WO2001068078A3 - Immunostimulatory polynucleotide sequences for use in suppressing hepatitis virus infection - Google Patents

Immunostimulatory polynucleotide sequences for use in suppressing hepatitis virus infection Download PDF

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Publication number
WO2001068078A3
WO2001068078A3 PCT/US2001/007931 US0107931W WO0168078A3 WO 2001068078 A3 WO2001068078 A3 WO 2001068078A3 US 0107931 W US0107931 W US 0107931W WO 0168078 A3 WO0168078 A3 WO 0168078A3
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotide sequences
virus infection
hepatitis virus
immunostimulatory polynucleotide
hbv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/007931
Other languages
French (fr)
Other versions
WO2001068078A2 (en
Inventor
Nest Gary Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dynavax Technologies Corp
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Dynavax Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dynavax Technologies Corp filed Critical Dynavax Technologies Corp
Priority to DE60142562T priority Critical patent/DE60142562D1/en
Priority to AT01913361T priority patent/ATE473750T1/en
Priority to AU2001242032A priority patent/AU2001242032B2/en
Priority to CA002402250A priority patent/CA2402250A1/en
Priority to EP01913361A priority patent/EP1282427B1/en
Priority to AU4203201A priority patent/AU4203201A/en
Priority to JP2001566642A priority patent/JP5128745B2/en
Publication of WO2001068078A2 publication Critical patent/WO2001068078A2/en
Anticipated expiration legal-status Critical
Publication of WO2001068078A3 publication Critical patent/WO2001068078A3/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Methods are provided for the treatment of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. A polynucleotide comprising an immunostimulatory sequence is administered to an individual who has been exposed to or infected by HBV and/or HCV. The polynucleotide is not administered with a HCV or HBV antigen. Administration of the polynucleotide results in amelioration of symptoms of HBV and/or HCV infection.
PCT/US2001/007931 2000-03-10 2001-03-12 Immunostimulatory polynucleotide sequences for use in suppressing hepatitis virus infection Ceased WO2001068078A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE60142562T DE60142562D1 (en) 2000-03-10 2001-03-12 IMMUNOSTIMULATING POLYNUCLEOTIDE SEQUENCES FOR USE IN THE SUPPRESSION OF HEPATITIS VIRUS INFECTION
AT01913361T ATE473750T1 (en) 2000-03-10 2001-03-12 IMMUNO-STIMULATING POLYNUCLEOTIDE SEQUENCES FOR USE IN SUPPRESSING HEPATITIS VIRUS INFECTION
AU2001242032A AU2001242032B2 (en) 2000-03-10 2001-03-12 Immunostimulatory polynucleotide sequences for use in suppressing hepatitis virus infection
CA002402250A CA2402250A1 (en) 2000-03-10 2001-03-12 Immunomodulatory polynucleotide sequences for use in suppressing hepatitis virus infection
EP01913361A EP1282427B1 (en) 2000-03-10 2001-03-12 Immunostimulatory polynucleotide sequences for use in suppressing hepatitis virus infection
AU4203201A AU4203201A (en) 2000-03-10 2001-03-12 Methods of suppressing hepatitis virus infection using immunomodulatory polynucleotide sequences
JP2001566642A JP5128745B2 (en) 2000-03-10 2001-03-12 Method for inhibiting hepatitis virus infection using immunoregulatory polynucleotide sequences

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18830100P 2000-03-10 2000-03-10
US60/188,301 2000-03-10
US09/802,370 US20020098199A1 (en) 2000-03-10 2001-03-09 Methods of suppressing hepatitis virus infection using immunomodulatory polynucleotide sequences
US09/802,370 2001-03-09

Publications (2)

Publication Number Publication Date
WO2001068078A2 WO2001068078A2 (en) 2001-09-20
WO2001068078A3 true WO2001068078A3 (en) 2002-09-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/007931 Ceased WO2001068078A2 (en) 2000-03-10 2001-03-12 Immunostimulatory polynucleotide sequences for use in suppressing hepatitis virus infection

Country Status (9)

Country Link
US (2) US20020098199A1 (en)
EP (1) EP1282427B1 (en)
JP (1) JP5128745B2 (en)
AT (1) ATE473750T1 (en)
AU (2) AU4203201A (en)
CA (1) CA2402250A1 (en)
DE (1) DE60142562D1 (en)
ES (1) ES2348877T3 (en)
WO (1) WO2001068078A2 (en)

Cited By (2)

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US7157437B2 (en) 2000-03-10 2007-01-02 Dynavax Technologies Corporation Methods of ameliorating symptoms of herpes infection using immunomodulatory polynucleotide sequences
US7255868B2 (en) 2001-06-21 2007-08-14 Dynavax Technologies Corporation Chimeric immunomodulatory compounds and methods of using the same—I

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US7223398B1 (en) * 1999-11-15 2007-05-29 Dynavax Technologies Corporation Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof
EP1322655B1 (en) 2000-01-14 2007-11-14 The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services Oligodeoxynucleotide and its use to induce an immune response
US20010044416A1 (en) * 2000-01-20 2001-11-22 Mccluskie Michael J. Immunostimulatory nucleic acids for inducing a Th2 immune response
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US20020028784A1 (en) * 2000-03-10 2002-03-07 Nest Gary Van Methods of preventing and treating viral infections using immunomodulatory polynucleotide sequences
US20010046967A1 (en) * 2000-03-10 2001-11-29 Gary Van Nest Methods of preventing and treating respiratory viral infection using immunomodulatory polynucleotide
US20030129251A1 (en) 2000-03-10 2003-07-10 Gary Van Nest Biodegradable immunomodulatory formulations and methods for use thereof
US7129222B2 (en) 2000-03-10 2006-10-31 Dynavax Technologies Corporation Immunomodulatory formulations and methods for use thereof
US20020107212A1 (en) * 2000-03-10 2002-08-08 Nest Gary Van Methods of reducing papillomavirus infection using immunomodulatory polynucleotide sequences
US20020098199A1 (en) * 2000-03-10 2002-07-25 Gary Van Nest Methods of suppressing hepatitis virus infection using immunomodulatory polynucleotide sequences
US7666674B2 (en) 2001-07-27 2010-02-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo
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AU2002366710A1 (en) 2001-12-20 2003-07-09 The Government Of The United States Of America As Represented By The Secretary Of The Department Of USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS
US8466116B2 (en) 2001-12-20 2013-06-18 The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of CpG oligodeoxynucleotides to induce epithelial cell growth
EP1551376A4 (en) * 2002-08-12 2010-10-06 Dynavax Tech Corp IMMUNOMODULATORY COMPOSITIONS, THEIR METHODS OF PREPARATION AND USE
US8263091B2 (en) * 2002-09-18 2012-09-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides
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JP2006512927A (en) 2002-12-11 2006-04-20 コーリー ファーマシューティカル グループ，インコーポレイテッド 5 'CPG nucleic acids and methods of use thereof
ATE544772T1 (en) 2002-12-23 2012-02-15 Dynavax Tech Corp IMMUNO-STIMULATING SEQUENCE OLIGONUCLEOTIDES AND METHOD OF USE THEREOF
US8158768B2 (en) 2002-12-23 2012-04-17 Dynavax Technologies Corporation Immunostimulatory sequence oligonucleotides and methods of using the same
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SG160336A1 (en) 2005-03-04 2010-04-29 Dynavax Tech Corp Vaccines comprising oligonucleotides having immunostimulatory sequences (iss) wherein the iss are conjugated to antigens and stabilized by buffer conditions and further excipients
AU2007268534B2 (en) 2006-05-31 2011-07-14 Osaka University Immunostimulatory oligonucleotide and pharmaceutical application thereof
US9452212B2 (en) * 2011-04-14 2016-09-27 Dynavax Technologies Corporation Methods and compositions for eliciting an immune response against hepatitis B virus
KR101475630B1 (en) * 2013-05-31 2014-12-22 동국대학교 산학협력단 Composition for the prevention or treatment of Hepatitis C, comprising extracts or fractions of Vitidis Vinferae Radix as an effective ingredient

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7157437B2 (en) 2000-03-10 2007-01-02 Dynavax Technologies Corporation Methods of ameliorating symptoms of herpes infection using immunomodulatory polynucleotide sequences
US7255868B2 (en) 2001-06-21 2007-08-14 Dynavax Technologies Corporation Chimeric immunomodulatory compounds and methods of using the same—I
US9028845B2 (en) 2001-06-21 2015-05-12 Dynavax Technologies Corporation Chimeric immunomodulatory compounds and methods of using the same-IV

Also Published As

Publication number Publication date
US7727712B2 (en) 2010-06-01
WO2001068078A2 (en) 2001-09-20
ATE473750T1 (en) 2010-07-15
JP2003526662A (en) 2003-09-09
EP1282427A2 (en) 2003-02-12
EP1282427B1 (en) 2010-07-14
ES2348877T3 (en) 2010-12-16
US20020098199A1 (en) 2002-07-25
AU2001242032B2 (en) 2005-09-15
JP5128745B2 (en) 2013-01-23
US20030216340A1 (en) 2003-11-20
AU4203201A (en) 2001-09-24
CA2402250A1 (en) 2001-09-20
DE60142562D1 (en) 2010-08-26

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