WO2001064950A3 - Device and method for preparing a sample for analysis - Google Patents

Device and method for preparing a sample for analysis Download PDF

Info

Publication number
WO2001064950A3
WO2001064950A3 PCT/US2001/006118 US0106118W WO0164950A3 WO 2001064950 A3 WO2001064950 A3 WO 2001064950A3 US 0106118 W US0106118 W US 0106118W WO 0164950 A3 WO0164950 A3 WO 0164950A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample
channel
fluid communication
valves
fractionation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/006118
Other languages
French (fr)
Other versions
WO2001064950A2 (en
Inventor
Stanley N Lapidus
Walker M Sloan Iii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exact Sciences Corp
Original Assignee
Exact Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exact Sciences Corp filed Critical Exact Sciences Corp
Priority to AU2001239886A priority Critical patent/AU2001239886A1/en
Priority to CA002401819A priority patent/CA2401819A1/en
Priority to EP01914503A priority patent/EP1261739A2/en
Publication of WO2001064950A2 publication Critical patent/WO2001064950A2/en
Publication of WO2001064950A3 publication Critical patent/WO2001064950A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0265—Drop counters; Drop formers using valves to interrupt or meter fluid flow, e.g. using solenoids or metering valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G01N2035/00247—Microvalves

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

The invention provides apparatus and methods for dividing a sample, into a plurality of subsamples without the need for pipetting or for other manual operations. Sample is placed, via inlet (2) into sample reservoir (4) in fluid communication with a main charging channel (1) which, in turn, is in fluid communication with a plurality of fractionation channels (5), with valves and vents and terminal purge channel (9). Prior to its use, the plate described above is mated with a receptacle plate, for receiving subsample via fractionation channel valves (6), and to a lid which seals the channels against leakage. The sealed device is subjected to centrifugation in order to distribute sample.
PCT/US2001/006118 2000-02-28 2001-02-27 Device and method for preparing a sample for analysis Ceased WO2001064950A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2001239886A AU2001239886A1 (en) 2000-02-28 2001-02-27 Device and method for preparing a sample for analysis
CA002401819A CA2401819A1 (en) 2000-02-28 2001-02-27 Device and method for preparing a sample for analysis
EP01914503A EP1261739A2 (en) 2000-02-28 2001-02-27 Device and method for preparing a sample for analysis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51455900A 2000-02-28 2000-02-28
US09/514,559 2000-02-28

Publications (2)

Publication Number Publication Date
WO2001064950A2 WO2001064950A2 (en) 2001-09-07
WO2001064950A3 true WO2001064950A3 (en) 2002-01-24

Family

ID=24047724

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/006118 Ceased WO2001064950A2 (en) 2000-02-28 2001-02-27 Device and method for preparing a sample for analysis

Country Status (4)

Country Link
EP (1) EP1261739A2 (en)
AU (1) AU2001239886A1 (en)
CA (1) CA2401819A1 (en)
WO (1) WO2001064950A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
US6964846B1 (en) 1999-04-09 2005-11-15 Exact Sciences Corporation Methods for detecting nucleic acids indicative of cancer
US7368233B2 (en) 1999-12-07 2008-05-06 Exact Sciences Corporation Methods of screening for lung neoplasm based on stool samples containing a nucleic acid marker indicative of a neoplasm

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
SE0004351D0 (en) * 2000-11-27 2000-11-27 Helen Andersson System and method for time-controlled liquid handling for reactions and processes in a microfluidic flow cell system
US6911308B2 (en) 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
US9777314B2 (en) 2005-04-21 2017-10-03 Esoterix Genetic Laboratories, Llc Analysis of heterogeneous nucleic acid samples
US20210387176A1 (en) * 2020-06-16 2021-12-16 Sani-Tech West, Inc. Closed fluid receiving and sampling container

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338666A (en) * 1991-01-23 1994-08-16 Becton, Dickinson And Company Method for distributing a liquid sample into a multiple aliquot device
EP0803288A2 (en) * 1996-04-26 1997-10-29 Kyoto Daiichi Kagaku Co., Ltd. Device and method for analyzing a sample
US5798215A (en) * 1993-02-18 1998-08-25 Biocircuits Corporation Device for use in analyte detection assays
WO1999058245A1 (en) * 1998-05-08 1999-11-18 Gyros Ab Microfluidic device
WO1999060397A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338666A (en) * 1991-01-23 1994-08-16 Becton, Dickinson And Company Method for distributing a liquid sample into a multiple aliquot device
US5798215A (en) * 1993-02-18 1998-08-25 Biocircuits Corporation Device for use in analyte detection assays
EP0803288A2 (en) * 1996-04-26 1997-10-29 Kyoto Daiichi Kagaku Co., Ltd. Device and method for analyzing a sample
WO1999058245A1 (en) * 1998-05-08 1999-11-18 Gyros Ab Microfluidic device
WO1999060397A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6964846B1 (en) 1999-04-09 2005-11-15 Exact Sciences Corporation Methods for detecting nucleic acids indicative of cancer
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
US7368233B2 (en) 1999-12-07 2008-05-06 Exact Sciences Corporation Methods of screening for lung neoplasm based on stool samples containing a nucleic acid marker indicative of a neoplasm
US7981612B2 (en) 1999-12-07 2011-07-19 Mayo Foundation For Medical Education And Research Methods of screening for supracolonic neoplasms based on stool samples containing a nucleic acid marker indicative of a neoplasm

Also Published As

Publication number Publication date
AU2001239886A1 (en) 2001-09-12
WO2001064950A2 (en) 2001-09-07
CA2401819A1 (en) 2001-09-07
EP1261739A2 (en) 2002-12-04

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