WO2001032697A3 - Virulence genes and proteins from brucella melitensis, and their use - Google Patents

Virulence genes and proteins from brucella melitensis, and their use Download PDF

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Publication number
WO2001032697A3
WO2001032697A3 PCT/EP2000/011123 EP0011123W WO0132697A3 WO 2001032697 A3 WO2001032697 A3 WO 2001032697A3 EP 0011123 W EP0011123 W EP 0011123W WO 0132697 A3 WO0132697 A3 WO 0132697A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
genes
virulence genes
brucella melitensis
virulence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/011123
Other languages
French (fr)
Other versions
WO2001032697A2 (en
Inventor
Pascal Lestrate
Jean-Jacques Letesson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Namur
Original Assignee
University of Namur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9926345.1A external-priority patent/GB9926345D0/en
Priority claimed from GBGB9926348.5A external-priority patent/GB9926348D0/en
Priority claimed from GBGB9926356.8A external-priority patent/GB9926356D0/en
Priority claimed from GBGB9926347.7A external-priority patent/GB9926347D0/en
Priority claimed from GBGB9926351.9A external-priority patent/GB9926351D0/en
Priority claimed from GBGB9926341.0A external-priority patent/GB9926341D0/en
Priority claimed from GBGB9926346.9A external-priority patent/GB9926346D0/en
Priority claimed from GBGB9926342.8A external-priority patent/GB9926342D0/en
Priority claimed from GBGB9926350.1A external-priority patent/GB9926350D0/en
Priority claimed from GBGB9926343.6A external-priority patent/GB9926343D0/en
Priority claimed from GBGB9926340.2A external-priority patent/GB9926340D0/en
Priority claimed from GBGB9926344.4A external-priority patent/GB9926344D0/en
Priority to EP00987229A priority Critical patent/EP1226254A2/en
Application filed by University of Namur filed Critical University of Namur
Priority to AU23554/01A priority patent/AU2355401A/en
Publication of WO2001032697A2 publication Critical patent/WO2001032697A2/en
Publication of WO2001032697A3 publication Critical patent/WO2001032697A3/en
Anticipated expiration legal-status Critical
Priority to US11/475,590 priority patent/US20060246086A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/23—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Brucella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A series of genes from Brucella spp are shown to encode products which are implicated in virulence. The identification of these genes therefore allows attenuated microorganisms to be produced. Furthermore, the genes or their encoded products can be used in the manufacture of vaccines for therapeutic application.
PCT/EP2000/011123 1999-11-05 2000-11-01 Virulence genes and proteins from brucella melitensis, and their use Ceased WO2001032697A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00987229A EP1226254A2 (en) 1999-11-05 2000-11-01 Virulence genes, proteins, and their use
AU23554/01A AU2355401A (en) 1999-11-05 2000-11-01 Virulence genes, proteins, and their use
US11/475,590 US20060246086A1 (en) 1999-11-05 2006-06-27 Virulence genes and proteins from Brucella melitensis, and their use

Applications Claiming Priority (24)

Application Number Priority Date Filing Date Title
GB9926347.7 1999-11-05
GBGB9926346.9A GB9926346D0 (en) 1999-11-05 1999-11-05 Virulence gene and protein, and their use
GBGB9926342.8A GB9926342D0 (en) 1999-11-05 1999-11-05 Virulence gene and protein, and their use
GB9926344.4 1999-11-05
GBGB9926343.6A GB9926343D0 (en) 1999-11-05 1999-11-05 Virulence gene and protein, and their use
GBGB9926350.1A GB9926350D0 (en) 1999-11-05 1999-11-05 Virulence gene and protein, and their use
GBGB9926348.5A GB9926348D0 (en) 1999-11-05 1999-11-05 Virulence gene and protein, and their use
GB9926343.6 1999-11-05
GBGB9926344.4A GB9926344D0 (en) 1999-11-05 1999-11-05 Virulence gene and protein, and their use
GB9926345.1 1999-11-05
GB9926350.1 1999-11-05
GB9926340.2 1999-11-05
GB9926341.0 1999-11-05
GBGB9926340.2A GB9926340D0 (en) 1999-11-05 1999-11-05 Virulence gene and protein, and their use
GBGB9926341.0A GB9926341D0 (en) 1999-11-05 1999-11-05 Virulence gene and protein, and their use
GB9926342.8 1999-11-05
GBGB9926351.9A GB9926351D0 (en) 1999-11-05 1999-11-05 Virulence gene and protein, and their use
GB9926348.5 1999-11-05
GBGB9926345.1A GB9926345D0 (en) 1999-11-05 1999-11-05 Virulence gene and protein, and their use
GB9926356.8 1999-11-05
GBGB9926347.7A GB9926347D0 (en) 1999-11-05 1999-11-05 Virulence gene and protein, and their use
GB9926351.9 1999-11-05
GBGB9926356.8A GB9926356D0 (en) 1999-11-05 1999-11-05 Virulence gene and protein, and their use
GB9926346.9 1999-11-05

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/475,590 Continuation US20060246086A1 (en) 1999-11-05 2006-06-27 Virulence genes and proteins from Brucella melitensis, and their use

Publications (2)

Publication Number Publication Date
WO2001032697A2 WO2001032697A2 (en) 2001-05-10
WO2001032697A3 true WO2001032697A3 (en) 2001-11-08

Family

ID=27583079

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/011123 Ceased WO2001032697A2 (en) 1999-11-05 2000-11-01 Virulence genes and proteins from brucella melitensis, and their use

Country Status (3)

Country Link
US (1) US20060246086A1 (en)
EP (1) EP1226254A2 (en)
WO (1) WO2001032697A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG119177A1 (en) 1994-12-09 2006-02-28 Imp College Innovations Ltd Identification of genes
ATE403728T1 (en) 1998-09-04 2008-08-15 Emergent Product Dev Uk Ltd ATTENUATED SALMONELLA SPI2 MUTANT AS ANTIGEN CARRIER
GB9910812D0 (en) 1999-05-10 1999-07-07 Microscience Ltd Vaccine composition
EP1493813A1 (en) * 2003-07-03 2005-01-05 Facultés Universitaires Notre-Dame de la Paix Flagellar genetic sequences of Brucella being of therapeutic and diagnostic use
GB0724668D0 (en) * 2007-12-19 2008-01-30 Secr Defence Vaccines for Brucellosis
US8703153B2 (en) 2008-06-16 2014-04-22 Prokarium Ltd. Salmonella vectored vaccines against Chlamydia and methods of use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939075A (en) * 1994-11-04 1999-08-17 The United States Of America As Represented By The Secretary Of The Army Mutants of Brucella melitensis

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929604A (en) * 1986-05-28 1990-05-29 Board Of Regents, The University Of Texas System Lipopolysaccharides of reduced toxicity and the production thereof
US5057520A (en) * 1989-03-24 1991-10-15 Abbott Laboratories 7-(peptidylpyrolidinyl)naphthyridine antibacterial compounds
US6693130B2 (en) * 1999-02-18 2004-02-17 Regents Of The University Of California Inhibitors of epoxide hydrolases for the treatment of hypertension
US6413751B1 (en) * 1996-09-19 2002-07-02 The Board Of Trustees Of The Leland Stanford Jr. University DNA adenine methyltransferases and uses thereof
US6024961A (en) * 1997-11-14 2000-02-15 Washington University Recombinant avirulent immunogenic S typhi having rpos positive phenotype
US20020077272A1 (en) * 1999-02-02 2002-06-20 Mahan Michael J. Reducing bacterial virulence
US7026155B2 (en) * 1999-02-02 2006-04-11 Regents Of The University Of California Method of reducing bacterial proliferation
US20020076417A1 (en) * 1999-02-02 2002-06-20 Mahan Michael J. Attenuated bacteria with altered DNA adenine methylase activity
US20020086032A1 (en) * 1999-02-02 2002-07-04 Mahan Michael J. Producing antibodies with attenuated bacteria with altered DNA adenine methylase activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939075A (en) * 1994-11-04 1999-08-17 The United States Of America As Represented By The Secretary Of The Army Mutants of Brucella melitensis

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CRAWFORD ROBERT M ET AL: "Deletion of purE attenuates Brucella melitensis infection in mice.", INFECTION AND IMMUNITY, vol. 64, no. 6, 1996, pages 2188 - 2192, XP002163108, ISSN: 0019-9567 *
DATABASE EMBL 1 November 1997 (1997-11-01), HUMMERJOHANN J. ET AL.: "Pseudomonas aeruginosa sulfite reductase (cysI) gene, complete cds.", XP002163111 *
DATABASE SWALL 1 January 1998 (1998-01-01), HUMMERJOHANN J. ET AL.: "SULFITE REDUCTASE", XP002163112 *
GODFROID FABRICE ET AL: "Identification of the peroxamine synthetase gene of Brucella melitensis 16M and involvement of lipopolysaccharide O side chain in Brucella survival in mice and in macrophages.", INFECTION AND IMMUNITY, vol. 66, no. 11, November 1998 (1998-11-01), pages 5485 - 5493, XP002163109, ISSN: 0019-9567 *
HENSEL M ET AL: "SIMULTANEOUS IDENTIFICATION OF BACTERIAL VIRULENCE GENES BY NEGATIVE SELECTION", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 269, 21 July 1995 (1995-07-21), pages 400 - 403, XP000645478, ISSN: 0036-8075 *
HOOVER DAVID L ET AL: "Protection of mice against brucellosis by vaccination with Brucella melitensis WR201(16MDELTApurEK).", INFECTION AND IMMUNITY, vol. 67, no. 11, November 1999 (1999-11-01), pages 5877 - 5884, XP002163107, ISSN: 0019-9567 *
HUMMERJOHANN J. ET AL.: "Regulation of the sulfate starvation response in Pseudomonas aeruginosa: role of cysteine biosynthetic intermediates", MICROBIOLOGY, vol. 144, 1998, pages 1375 - 1386, XP002163106 *
LESTRATE P ET AL: "Identification and characterization of in vivo attenuated mutants of Brucella melitensis.", MOLECULAR MICROBIOLOGY, vol. 38, no. 3, November 2000 (2000-11-01), pages 543 - 551, XP000985056, ISSN: 0950-382X *

Also Published As

Publication number Publication date
WO2001032697A2 (en) 2001-05-10
EP1226254A2 (en) 2002-07-31
US20060246086A1 (en) 2006-11-02

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