WO2001049729A3 - Novex polypeptides, nucleic acids encoding same and their diagnostic and therapeutic use - Google Patents

Novex polypeptides, nucleic acids encoding same and their diagnostic and therapeutic use Download PDF

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Publication number
WO2001049729A3
WO2001049729A3 PCT/US2001/000299 US0100299W WO0149729A3 WO 2001049729 A3 WO2001049729 A3 WO 2001049729A3 US 0100299 W US0100299 W US 0100299W WO 0149729 A3 WO0149729 A3 WO 0149729A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
novex
diagnostic
nucleic acids
acids encoding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/000299
Other languages
French (fr)
Other versions
WO2001049729A8 (en
WO2001049729A2 (en
Inventor
Sudhirdas K Prayaga
Kumud Majumder
Bruce E Taillon
Steven K Spaderna
Kimberley A Spytek
John Macdougall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CuraGen Corp
Original Assignee
CuraGen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CuraGen Corp filed Critical CuraGen Corp
Priority to AU27627/01A priority Critical patent/AU2762701A/en
Priority to CA002394730A priority patent/CA2394730A1/en
Priority to EP01901759A priority patent/EP1244697A2/en
Publication of WO2001049729A2 publication Critical patent/WO2001049729A2/en
Publication of WO2001049729A8 publication Critical patent/WO2001049729A8/en
Publication of WO2001049729A3 publication Critical patent/WO2001049729A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention provides isolated NOVX polynucleotides and polypeptides encoded by the NOVX polynucleotides. Also provided are the antibodies that immunospecifically bind to a NOVX polypeptide or any derivative, variant, mutant or fragment of the NOVX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the NOVX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
PCT/US2001/000299 2000-01-06 2001-01-05 Novex polypeptides, nucleic acids encoding same and their diagnostic and therapeutic use Ceased WO2001049729A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU27627/01A AU2762701A (en) 2000-01-06 2001-01-05 Novel polypeptides and nucleic acids encoding same
CA002394730A CA2394730A1 (en) 2000-01-06 2001-01-05 Novex polypeptides, nucleic acids encoding same and their diagnostic and therapeutic use
EP01901759A EP1244697A2 (en) 2000-01-06 2001-01-05 Novx polypeptides nucleic acids encoding same and their diagnostic and thereapeutic use

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US17472400P 2000-01-06 2000-01-06
US60/174,724 2000-01-06
US17548800P 2000-01-11 2000-01-11
US17543400P 2000-01-11 2000-01-11
US60/175,434 2000-01-11
US60/175,488 2000-01-11
US17574300P 2000-01-12 2000-01-12
US17569600P 2000-01-12 2000-01-12
US60/175,696 2000-01-12
US60/175,743 2000-01-12
US17581900P 2000-01-13 2000-01-13
US60/175,819 2000-01-13
US22352400P 2000-08-07 2000-08-07
US60/223,524 2000-08-07
US09/755,665 US6600019B2 (en) 2000-01-06 2001-01-04 Polypeptides and nucleic acids encoding same
US09/755,665 2001-01-04

Publications (3)

Publication Number Publication Date
WO2001049729A2 WO2001049729A2 (en) 2001-07-12
WO2001049729A8 WO2001049729A8 (en) 2001-11-15
WO2001049729A3 true WO2001049729A3 (en) 2002-03-28

Family

ID=27575058

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/000299 Ceased WO2001049729A2 (en) 2000-01-06 2001-01-05 Novex polypeptides, nucleic acids encoding same and their diagnostic and therapeutic use

Country Status (4)

Country Link
US (2) US6600019B2 (en)
EP (1) EP1244697A2 (en)
CA (1) CA2394730A1 (en)
WO (1) WO2001049729A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070015696A1 (en) * 1997-03-07 2007-01-18 Rosen Craig A 621 human secreted proteins
US20070020724A1 (en) * 1998-06-16 2007-01-25 Ruben Steven M 94 human secreted proteins
GB0028971D0 (en) * 2000-11-28 2001-01-10 Inpharmatica Ltd Novel proteins
US7763256B2 (en) * 2002-12-23 2010-07-27 William Marsh Rice University Compositions and methods for suppressing fibrocytes and for detecting fibrocyte differentiation
JP4922560B2 (en) 2002-12-23 2012-04-25 ウイリアム、マーシュ、ライス、ユーニヴァーサティ Method for detecting differentiation into fibrocytes, composition and method for inhibiting fibrosis
US20100297074A1 (en) * 2002-12-23 2010-11-25 Richard Hans Gomer Wound healing compositions, systems, and methods
US8012472B2 (en) 2002-12-23 2011-09-06 William Marsh Rice University Compositions and methods for suppressing fibrocytes
JP5220025B2 (en) * 2006-12-04 2013-06-26 プロメディオール， インコーポレイテッド Combination therapy to treat fibrotic diseases
US8497243B2 (en) * 2007-07-06 2013-07-30 Promedior, Inc. Methods and compositions useful in the treatment of mucositis
US9884899B2 (en) 2007-07-06 2018-02-06 Promedior, Inc. Methods for treating fibrosis using CRP antagonists
PT2405928T (en) * 2009-03-11 2017-02-07 Promedior Inc Treatment and diagnostic methods for hypersensitive disorders
PT2405929T (en) * 2009-03-11 2018-07-23 Promedior Inc A sap polypeptide for use in the treatment of autoimmune disorders and graft vs host disease
UA110323C2 (en) * 2009-06-04 2015-12-25 Promedior Inc Derivative of serum amyloid p and their receipt and application
HUE041034T2 (en) * 2009-06-17 2019-05-28 Promedior Inc Sap variants and their use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0440321A2 (en) * 1990-02-01 1991-08-07 IHF INSTITUT FÜR HORMON- UND FORTPFLANZUNGSFORSCHUNG GmbH Epididymis specific DNA sequences and their use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4422463A (en) * 1978-03-24 1983-12-27 Deere & Company Rotor for an axial flow rotary separator
CA1107168A (en) * 1979-01-12 1981-08-18 White Motor Corporation Of Canada Limited Rotor for an axial flow combine
US4274426A (en) * 1980-03-31 1981-06-23 Williams Dennis W Threshing apparatus
US5376047A (en) * 1993-04-26 1994-12-27 Deere & Company Crop engaging element for an axial agricultural combine
GB9321469D0 (en) 1993-10-18 1993-12-08 Zeneca Ltd Insecticidal proteins
US6036598A (en) * 1998-05-21 2000-03-14 Deere & Company Crop processing element for a rotary combine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0440321A2 (en) * 1990-02-01 1991-08-07 IHF INSTITUT FÜR HORMON- UND FORTPFLANZUNGSFORSCHUNG GmbH Epididymis specific DNA sequences and their use

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
C KIRCHLOF ET AL: "Cloning and analysis of mRNAs expressed specifically in the human epididymis", INTERNATIONAL JOURNAL OF ANDROLOGY,GB,BLACKWELL SCIENTIFIC PUBLICATIONS, OXFORD, vol. 2, no. 13, 1 April 1990 (1990-04-01), pages 155 - 167, XP002075040, ISSN: 0105-6263 *
DATABASE EMBL [online] 10 December 1993 (1993-12-10), KIRCHHOFF C. ET AL.: "H. sapiens mRNA for HE3 (beta)", XP002173500, retrieved from EMBL accession no. X76386 *
KIRCHHOFF CHRISTIANE ET AL.: "Major human epididymis-specific gene product, HE3, is the first representative of a novel gene family", MOLECULAR REPRODUCTION AND DEVELOPMENT, vol. 37, no. 2, 1994, pages 130 - 137, XP001008544 *
KIRCHHOFF CHRISTIANE ET AL: "A major mRNA of the human epididymal principal cells, HE5, encodes the leucocyte differentiation CDw52 antigen peptide backbone.", MOLECULAR REPRODUCTION AND DEVELOPMENT, vol. 34, no. 1, 1993, pages 8 - 15, XP001008536, ISSN: 1040-452X *
KIRCHHOFF, C.: "Molecular Aspects of Epididymal Function and Sperm Maturation", CURRENT ADVANCES IN ANDROLOGY, PROC. INT. CONGR. ANDROL., 6TH, 1997, pages 253 - 259, XP001008538 *
OSTERHOFF CAROLINE ET AL: "Molecular cloning and characterization of a novel human sperm antigen (HE2) specifically expressed in the proximal epididymis.", BIOLOGY OF REPRODUCTION, vol. 50, no. 3, 1994, pages 516 - 525, XP001008567, ISSN: 0006-3363 *

Also Published As

Publication number Publication date
US20020107186A1 (en) 2002-08-08
US20040116671A1 (en) 2004-06-17
EP1244697A2 (en) 2002-10-02
WO2001049729A8 (en) 2001-11-15
WO2001049729A2 (en) 2001-07-12
CA2394730A1 (en) 2001-07-12
US6600019B2 (en) 2003-07-29

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