WO2001087930A3 - Human galanin receptor-like g protein coupled receptor - Google Patents

Human galanin receptor-like g protein coupled receptor Download PDF

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Publication number
WO2001087930A3
WO2001087930A3 PCT/EP2001/005569 EP0105569W WO0187930A3 WO 2001087930 A3 WO2001087930 A3 WO 2001087930A3 EP 0105569 W EP0105569 W EP 0105569W WO 0187930 A3 WO0187930 A3 WO 0187930A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
disorders
human galanin
protein coupled
reagents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/005569
Other languages
French (fr)
Other versions
WO2001087930A2 (en
Inventor
Shyam Ramakrishnan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to EP01947284A priority Critical patent/EP1287021A2/en
Priority to US10/276,548 priority patent/US20040053244A1/en
Priority to AU2001269013A priority patent/AU2001269013A1/en
Publication of WO2001087930A2 publication Critical patent/WO2001087930A2/en
Publication of WO2001087930A3 publication Critical patent/WO2001087930A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reagents which regulate human galanin receptor-like GPCR and reagents which bind to human galanin receptor-like gene products can be used to regulate the effect of galanin for therapeutic purposes. Treatment of pathophysiological disorders such as eating disorders, cancer, diabetes, osteoporosis, obesity, pain, depression, ischemia, Alzheimer's disease, sleep disorders, migraine, anxiety, and reproductive disorders can be treated. Processes such as cognition, analgesia, sensory processing (olfactory, visual), processing or visceral information, motor coordination, modulation of dopaminergic activity, and neuroendocrine function can be modulated.
PCT/EP2001/005569 2000-05-18 2001-05-16 Human galanin receptor-like g protein coupled receptor Ceased WO2001087930A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01947284A EP1287021A2 (en) 2000-05-18 2001-05-16 Human galanin receptor-like g protein coupled receptor
US10/276,548 US20040053244A1 (en) 2000-05-18 2001-05-16 Regulation of human galanin receptor-like g protein coupled receptor
AU2001269013A AU2001269013A1 (en) 2000-05-18 2001-05-16 Human galanin receptor-like g protein coupled receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20507100P 2000-05-18 2000-05-18
US60/205,071 2000-05-18

Publications (2)

Publication Number Publication Date
WO2001087930A2 WO2001087930A2 (en) 2001-11-22
WO2001087930A3 true WO2001087930A3 (en) 2002-08-29

Family

ID=22760666

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/005569 Ceased WO2001087930A2 (en) 2000-05-18 2001-05-16 Human galanin receptor-like g protein coupled receptor

Country Status (4)

Country Link
US (1) US20040053244A1 (en)
EP (1) EP1287021A2 (en)
AU (1) AU2001269013A1 (en)
WO (1) WO2001087930A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670358B2 (en) 2000-05-16 2003-12-30 Cephalon, Inc. Substituted thioacetamides
EP1781239A2 (en) * 2003-11-17 2007-05-09 Patus Ltd Compositions effective in altering the perception of malodor
JP2008503712A (en) * 2004-06-21 2008-02-07 ガラパゴス・ナムローゼ・フェンノートシャップ Methods and means for treatment of osteoarthritis
AU2005301957B2 (en) * 2004-11-03 2012-02-23 Department Of Health And Human Services Novobiocin analogues as anticancer agents
WO2012009258A2 (en) * 2010-07-13 2012-01-19 Edward Roberts Peptidomimetic galanin receptor modulators
GB201512733D0 (en) * 2015-07-20 2015-08-26 Genagon Therapeutics Ab Therapeutic agents for treating conditions associated with elevated GDF15
GB201700567D0 (en) 2017-01-12 2017-03-01 Genagon Therapeutics Ab Therapeutic agents
CN108949880B (en) * 2018-08-03 2021-07-20 吉林大学 A kind of preparation method of bovine spinal cord peptide and its application

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998015570A1 (en) * 1996-10-09 1998-04-16 Synaptic Pharmaceutical Corporation Dna encoding galanin galr3 receptors and uses thereof
WO1998029441A1 (en) * 1996-12-27 1998-07-09 Merck & Co., Inc. Human galanin receptor galr2 and nucleotides encoding same
WO2000011015A1 (en) * 1998-08-24 2000-03-02 Alphagene, Inc. Secreted proteins and polynucleotides encoding them
WO2000022131A2 (en) * 1998-10-13 2000-04-20 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human g protein-coupled receptors
WO2000078809A1 (en) * 1999-06-21 2000-12-28 Smithkline Beecham Corporation Axor16, a g protein coupled receptor
WO2001016316A1 (en) * 1999-08-27 2001-03-08 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor protein and dna thereof
WO2001048189A1 (en) * 1999-12-28 2001-07-05 Helix Research Institute Novel guanosine triphosphate-binding protein-coupled receptors, genes thereof and production and use of the same
WO2001074897A2 (en) * 2000-04-03 2001-10-11 Curagen Corporation Protein amf-1 to amf-10 and nucleic acids encoding the same

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998015570A1 (en) * 1996-10-09 1998-04-16 Synaptic Pharmaceutical Corporation Dna encoding galanin galr3 receptors and uses thereof
WO1998029441A1 (en) * 1996-12-27 1998-07-09 Merck & Co., Inc. Human galanin receptor galr2 and nucleotides encoding same
WO2000011015A1 (en) * 1998-08-24 2000-03-02 Alphagene, Inc. Secreted proteins and polynucleotides encoding them
WO2000022131A2 (en) * 1998-10-13 2000-04-20 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human g protein-coupled receptors
WO2000078809A1 (en) * 1999-06-21 2000-12-28 Smithkline Beecham Corporation Axor16, a g protein coupled receptor
WO2001016316A1 (en) * 1999-08-27 2001-03-08 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor protein and dna thereof
WO2001048189A1 (en) * 1999-12-28 2001-07-05 Helix Research Institute Novel guanosine triphosphate-binding protein-coupled receptors, genes thereof and production and use of the same
WO2001074897A2 (en) * 2000-04-03 2001-10-11 Curagen Corporation Protein amf-1 to amf-10 and nucleic acids encoding the same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BLOOMQUIST B T ET AL: "CLONING AND EXPRESSION OF THE HUMAN GALANIN RECEPTOR GALR2", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 243, 1998, pages 474 - 479, XP002935073, ISSN: 0006-291X *
BRANCHEK T A T A ET AL: "Galanin receptor subtypes", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 21, no. 3, March 2000 (2000-03-01), pages 109 - 117, XP004202574, ISSN: 0165-6147 *
DATABASE EMBL 11 December 1998 (1998-12-11), STRAUSBERG, R.: "tb27a03.x1 NCI_CGAP_Kid12 Homo sapiens cDNA clone IMAGE:2055532 3' similar", XP002190600 *
HABERT-ORTOLI E ET AL: "MOLECULAR CLONING OF A FUNCTIONAL HUMAN GALANIN RECEPTOR", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 91, no. 21, 11 October 1994 (1994-10-11), pages 9780 - 9783, XP002029082, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2001087930A2 (en) 2001-11-22
EP1287021A2 (en) 2003-03-05
AU2001269013A1 (en) 2001-11-26
US20040053244A1 (en) 2004-03-18

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