WO2001085932A3 - Immunogenic polypeptides encoded by mage minigenes and uses thereof - Google Patents

Immunogenic polypeptides encoded by mage minigenes and uses thereof Download PDF

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Publication number
WO2001085932A3
WO2001085932A3 PCT/CA2001/000646 CA0100646W WO0185932A3 WO 2001085932 A3 WO2001085932 A3 WO 2001085932A3 CA 0100646 W CA0100646 W CA 0100646W WO 0185932 A3 WO0185932 A3 WO 0185932A3
Authority
WO
WIPO (PCT)
Prior art keywords
mage
immunogenic polypeptides
minigenes
polypeptides encoded
nucleic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2001/000646
Other languages
French (fr)
Other versions
WO2001085932A2 (en
Inventor
Neil Berinstein
Jim Tartaglia
John A Tine
Philippe Moingeon
Thierry Boon-Falleur
Der Bruggen Pierre Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur Ltd
Ludwig Institute for Cancer Research Ltd
Sanofi Pasteur SA
Ludwig Cancer Research
Original Assignee
Aventis Pasteur Ltd
Ludwig Institute for Cancer Research Ltd
Aventis Pasteur SA
Ludwig Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU5810201A priority Critical patent/AU5810201A/en
Priority to US10/275,993 priority patent/US7851212B2/en
Priority to DE60124899T priority patent/DE60124899T2/en
Priority to EP01931269A priority patent/EP1282702B1/en
Priority to AU2001258102A priority patent/AU2001258102B2/en
Priority to CA2408328A priority patent/CA2408328C/en
Priority to DK01931269T priority patent/DK1282702T3/en
Application filed by Aventis Pasteur Ltd, Ludwig Institute for Cancer Research Ltd, Aventis Pasteur SA, Ludwig Cancer Research filed Critical Aventis Pasteur Ltd
Publication of WO2001085932A2 publication Critical patent/WO2001085932A2/en
Publication of WO2001085932A3 publication Critical patent/WO2001085932A3/en
Anticipated expiration legal-status Critical
Priority to AU2007200600A priority patent/AU2007200600B2/en
Priority to US12/913,271 priority patent/US8257717B2/en
Priority to US13/564,046 priority patent/US20130216563A1/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/023—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a poxvirus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention discloses immunogenic polypeptides comprising several MAGE-specific antigen epitopes selected from different (i.e. discrete) members of the MAGE protein family, nucleic acids coding therefor, recombinant viruses and/or cells comprising said nucleic acids, and compositions thereof. Methods for eliciting or inducing MAGE-specific immune responses utilizing the aforementioned immunogenic agents are also disclosed.
PCT/CA2001/000646 2000-05-10 2001-05-07 Immunogenic polypeptides encoded by mage minigenes and uses thereof Ceased WO2001085932A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
DK01931269T DK1282702T3 (en) 2000-05-10 2001-05-07 Immunogenic polypeptides encoded by KAGE minigens and uses thereof
DE60124899T DE60124899T2 (en) 2000-05-10 2001-05-07 BY MAGE MINIGENE, IMMUNOGENIC POLYPEPTIDES AND THEIR USES COODED
EP01931269A EP1282702B1 (en) 2000-05-10 2001-05-07 Immunogenic polypeptides encoded by mage minigenes and uses thereof
AU2001258102A AU2001258102B2 (en) 2000-05-10 2001-05-07 Immunogenic polypeptides encoded by mage minigenes and uses thereof
CA2408328A CA2408328C (en) 2000-05-10 2001-05-07 Immunogenic polypeptides encoded by mage minigenes and uses thereof
AU5810201A AU5810201A (en) 2000-05-10 2001-05-07 Immunogenic polypeptides encoded by mage minigenes and uses thereof
US10/275,993 US7851212B2 (en) 2000-05-10 2001-05-07 Immunogenic polypeptides encoded by MAGE minigenes and uses thereof
AU2007200600A AU2007200600B2 (en) 2000-05-10 2007-02-12 Immunogenic polypeptides encoded by MAGE minigenes and uses thereof
US12/913,271 US8257717B2 (en) 2000-05-10 2010-10-27 Immunogenic polypeptides encoded by MAGE minigenes and uses thereof
US13/564,046 US20130216563A1 (en) 2000-05-10 2012-08-01 Immunogenic Polypeptides Encoded by MAGE Minigenes and Uses Thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US20297000P 2000-05-10 2000-05-10
US60/202,970 2000-05-10
US20357800P 2000-05-11 2000-05-11
US60/203,578 2000-05-11
US24238800P 2000-10-20 2000-10-20
US60/242,388 2000-10-20

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/913,217 Continuation US20110090032A1 (en) 2000-05-10 2010-10-27 Rare earth permanent magnet and its preparation

Publications (2)

Publication Number Publication Date
WO2001085932A2 WO2001085932A2 (en) 2001-11-15
WO2001085932A3 true WO2001085932A3 (en) 2002-09-06

Family

ID=27394488

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2001/000646 Ceased WO2001085932A2 (en) 2000-05-10 2001-05-07 Immunogenic polypeptides encoded by mage minigenes and uses thereof

Country Status (11)

Country Link
US (3) US7851212B2 (en)
EP (2) EP1282702B1 (en)
AT (2) ATE513913T1 (en)
AU (3) AU2001258102B2 (en)
CA (1) CA2408328C (en)
CY (1) CY1107570T1 (en)
DE (1) DE60124899T2 (en)
DK (1) DK1282702T3 (en)
ES (1) ES2276788T3 (en)
PT (1) PT1282702E (en)
WO (1) WO2001085932A2 (en)

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US7273605B2 (en) 2001-11-30 2007-09-25 Isis Innovation Limited Vaccine
US7407661B2 (en) 1997-06-09 2008-08-05 Oxxon Therapeutics Limited Methods and reagents that generate a CD8 T cell immune response
US8282935B2 (en) 2001-07-30 2012-10-09 Isis Innovation Limited Materials and methods relating to improved vaccination strategies

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US6096323A (en) * 1997-10-03 2000-08-01 The Regents Of The University Of California Vaccine against papillomatous digital dermatitis (PDD)
US20070026021A1 (en) * 1998-05-01 2007-02-01 Chiron S.R.I. Neisseria meningitidis antigens and compositions
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US6610306B2 (en) * 1998-10-22 2003-08-26 The University Of Montana OMP85 protein of neisseria meningitidis, compositions containing the same and methods of use thereof
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US7842480B2 (en) * 2001-05-18 2010-11-30 Mayo Foundation For Medical Education And Research Chimeric antigen-specific t cell-activating polypeptides
US20060222656A1 (en) * 2005-04-01 2006-10-05 University Of Maryland, Baltimore MAGE-A3/HPV 16 peptide vaccines for head and neck cancer
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