WO2001077079A3 - Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade - Google Patents

Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade Download PDF

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Publication number
WO2001077079A3
WO2001077079A3 PCT/US2001/011014 US0111014W WO0177079A3 WO 2001077079 A3 WO2001077079 A3 WO 2001077079A3 US 0111014 W US0111014 W US 0111014W WO 0177079 A3 WO0177079 A3 WO 0177079A3
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WO
WIPO (PCT)
Prior art keywords
heteroaryl substituted
coagulation cascade
polycyclic aryl
selective inhibition
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/011014
Other languages
French (fr)
Other versions
WO2001077079A2 (en
Inventor
Michael S South
Chun C Ma
Kevin J Koeller
Hayat K Rahman
William L Neumann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia LLC
Original Assignee
Pharmacia LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia LLC filed Critical Pharmacia LLC
Priority to CA002405306A priority Critical patent/CA2405306A1/en
Priority to JP2001575554A priority patent/JP2004505013A/en
Priority to AU2001251315A priority patent/AU2001251315A1/en
Priority to EP01924684A priority patent/EP1268428A2/en
Priority to US10/240,817 priority patent/US20030236257A1/en
Publication of WO2001077079A2 publication Critical patent/WO2001077079A2/en
Publication of WO2001077079A3 publication Critical patent/WO2001077079A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to polycyclic aryl and heteroaryl substituted 4-pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
PCT/US2001/011014 2000-04-05 2001-04-04 Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade Ceased WO2001077079A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002405306A CA2405306A1 (en) 2000-04-05 2001-04-04 Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
JP2001575554A JP2004505013A (en) 2000-04-05 2001-04-04 Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selectively inhibiting the coagulation cascade
AU2001251315A AU2001251315A1 (en) 2000-04-05 2001-04-04 Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
EP01924684A EP1268428A2 (en) 2000-04-05 2001-04-04 Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
US10/240,817 US20030236257A1 (en) 2001-04-04 2001-04-04 Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the cogulation cascade

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19485100P 2000-04-05 2000-04-05
US60/194,851 2000-04-05
US25203100P 2000-11-20 2000-11-20
US60/252,031 2000-11-20

Publications (2)

Publication Number Publication Date
WO2001077079A2 WO2001077079A2 (en) 2001-10-18
WO2001077079A3 true WO2001077079A3 (en) 2002-04-11

Family

ID=26890461

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/011014 Ceased WO2001077079A2 (en) 2000-04-05 2001-04-04 Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade

Country Status (6)

Country Link
US (2) US6693121B2 (en)
EP (1) EP1268428A2 (en)
JP (1) JP2004505013A (en)
AU (1) AU2001251315A1 (en)
CA (1) CA2405306A1 (en)
WO (1) WO2001077079A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030236257A1 (en) * 2001-04-04 2003-12-25 South Michael S. Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the cogulation cascade
MXPA04003163A (en) * 2001-10-03 2004-07-08 Pharmacia Corp 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade.
CN113698386B (en) * 2020-05-22 2022-12-27 上海美悦生物科技发展有限公司 4 (1H) -pyridone compound, and pharmaceutical composition and application thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0354495A1 (en) * 1988-08-06 1990-02-14 Gödecke Aktiengesellschaft Alkoxy-4(1H)-pyridone derivatives, process for their preparation and their pharmaceutical use
WO1997001338A1 (en) * 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
WO1998016547A1 (en) * 1996-10-11 1998-04-23 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
WO1999011267A1 (en) * 1997-09-05 1999-03-11 Merck & Co., Inc. Pyrazinone thrombin inhibitors
WO1999043660A1 (en) * 1998-02-26 1999-09-02 Neurogen Corporation Substituted 1,4-dihydro-4-oxonicotinic carboxamides: gaba brain receptor ligands
WO1999048892A1 (en) * 1998-03-20 1999-09-30 Merck Sharp & Dohme Limited Pyrazolo-pyridine derivatives as ligands for gaba receptors

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5910541A (en) 1982-07-09 1984-01-20 Takeda Chem Ind Ltd Quinone compound
JPS60255749A (en) 1984-05-31 1985-12-17 Univ Nagoya Quinone derivative
US5304658A (en) 1984-08-01 1994-04-19 Takeda Chemical Industries, Ltd. Quinone derivatives, their production and use
IL81264A (en) 1986-01-30 1990-11-05 Takeda Chemical Industries Ltd Quinone derivatives,their production and pharmaceutical compositions containing them
US5008267A (en) 1988-10-29 1991-04-16 Mitsui Toatsu Chemicals, Incorporated Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same
GB9216272D0 (en) 1991-08-15 1992-09-09 Ici Plc Substituted heterocycles
US5441960A (en) 1992-04-16 1995-08-15 Zeneca Limited 1-pyrimidinylacetamide human leukocyte elastate inhibitors
DE69314169T2 (en) 1992-04-16 1998-01-15 Zeneca Ltd PEPTIDES WITH AN ALPHAAMINOBORONAIRE GROUP AND THEIR USE AS AN ELASTASE INHIBITOR
US5618792A (en) 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
US5658930A (en) 1994-12-13 1997-08-19 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
EP0804464B1 (en) 1994-12-13 2002-05-08 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
US6011158A (en) 1994-12-13 2000-01-04 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
US5656645A (en) 1994-12-13 1997-08-12 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
US5948785A (en) 1995-04-27 1999-09-07 The Green Cross Corporation Heterocyclic amide compounds and pharmaceutical use of the same
US5612378A (en) 1995-06-06 1997-03-18 3-Dimensional Pharmaceuticals, Inc. Bis-arylsulfonylaminobenzamide derivatives and the use thereof as factor Xa inhibitors
US5741819A (en) 1995-06-07 1998-04-21 3-Dimensional Pharmaceuticals, Inc. Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors
WO1997017274A2 (en) 1995-11-08 1997-05-15 Koenig & Bauer-Albert Ag Folding device
CA2245811A1 (en) 1996-02-22 1997-08-28 Merck & Co., Inc. Pyridinone thrombin inhibitors
JP3140790B2 (en) 1996-04-23 2001-03-05 メルク エンド カンパニー インコーポレーテッド Pyrazinone thrombin inhibitors
US5668289A (en) 1996-06-24 1997-09-16 Merck & Co., Inc. Pyridinone thrombin inhibitors
WO1998008840A1 (en) 1996-08-29 1998-03-05 Merck & Co., Inc. Integrin antagonists
AU4172397A (en) 1996-09-06 1998-03-26 Biochem Pharma Inc. Lactam inhibitors of thrombin
BR9712000A (en) 1996-09-06 1999-08-24 Nippon Kayaku Kk Derivatives of acetamide salts of the same pharmaceutical composition chymase protease inhibitors of mast degranulation or histamine release from mast cells and eosinophil activation or active oxygen release from eosinophil eosinophile and process for producing acetamide denervates
CA2264037A1 (en) 1996-09-13 1998-03-19 Merck & Co., Inc. Thrombin inhibitors
US5872138A (en) 1996-09-13 1999-02-16 Merck & Co., Inc. Thrombin inhibitors
AU743544B2 (en) 1996-10-11 2002-01-31 Millennium Pharmaceuticals, Inc. Selective factor Xa inhibitors
US5869487A (en) 1996-10-24 1999-02-09 Merck & Co., Inc. Pyrido 3,4-B!pyrazines for use as thrombin inhibitors
EP0940400A4 (en) 1996-10-25 2002-10-02 Mitsubishi Pharma Corp NOVEL HETEROCYCLIC AMIDE COMPOUNDS AND THEIR USE FOR MEDICINAL PURPOSES
WO1998031670A1 (en) 1997-01-22 1998-07-23 Merck & Co., Inc. Thrombin inhibitors
US5792779A (en) 1997-02-19 1998-08-11 Merck & Co., Inc. Pyridinone thrombin inhibitors
CA2283704A1 (en) 1997-03-24 1998-10-01 Merck & Co., Inc. Thrombin inhibitors
US5866573A (en) 1997-04-21 1999-02-02 Merck & Co., Inc. Pyrazinone thrombin inhibitors
IL123986A (en) 1997-04-24 2011-10-31 Organon Nv Serine protease inhibiting antithrombotic agents and pharmaceutical compositions comprising them
ID22904A (en) 1997-05-02 1999-12-16 Akzo Nobel Nv SERIN PROTEASE OBSTACLES
EP1014962A4 (en) 1997-06-26 2007-06-27 Lilly Co Eli Antithrombotic agents
IL133627A0 (en) 1997-06-26 2001-04-30 Lilly Co Eli Antithrombotic agents
US6372759B1 (en) 1997-06-26 2002-04-16 Eli Lilly And Company Antithrombotic agents
WO1999026920A1 (en) 1997-11-26 1999-06-03 Corvas International, Inc. Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (ii)
TWI222441B (en) 1997-11-26 2004-10-21 Dimensional Pharm Inc Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
JP2002509153A (en) 1998-01-20 2002-03-26 ワーナー−ランバート・カンパニー N- [2- (5-benzyloxycarbonyl-amino-6-oxo-2- (4-fluorophenyl) -1,6-dihydro-1-) as an in vivo inhibitor of interleukin-1β converting enzyme (ICE) Pyrimidinyl) acetoxyl] -L-aspartic aldehyde
WO1999059591A1 (en) 1998-05-19 1999-11-25 Merck & Co., Inc. Pyrazinone thrombin inhibitors
EP1082324A4 (en) 1998-05-26 2002-01-02 Merck & Co Inc THROMBIN INHIBITOR IMIDAZOPYRIDINE COMPOUNDS
AU4330899A (en) 1998-06-03 2000-06-19 Cortech, Inc. Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors
JP4554077B2 (en) 1998-06-11 2010-09-29 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド Pyrazinone protease inhibitor
EP0997474B1 (en) 1998-08-14 2003-10-29 Pfizer Inc. Antithrombotic agents
EP1117660A4 (en) 1998-09-28 2002-01-09 Merck & Co Inc THROMBIN INHIBITORS
WO2000026210A1 (en) 1998-10-30 2000-05-11 Merck & Co., Inc. Thrombin inhibitors
CA2348734A1 (en) 1998-10-30 2000-05-11 Merck & Co., Inc. Thrombin inhibitors
DE19851421A1 (en) 1998-11-07 2000-05-11 Boehringer Ingelheim Pharma New pyrimidines, their production and use
FR2786482B1 (en) 1998-11-27 2002-08-09 Synthelabo NOVEL 2-PYRIDONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
WO2000038683A1 (en) 1998-12-23 2000-07-06 Du Pont Pharmaceuticals Company THROMBIN OR FACTOR Xa INHIBITORS
KR20010113969A (en) 1999-05-19 2001-12-28 추후보정 Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
CA2373509A1 (en) 1999-05-19 2000-11-23 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
EA004867B1 (en) 1999-05-19 2004-08-26 Фармация Корпорейшн Substituted pyrymidinone compounds, composition and method for the treatment, inhibiting and prevention of thrombotic conditions in mammals
EP1351686A2 (en) * 2000-11-20 2003-10-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0354495A1 (en) * 1988-08-06 1990-02-14 Gödecke Aktiengesellschaft Alkoxy-4(1H)-pyridone derivatives, process for their preparation and their pharmaceutical use
WO1997001338A1 (en) * 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
WO1998016547A1 (en) * 1996-10-11 1998-04-23 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
WO1999011267A1 (en) * 1997-09-05 1999-03-11 Merck & Co., Inc. Pyrazinone thrombin inhibitors
WO1999043660A1 (en) * 1998-02-26 1999-09-02 Neurogen Corporation Substituted 1,4-dihydro-4-oxonicotinic carboxamides: gaba brain receptor ligands
WO1999048892A1 (en) * 1998-03-20 1999-09-30 Merck Sharp & Dohme Limited Pyrazolo-pyridine derivatives as ligands for gaba receptors

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ARZNEIM.-FORSCH. (1979), 29(9), 1334-9 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DARVAS, F. ET AL: "Investigation of the common mechanism of action of antibacterial compounds containing.gamma.-pyridone-.beta.-carboxylic acid structure by principal component", XP002182132, retrieved from STN Database accession no. 93:1350 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TRECOURT, FRANCOIS ET AL: "First synthesis of (.+-.)-harzianopyridone by metalation of polysubstituted O-pyridylcarbamates", XP002182410, retrieved from STN Database accession no. 123:256397 *
J. HETEROCYCL. CHEM. (1995), 32(4), 1117-24 *
PATEL M K ET AL: "Directed Aminomethylation of 3-Hydroxy-2(1H)-pyridinones and 3-Hydroxy-4(1H)-pyridinones: Synthesis of iso-Deferiprone", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 52, no. 5, 29 January 1996 (1996-01-29), pages 1835 - 1840, XP004104485, ISSN: 0040-4020 *

Also Published As

Publication number Publication date
EP1268428A2 (en) 2003-01-02
US20040162319A1 (en) 2004-08-19
CA2405306A1 (en) 2001-10-18
AU2001251315A1 (en) 2001-10-23
US20020032174A1 (en) 2002-03-14
JP2004505013A (en) 2004-02-19
WO2001077079A2 (en) 2001-10-18
US6693121B2 (en) 2004-02-17

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