WO2001049247A3 - Assays for analytes and enzymes practiced in the presence of nad and nadp analogues, and related assay kits - Google Patents

Assays for analytes and enzymes practiced in the presence of nad and nadp analogues, and related assay kits Download PDF

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Publication number
WO2001049247A3
WO2001049247A3 PCT/US2000/035299 US0035299W WO0149247A3 WO 2001049247 A3 WO2001049247 A3 WO 2001049247A3 US 0035299 W US0035299 W US 0035299W WO 0149247 A3 WO0149247 A3 WO 0149247A3
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WO
WIPO (PCT)
Prior art keywords
nad
nadp
analogs
analytes
analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/035299
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French (fr)
Other versions
WO2001049247A2 (en
Inventor
Richard A Kaufman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Specialty Assays Inc
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Specialty Assays Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Specialty Assays Inc filed Critical Specialty Assays Inc
Priority to AU27388/01A priority Critical patent/AU2738801A/en
Priority to EP00990352.7A priority patent/EP1242440B1/en
Publication of WO2001049247A2 publication Critical patent/WO2001049247A2/en
Publication of WO2001049247A3 publication Critical patent/WO2001049247A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/61—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving triglycerides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)

Abstract

Kits and methods for measuring enzyme activities and metabolites using NAD analogs and NADP analogs are disclosed. The analogs can be used as replacements for NAD and NADP cofactors in analytical procedures. Preferred aspects of the invention include kits containing the NAD analogs and NADP analogs for use in the measurement of ethanol, lactic acid, 3-hydroxybutyric acid, glucose, glycerol, triglycerides, alpha-glycerophosphate, bile acids and glucose-6-phosphate dehydrogenase activity in analytical samples.
PCT/US2000/035299 1999-12-30 2000-12-27 Assays for analytes and enzymes practiced in the presence of nad and nadp analogues, and related assay kits Ceased WO2001049247A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU27388/01A AU2738801A (en) 1999-12-30 2000-12-27 Use of nicotinamide adenine dinucleotide (nad) and nicotinamide adenine dinucleotide phosphate (nadp) analogs to measure enzyme activities, metabolites and substrates
EP00990352.7A EP1242440B1 (en) 1999-12-30 2000-12-27 Use of nicotinamide adenine dinucleotide (nad) analogs to measure ethanol

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/475,736 US6380380B1 (en) 1999-01-04 1999-12-30 Use of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucliotide phosphate (NADP) analogs to measure enzyme activities metabolites and substrates
US09/475,736 1999-12-30

Publications (2)

Publication Number Publication Date
WO2001049247A2 WO2001049247A2 (en) 2001-07-12
WO2001049247A3 true WO2001049247A3 (en) 2002-01-31

Family

ID=23888897

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/035299 Ceased WO2001049247A2 (en) 1999-12-30 2000-12-27 Assays for analytes and enzymes practiced in the presence of nad and nadp analogues, and related assay kits

Country Status (4)

Country Link
US (1) US6380380B1 (en)
EP (1) EP1242440B1 (en)
AU (1) AU2738801A (en)
WO (1) WO2001049247A2 (en)

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Publication number Priority date Publication date Assignee Title
US10260085B2 (en) 2009-12-16 2019-04-16 Roche Diabetes Care, Inc. Detecting the decomposition of enzymes in a test element by means of controlled release of a protected analyte

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AU2003268331A1 (en) * 2002-08-30 2004-03-19 The State Of Oregon, Acting By And Through The State Board Of Higher Education On Behalf Of The Univ Immunocapture-based measurements of mammalian pyruvate dehydrogenase complex
DE10315640A1 (en) * 2003-04-04 2004-10-14 Ignatov, Konstantin Process for the controlled release of components into a solution
US7338775B1 (en) 2005-02-09 2008-03-04 Myriad Genetics, Inc. Enzyme assay and use thereof
DE102005035461A1 (en) 2005-07-28 2007-02-15 Roche Diagnostics Gmbh Stable NAD / NADH derivatives
US7553615B2 (en) 2005-07-28 2009-06-30 Roche Diagnostics Operations, Inc. Compounds, methods, complexes, apparatuses and uses relating to stabile forms of NAD/NADH
US7855079B2 (en) * 2006-07-25 2010-12-21 General Atomics Methods for assaying percentage of glycated hemoglobin
US7943385B2 (en) 2006-07-25 2011-05-17 General Atomics Methods for assaying percentage of glycated hemoglobin
EP2093284A1 (en) * 2008-02-19 2009-08-26 F.Hoffmann-La Roche Ag Stabilisation of dehydrogenases with stable coenzymes
WO2009135035A1 (en) * 2008-05-02 2009-11-05 Specialty Assays, Inc. Enzymatic determination of potassium ions using stable nad(p)h analogs.
EP2283149A1 (en) * 2008-05-13 2011-02-16 General Atomics Electrochemical biosensor for direct determination of percentage of glycated hemoglobin
KR100986733B1 (en) * 2008-08-08 2010-10-08 한국화학연구원 Methods for preparing enhanced butanol-resistant and butanol-producing strains
EP2398909B1 (en) 2009-02-19 2015-07-22 F. Hoffmann-La Roche AG Fast reaction kinetics of enzymes having low activity in dry chemistry layers
KR20130127555A (en) 2009-02-19 2013-11-22 에프. 호프만-라 로슈 아게 Fast reaction kinetics of enzymes having low activity in dry chemistry layers
EP2287605A1 (en) 2009-08-20 2011-02-23 Roche Diagnostics GmbH Simplified magazining of integrated systems
EP2292751A1 (en) 2009-08-20 2011-03-09 Roche Diagnostics GmbH Stabilisation of enzymes with stable coenzymes
EP2333544A1 (en) 2009-12-11 2011-06-15 F. Hoffmann-La Roche AG Sterilisable chemistry for test elements
KR101609083B1 (en) 2011-09-28 2016-04-04 에프. 호프만-라 로슈 아게 Azo mediators
US8921061B2 (en) * 2012-11-02 2014-12-30 Roche Diagnostics Operations, Inc. Reagent materials and associated test elements
EP2770064A1 (en) 2013-02-22 2014-08-27 F. Hoffmann-La Roche AG Highly efficient production of blood glucose test strips
CA2945612C (en) 2014-04-14 2019-09-10 F. Hoffmann-La Roche Ag Phenazinium mediators
EP3183246B1 (en) 2014-08-22 2020-09-23 Roche Diagnostics GmbH Redoxindicators
CN106381287A (en) * 2015-07-28 2017-02-08 上海张江生物技术有限公司 Method for culturing animal cells for over expression of lactic dehydrogenase C
CN105588936A (en) * 2015-12-14 2016-05-18 浙江达美生物技术有限公司 Determination reagent for glycocholic acid and preparation method of determination reagent
CA3035874C (en) 2016-10-05 2025-09-09 F. Hoffmann-La Roche Ag Detection reagents and electrode arrangements for multi-analyte diagnostic test elements, as well as methods of using the same

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WO1989002925A1 (en) * 1987-09-22 1989-04-06 Abbott Laboratories Simultaneous assay for cholesterol and triglycerides
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WO1991019974A1 (en) * 1990-06-14 1991-12-26 Flow, Inc. Method and composition for diagnosing malaria
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EP0639646A1 (en) * 1991-05-14 1995-02-22 Asahi Kasei Kogyo Kabushiki Kaisha High precision determination of d-glucose-6-phosphate and composition therefor
US5705356A (en) * 1993-09-17 1998-01-06 Trace Scientific Limited Reagent for invitro diagnostic determination of bicarbonate
US5801006A (en) * 1997-02-04 1998-09-01 Specialty Assays, Inc. Use of NADPH and NADH analogs in the measurement of enzyme activities and metabolites

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US5037738A (en) * 1987-06-03 1991-08-06 Abbott Laboratories Simultaneous assay for glucose and urea
WO1989002925A1 (en) * 1987-09-22 1989-04-06 Abbott Laboratories Simultaneous assay for cholesterol and triglycerides
WO1991019974A1 (en) * 1990-06-14 1991-12-26 Flow, Inc. Method and composition for diagnosing malaria
EP0639646A1 (en) * 1991-05-14 1995-02-22 Asahi Kasei Kogyo Kabushiki Kaisha High precision determination of d-glucose-6-phosphate and composition therefor
EP0632133A1 (en) * 1991-12-12 1995-01-04 Asahi Kasei Kogyo Kabushiki Kaisha Highly sensitive determination of d-3-hydroxybutyric acid or acetoacetic acid and composition therefor
US5705356A (en) * 1993-09-17 1998-01-06 Trace Scientific Limited Reagent for invitro diagnostic determination of bicarbonate
US5801006A (en) * 1997-02-04 1998-09-01 Specialty Assays, Inc. Use of NADPH and NADH analogs in the measurement of enzyme activities and metabolites

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Title
"Biochemicals organic compounds and diagnostic reagents (catalog)", SIGMA CHEMICAL COMPANY, 1996, ST. LOUIS, MO, pages 35, 902-903, 994, XP002939584 *
See also references of EP1242440A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10260085B2 (en) 2009-12-16 2019-04-16 Roche Diabetes Care, Inc. Detecting the decomposition of enzymes in a test element by means of controlled release of a protected analyte

Also Published As

Publication number Publication date
WO2001049247A2 (en) 2001-07-12
EP1242440B1 (en) 2015-09-16
US6380380B1 (en) 2002-04-30
EP1242440A4 (en) 2003-01-15
EP1242440A2 (en) 2002-09-25
AU2738801A (en) 2001-07-16

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