WO2001037863A3 - Compositions comprising neisseria meningitidis antigens from serogroups b and c as well as a further antigen - Google Patents

Compositions comprising neisseria meningitidis antigens from serogroups b and c as well as a further antigen Download PDF

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Publication number
WO2001037863A3
WO2001037863A3 PCT/IB2000/001940 IB0001940W WO0137863A3 WO 2001037863 A3 WO2001037863 A3 WO 2001037863A3 IB 0001940 W IB0001940 W IB 0001940W WO 0137863 A3 WO0137863 A3 WO 0137863A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
serogroups
well
neisseria meningitidis
further antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2000/001940
Other languages
French (fr)
Other versions
WO2001037863A2 (en
Inventor
Marzia Monica Giuliani
Mariagrazia Pizza
Rino Rappuoli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GSK Vaccines SRL
Original Assignee
Chiron SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ519608A priority Critical patent/NZ519608A/en
Priority to BR0015958-1A priority patent/BR0015958A/en
Priority to AU18785/01A priority patent/AU784375B2/en
Priority to JP2001539477A priority patent/JP5670003B2/en
Priority to DK00981554T priority patent/DK1235589T3/en
Priority to CA2392880A priority patent/CA2392880C/en
Priority to DE60041981T priority patent/DE60041981D1/en
Priority to US10/148,533 priority patent/US9636393B2/en
Application filed by Chiron SRL filed Critical Chiron SRL
Priority to MXPA02005322A priority patent/MXPA02005322A/en
Priority to EP00981554A priority patent/EP1235589B1/en
Publication of WO2001037863A2 publication Critical patent/WO2001037863A2/en
Publication of WO2001037863A3 publication Critical patent/WO2001037863A3/en
Anticipated expiration legal-status Critical
Priority to AU2006202664A priority patent/AU2006202664B2/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/116—Polyvalent bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

International patent application WO99/61053 discloses immunogenic compositions that comprise N.meningitidis serogroup C oligosaccharide conjugated to a carrier, in combination with N.meningitidis serogroup B outer membrane protein. These are disclosed in the present application in combination with further Neisserial proteins and/or protective antigens against other pathogenic organisms (e.g. Haemophilus influenzae, DTP, HBV, etc.).
PCT/IB2000/001940 1999-11-29 2000-11-29 Compositions comprising neisseria meningitidis antigens from serogroups b and c as well as a further antigen Ceased WO2001037863A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE60041981T DE60041981D1 (en) 1999-11-29 2000-11-29 NEISSERIA MENINGITIDIS SERUM GROUPS B AND C ANTIGENES AND COMPOSITIONS CONTAINING ADDITIONAL ANTIGEN
AU18785/01A AU784375B2 (en) 1999-11-29 2000-11-29 Compositions comprising neisseria meningitidis antigens from serogroups B and C as well as a further antigen
JP2001539477A JP5670003B2 (en) 1999-11-29 2000-11-29 Neisseria meningitidis antigens from serotypes B and C, and compositions comprising further antigens
DK00981554T DK1235589T3 (en) 1999-11-29 2000-11-29 Compositions comprising neisseria meningitidis antigens from serogroup B and C as well as an additional antigen
CA2392880A CA2392880C (en) 1999-11-29 2000-11-29 Compositions comprising neisseria meningitidis antigens from serogroups b and c
US10/148,533 US9636393B2 (en) 1999-11-29 2000-11-29 Compositions comprising Neisseria meningitidis antigens from serogroups B and C
MXPA02005322A MXPA02005322A (en) 1999-11-29 2000-11-29 Compositions comprising neisseria meningitidis.
NZ519608A NZ519608A (en) 1999-11-29 2000-11-29 Immunogenic compositions comprising NmC oligosaccharide and NmB outer membrane protein and additional proteins and protective antigens
BR0015958-1A BR0015958A (en) 1999-11-29 2000-11-29 Compositions comprising neisseria meningitidis antigens from serogroups b and c
EP00981554A EP1235589B1 (en) 1999-11-29 2000-11-29 Compositions comprising neisseria meningitidis antigens from serogroups b and c as well as a further antigen
AU2006202664A AU2006202664B2 (en) 1999-11-29 2006-06-22 Compositions comprising Neisseria meningitidis antigens from serogroups B and C as well as a further antigen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9928196.6 1999-11-29
GBGB9928196.6A GB9928196D0 (en) 1999-11-29 1999-11-29 Combinations of B, C and other antigens

Publications (2)

Publication Number Publication Date
WO2001037863A2 WO2001037863A2 (en) 2001-05-31
WO2001037863A3 true WO2001037863A3 (en) 2001-12-27

Family

ID=10865363

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2000/001940 Ceased WO2001037863A2 (en) 1999-11-29 2000-11-29 Compositions comprising neisseria meningitidis antigens from serogroups b and c as well as a further antigen

Country Status (18)

Country Link
US (1) US9636393B2 (en)
EP (3) EP1902726A3 (en)
JP (5) JP5670003B2 (en)
CN (4) CN1507916A (en)
AT (1) ATE427756T1 (en)
AU (2) AU784375B2 (en)
BR (1) BR0015958A (en)
CA (2) CA2392880C (en)
CY (1) CY1109202T1 (en)
DE (1) DE60041981D1 (en)
DK (1) DK1235589T3 (en)
ES (1) ES2322753T3 (en)
GB (1) GB9928196D0 (en)
MX (1) MXPA02005322A (en)
NZ (2) NZ529213A (en)
PT (1) PT1235589E (en)
RU (2) RU2508122C2 (en)
WO (1) WO2001037863A2 (en)

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