WO2001079473A3 - 21953, a human prolyl oligopeptidase family member and uses thereof - Google Patents

21953, a human prolyl oligopeptidase family member and uses thereof Download PDF

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Publication number
WO2001079473A3
WO2001079473A3 PCT/US2001/040483 US0140483W WO0179473A3 WO 2001079473 A3 WO2001079473 A3 WO 2001079473A3 US 0140483 W US0140483 W US 0140483W WO 0179473 A3 WO0179473 A3 WO 0179473A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid molecules
prolyl oligopeptidase
family member
expression vectors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/040483
Other languages
French (fr)
Other versions
WO2001079473A2 (en
Inventor
Rachel A Meyers
Mark Williamson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Priority to EP01931127A priority Critical patent/EP1280922A2/en
Priority to AU2001257594A priority patent/AU2001257594A1/en
Publication of WO2001079473A2 publication Critical patent/WO2001079473A2/en
Publication of WO2001079473A3 publication Critical patent/WO2001079473A3/en
Priority to US10/170,789 priority patent/US7070947B2/en
Anticipated expiration legal-status Critical
Priority to US11/151,601 priority patent/US7198930B2/en
Priority to US11/636,948 priority patent/US7282360B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides isolated nucleic acids molecules, designated 21953 nucleic acid molecules, which encode novel prolyl oligopeptidase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 21953 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 21953 gene has been introduced or disrupted. The invention still further provides isolated 21953 proteins, fusion proteins, antigenic pepides and anti-21953 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
PCT/US2001/040483 2000-02-29 2001-04-11 21953, a human prolyl oligopeptidase family member and uses thereof Ceased WO2001079473A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01931127A EP1280922A2 (en) 2000-04-18 2001-04-11 21953, a human prolyl oligopeptidase family member and uses thereof
AU2001257594A AU2001257594A1 (en) 2000-04-18 2001-04-11 21953, a novel human prolyl oligopeptidase family member and uses thereof
US10/170,789 US7070947B2 (en) 2000-02-29 2002-06-13 Human protein kinase, phosphatase, and protease family members and uses thereof
US11/151,601 US7198930B2 (en) 2000-02-29 2005-06-13 Human protein kinase, phosphatase, and protease family members and uses thereof
US11/636,948 US7282360B2 (en) 2000-02-29 2006-12-11 Human protein kinase, phosphatase, and protease family members and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19750800P 2000-04-18 2000-04-18
US60/197,508 2000-04-18

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/170,789 Continuation-In-Part US7070947B2 (en) 2000-02-29 2002-06-13 Human protein kinase, phosphatase, and protease family members and uses thereof

Publications (2)

Publication Number Publication Date
WO2001079473A2 WO2001079473A2 (en) 2001-10-25
WO2001079473A3 true WO2001079473A3 (en) 2002-04-25

Family

ID=22729698

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/040483 Ceased WO2001079473A2 (en) 2000-02-29 2001-04-11 21953, a human prolyl oligopeptidase family member and uses thereof

Country Status (3)

Country Link
EP (1) EP1280922A2 (en)
AU (1) AU2001257594A1 (en)
WO (1) WO2001079473A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6979697B1 (en) 1998-08-21 2005-12-27 Point Therapeutics, Inc. Regulation of substrate activity
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
GB0101760D0 (en) * 2001-01-23 2001-03-07 Glaxo Group Ltd Novel protein
EP1422293A1 (en) * 2002-11-25 2004-05-26 F. Hoffmann-La Roche Ag Crystal structure of dipeptidyl peptidase IV
WO2005106021A1 (en) * 2004-04-28 2005-11-10 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with dipeptidyl-peptidase 8 (dpp8)
RU2542414C2 (en) * 2010-07-15 2015-02-20 Олег Ильич Эпштейн Medication for treating erectile dysfunctions and method of treating erectile dysfunctions

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1074617A2 (en) * 1999-07-29 2001-02-07 Helix Research Institute Primers for synthesising full-length cDNA and their use
WO2001010903A2 (en) * 1999-08-09 2001-02-15 Incyte Genomics, Inc. Proteases and protease inhibitors
WO2001019866A1 (en) * 1999-09-10 2001-03-22 The University Of Sydney Dipeptidyl peptidases
WO2001083775A2 (en) * 2000-05-04 2001-11-08 Incyte Genomics, Inc. Proteases
WO2001098468A2 (en) * 2000-06-16 2001-12-27 Incyte Genomics, Inc. Proteases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1074617A2 (en) * 1999-07-29 2001-02-07 Helix Research Institute Primers for synthesising full-length cDNA and their use
WO2001010903A2 (en) * 1999-08-09 2001-02-15 Incyte Genomics, Inc. Proteases and protease inhibitors
WO2001019866A1 (en) * 1999-09-10 2001-03-22 The University Of Sydney Dipeptidyl peptidases
WO2001083775A2 (en) * 2000-05-04 2001-11-08 Incyte Genomics, Inc. Proteases
WO2001098468A2 (en) * 2000-06-16 2001-12-27 Incyte Genomics, Inc. Proteases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL/GENBANK NEDO human cDNA sequencing project; 15 January 2000 (2000-01-15), KAWAKAMI ET AL: "Homo sapiens cDNA FLJ20283 fis, clone HEP04088", XP002188742 *
DATABASE GENEBANK Homo sapiens clone for prolyl endopeptidase; 20 November 1999 (1999-11-20), YOSHIMOTO ET AL.: "Cloning and expression of the cDNA encoding prolyl oligopeptidase (prolyl endopeptidase) from human brain", XP002188743 *

Also Published As

Publication number Publication date
AU2001257594A1 (en) 2001-10-30
WO2001079473A2 (en) 2001-10-25
EP1280922A2 (en) 2003-02-05

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