WO2001046219A3 - Method for production of a c1 esterase inhibitor (c1-inh)-containing composition - Google Patents

Method for production of a c1 esterase inhibitor (c1-inh)-containing composition Download PDF

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Publication number
WO2001046219A3
WO2001046219A3 PCT/EP2000/013086 EP0013086W WO0146219A3 WO 2001046219 A3 WO2001046219 A3 WO 2001046219A3 EP 0013086 W EP0013086 W EP 0013086W WO 0146219 A3 WO0146219 A3 WO 0146219A3
Authority
WO
WIPO (PCT)
Prior art keywords
inh
containing composition
production
esterase inhibitor
anion exchanger
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/013086
Other languages
French (fr)
Other versions
WO2001046219A2 (en
Inventor
Wolfgang Schoenhofer
Hans-Peter Schwarz
Oliver Zoechling
Yendra Linnau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter AG
Original Assignee
Baxter AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter AG filed Critical Baxter AG
Priority to EP00991244A priority Critical patent/EP1244706A2/en
Priority to AU31628/01A priority patent/AU3162801A/en
Publication of WO2001046219A2 publication Critical patent/WO2001046219A2/en
Publication of WO2001046219A3 publication Critical patent/WO2001046219A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A method is described for production of a C1-INH esterase inhibitor (C1-INH)-containing composition, which includes the following steps: treating a C1-INH-containing starting material with an anion exchanger under acidic conditions and eluting the C1-INH from the anion exchanger, in which a C1-INH-containing composition is obtained.
PCT/EP2000/013086 1999-12-22 2000-12-21 Method for production of a c1 esterase inhibitor (c1-inh)-containing composition Ceased WO2001046219A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00991244A EP1244706A2 (en) 1999-12-22 2000-12-21 Method for production of a c1 esterase inhibitor (c1-inh)-containing composition
AU31628/01A AU3162801A (en) 1999-12-22 2000-12-21 Method for production of a c1 esterase inhibitor (c1-inh)-containing composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA2166/99 1999-12-22
AT0216699A AT409336B (en) 1999-12-22 1999-12-22 METHOD FOR PRODUCING A C1-ESTERASE INHIBITOR (C1-INH) COMPOSITION

Publications (2)

Publication Number Publication Date
WO2001046219A2 WO2001046219A2 (en) 2001-06-28
WO2001046219A3 true WO2001046219A3 (en) 2002-01-03

Family

ID=3529164

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/013086 Ceased WO2001046219A2 (en) 1999-12-22 2000-12-21 Method for production of a c1 esterase inhibitor (c1-inh)-containing composition

Country Status (5)

Country Link
US (1) US20010019839A1 (en)
EP (1) EP1244706A2 (en)
AT (1) AT409336B (en)
AU (1) AU3162801A (en)
WO (1) WO2001046219A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011116291A1 (en) * 2010-03-18 2011-09-22 Thrombolytic Science International Production of human c1 inhibitor in human cells
ME03326B (en) * 2013-03-15 2019-10-20 Shire Viropharma Inc C1-INH COMPOSITIONS AND PROCEDURES FOR THE PREVENTION AND TREATMENT OF DISORDERS RELATED TO DEFICIENCY OF C1 ESTERASE INHIBITORS
BR112019023737A2 (en) 2017-05-16 2020-05-26 Octapharma Ag PREPARATION OF C1-ESTERASE INHIBITOR (C1-INH), KIT THAT CONSISTS OF A FIRST RECEPTACLE CONTAINING THE PREPARATION OF C1-INH, KIT THAT CONSISTS OF A PRE-FILLED SYRINGE WITH THE PREPARATION OF C1-INH, KIT THAT CONSISTS OF ONE SUITABLE DEVICE FOR SUBCUTANEOUS APPLICATION, SUCH AS AN INJECTOR IN THE BODY AND USE OF HISTIDINE TO INCREASE THE CIO-INH BIOAVAILABILITY ADMINISTERED SUBCUTANEOUSLY
EP3867262A1 (en) * 2018-10-17 2021-08-25 CSL Behring GmbH Process for purifying c1-inh
KR20220029732A (en) 2019-07-04 2022-03-08 체에스엘 베링 게엠베하 How to purify C1-INH
CN111269307B (en) * 2020-02-26 2021-12-21 国药集团武汉血液制品有限公司 Method for removing hybrid protein IgM in raw material for preparing C1 esterase inhibitor
CA3173539A1 (en) 2020-03-31 2021-10-07 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation from c-1 inhibitor depleted plasma

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4670539A (en) * 1984-07-27 1987-06-02 Board Of Regents, The University Of Texas Peptide growth factors derived from estrogen responsive kidney tissue
US4915945A (en) * 1982-07-30 1990-04-10 Behringwerke Aktiengesellschaft Process for the preparation of the C1 inactivator
US5304383A (en) * 1990-10-11 1994-04-19 Immuno Aktiengesellschaft Pharmaceutical preparation based on Lys-plasminogen
EP0698616A1 (en) * 1994-07-28 1996-02-28 Association Pour L'essor De La Transfusion Sanguine Dans La Region Du Nord Process for the preparation of a C1-esterase inhibitor (C1-1NH) concentrate and therapeutical use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4915945A (en) * 1982-07-30 1990-04-10 Behringwerke Aktiengesellschaft Process for the preparation of the C1 inactivator
US4670539A (en) * 1984-07-27 1987-06-02 Board Of Regents, The University Of Texas Peptide growth factors derived from estrogen responsive kidney tissue
US5304383A (en) * 1990-10-11 1994-04-19 Immuno Aktiengesellschaft Pharmaceutical preparation based on Lys-plasminogen
EP0698616A1 (en) * 1994-07-28 1996-02-28 Association Pour L'essor De La Transfusion Sanguine Dans La Region Du Nord Process for the preparation of a C1-esterase inhibitor (C1-1NH) concentrate and therapeutical use thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SAGUER I.M. ET AL.: "Prophylactic treatment with pasteurized C1-inhibitor in hereditary angioedema (HAE)", BLOOD, vol. 94, no. 10 (Suppl. 1, Part 1), 15 November 1999 (1999-11-15), pages 233a, XP001010637 *
VAN DEN BERG C.W. ET AL.: "C1-inhibitor prevents PEG fractionation-induced, EDTA-resistant activation of mouse complement", MOLECULAR IMMUNOLOGY, vol. 29, no. 3, 1992, pages 363 - 369, XP001011476 *

Also Published As

Publication number Publication date
WO2001046219A2 (en) 2001-06-28
ATA216699A (en) 2001-12-15
AU3162801A (en) 2001-07-03
EP1244706A2 (en) 2002-10-02
US20010019839A1 (en) 2001-09-06
AT409336B (en) 2002-07-25

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