WO2001042502A3 - Methods for disease detection - Google Patents

Methods for disease detection Download PDF

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Publication number
WO2001042502A3
WO2001042502A3 PCT/US2000/024834 US0024834W WO0142502A3 WO 2001042502 A3 WO2001042502 A3 WO 2001042502A3 US 0024834 W US0024834 W US 0024834W WO 0142502 A3 WO0142502 A3 WO 0142502A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
disease detection
sample
disease
integrity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/024834
Other languages
French (fr)
Other versions
WO2001042502A2 (en
Inventor
Anthony P Shuber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exact Sciences Corp
Original Assignee
Exact Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exact Laboratories Inc filed Critical Exact Laboratories Inc
Priority to EP00960085A priority Critical patent/EP1238103B1/en
Priority to AU71301/00A priority patent/AU7130100A/en
Priority to CA2393709A priority patent/CA2393709C/en
Priority to DE60041355T priority patent/DE60041355D1/en
Priority to JP2001544373A priority patent/JP2003516161A/en
Publication of WO2001042502A2 publication Critical patent/WO2001042502A2/en
Publication of WO2001042502A3 publication Critical patent/WO2001042502A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

The present invention provides methods for detecting disease by analysis of a patient sample to determine the integrity of nucleic acids in the sample.
PCT/US2000/024834 1999-12-07 2000-09-08 Methods for disease detection Ceased WO2001042502A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP00960085A EP1238103B1 (en) 1999-12-07 2000-09-08 Methods for disease detection
AU71301/00A AU7130100A (en) 1999-12-07 2000-09-08 Methods for disease detection
CA2393709A CA2393709C (en) 1999-12-07 2000-09-08 Methods for identifying nucleic acids indicative of cancer
DE60041355T DE60041355D1 (en) 1999-12-07 2000-09-08 METHOD FOR DETECTING ILLNESSES
JP2001544373A JP2003516161A (en) 1999-12-07 2000-09-08 Methods for nucleic acid detection

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16945799P 1999-12-07 1999-12-07
US60/169,457 1999-12-07
US09/514,865 US6919174B1 (en) 1999-12-07 2000-02-28 Methods for disease detection
US09/514,865 2000-02-28

Publications (2)

Publication Number Publication Date
WO2001042502A2 WO2001042502A2 (en) 2001-06-14
WO2001042502A3 true WO2001042502A3 (en) 2002-01-17

Family

ID=26865071

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/024834 Ceased WO2001042502A2 (en) 1999-12-07 2000-09-08 Methods for disease detection

Country Status (8)

Country Link
US (3) US6919174B1 (en)
EP (1) EP1238103B1 (en)
JP (1) JP2003516161A (en)
AT (1) ATE420204T1 (en)
AU (1) AU7130100A (en)
CA (1) CA2393709C (en)
DE (1) DE60041355D1 (en)
WO (1) WO2001042502A2 (en)

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US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US8969021B2 (en) 2001-10-11 2015-03-03 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US8986945B2 (en) 2006-07-14 2015-03-24 Aviva Biosciences Corporation Methods and compositions for detecting rare cells from a biological sample
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence

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US6586177B1 (en) * 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
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US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
CA2394921A1 (en) 1999-12-07 2001-06-14 Anthony P. Shuber Supracolonic aerodigestive neoplasm detection
US6911308B2 (en) 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
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US20040259101A1 (en) * 2003-06-20 2004-12-23 Shuber Anthony P. Methods for disease screening
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WO2005111244A2 (en) * 2004-05-10 2005-11-24 Exact Sciences Corporation Methods for detecting a mutant nucleic acid
WO2005113769A1 (en) * 2004-05-14 2005-12-01 Exact Sciences Corporation Method for stabilizing biological samples for nucleic acid analysis
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US8883440B2 (en) * 2007-07-26 2014-11-11 Nancy M. Lee Method to predict or diagnose a gastrointestinal disorder or disease
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US10253358B2 (en) 2013-11-04 2019-04-09 Exact Sciences Development Company, Llc Multiple-control calibrators for DNA quantitation
US10138524B2 (en) 2013-12-19 2018-11-27 Exact Sciences Development Company, Llc Synthetic nucleic acid control molecules
KR102392407B1 (en) 2014-03-07 2022-04-29 디엔에이 제노텍 인코퍼레이티드 Composition and method for stabilizing nucleic acids in biological samples
EP3978624B1 (en) 2016-07-19 2025-03-26 Exact Sciences Corporation Methylated control dna
WO2018017710A1 (en) 2016-07-19 2018-01-25 Exact Sciences Development Company, Llc Nucleic acid control molecules from non-human organisms
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CA3057420C (en) 2017-05-12 2023-08-01 Laboratory Corporation Of America Holdings Systems and methods for biomarker identificaton
EP4455310A3 (en) 2017-12-20 2025-01-08 Laboratory Corporation of America Holdings Identification of biomarkers for head and neck cancer
CN112424605A (en) 2018-05-11 2021-02-26 美国控股实验室公司 Compositions and methods for detecting renal fibrosis
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