WO2001035100A3 - Binding acceleration techniques for the detection of analytes - Google Patents

Binding acceleration techniques for the detection of analytes Download PDF

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Publication number
WO2001035100A3
WO2001035100A3 PCT/US2000/031233 US0031233W WO0135100A3 WO 2001035100 A3 WO2001035100 A3 WO 2001035100A3 US 0031233 W US0031233 W US 0031233W WO 0135100 A3 WO0135100 A3 WO 0135100A3
Authority
WO
WIPO (PCT)
Prior art keywords
detection
analytes
acceleration techniques
binding
etm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/031233
Other languages
French (fr)
Other versions
WO2001035100A9 (en
WO2001035100A2 (en
Inventor
Gary Blackburn
Jost G Vielmetter
Jon Faiz Kayyem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Clinical Micro Sensors Inc
Original Assignee
Clinical Micro Sensors Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clinical Micro Sensors Inc filed Critical Clinical Micro Sensors Inc
Priority to AU16063/01A priority Critical patent/AU778556B2/en
Priority to AT00978615T priority patent/ATE269977T1/en
Priority to JP2001536580A priority patent/JP3548159B2/en
Priority to CA002388780A priority patent/CA2388780C/en
Priority to EP00978615A priority patent/EP1254372B1/en
Priority to DE60011821T priority patent/DE60011821T2/en
Publication of WO2001035100A2 publication Critical patent/WO2001035100A2/en
Publication of WO2001035100A3 publication Critical patent/WO2001035100A3/en
Anticipated expiration legal-status Critical
Publication of WO2001035100A9 publication Critical patent/WO2001035100A9/en
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Composite Materials (AREA)
  • Pathology (AREA)
  • Materials Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly of indirectly, to allow electronic detection of the ETM.
PCT/US2000/031233 1999-11-12 2000-11-13 Binding acceleration techniques for the detection of analytes Ceased WO2001035100A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU16063/01A AU778556B2 (en) 1999-11-12 2000-11-13 Binding acceleration techniques for the detection of analytes
AT00978615T ATE269977T1 (en) 1999-11-12 2000-11-13 BINDING ACCELERATION METHOD FOR DETECTING ANALYTES
JP2001536580A JP3548159B2 (en) 1999-11-12 2000-11-13 Binding promotion method for analyte detection
CA002388780A CA2388780C (en) 1999-11-12 2000-11-13 Binding acceleration techniques for the detection of analytes
EP00978615A EP1254372B1 (en) 1999-11-12 2000-11-13 Binding acceleration techniques for the detection of analytes
DE60011821T DE60011821T2 (en) 1999-11-12 2000-11-13 BINDING ACCELERATION PROCEDURE FOR THE DETECTION OF ANALYTES

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US44037199A 1999-11-12 1999-11-12
US09/440,371 1999-11-12
US17198199P 1999-12-23 1999-12-23
US60/171,981 1999-12-23

Publications (3)

Publication Number Publication Date
WO2001035100A2 WO2001035100A2 (en) 2001-05-17
WO2001035100A3 true WO2001035100A3 (en) 2002-01-03
WO2001035100A9 WO2001035100A9 (en) 2002-07-04

Family

ID=26867628

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/031233 Ceased WO2001035100A2 (en) 1999-11-12 2000-11-13 Binding acceleration techniques for the detection of analytes

Country Status (8)

Country Link
EP (1) EP1254372B1 (en)
JP (1) JP3548159B2 (en)
AT (1) ATE269977T1 (en)
AU (1) AU778556B2 (en)
CA (1) CA2388780C (en)
DE (1) DE60011821T2 (en)
ES (1) ES2225264T3 (en)
WO (1) WO2001035100A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US7655129B2 (en) 1998-06-23 2010-02-02 Osmetech Technology Inc. Binding acceleration techniques for the detection of analytes
US7851146B2 (en) 1993-12-10 2010-12-14 California Institute Of Technology Nucleic acid mediated electron transfer
US8012743B2 (en) 1998-10-27 2011-09-06 Osmetech Technology Inc. Detection of target analytes using particles and electrodes

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US6361958B1 (en) 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6602400B1 (en) 2000-06-15 2003-08-05 Motorola, Inc. Method for enhanced bio-conjugation events
DE10049901C2 (en) * 2000-10-10 2003-01-02 Aventis Res & Tech Gmbh & Co Apparatus and method for electrically accelerated immobilization and for detection of molecules
AU2002220583A1 (en) * 2000-10-10 2002-04-22 Aventis Research And Technologies Gmbh And Co Kg Device and method for electrically accelerated immobilisation of molecules
US7198754B2 (en) 2001-08-31 2007-04-03 Kabushiki Kaisha Toshiba Biological material detection element, biological material detection method and apparatus, charged material moving apparatus
EP1461596B1 (en) * 2001-11-30 2013-07-17 Northwestern University Direct write nanolithographic deposition of nucleic acids from nanoscopic tips
CA2474530A1 (en) * 2002-02-07 2003-08-14 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Diagnostic microarray and method of use thereof
TWI221523B (en) 2002-05-21 2004-10-01 Sony Corp Bioassay method, bioassay device, and bioassay substrate
WO2004101785A1 (en) * 2003-05-13 2004-11-25 Jsr Corporation Method of extracting target gene and particle having probe dna bound thereto
JP4464664B2 (en) * 2003-06-13 2010-05-19 独立行政法人理化学研究所 Biomolecule microarray substrate, biomolecule microarray, device and method for promoting interaction, and method for detecting interaction
US8455088B2 (en) 2005-12-23 2013-06-04 Boston Scientific Scimed, Inc. Spun nanofiber, medical devices, and methods
US7470466B2 (en) 2005-12-23 2008-12-30 Boston Scientific Scimed, Inc. Nanoparticle structures and composite materials comprising a silicon-containing compound having a chemical linker that forms a non-covalent bond with a polymer
US20070151856A1 (en) * 2005-12-29 2007-07-05 Fazzio R S Fluidic device having contiguous conductive layer over interior and exterior surfaces thereof
JP2007267644A (en) * 2006-03-30 2007-10-18 Toshiba Corp Method for measuring the number of repetitions of unit base
WO2008020364A2 (en) * 2006-08-14 2008-02-21 Koninklijke Philips Electronics N. V. Biochemical sensor device
US20100168609A1 (en) * 2007-03-14 2010-07-01 Ogeno Gmbh Biopsy device for the enrichment of tissue, cells, or analytes
CN104271771A (en) * 2012-06-20 2015-01-07 东丽株式会社 Method for detecting nucleic acid and nucleic acid detection kit
US9618510B2 (en) 2013-03-13 2017-04-11 Meso Scale Technologies, Llc. Assay methods
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
US9587268B2 (en) * 2014-01-29 2017-03-07 Agilent Technologies Inc. Fast hybridization for next generation sequencing target enrichment
US10408823B2 (en) * 2014-05-15 2019-09-10 Meso Scale Technologies, Llc. Assay methods
WO2019147525A1 (en) 2018-01-26 2019-08-01 Advanced Electrofluidic Systems, Llc Method and apparatus for isolating and detecting biological and other particles
KR20260021093A (en) 2019-03-01 2026-02-12 메소 스케일 테크놀러지즈, 엘엘시 Electrochemiluminescent labeled probes for use in immunoassay methods, methods using such and kits comprising same
CN116250060A (en) * 2020-07-27 2023-06-09 南京金斯瑞生物科技有限公司 A surface connector of a semiconductor chip and its preparation method and application
CA3229708A1 (en) * 2021-08-16 2023-02-23 Diagmetrics, Inc. Diagnostic platform for testing exhaled breath condensate and universal biosensor
CN115895279B (en) * 2022-11-24 2023-07-21 西北大学 A SPAN/MOFs@Luminol luminescent material and its preparation method and application

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4787963A (en) * 1987-05-04 1988-11-29 Syntro Corporation Method and means for annealing complementary nucleic acid molecules at an accelerated rate
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
WO1997031256A2 (en) * 1996-02-09 1997-08-28 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
WO1998051823A1 (en) * 1997-05-16 1998-11-19 Mosaic Technologies Electrophoretic analysis of molecules using immobilized probes
WO1999029711A1 (en) * 1997-12-05 1999-06-17 Nanogen, Inc. Self-addressable self-assembling microelectronic integrated systems, component devices, mechanisms, methods, and procedures for molecular biological analysis and diagnostics
WO1999057319A1 (en) * 1998-05-06 1999-11-11 Clinical Micro Sensors Electronic detection of nucleic acids using monolayers
WO1999067425A2 (en) * 1998-06-23 1999-12-29 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017696A (en) * 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
WO1999037819A2 (en) * 1998-01-27 1999-07-29 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4787963A (en) * 1987-05-04 1988-11-29 Syntro Corporation Method and means for annealing complementary nucleic acid molecules at an accelerated rate
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
WO1997031256A2 (en) * 1996-02-09 1997-08-28 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
WO1998051823A1 (en) * 1997-05-16 1998-11-19 Mosaic Technologies Electrophoretic analysis of molecules using immobilized probes
WO1999029711A1 (en) * 1997-12-05 1999-06-17 Nanogen, Inc. Self-addressable self-assembling microelectronic integrated systems, component devices, mechanisms, methods, and procedures for molecular biological analysis and diagnostics
WO1999057319A1 (en) * 1998-05-06 1999-11-11 Clinical Micro Sensors Electronic detection of nucleic acids using monolayers
WO1999067425A2 (en) * 1998-06-23 1999-12-29 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7851146B2 (en) 1993-12-10 2010-12-14 California Institute Of Technology Nucleic acid mediated electron transfer
US7655129B2 (en) 1998-06-23 2010-02-02 Osmetech Technology Inc. Binding acceleration techniques for the detection of analytes
US8012743B2 (en) 1998-10-27 2011-09-06 Osmetech Technology Inc. Detection of target analytes using particles and electrodes
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing

Also Published As

Publication number Publication date
AU1606301A (en) 2001-06-06
DE60011821T2 (en) 2005-07-07
EP1254372B1 (en) 2004-06-23
JP2003514227A (en) 2003-04-15
AU778556B2 (en) 2004-12-09
DE60011821D1 (en) 2004-07-29
ATE269977T1 (en) 2004-07-15
CA2388780C (en) 2006-06-06
CA2388780A1 (en) 2001-05-17
WO2001035100A9 (en) 2002-07-04
EP1254372A2 (en) 2002-11-06
ES2225264T3 (en) 2005-03-16
WO2001035100A2 (en) 2001-05-17
JP3548159B2 (en) 2004-07-28

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