WO2001068911A3 - Diagnosis of diseases associated with the cell cycle - Google Patents

Diagnosis of diseases associated with the cell cycle Download PDF

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Publication number
WO2001068911A3
WO2001068911A3 PCT/EP2001/002945 EP0102945W WO0168911A3 WO 2001068911 A3 WO2001068911 A3 WO 2001068911A3 EP 0102945 W EP0102945 W EP 0102945W WO 0168911 A3 WO0168911 A3 WO 0168911A3
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WO
WIPO (PCT)
Prior art keywords
cell cycle
diagnosis
diseases associated
genes associated
pna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/002945
Other languages
French (fr)
Other versions
WO2001068911A2 (en
WO2001068911A8 (en
Inventor
Alexander Olek
Christian Piepenbrock
Kurt Berlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epigenomics AG
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Epigenomics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10013847A external-priority patent/DE10013847A1/en
Priority claimed from DE10019058A external-priority patent/DE10019058A1/en
Priority claimed from DE10032529A external-priority patent/DE10032529A1/en
Priority to EP01921343A priority Critical patent/EP1283905A2/en
Priority to AU2001248352A priority patent/AU2001248352A1/en
Application filed by Epigenomics AG filed Critical Epigenomics AG
Priority to US10/221,613 priority patent/US20040029123A1/en
Priority to JP2001567390A priority patent/JP2004507213A/en
Publication of WO2001068911A2 publication Critical patent/WO2001068911A2/en
Anticipated expiration legal-status Critical
Publication of WO2001068911A8 publication Critical patent/WO2001068911A8/en
Publication of WO2001068911A3 publication Critical patent/WO2001068911A3/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

The present invention relates to the chemically modified genomic sequences of genes associated with cell cycle, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genes associated with cell cycle which are directed against the sequence, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes associated with cell cycle.
PCT/EP2001/002945 2000-03-15 2001-03-15 Diagnosis of diseases associated with the cell cycle Ceased WO2001068911A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001567390A JP2004507213A (en) 2000-03-15 2001-03-15 Diagnosis of diseases related to the cell cycle
US10/221,613 US20040029123A1 (en) 2000-03-15 2001-03-15 Diagnosis of diseases associated with the cell cycle
EP01921343A EP1283905A2 (en) 2000-03-15 2001-03-15 Diagnosis of diseases associated with the cell cycle
AU2001248352A AU2001248352A1 (en) 2000-03-15 2001-03-15 Diagnosis of diseases associated with the cell cycle

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
DE10013847A DE10013847A1 (en) 2000-03-15 2000-03-15 Parallel detection of methylation in genomic DNA where DNA is chemically modified, fragmented, amplified and hybridized to probes, useful to investigate gene expression regulation
DE10013847.0 2000-03-15
DE10019058A DE10019058A1 (en) 2000-04-06 2000-04-06 Designing primers and probes for analyzing diseases associated with cytosine methylation state e.g. arthritis, cancer, aging, arteriosclerosis comprising fragments of chemically modified genes associated with cell cycle
DE10019058.8 2000-04-06
DE10019173.8 2000-04-07
DE10019173 2000-04-07
DE10032529A DE10032529A1 (en) 2000-06-30 2000-06-30 Diagnosis of major genetic parameters within the Major Histocompatibility Complex (MHC)
DE10032529.7 2000-06-30
DE10043826 2000-09-01
DE10043826.1 2000-09-01

Publications (3)

Publication Number Publication Date
WO2001068911A2 WO2001068911A2 (en) 2001-09-20
WO2001068911A8 WO2001068911A8 (en) 2002-10-24
WO2001068911A3 true WO2001068911A3 (en) 2002-11-28

Family

ID=27512367

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2001/002955 Ceased WO2001068912A2 (en) 2000-03-15 2001-03-15 Diagnosis of diseases associated with tumor suppressor genes and oncogenes
PCT/EP2001/002945 Ceased WO2001068911A2 (en) 2000-03-15 2001-03-15 Diagnosis of diseases associated with the cell cycle

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/002955 Ceased WO2001068912A2 (en) 2000-03-15 2001-03-15 Diagnosis of diseases associated with tumor suppressor genes and oncogenes

Country Status (5)

Country Link
US (2) US20040048254A1 (en)
EP (2) EP1268855A2 (en)
JP (2) JP2004507214A (en)
AU (2) AU2001248352A1 (en)
WO (2) WO2001068912A2 (en)

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KR20000070174A (en) 1997-01-14 2000-11-25 벤슨 로버트 에이치. Tumor necrosis factor receptors 6α and 6β
US6818404B2 (en) * 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
EP1274865B1 (en) * 2000-04-06 2007-02-14 Epigenomics AG Diagnosis of diseases associated with apoptosis by means of assessing the methylation status of genes associated with apoptosis
WO2002000926A2 (en) * 2000-06-30 2002-01-03 Epigenomics Ag Diagnosis of diseases associated with signal transduction
EP1942197A1 (en) * 2000-09-01 2008-07-09 Epigenomics AG Method for determining the methylation degree of certain cytosines in genome DNA in the sequence context 5'-CpG-3'
DE10054974A1 (en) * 2000-11-06 2002-06-06 Epigenomics Ag Diagnosis of diseases associated with Cdk4
US20020160388A1 (en) * 2000-11-20 2002-10-31 Roberto Macina Compositions and methods relating to lung specific genes and proteins
EP1410304A2 (en) * 2001-03-26 2004-04-21 Epigenomics AG Method for epigenetic feature selection
DE10128508A1 (en) * 2001-06-14 2003-02-06 Epigenomics Ag Methods and nucleic acids for the differentiation of prostate tumors
AU2002342004A1 (en) 2001-10-05 2003-04-22 Case Western Reserve University Methods and compositions for detecting colon cancers
CA2462615C (en) * 2001-11-07 2012-06-26 Syngenta Participations Ag Promoters for regulation of gene expression in plant roots
EP1470254A2 (en) * 2002-01-30 2004-10-27 Epigenomics AG Method for the analysis of cytosine methylation patterns
EP1340818A1 (en) * 2002-02-27 2003-09-03 Epigenomics AG Method and nucleic acids for the analysis of a colon cell proliferative disorder
WO2003085125A1 (en) * 2002-04-03 2003-10-16 Agy Therapeutics, Inc. Use of biomolecular targets in the treatment and visualization of brain tumors
US7678889B2 (en) * 2002-08-06 2010-03-16 Diadexus, Inc. Compositions and methods relating to ovarian specific genes and proteins
US20040029128A1 (en) * 2002-08-08 2004-02-12 Epigenomics, Inc. Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene
ATE437962T1 (en) * 2002-10-01 2009-08-15 Epigenomics Ag METHOD FOR THE TREATMENT OF PROLIFERATIVE DISEASES OF BREAST CELLS
US7238518B2 (en) 2002-10-04 2007-07-03 Nisshinbo Industries, Inc. Oligonucleotide-immobilized substrate for detecting methylation
CA2743564C (en) * 2003-01-13 2013-11-12 Monsanto Technology Llc Glyphosate tolerant alfalfa events and methods for detection thereof
EP1693468A1 (en) 2005-02-16 2006-08-23 Epigenomics AG Method for determining the methylation pattern of a polynucleic acid
WO2006113770A1 (en) 2005-04-15 2006-10-26 Epigenomics Ag A method for providing dna fragments derived from a remote sample
JP2008538700A (en) * 2005-04-22 2008-11-06 モルフォテック、インク． Antibodies internalized into endosialin cells with immune effector activity
WO2007032748A1 (en) * 2005-09-15 2007-03-22 Agency For Science, Technology & Research Method for detecting dna methylation
US20070161006A1 (en) * 2006-01-10 2007-07-12 Vita Genomics, Inc. Single nucleotide polymorphisms in protein-tyrosine phosphatase receptor-type delta for the diagnosis of susceptibility to infection and asthma
US8084734B2 (en) 2006-05-26 2011-12-27 The George Washington University Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
ES2599816T3 (en) * 2006-07-21 2017-02-03 Epigenomics Ag Methods related to the GLI3 gene for the detection of colorectal cancer
SI2137217T1 (en) * 2007-04-05 2014-07-31 Morphotek, Inc. Methods for inhibiting the binding of endosialin to ligands
US8043815B2 (en) * 2007-08-06 2011-10-25 Health Research, Inc. Methods for analysis of PDEF and survivin as interconnected cancer biomarkers and targets for personalized medicine
EP2058403A1 (en) * 2007-11-09 2009-05-13 Rheinische Friedrich-Wilhelms-Universität Bonn DUSP4 as clinically relevant epigenetic marker and therapeutic target in gliomas and other tumors
US20100273859A1 (en) * 2007-12-14 2010-10-28 The Brigham And Women's Hospital, Inc. Treatment and prevention of hiv infection
US20110053149A1 (en) * 2007-12-28 2011-03-03 Judith Mary Boer Methylation detection in the genomic region of a receptor proteintyrosine phosphatase gamma gene for detection and/or diagnosis of a tumour
US8110796B2 (en) 2009-01-17 2012-02-07 The George Washington University Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
US9490113B2 (en) * 2009-04-07 2016-11-08 The George Washington University Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry
US8962585B2 (en) 2009-12-29 2015-02-24 Curna, Inc. Treatment of tumor protein 63 (p63) related diseases by inhibition of natural antisense transcript to p63
WO2012018982A2 (en) * 2010-08-05 2012-02-09 Tufts Medical Center, Inc. Methods and kits for modulating tumor invasiveness and metastatic potential
EP2702173A1 (en) 2011-04-25 2014-03-05 OSI Pharmaceuticals, LLC Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
CA2921809A1 (en) 2013-08-22 2015-02-26 Apton Biosystems, Inc. Digital analysis of molecular analytes using electrical methods
CN108186665B (en) * 2018-01-02 2020-03-20 深圳市第二人民医院 Reagent for interfering expression of long-chain non-coding RNA PVT1 and application thereof
CN108977457B (en) * 2018-08-31 2021-04-02 长江大学 A kind of preparation method of eel antibacterial peptide
CN113528657B (en) * 2020-06-18 2022-09-30 广州达健生物科技有限公司 Composition for detecting esophageal cancer, kit and application thereof
CN114480631B (en) * 2020-10-28 2024-09-24 中山大学孙逸仙纪念医院 Use of INPP5F for preparing drugs for prognosis, diagnosis or prevention of liver cancer tissue tumors
CN118289145B (en) * 2024-04-23 2024-10-22 江西中船航海仪器有限公司 Ocean weather drifting observer
CN119466578B (en) * 2024-09-23 2026-03-17 国网湖南省电力有限公司电力科学研究院 A vertical drilling device and control method for pole erection

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Also Published As

Publication number Publication date
JP2004507213A (en) 2004-03-11
WO2001068911A2 (en) 2001-09-20
WO2001068911A8 (en) 2002-10-24
EP1283905A2 (en) 2003-02-19
WO2001068912A2 (en) 2001-09-20
AU2001250381A1 (en) 2001-09-24
US20040048254A1 (en) 2004-03-11
AU2001248352A1 (en) 2001-09-24
JP2004507214A (en) 2004-03-11
EP1268855A2 (en) 2003-01-02
US20040029123A1 (en) 2004-02-12
WO2001068912A3 (en) 2002-04-18

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