WO2001074401A3 - Camptothecin complexes - Google Patents

Camptothecin complexes Download PDF

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Publication number
WO2001074401A3
WO2001074401A3 PCT/US2001/006829 US0106829W WO0174401A3 WO 2001074401 A3 WO2001074401 A3 WO 2001074401A3 US 0106829 W US0106829 W US 0106829W WO 0174401 A3 WO0174401 A3 WO 0174401A3
Authority
WO
WIPO (PCT)
Prior art keywords
camptothecin
disclosed
complexes
compositions
inventive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/006829
Other languages
French (fr)
Other versions
WO2001074401A2 (en
Inventor
Joseph Rubinfeld
Simeon M Wrenn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astex Pharmaceuticals Inc
Original Assignee
Supergen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Supergen Inc filed Critical Supergen Inc
Priority to EP01914662A priority Critical patent/EP1267936A2/en
Priority to AU2001240024A priority patent/AU2001240024A1/en
Publication of WO2001074401A2 publication Critical patent/WO2001074401A2/en
Publication of WO2001074401A3 publication Critical patent/WO2001074401A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
    • B65G21/00—Supporting or protective framework or housings for endless load-carriers or traction elements of belt or chain conveyors
    • B65G21/10—Supporting or protective framework or housings for endless load-carriers or traction elements of belt or chain conveyors movable, or having interchangeable or relatively movable parts; Devices for moving framework or parts thereof
    • B65G21/14—Supporting or protective framework or housings for endless load-carriers or traction elements of belt or chain conveyors movable, or having interchangeable or relatively movable parts; Devices for moving framework or parts thereof to allow adjustment of length or configuration of load-carrier or traction element

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Mechanical Engineering (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Disclosed are compositions that include a camptothecin and an amorphous cyclodextrin. The camptothecin may be substituted or unsubstituted. Also disclosed are methods of treating undesirable or uncontrolled cell proliferation by administering the inventive compositions. Finally, implants including an implant structure and the inventive composition are disclosed.
PCT/US2001/006829 2000-03-31 2001-03-02 Camptothecin complexes Ceased WO2001074401A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01914662A EP1267936A2 (en) 2000-03-31 2001-03-02 Camptothecin complexes
AU2001240024A AU2001240024A1 (en) 2000-03-31 2001-03-02 Camptothecin complexes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53998200A 2000-03-31 2000-03-31
US09/539,982 2000-03-31

Publications (2)

Publication Number Publication Date
WO2001074401A2 WO2001074401A2 (en) 2001-10-11
WO2001074401A3 true WO2001074401A3 (en) 2002-05-02

Family

ID=24153476

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/006829 Ceased WO2001074401A2 (en) 2000-03-31 2001-03-02 Camptothecin complexes

Country Status (3)

Country Link
EP (1) EP1267936A2 (en)
AU (1) AU2001240024A1 (en)
WO (1) WO2001074401A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7049322B2 (en) * 2002-02-21 2006-05-23 Supergen, Inc. Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use therefor
EP2277551B1 (en) * 2002-09-06 2013-05-08 Cerulean Pharma Inc. Cyclodextrin-based polymers for delivering the therapeutic agents covalently bound thereto
EP2153821A1 (en) * 2008-08-06 2010-02-17 BioAlliance Pharma Oral formulations of camptothecin derivatives
US20110207760A1 (en) * 2010-02-23 2011-08-25 Valery Alakhov Sn-38 compositions
CA2816418C (en) * 2010-10-29 2020-05-26 Health Research, Inc. Novel formulations of water-insoluble chemical compounds and methods of using a formulation of compound fl118 for cancer therapy
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
CN105561406A (en) * 2016-02-15 2016-05-11 丹阳纳瑞康纳米科技有限公司 Intravascular stent including composite medicine coating

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0623354A1 (en) * 1993-04-26 1994-11-09 Medtronic, Inc. Intravascular stents
WO1999030684A1 (en) * 1997-12-12 1999-06-24 Supergen, Inc. Local delivery of therapeutic agents
WO1999062510A2 (en) * 1998-06-01 1999-12-09 Angiotech Pharmaceuticals, Inc. Compositions comprising anti-microtubule agents for treating or preventing inflammatory diseases
WO2000000238A1 (en) * 1998-06-26 2000-01-06 Quanam Medical Corporation Topoisomerase inhibitors for prevention of restenosis
US20010021703A1 (en) * 1998-12-30 2001-09-13 Kosak Kenneth M. Biocleavable micelle compositions for use as drug carriers

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0623354A1 (en) * 1993-04-26 1994-11-09 Medtronic, Inc. Intravascular stents
US5464650A (en) * 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
WO1999030684A1 (en) * 1997-12-12 1999-06-24 Supergen, Inc. Local delivery of therapeutic agents
WO1999062510A2 (en) * 1998-06-01 1999-12-09 Angiotech Pharmaceuticals, Inc. Compositions comprising anti-microtubule agents for treating or preventing inflammatory diseases
WO2000000238A1 (en) * 1998-06-26 2000-01-06 Quanam Medical Corporation Topoisomerase inhibitors for prevention of restenosis
US20010021703A1 (en) * 1998-12-30 2001-09-13 Kosak Kenneth M. Biocleavable micelle compositions for use as drug carriers

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
FRIEDMAN HENRY S ET AL: "Treatment of central nervous system xenografts with camptothecins.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 803, 1996, Conference;Bethesda, Maryland, USA; February 7-10, 1996, discovery to the patient. 1996 New York Academy of Sciences 2 East 63rd Street, New York, New York 10021, USA, pages 210 - 212, XP001053589, ISBN: 1-57331-057-3 *
GIOVANELLA B C ET AL: "Protocols for the treatment of human tumor xenografts with camptothecins.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 803, 1996, Conference;Bethesda, Maryland, USA; February 7-10, 1996, discovery to the patient. 1996 New York Academy of Sciences 2 East 63rd Street, New York, New York 10021, USA, pages 181 - 187, XP001053591, ISBN: 1-57331-057-3 *
JONKMAN-DE VRIES J.D. ET AL: "Pharmaceutical development of (investigational) anticancer agents for parenteral use - A review", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1996, VOL. 22, NO. 6, PAGE(S) 475-494, XP001053466 *
NATELSON ETHAN A ET AL: "Phase I clinical and pharmacological studies of 20-(S)-camptothecin and 20-(S)-9-nitrocamptothecin as anticancer agents.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 803, 1996, Conference;Bethesda, Maryland, USA; February 7-10, 1996, discovery to the patient. 1996 New York Academy of Sciences 2 East 63rd Street, New York, New York 10021, USA, pages 224 - 230, XP001053588, ISBN: 1-57331-057-3 *
SAIJO NAGAHIRO: "Clinical trials of irinotecan hydrochloride (CPT, campto injection, topotecan injection) in Japan.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 803, 1996, Conference;Bethesda, Maryland, USA; February 7-10, 1996, discovery to the patient. 1996 New York Academy of Sciences 2 East 63rd Street, New York, New York 10021, USA, pages 292 - 305, XP001053587, ISBN: 1-57331-057-3 *
SHARMA U S ET AL: "PHARMACEUTICAL AND PHYSICAL PROPERTIES OF PACLITAXEL (TAXOL) COMPLEXES WITH CYCLODEXTRINS", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 84, no. 10, 1 October 1995 (1995-10-01), pages 1223 - 1230, XP000529731, ISSN: 0022-3549 *
UNDERBERG WJ ET AL: "Equilibrium kinetics of the new experimental anti-tumour compound SK&F 104864-A in aqueous solution.", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1990, VOL. 8, NO. 8-12, PAGE(S) 681-3, XP001053447 *

Also Published As

Publication number Publication date
EP1267936A2 (en) 2003-01-02
AU2001240024A1 (en) 2001-10-15
WO2001074401A2 (en) 2001-10-11

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