WO2001036465A3 - Human zven proteins - Google Patents

Human zven proteins Download PDF

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Publication number
WO2001036465A3
WO2001036465A3 PCT/US2000/031278 US0031278W WO0136465A3 WO 2001036465 A3 WO2001036465 A3 WO 2001036465A3 US 0031278 W US0031278 W US 0031278W WO 0136465 A3 WO0136465 A3 WO 0136465A3
Authority
WO
WIPO (PCT)
Prior art keywords
human
proteins
human zven
zven proteins
zvenl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/031278
Other languages
French (fr)
Other versions
WO2001036465A2 (en
Inventor
Paul O Sheppard
Paul D Bishop
Theodore E Whitmore
Penny P Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to JP2001538954A priority Critical patent/JP2003515322A/en
Priority to EP00978641A priority patent/EP1230362A2/en
Priority to AU16082/01A priority patent/AU1608201A/en
Priority to CA002392128A priority patent/CA2392128A1/en
Publication of WO2001036465A2 publication Critical patent/WO2001036465A2/en
Publication of WO2001036465A3 publication Critical patent/WO2001036465A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention provides two members of a new family of human proteins, designated as 'Zven.' The Zvenl gene, which resides in human chromosome 3p21.1 - 3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
PCT/US2000/031278 1999-11-16 2000-11-14 Human zven proteins Ceased WO2001036465A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001538954A JP2003515322A (en) 1999-11-16 2000-11-14 Human Zven protein
EP00978641A EP1230362A2 (en) 1999-11-16 2000-11-14 Human zven proteins
AU16082/01A AU1608201A (en) 1999-11-16 2000-11-14 Human zven proteins
CA002392128A CA2392128A1 (en) 1999-11-16 2000-11-14 Human zven proteins

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US44216499A 1999-11-16 1999-11-16
US09/442,164 1999-11-16
US51187900A 2000-02-25 2000-02-25
US09/511,879 2000-02-25
US55220300A 2000-04-19 2000-04-19
US09/552,203 2000-04-19
US21033200P 2000-06-07 2000-06-07
US60/210,332 2000-06-07

Publications (2)

Publication Number Publication Date
WO2001036465A2 WO2001036465A2 (en) 2001-05-25
WO2001036465A3 true WO2001036465A3 (en) 2001-11-22

Family

ID=27498801

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/031278 Ceased WO2001036465A2 (en) 1999-11-16 2000-11-14 Human zven proteins

Country Status (4)

Country Link
EP (1) EP1230362A2 (en)
AU (1) AU1608201A (en)
CA (1) CA2392128A1 (en)
WO (1) WO2001036465A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030068623A1 (en) 1997-06-16 2003-04-10 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20020172678A1 (en) * 2000-06-23 2002-11-21 Napoleone Ferrara EG-VEGF nucleic acids and polypeptides and methods of use
US7264801B2 (en) 1998-08-11 2007-09-04 Genentech, Inc. EG-VEGF nucleic acids and polypeptides and method of use
JP2004522402A (en) * 1999-06-02 2004-07-29 ジェネンテック・インコーポレーテッド Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6485938B1 (en) 1999-11-16 2002-11-26 Zymogenetics, Inc. Nucleic acid molecules that encodes human Zven1
EP1302542B1 (en) * 2000-07-18 2007-06-13 Takeda Pharmaceutical Company Limited Novel physiologically active peptide and use thereof
JP2004532609A (en) * 2000-11-03 2004-10-28 ザ リージェント オブ ザ ユニバーシティ オブ カリフォルニア Prokineticin polypeptides, related compositions and methods
EP1506971A1 (en) * 2000-11-03 2005-02-16 The Regents of the University of California Prokineticin polypeptides, related compositions and methods
EP1357129A4 (en) * 2001-02-02 2006-09-06 Takeda Pharmaceutical NEW PHYSIOLOGICALLY ACTIVE PEPTIDE AND USE THEREOF
EP2311960A3 (en) 2001-08-29 2011-06-01 Genentech, Inc. Bv8 nucleic acids and polypeptides with mitogenic activity
WO2004032851A2 (en) 2002-10-04 2004-04-22 The Regents Of The University Of California Screening and therapeutic methods relating to neurogenesis
JP2006514683A (en) * 2002-10-07 2006-05-11 ザイモジェネティクス，インコーポレイティド Use of human ZVEN antagonists
JP2006515989A (en) * 2002-10-07 2006-06-15 ザイモジェネティクス，インコーポレイティド Use of human ZVEN proteins and polynucleotides
EP1551440A4 (en) * 2002-10-07 2009-07-15 Zymogenetics Inc Uses of human zven proteins and polynucleotides
JP4912144B2 (en) 2003-03-12 2012-04-11 ジェネンテック， インコーポレイテッド Use of BV8 and / or EG-VEGF to promote hematopoiesis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006550A2 (en) * 1997-08-01 1999-02-11 Genset 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN PROSTATE
WO1999063088A2 (en) * 1998-06-02 1999-12-09 Genentech, Inc. Membrane-bound proteins and nucleic acids encoding the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006550A2 (en) * 1997-08-01 1999-02-11 Genset 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN PROSTATE
WO1999063088A2 (en) * 1998-06-02 1999-12-09 Genentech, Inc. Membrane-bound proteins and nucleic acids encoding the same

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 14 December 1999 (1999-12-14), WECHSELBERGER C ET AL: "Mus musculus Bv8 variant 3 precursor (Bv8) mRNA, complete cds.", XP002173443 *
DATABASE EMBL 2 October 2000 (2000-10-02), JILEK A ET AL: "Homo sapiens Bv8 protein (BV8) mRNA, partial cds.", XP002173444 *
DATABASE EMBL 5 May 2001 (2001-05-05), LI M ET AL: "Homo sapiens prokineticin 1 precursor (PROK1) mRNA, complete cds.", XP002173446 *
DATABASE EMBL 5 May 2001 (2001-05-05), LI M ET AL: "Homo sapiens prokineticin 2 precursor (PROK2) mRNA, complete cds.", XP002173445 *
FEDI PAOLO ET AL: "Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 27, 2 July 1999 (1999-07-02), pages 19465 - 19472, XP002173440, ISSN: 0021-9258 *
HSIEH JEN-CHIH ET AL: "A new secreted protein that binds to Wnt proteins and inhibits their activities.", NATURE (LONDON), vol. 398, no. 6726, 1 April 1999 (1999-04-01), pages 431 - 436, XP002173441, ISSN: 0028-0836 *
JILEK A ET AL: "Murine Bv8 gene maps near a synteny breakpoint of mouse chromosome 6 and human 3p21.", GENE (AMSTERDAM), vol. 256, no. 1-2, 3 October 2000 (2000-10-03), pages 189 - 195, XP004238404, ISSN: 0378-1119 *
LI M ET AL: "Identification of two prokineticin cDNAs: Recombinant proteins potently contract gastrointestinal smooth muscle.", MOLECULAR PHARMACOLOGY, vol. 59, no. 4, April 2001 (2001-04-01), pages 692 - 698, XP001010437, ISSN: 0026-895X *
WECHSELBERGER CHRISTIAN ET AL: "The mammalian homologues of frog Bv8 are mainly expressed in spermatocytes.", FEBS LETTERS, vol. 462, no. 1-2, 26 November 1999 (1999-11-26), pages 177 - 181, XP002173442, ISSN: 0014-5793 *

Also Published As

Publication number Publication date
WO2001036465A2 (en) 2001-05-25
CA2392128A1 (en) 2001-05-21
EP1230362A2 (en) 2002-08-14
AU1608201A (en) 2001-05-30

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