WO2001062959A3 - Endometriosis-related markers and uses thereof - Google Patents

Endometriosis-related markers and uses thereof Download PDF

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Publication number
WO2001062959A3
WO2001062959A3 PCT/CA2001/000245 CA0100245W WO0162959A3 WO 2001062959 A3 WO2001062959 A3 WO 2001062959A3 CA 0100245 W CA0100245 W CA 0100245W WO 0162959 A3 WO0162959 A3 WO 0162959A3
Authority
WO
WIPO (PCT)
Prior art keywords
endometriosis
methods
females
much less
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2001/000245
Other languages
French (fr)
Other versions
WO2001062959A2 (en
Inventor
Soheyl Baban
Monique Bernard
Elana Cherry
Diane Gosselin
Patrice Hugo
Brigitte Malette
Pierre Miron
Charles Prive
Kamran Shazand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procrea Biosciences Inc
Original Assignee
Procrea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procrea Biosciences Inc filed Critical Procrea Biosciences Inc
Priority to EP01909382A priority Critical patent/EP1290218B8/en
Priority to BR0108685-5A priority patent/BR0108685A/en
Priority to DE60129018T priority patent/DE60129018T2/en
Priority to CA002399259A priority patent/CA2399259A1/en
Priority to AU2001237178A priority patent/AU2001237178A1/en
Priority to JP2001561767A priority patent/JP2003531580A/en
Publication of WO2001062959A2 publication Critical patent/WO2001062959A2/en
Anticipated expiration legal-status Critical
Publication of WO2001062959A3 publication Critical patent/WO2001062959A3/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Radar Systems Or Details Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to markers of endometriosis which are differentially expressed in the endometrial cells of females with endometriosis compared to endometriosis-free females. The invention also relates to methods for determining likelihood of endometriosis in female subjects, to methods for grading endometriosis in females suffering from endometriosis and to methods for treating this disease. The invention is also concerned with polynucleotides, probes, primers and kits useful for reducing into practice the above-mentioned methods which are more rapid, non invasive, much less complicated and much less costly than laparoscopy.
PCT/CA2001/000245 2000-02-25 2001-02-26 Endometriosis-related markers and uses thereof Ceased WO2001062959A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP01909382A EP1290218B8 (en) 2000-02-25 2001-02-26 Endometriosis-related markers and uses thereof
BR0108685-5A BR0108685A (en) 2000-02-25 2001-02-26 Endometriosis Related Markers
DE60129018T DE60129018T2 (en) 2000-02-25 2001-02-26 ENDOMETRIOSIS MARKERS AND USE OF THE SAME
CA002399259A CA2399259A1 (en) 2000-02-25 2001-02-26 Endometriosis-related markers and uses thereof
AU2001237178A AU2001237178A1 (en) 2000-02-25 2001-02-26 Endometriosis-related markers and uses thereof
JP2001561767A JP2003531580A (en) 2000-02-25 2001-02-26 Endometriosis-related markers and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18506300P 2000-02-25 2000-02-25
US60/185,063 2000-02-25
US22574500P 2000-08-17 2000-08-17
US60/225,745 2000-08-17

Publications (2)

Publication Number Publication Date
WO2001062959A2 WO2001062959A2 (en) 2001-08-30
WO2001062959A3 true WO2001062959A3 (en) 2003-01-03

Family

ID=26880752

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2001/000245 Ceased WO2001062959A2 (en) 2000-02-25 2001-02-26 Endometriosis-related markers and uses thereof

Country Status (10)

Country Link
US (3) US6777182B2 (en)
EP (1) EP1290218B8 (en)
JP (1) JP2003531580A (en)
AT (1) ATE365227T1 (en)
AU (1) AU2001237178A1 (en)
BR (1) BR0108685A (en)
CA (1) CA2399259A1 (en)
DE (2) DE60140580D1 (en)
ES (2) ES2336817T3 (en)
WO (1) WO2001062959A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7268117B2 (en) 2003-07-11 2007-09-11 Praecis Pharmaceuticals Incorporated Compositions, kits, and methods for identification, assessment, prevention, and therapy of endometriosis
US11287425B2 (en) 2009-04-22 2022-03-29 Juneau Biosciences, Llc Genetic markers associated with endometriosis and use thereof

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100414637B1 (en) * 2000-02-08 2004-01-13 (주)에스제이바이오메드 Anti-human mitochondrial adenylate kinase isozyme antibody, diagnostic formulation and diagnositc kit for cardiac disease
US6884578B2 (en) * 2000-03-31 2005-04-26 Affymetrix, Inc. Genes differentially expressed in secretory versus proliferative endometrium
EP1511863A4 (en) * 2002-05-14 2006-12-27 Univ Leland Stanford Junior ENDOMETRIAL GENES IN DISEASES OF THE ENDOMETRIUM
US20050214836A1 (en) * 2002-08-30 2005-09-29 Oncotherapy Science, Inc. Method of diagnosing ovarian endometriosis
US20050100967A1 (en) * 2003-07-11 2005-05-12 Science & Technology Corporation @ Unm Detection of endometrial pathology
DE602004028513D1 (en) * 2003-12-23 2010-09-16 Mount Sinai Hospital Corp PROCEDURE FOR DETECTING MARKERS ASSOCIATED WITH ENDOMETRIAL DISEASE OR PHASE
EP1730183A2 (en) * 2004-01-27 2006-12-13 Compugen USA, Inc. Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of endometriosis
US20060008876A1 (en) * 2004-07-07 2006-01-12 Shami A S E ME-5, ME-2, and EPP2: human protein antigens reactive with autoantibodies present in the serum of women suffering from endometriosis
US7943324B2 (en) * 2004-12-22 2011-05-17 The Trustees Of The University Of Pennsylvania Endometriosis markers
KR20080044836A (en) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. KUN inhibitors for the treatment of endometriosis
BRPI0613042A2 (en) * 2005-07-15 2010-12-14 Serono Lab jnk inhibitors for the treatment of endometriosis
US8338111B2 (en) * 2006-12-22 2012-12-25 The Trustees Of The University Of Pennsylvania Endometriosis markers
US20080305967A1 (en) * 2007-06-11 2008-12-11 Juneau Biosciences, Llc Genetic Markers Associated with Endometriosis and Use Thereof
US20080306034A1 (en) * 2007-06-11 2008-12-11 Juneau Biosciences, Llc Method of Administering a Therapeutic
US8932993B1 (en) 2007-06-11 2015-01-13 Juneau Biosciences, LLC. Method of testing for endometriosis and treatment therefor
US20090136465A1 (en) 2007-09-28 2009-05-28 Intrexon Corporation Therapeutic Gene-Switch Constructs and Bioreactors for the Expression of Biotherapeutic Molecules, and Uses Thereof
CA2753524A1 (en) 2009-03-06 2010-09-10 Mochida Phamaceutical Co., Ltd. Method for diagnosing endometriosis and diagnostic kit for endometriosis
WO2010107734A2 (en) * 2009-03-16 2010-09-23 Ozgul Muneyyirci-Delale Methods for detecting endometriosis
GB201012662D0 (en) * 2010-07-28 2010-09-15 Valirx Plc Method for detecting the presence of a gynaecological growth
DE102012002929A1 (en) 2012-02-14 2013-08-14 Jürgen Lewald Analyzing a peripheral blood sample of a female subject based on concentration of a steroid hormone that indicates endometriosis, comprising e.g. testosterone, progesterone, cortisol, dehydroepiandrosterone and androstenedione
GB201302837D0 (en) * 2013-02-19 2013-04-03 Univ Singapore Therapeutic Agents
US9434991B2 (en) 2013-03-07 2016-09-06 Juneau Biosciences, LLC. Method of testing for endometriosis and treatment therefor
WO2016011377A1 (en) * 2014-07-17 2016-01-21 Celmatix Inc. Methods and systems for assessing infertility and related pathologies
EP3436580B1 (en) 2016-03-30 2021-03-17 Life Technologies AS Improved methods and compositions for nucleic acid isolation
WO2017201748A1 (en) * 2016-05-27 2017-11-30 曾启瑞 Method for detecting endometriosis and application thereof
WO2019115829A1 (en) * 2017-12-15 2019-06-20 Endodiag Pépinière Génopole Entreprises Method of diagnosing endometriosis
KR102897619B1 (en) * 2018-04-20 2025-12-09 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 Compositions and methods for treating endometriosis
JP7191361B2 (en) * 2018-08-13 2022-12-19 学校法人 埼玉医科大学 Method for assisting determination of susceptibility to obstetrics and gynecology disease, method for collecting data for diagnosing susceptibility to obstetrics and gynecology disease, and diagnostic kit for obstetrics and gynecology disease
KR102255691B1 (en) * 2018-12-14 2021-05-26 대한민국 Porcine endometrial genes for detecting estrous cycle in pig, and use thereof
JP7535270B2 (en) * 2019-04-26 2024-08-16 中外製薬株式会社 Method for diagnosing endometriosis, method for monitoring pathology, and kit
GB202310300D0 (en) 2023-07-05 2023-08-16 Univ Edinburgh Endometrosis markers and methods of diagnosing nedometriosis

Citations (4)

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Publication number Priority date Publication date Assignee Title
WO1995013821A1 (en) * 1993-11-19 1995-05-26 The Trustees Of The University Of Pennsylania αvβ3 INTEGRIN AS A PREDICTOR OF ENDOMETRIOSIS
DE19824230A1 (en) * 1998-05-29 1999-12-02 Starzinski Powitz Anna New endometriosis-associated gene
WO1999063115A2 (en) * 1998-06-04 1999-12-09 Reprogen, Inc. Use of cathepsin s in the diagnosis and treatment of endometriosis
WO1999063116A2 (en) * 1998-06-04 1999-12-09 Reprogen, Inc. Use of prothymosin in the diagnosis and treatment of endometriosis

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TW486377B (en) * 2000-02-24 2002-05-11 Tokyo Electron Ltd Gas leak detecting system, gas leak detecting method and semiconductor manufacturing device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013821A1 (en) * 1993-11-19 1995-05-26 The Trustees Of The University Of Pennsylania αvβ3 INTEGRIN AS A PREDICTOR OF ENDOMETRIOSIS
DE19824230A1 (en) * 1998-05-29 1999-12-02 Starzinski Powitz Anna New endometriosis-associated gene
WO1999063115A2 (en) * 1998-06-04 1999-12-09 Reprogen, Inc. Use of cathepsin s in the diagnosis and treatment of endometriosis
WO1999063116A2 (en) * 1998-06-04 1999-12-09 Reprogen, Inc. Use of prothymosin in the diagnosis and treatment of endometriosis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BERGQVIST A ET AL: "A COMPARISON OF CATHEPSIN D LEVELS IN ENDOMETRIOTIC TISSUE AND IN UTERINE ENDOMETRIUM", FERTILITY AND STERILITY, ELSEVIER SCIENCE INC, NEW YORK, NY, US, vol. 65, no. 6, June 1996 (1996-06-01), pages 1130 - 1134, XP000978984, ISSN: 0015-0282 *
BIOLOGICAL ABSTRACTS, 1 January 1900, Philadelphia, PA, US; abstract no. 1995982888484, MISAO R ET AL: "Levels of sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) messenger ribonucleic acid (mRNAs) in ovarian endometriosis." XP002176157 *
BIOLOGICAL ABSTRACTS, 1 January 1900, Philadelphia, PA, US; abstract no. PREV199598004176, HUANG JAOU-CHEN, YEH JOHN: "Quantitative analysis of epidermal growth factor receptor gene expression in endometriosis." XP002176156 *
BIOLOGICAL ABSTRACTS, 1 January 1900, Philadelphia, PA, US; abstract no. PREV199799745062, KITAWAKI JO ET AL: "Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium." XP002176158 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7268117B2 (en) 2003-07-11 2007-09-11 Praecis Pharmaceuticals Incorporated Compositions, kits, and methods for identification, assessment, prevention, and therapy of endometriosis
US11287425B2 (en) 2009-04-22 2022-03-29 Juneau Biosciences, Llc Genetic markers associated with endometriosis and use thereof

Also Published As

Publication number Publication date
EP1290218A2 (en) 2003-03-12
JP2003531580A (en) 2003-10-28
US20020127555A1 (en) 2002-09-12
ATE365227T1 (en) 2007-07-15
ES2336817T3 (en) 2010-04-16
CA2399259A1 (en) 2001-08-30
DE60140580D1 (en) 2009-12-31
AU2001237178A1 (en) 2001-09-03
WO2001062959A2 (en) 2001-08-30
US20060057584A1 (en) 2006-03-16
ES2287100T3 (en) 2007-12-16
US20120208869A1 (en) 2012-08-16
BR0108685A (en) 2003-12-30
US8148061B2 (en) 2012-04-03
US6777182B2 (en) 2004-08-17
EP1290218B8 (en) 2007-10-03
US8541173B2 (en) 2013-09-24
DE60129018T2 (en) 2008-02-21
DE60129018D1 (en) 2007-08-02
EP1290218B1 (en) 2007-06-20

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