIONAL JOURNAL OF CANCER,US,NEW YORK, NY, vol. 53, no. 2, 21 January 1993 (1993-01-21), pages 278 - 284, XP002041675, ISSN: 0020-7136 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9688987B2 (en) 2008-08-25 2017-06-27 Excaliard Pharmaceuticals, Inc. Antisense oligonucleotides directed against connective tissue growth factor and uses thereof

Also Published As

Publication number Publication date
AU1204301A (en) 2001-04-30
EP1222272A2 (en) 2002-07-17
WO2001029217A2 (en) 2001-04-26

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