WO2001074862A3 - Method for the production of bacterial toxins - Google Patents

Method for the production of bacterial toxins Download PDF

Info

Publication number
WO2001074862A3
WO2001074862A3 PCT/US2001/010938 US0110938W WO0174862A3 WO 2001074862 A3 WO2001074862 A3 WO 2001074862A3 US 0110938 W US0110938 W US 0110938W WO 0174862 A3 WO0174862 A3 WO 0174862A3
Authority
WO
WIPO (PCT)
Prior art keywords
toxin
compositions
bacterial toxins
methods
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/010938
Other languages
French (fr)
Other versions
WO2001074862A2 (en
Inventor
Milan S Blake
John A Bogdan Jr
Javier Nazario-Larrieu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Healthcare SA
Baxter International Inc
Original Assignee
Baxter Healthcare SA
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Healthcare SA, Baxter International Inc filed Critical Baxter Healthcare SA
Priority to DE60111835T priority Critical patent/DE60111835T9/en
Priority to EP01926612A priority patent/EP1268531B1/en
Priority to DK01926612T priority patent/DK1268531T3/en
Priority to AU5313401A priority patent/AU5313401A/en
Priority to CA2405035A priority patent/CA2405035C/en
Priority to JP2001572551A priority patent/JP4964385B2/en
Priority to AT01926612T priority patent/ATE299149T1/en
Priority to AU2001253134A priority patent/AU2001253134B2/en
Publication of WO2001074862A2 publication Critical patent/WO2001074862A2/en
Publication of WO2001074862A3 publication Critical patent/WO2001074862A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression inhibitors are provided including, but not limited to, addition of toxin expression inhibitor binding compounds, culture media having reduced concentrations of toxin inhibitor metabolic precursors and genetically modified toxogenic bacteria lacking enzymes required to metabolize the toxin inhibitor metabolic precursors.
PCT/US2001/010938 2000-04-04 2001-04-04 Method for the production of bacterial toxins Ceased WO2001074862A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE60111835T DE60111835T9 (en) 2000-04-04 2001-04-04 PROCESS FOR THE PRODUCTION OF BACTERIAL TOXINS
EP01926612A EP1268531B1 (en) 2000-04-04 2001-04-04 Method for the production of bacterial toxins
DK01926612T DK1268531T3 (en) 2000-04-04 2001-04-04 Process for the preparation of bacterial toxins
AU5313401A AU5313401A (en) 2000-04-04 2001-04-04 Improved method for the production of bacterial toxins
CA2405035A CA2405035C (en) 2000-04-04 2001-04-04 Improved method for the production of bacterial toxins
JP2001572551A JP4964385B2 (en) 2000-04-04 2001-04-04 Methods for the production of bacterial toxins
AT01926612T ATE299149T1 (en) 2000-04-04 2001-04-04 METHOD FOR PRODUCING BACTERIAL TOXINS
AU2001253134A AU2001253134B2 (en) 2000-04-04 2001-04-04 Method for the production of bacterial toxins

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19448200P 2000-04-04 2000-04-04
US19447800P 2000-04-04 2000-04-04
US60/194,482 2000-04-04
US60/194,478 2000-04-04

Publications (2)

Publication Number Publication Date
WO2001074862A2 WO2001074862A2 (en) 2001-10-11
WO2001074862A3 true WO2001074862A3 (en) 2002-10-03

Family

ID=26890056

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010938 Ceased WO2001074862A2 (en) 2000-04-04 2001-04-04 Method for the production of bacterial toxins

Country Status (9)

Country Link
EP (1) EP1268531B1 (en)
JP (2) JP4964385B2 (en)
AT (1) ATE299149T1 (en)
AU (2) AU2001253134B2 (en)
CA (1) CA2405035C (en)
DE (1) DE60111835T9 (en)
ES (1) ES2245357T3 (en)
PT (1) PT1268531E (en)
WO (1) WO2001074862A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014017898B1 (en) * 2012-02-01 2021-10-13 Glaxosmithkline Biologicals S.A. FERMENTATION PROCESS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2596413B1 (en) * 1986-03-27 1988-06-10 Merieux Inst NOVEL BACTERIA CULTURE MEDIA BELONGING TO THE GENUS BORDETELLA, CONTAINING ETHERIFIC DERIVATIVES OF D-GLUCOSE POLYMERS, AND THEIR APPLICATION
US5338670A (en) * 1986-07-28 1994-08-16 The United States Of America As Represented By The Department Of Health And Human Services Production of bordetella pertussis toxin with a low concentration of iron

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FROHLICH ET AL: "Improved pertussis toxin production by Bordetella pertussis through adjusting the growth medium's ionic composition", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 39, no. 3, 1 May 1995 (1995-05-01), pages 205 - 219, XP004036970, ISSN: 0168-1656 *

Also Published As

Publication number Publication date
JP4964385B2 (en) 2012-06-27
DE60111835T2 (en) 2006-05-18
ATE299149T1 (en) 2005-07-15
DE60111835T9 (en) 2006-10-12
AU5313401A (en) 2001-10-15
EP1268531A2 (en) 2003-01-02
CA2405035C (en) 2013-10-22
CA2405035A1 (en) 2001-10-11
EP1268531B1 (en) 2005-07-06
JP2011152141A (en) 2011-08-11
WO2001074862A2 (en) 2001-10-11
AU2001253134B2 (en) 2006-09-21
PT1268531E (en) 2005-11-30
JP2003531586A (en) 2003-10-28
DE60111835D1 (en) 2005-08-11
ES2245357T3 (en) 2006-01-01

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