WO2001070816A3 - Ecdysone receptor-based inducible gene expression system - Google Patents

Ecdysone receptor-based inducible gene expression system Download PDF

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Publication number
WO2001070816A3
WO2001070816A3 PCT/US2001/009050 US0109050W WO0170816A3 WO 2001070816 A3 WO2001070816 A3 WO 2001070816A3 US 0109050 W US0109050 W US 0109050W WO 0170816 A3 WO0170816 A3 WO 0170816A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene expression
expression system
inducible gene
relates
ecdysone receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/009050
Other languages
French (fr)
Other versions
WO2001070816A2 (en
Inventor
Subba Reddy Palli
Marianna Zinovjevna Kapitskaya
Dean Ervin Cress
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rohm and Haas Co
Original Assignee
Rohm and Haas Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MXPA02009157A priority Critical patent/MXPA02009157A/en
Priority to DE60122685T priority patent/DE60122685T2/en
Priority to EP01922524A priority patent/EP1266015B1/en
Priority to US10/239,134 priority patent/US20040033600A1/en
Priority to AU2001249315A priority patent/AU2001249315A1/en
Priority to JP2001569016A priority patent/JP5031967B2/en
Priority to CA2404253A priority patent/CA2404253C/en
Application filed by Rohm and Haas Co filed Critical Rohm and Haas Co
Priority to ARP010101339A priority patent/AR028276A1/en
Priority to US09/965,703 priority patent/US7091038B2/en
Publication of WO2001070816A2 publication Critical patent/WO2001070816A2/en
Publication of WO2001070816A3 publication Critical patent/WO2001070816A3/en
Anticipated expiration legal-status Critical
Priority to US11/677,968 priority patent/US7807417B2/en
Priority to AU2007200882A priority patent/AU2007200882B2/en
Priority to US11/841,495 priority patent/US7776587B2/en
Priority to US12/818,034 priority patent/US8202718B2/en
Priority to US12/859,940 priority patent/US20110059530A1/en
Priority to US13/463,527 priority patent/US8822754B2/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic plants and animals.
PCT/US2001/009050 2000-03-22 2001-03-21 Ecdysone receptor-based inducible gene expression system Ceased WO2001070816A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
DE60122685T DE60122685T2 (en) 2000-03-22 2001-03-21 INDUCED GENE EXPRESSION SYSTEM BASED ON ECDYSON RECEPTORS
EP01922524A EP1266015B1 (en) 2000-03-22 2001-03-21 Ecdysone receptor-based inducible gene expression system
US10/239,134 US20040033600A1 (en) 2001-03-21 2001-03-21 Ecdysone receptor-based inducible gene expression system
AU2001249315A AU2001249315A1 (en) 2000-03-22 2001-03-21 Ecdysone receptor-based inducible gene expression system
JP2001569016A JP5031967B2 (en) 2000-03-22 2001-03-21 A novel ecdysone receptor-based inducible gene expression system
MXPA02009157A MXPA02009157A (en) 2000-03-22 2001-03-21 Novel ecdysone receptor-based inducible gene expression system.
CA2404253A CA2404253C (en) 2000-03-22 2001-03-21 Novel ecdysone receptor-based inducible gene expression system
ARP010101339A AR028276A1 (en) 2000-03-22 2001-03-22 NEW INDUCIBLE GCNICA EXPRESSION SYSTEM BASED ON ECDISONA RECEIVER
US09/965,703 US7091038B2 (en) 2000-03-22 2001-09-26 Ecdysone receptor-based inducible gene expression system
US11/677,968 US7807417B2 (en) 2000-03-22 2007-02-22 Ecdysone receptor-based inducible gene expression system
AU2007200882A AU2007200882B2 (en) 2000-03-22 2007-02-28 Ecdysone receptor-based inducible gene expression system
US11/841,495 US7776587B2 (en) 2000-03-22 2007-08-20 Ecdysone receptor-based inducible gene expression system
US12/818,034 US8202718B2 (en) 2000-03-22 2010-06-17 Ecdysone receptor-based inducible gene expression system
US12/859,940 US20110059530A1 (en) 2000-03-22 2010-08-20 Novel Ecdysone Receptor-Based Inducible Gene Expression System
US13/463,527 US8822754B2 (en) 2000-03-22 2012-05-03 Ecdysone receptor-based inducible gene expression system

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19135500P 2000-03-22 2000-03-22
US60/191,355 2000-03-22
US26979901P 2001-02-20 2001-02-20
US60/269,799 2001-02-20

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10239134 A-371-Of-International 2001-03-21
US09/965,703 Continuation-In-Part US7091038B2 (en) 2000-03-22 2001-09-26 Ecdysone receptor-based inducible gene expression system
US11/677,968 Continuation US7807417B2 (en) 2000-03-22 2007-02-22 Ecdysone receptor-based inducible gene expression system

Publications (2)

Publication Number Publication Date
WO2001070816A2 WO2001070816A2 (en) 2001-09-27
WO2001070816A3 true WO2001070816A3 (en) 2002-08-29

Family

ID=26886975

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/009050 Ceased WO2001070816A2 (en) 2000-03-22 2001-03-21 Ecdysone receptor-based inducible gene expression system

Country Status (11)

Country Link
US (1) US7091038B2 (en)
EP (1) EP1266015B1 (en)
JP (1) JP5031967B2 (en)
CN (1) CN1304578C (en)
AR (1) AR028276A1 (en)
AT (1) ATE338135T1 (en)
AU (2) AU2001249315A1 (en)
CA (1) CA2404253C (en)
DE (1) DE60122685T2 (en)
MX (1) MXPA02009157A (en)
WO (1) WO2001070816A2 (en)

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US7563928B2 (en) 2003-02-28 2009-07-21 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US11555197B2 (en) 2016-07-25 2023-01-17 Greenvenus, Llc Control of phenotype in plants

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US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
US8105825B2 (en) * 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
EP1356066A2 (en) * 2000-10-24 2003-10-29 Syngenta Participations AG Control of gene expression in plants
ES2385598T3 (en) 2001-02-20 2012-07-27 Intrexon Corporation Novel inducible gene expression system based on the ecdysone receptor / X retinoid invertebrate receptor
EP1534738B1 (en) 2001-02-20 2012-06-20 Intrexon Corporation Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
CA2438119C (en) 2001-02-20 2014-12-16 Rheogene Holdings, Inc. Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
AU2002306550B2 (en) 2001-02-20 2007-10-25 Intrexon Corporation Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
WO2003030125A1 (en) * 2001-09-25 2003-04-10 Werner Keber Method and device for preventing unpermitted approach of airplanes to objects on the ground which are to be protected
JP2005532781A (en) 2001-09-26 2005-11-04 レオジーン・ホールディングス，インコーポレーテッド Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
EP1490686A2 (en) 2001-09-26 2004-12-29 RheoGene Holdings Inc. Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
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US9154906B2 (en) 2002-03-28 2015-10-06 Telecommunication Systems, Inc. Area watcher for wireless network
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US7304161B2 (en) * 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
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US8637237B2 (en) 2003-08-29 2014-01-28 The University Of North Carolina At Greensboro Methods, compositions, and systems for the identification of species-specific or developmental stage-specific insecticides
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US7563928B2 (en) 2003-02-28 2009-07-21 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US11555197B2 (en) 2016-07-25 2023-01-17 Greenvenus, Llc Control of phenotype in plants
US12344852B2 (en) 2016-07-25 2025-07-01 Greenvenus, Llc Control of phenotype in plants

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