WO2001083721A3 - 32132, a novel fucosyltransferase family member and uses therefor - Google Patents

32132, a novel fucosyltransferase family member and uses therefor Download PDF

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Publication number
WO2001083721A3
WO2001083721A3 PCT/US2001/013805 US0113805W WO0183721A3 WO 2001083721 A3 WO2001083721 A3 WO 2001083721A3 US 0113805 W US0113805 W US 0113805W WO 0183721 A3 WO0183721 A3 WO 0183721A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid molecules
family member
expression vectors
uses therefor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/013805
Other languages
French (fr)
Other versions
WO2001083721A2 (en
Inventor
Rachel A Meyers
Mark Williamson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Priority to AU2001255764A priority Critical patent/AU2001255764A1/en
Priority to EP01928964A priority patent/EP1307544A2/en
Publication of WO2001083721A2 publication Critical patent/WO2001083721A2/en
Publication of WO2001083721A3 publication Critical patent/WO2001083721A3/en
Priority to US10/184,648 priority patent/US7301016B2/en
Anticipated expiration legal-status Critical
Priority to US11/786,411 priority patent/US7799898B2/en
Priority to US12/828,319 priority patent/US8252915B2/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides isolated nucleic acids molecules, designated 32132 nucleic acid molecules, which encode novel fucosyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 32132 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 32132 gene has been introduced or disrupted. The invention still further provides isolated 32132 proteins, fusion proteins, antigenic peptides and anti-32132 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
PCT/US2001/013805 2000-03-07 2001-04-27 32132, a novel fucosyltransferase family member and uses therefor Ceased WO2001083721A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2001255764A AU2001255764A1 (en) 2000-04-28 2001-04-27 32132, a novel fucosyltransferase family member and uses therefor
EP01928964A EP1307544A2 (en) 2000-04-28 2001-04-27 32132, a fucosyltransferase family member and uses therefor
US10/184,648 US7301016B2 (en) 2000-03-07 2002-06-27 Human transferase family members and uses thereof
US11/786,411 US7799898B2 (en) 2000-03-07 2007-04-11 Human transferase family members and uses thereof
US12/828,319 US8252915B2 (en) 2000-03-07 2010-07-01 Human transferase family members and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20060400P 2000-04-28 2000-04-28
US60/200,604 2000-04-28

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09/844,948 Continuation-In-Part US20030119161A1 (en) 2000-03-07 2001-04-27 32132, a novel fucosyltransferase family member and uses therefor
US10/184,648 Continuation-In-Part US7301016B2 (en) 2000-03-07 2002-06-27 Human transferase family members and uses thereof

Publications (2)

Publication Number Publication Date
WO2001083721A2 WO2001083721A2 (en) 2001-11-08
WO2001083721A3 true WO2001083721A3 (en) 2002-04-18

Family

ID=22742408

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/013805 Ceased WO2001083721A2 (en) 2000-03-07 2001-04-27 32132, a novel fucosyltransferase family member and uses therefor

Country Status (3)

Country Link
EP (1) EP1307544A2 (en)
AU (1) AU2001255764A1 (en)
WO (1) WO2001083721A2 (en)

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL EBI; 1 July 2000 (2000-07-01), NEIMAN PE AND RUDDELL AR: "EST00509 DTsubNB Gallus gallus cDNA clone 10F9", XP002189878 *
DATABASE EMBL EBI; 1 October 2000 (2000-10-01), STRAUSBERG R: "601663326F1 NCI_CGAP_Mam1 Mus musculus cDNA clone", XP002189876 *
DATABASE EMBL EBI; 23 February 2001 (2001-02-23), STRAUSBERG R: "602406279F1 NIH_MGC_91 Homo sapiens cDNA clone", XP002189875 *
DATABASE EMBL EBI; 4 February 2000 (2000-02-04), SMITH DR: "Homo sapiens chromosome 10 clone RP11-574K11", XP002189870 *
DATABASE EMBL EBI; 7 May 2000 (2000-05-07), NEIMAN PE AND RUDDELL AR: "EST00191 DT40subNB Gallus gallus cDNA clone 4D7", XP002189877 *
DATABASE EMBL EBI; 8 February 2001 (2001-02-08), ADACHI J ET AL.: "Mus musculus 13 days embryo head cDNA, alpha-(1,3)-fucosyltransferase", XP002189874 *
DATABASE EMBL EBI; 8 October 1998 (1998-10-08), LEE NH ET AL: "EST218119 Normalized rat muscle, Bento Soares Rattus sp. cDNA clone RMUBV23 3' end", XP002189873 *
DATABASE EMBL EBI; 9 February 2000 (2000-02-09), BIRREN B ET AL: "Homo sapiens chromosome 2 clone RP11-459P11 map 2", XP002189871 *
DATABASE EMBL EBI; 9 September 1999 (1999-09-09), STRAUSBERG R: "ws20h09.x1 NCI_CGAP_GC6 Homo sapiens cDNA clone", XP002189872 *
STAUDACHER E ET AL: "FUCOSE IN N-GLYCANS: FROM PLANT TO MAN", BIOCHIMICA ET BIOPHYSICA ACTA, AMSTERDAM, NL, vol. 1473, no. 1, 1999, pages 216 - 236, XP000921407, ISSN: 0006-3002 *

Also Published As

Publication number Publication date
EP1307544A2 (en) 2003-05-07
WO2001083721A2 (en) 2001-11-08
AU2001255764A1 (en) 2001-11-12

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