WO2001090094A1 - Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 - Google Patents

Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 Download PDF

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Publication number
WO2001090094A1
WO2001090094A1 PCT/SE2001/001157 SE0101157W WO0190094A1 WO 2001090094 A1 WO2001090094 A1 WO 2001090094A1 SE 0101157 W SE0101157 W SE 0101157W WO 0190094 A1 WO0190094 A1 WO 0190094A1
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WO
WIPO (PCT)
Prior art keywords
methyl
benzothiazol
oxo
benzenesulfonamide
bromo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SE2001/001157
Other languages
French (fr)
Inventor
Tjeerd Barf
Marianne Nilsson
Jerk VALLGÅRDA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Swedish Orphan Biovitrum AB
Original Assignee
Biovitrum AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/296,132 priority Critical patent/US7030135B2/en
Priority to AT01937063T priority patent/ATE443055T1/en
Priority to AU2001262831A priority patent/AU2001262831B9/en
Priority to CA002408144A priority patent/CA2408144C/en
Priority to EP01937063A priority patent/EP1283834B1/en
Priority to JP2001586282A priority patent/JP2003534339A/en
Priority to HK03109254.9A priority patent/HK1056878B/en
Priority to DE60139931T priority patent/DE60139931D1/en
Priority to AU6283101A priority patent/AU6283101A/en
Priority to NZ522538A priority patent/NZ522538A/en
Application filed by Biovitrum AB filed Critical Biovitrum AB
Priority to IL15275301A priority patent/IL152753A0/en
Publication of WO2001090094A1 publication Critical patent/WO2001090094A1/en
Priority to NO20025586A priority patent/NO323832B1/en
Anticipated expiration legal-status Critical
Priority to US11/289,634 priority patent/US20060160797A1/en
Ceased legal-status Critical Current

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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
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Definitions

  • ll ⁇ HSDl is suggested to have a role in aqueous production, rather than drainage, but it is presently unknown if this is by interfering with activation of the glucocorticoid or the mineralocorticoid receptor, or both.
  • R 8 and R 9 are independently hydrogen or methyl.
  • the compounds as described above can be prepared by methods comprising at least one of the following steps: a) sulfonamide coupling by reacting a 2-aminothiazole with a sulfonylchloride in the presence of a base, b) sulfonamide coupling by reacting a 2-aminothiazole derivative with a sulfonylchloride in the presence of a base.
  • R 3 is methyl, acetyl or -COR 4 ;
  • R 4 is morpholinyl or propionamido
  • R and R are both hydrogen
  • R 8 and R 9 are independently hydrogen or methyl.
  • Another object of the present invention is a pharmaceutical composition
  • a pharmaceutical composition comprising at least one compound of the formula (I) as defined above, and a pharmaceutically acceptable carrier.
  • heteroaryl means in the present description a monocyclic, bi- or tricyclic aromatic ring system (only one ring need to be aromatic) having from 5 to 14, preferably 5 to 10 ring atoms such as 5, 6, 7, 8, 9 or 10 ring atoms (mono- or bicyclic), in which one or more of the ring atoms are other than carbon, such as nitrogen, sulfur, oxygen and selenium.
  • halogen in the present description is intended to include fluorine, chlorine, bromine and iodine.
  • aqueous carriers are well known in the art.
  • exemplary of liquid carriers are sterile aqueous solutions that contain no materials in addition to the active ingredients and water, or contain a buffer such as sodium phosphate at physiological pH value, physiological saline or both, such as phosphate-buffered saline.
  • aqueous carriers can contain more than one buffer salt, as well as salts such as sodium and potassium chlorides, dextrose, propylene glycol, polyethylene glycol and other solutes.
  • Salts formed with the free carboxyl groups can also be derived from inorganic bases such as, for example, sodium, potassium, ammonium, calcium or ferric hydroxides, and such organic bases as isopropylamine, nimemylamine, 2-ethylamino ethanol, histidine, procaine and the like.
  • the preparations according to the preferred embodiments may be administered orally, topically, intraperitoneally, intraarticularly, intracranially, intradermally, intramuscularly, intraocularly, intrathecally, intravenously, subcutaneously. Other routes which are known for the skilled person in the art are thinkable.
  • compositions according to the present invention may be in the form of tablets, capsules, powders, granules, lozenges, liquid or gel preparations, such as oral, topical or sterile parenteral solutions or suspensions.
  • Tablets and capsules for oral administration may be in unit dose presentation form and may contain conventional excipients such as binding agents, for example syrup, acacia, gelatin, sorbitol, traganath or polyvinyl-pyrrolidone; fillers e.g. lactose, sugar, maize-starch, calcium phosphate, sorbitol or glycine; tabletting lubricant e.g.
  • [1, 2(n) - 3 H]-cortisone was purchased from Amersham Pharmacia Biotech.
  • Anti- cortisol monoclonal mouse antibody, clone 6D6.7 was obtained from Immunotech and Scintillation proximity assay (SPA) beads coated with monoclonal antimouse antibodies were from Amersham Pharmacia Biotech.
  • NADPH, tetrasodium salt was from Calbiochem and glucose-6-phosphate (G-6-P) was supplied by Sigma.
  • the human 11- ⁇ -hydroxysteroid dehydrogenase type-1 enzyme (11- ⁇ -HSD ⁇ ) was expressed in Pichiapastoris.
  • 18- ⁇ -glycyrrhetinic acid (GA) was obtained from Sigma.
  • the title compound was prepared from 2-amino-5,6-dihydro-4H-cyclopentathiazole hydrochloride (48 mg) and 2,3,4-trichlorobenzenesulfonyl chloride (76 mg) as described in the synthetic METHOD B to give a yellow solid (4.5 mg): MS (pos) m/z 383.3, 385.3, 387.3; MS (neg) m/z 381.4, 383.4, 385.4.

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Abstract

The present invention relates to using a compound having the formula (I) wherein T is I) thienyl, which optionally is substituted with halogen, or II) phenyl optionally substituted with halogen and/or C1-6-alkyl; E is a bond, -CH2- or -CO-; L is a bond, -CH2-, -CHR4- or -NR3-; R3 is H, C¿1-6?-alkyl, C1-6-acyl or -COR?4; R4¿ is morpholino or C¿1-6?-amido; R?6 and R7¿ are independently hydrogen or C¿1-6?-alkyl; and R?8 and R9¿ are independently hydrogen or C¿1-6?-alkyl, as well as pharmaceutically acceptable salts, hydrates and solvates thereof, in the manufacture of a medicament for the treatment or prevention of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, dementia, depression, virus diseases and inflammatory disorders.

Description

INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1
TECHNICAL FIELD
The present invention relates to novel compounds, to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme (llβHSDl).
BACKGROUND ART
1. Glucorticoids- diabetes and hepatic glucose production
It has been known for more than half a century that glucocor icoids have a central role in diabetes, e.g. the removal of the pituitary or the adrenal gland from a diabetic animal alleviates the most severe symptoms of diabetes and lowers the concentration of glucose in the blood (Long, CD. and F.D.W. Leukins (1936) J. Exp. Med. 63: 465- 490; Houssay, B.A. (1942) Endocrinology 30: 884-892). It is also well established that glucocorticoids enable the effect of glucagon on the liver.
The role of llβHSDl as an important regulator of local glucocorticoid effect and thus of hepatic glucose production is well substantiated (see e.g. Jamieson et al. (2000) J. Endocrinol. 165: p. 685-692). The hepatic insulin sensitivity was improved in healthy human volunteers treated with the non-specific 1 lβHSDl inhibitor carbenoxolone (Walker, B.R. et al. (1995) J. Clin. Endocrinol. Metab. 80: 3155-3159). Furthermore, the expected mechanism has been established by different experiments with mice and rats. These studies showed that the mRNA levels and activities of two key enzymes in hepatic glucose production were reduced, namely: the rate-limiting enzyme in gluconeogenesis, phosphoenolpyruvate carboxykinase (PEPCK), and glucose-6- phosphatase (G6Pase) catalyzing the last common step of gluconeogenesis and glycogenolysis. Finally, the blood glucose level and hepatic glucose production is reduced in mice having the 1 lβHSDl gene knocked-out. Data from this model also confirai that inhibition of 1 lβHSDl will not cause hypoglycemia, as predicted since the basal levels of PEPCK and G6Pase are regulated independently of glucocorticoids (Kotelevtsev, Y. et al., (1997) Proc. Natl. Acad. Sci. USA 94: 14924-14929).
2. Possible reduction of obesity and obesity related cardiovascular risk factors
Obesity is an important factor in syndrome X as well as in the majority (> 80%) of type 2 diabetic, and omental fat appears to be of central importance. Abdominal obesity is closely associated with glucose intolerance, hyperinsulinemia, hypertriglyceridemia, and other factors of the so-called syndrome X (e.g. raised blood pressure, decreased levels of HDL and increased levels of VLDL) (Montague & O'Rahilly, Diabetes 49: 883-888, 2000). Inhibition of the enzyme in pre-adipocytes (stromal cells) has been shown to decrease the rate of differentiation into adipocytes. This is predicted to result in diminished expansion (possibly reduction) of the omental fat depot, i.e. reduced central obesity (Bujalska, I.J., S. Kumar, and P.M. Stewart (1997) Lancet 349: 1210-1213).
Inhibition of 1 lβHSDl in mature adipocytes is expected to attenuate secretion of the plasminogen activator inhibitor 1 (PAI-1) - an independent cardiovascular risk factor (Halleux, CM. et al. (1999) J. Clin. Endocrinol. Metab. 84: 4097-4105). Furthermore, there is a clear correlation between glucocorticoid "activity" and cardiovascular risk factore suggesting that a reduction of the glucocorticoid effects would be beneficial (Walker, B.R. et al. (1998) Hypertension 31: 891-895; Fraser, R. et al. (1999) Hypertension 33: 1364-1368).
Adrenalectomy attenuates the effect of fasting to increase both food intake and hypothalamic neuropeptide Y expression. This supports the role of glucocoilicoids in promoting food intake and suggests that inhibition of 1 lβHSDl in the brain might increase satiety and therefore reduce food intake (Woods, S.C et al. (1998) Science, 280: 1378-1383).
3. Possible beneficial effect on the pancreas
Inhibition of llβHSDl in isolated murine pancreatic β-cells improves the glucose- stimulated insulin secretion (Davani, B. et al. (2000) J. Biol. Chem. 2000 Nov 10; 275(45): 34841-4). Glucocorticoids were previously known to reduce pancreatic insulin release in vivo (Billaudel, B. and B.C.J. Sutter (1979) Horm. Metab. Res. 11: 555-560). Thus, inhibition of 1 lβHSDl is predicted to yield other beneficial effects for diabetes treatment, besides effects on liver and fat.
4. Possible beneficial effects on cognition and dementia
Stress and glucocorticoids influence cognitive function (de Quervain, D.J.-F., B.
Roozendaal, and J.L. McGaugh (1998) Nature 394: 787-790). The enzyme llβHSDl controls the level of glucocorticoid action in the brain and thus contributes to neurotoxicity (Rajan, V., C.R.W. Edwards, and J.R. Seckl, J. (1996) Neuroscience 16: 65-70; Seckl, J.R., Front. (2000) Neuroendocrinol. 18: 49-99). Unpublished results indicate significant memory improvement in rats treated with a non-specific 1 lβHSD 1 inhibitor (J. Seckl, personal communication). Based the above and on the known effects of glucocorticoids in the brain, it may also be suggested that inhibiting 1 lβHSDl in the brain may result in reduced anxiety (Tronche, F. et al. (1999) Nature Genetics 23 : 99-103). Thus, taken together, the hypothesis is that inhibition of 1 lβHSD 1 in the human brain would prevent reactivation of cortisone into cortisol and protect against deleterious glucocorticoid-mediated effects on neuronal survival and other aspects of neuronal function, including cognitive impairment, depression, and increased appetite (previous section). O 01/90094 4
5. Possible use of immuno-modulation using llβHSDl inhibitors
The general perception is that glucocorticoids suppress the immune system. But in fact there is a dynamic interaction between the immune system and the HPA (hypothalamo-pituitary-adrenal) axis (Rook, G.A.W. (1999) Baillier's Clin.
Endocrinol. Metab. 13: 576-581). The balance between the cell-mediated response and humoral responses is modulated by glucocorticoids. A high glucocorticoid activity, such as at a state of stress, is associated with a humoral response. Thus, inhibition of the enzyme llβHSDl has been suggested as a means of shifting the response towards a cell-based reaction.
In certain disease states, including tuberculosis, lepra and psoriasis the immune reaction is noπnaly biased towards a humoral response when in fact the appropriate response would be cell based. Temporal inhibition of llβHSDl, local or systemic, might be used to push the immune system into the appropriate response (Mason, D. (1991) Immunology Today 12: 57-60; Rook et al., supra).
An analogous use of llβHSDl inhibition, in this case temporal, would be to booster the immune response in association with immunization to ensure that a cell based response would be obtained, when desired.
6. Reduction of intraocular pressure
Recent data suggest that the levels of the glucocorticoid target receptors and the 1 lβHSD enzymes determines the susceptibility to glaucoma (Stokes, J. et al. (2000) Invest. Ophthalmol. 41: 1629-1638). Further, inhibition of llβHSDl was recently presented as a novel approach to lower the intraocular pressure (Walker E. A. et al, poster P3-698 at the Endocrine society meeting June 12-15, 1999, San Diego). Ingestion of carbenoxolone, a non-specific inhibitor of llβHSDl, was shown to reduce the intraocular pressure by 20% in normal subjects. In the eye, expression of llβHSDl is confined to basal cells of the corneal epithelium and the non-pigmented epithelialium of the cornea (the site of aqueous production), to ciliary muscle and to the sphincter and dilator muscles of the iris. In contrast, the distant isoenzyme llβHSD2 is highly expressed in the non-pigmented ciliary epithelium and corneal endothelium. None of the enzymes is found at the trabecular meshwork, the site of drainage. Thus, llβHSDl is suggested to have a role in aqueous production, rather than drainage, but it is presently unknown if this is by interfering with activation of the glucocorticoid or the mineralocorticoid receptor, or both.
7. Reduced osteoporosis
Glucocorticoids have an essential role in skeletal development and function but are detrimental in excess. Glucocorticoid-induced bone loss is derived, at least in part, via inhibition of bone formation, which includes suppression of osteoblast proliferation and collagen synthesis (Kim, C.H., S.L. Cheng, and G.S. Kim (1999) J. Endocrinol. 162: 371-379). The negative effect on bone nodule formation could be blocked by the non-specific inhibitor carbenoxolone suggesting an important role of llβHSDl in the glucocorticoid effect (Bellows, C.G., A. Ciaccia, and J.N.M. Heersche, (1998) Bone 23 : 119-125). Other data suggest a role of 1 lβHSDl in providing sufficiently high levels of active glucocorticoid in osteoclasts, and thus in augmenting bone resorption (Cooper, M.S. et al. (2000) Bone 27: 375-381). Taken together, these different data suggest that inhibition of llβHSDl may have beneficial effects against osteoporosis by more than one mechanism working in parallel.
WO 99/65884 discloses carbon subtituted aminothiazole inhibitors of cyclin dependent kinases. These compounds may e.g. be used against cancer, inflammation and arthritis. US 5,856,347 discloses an antibacterial preparation or bactericide comprising 2- aminothiazole derivative and or salt thereof. Further, US 5,403,857 discloses benzenesulfonamide derivatives having 5-lipoxygenase inhibitory activity. Additionally, tetrahydrothiazolo[5,4-c]pyridines are disclosed in: Analgesic tetrahydrothiazolo[5,4-c]pyridines. Fr. Addn. (1969), 18 pp, Addn. to Fr. 1498465.
CODEN: FAXXA3; FR 94123 19690704 CAN 72:100685 AN 1970:100685 CAPLUS and 4,5,6, 7-Tetrahydrothiazolo[5,4-c]pyridiιιes. Neth. Appl. (1967), 39 pp. CODEN: NAXXAN NL 6610324 19670124 CAN 68:49593, AN 1968: 49593 CAPLUS.
FR 2384498 discloses thiazolo-benzenesulfonamides which show antibacterial, antifungal and hypoglycaemic properties. WO99/28306 and EP 0 819 681 A2 relate to thiazolobenzenesulfonamides which can be used for treating neurodegenerative pathologies, such as Alzheimer's disease. JP 7149745 A2 and JP 7149746 A2 both describe 2-aminothiazole derivatives as esterase inhibitors. Nothing is disclosed about inhibiting llβHSDl. JP 7309757 A2 relates to treating Alzheimer's disease using N- (5-nitro-2-tltiazolyl)benzenesulfonamides. JP 3173876 A2 presents preparation of diphenylthiazoles. These compounds are used as anti-inflammatories, analgesics, anti- allergy agents, uric acid accelerators and blood platelet aggregation inhibitors. EP 0 790 057 Al discloses an antibacterial or bactericide comprising a 2-aminothiazole derivative. US 2 362 087 describes the preparation of thiazolobenzenesulfonamides, such as 2-bromobenzenesulfonamido-4-methylthiazole. Nothing is disclosed about inhibiting llβHSDl and no therapeutic use of such substances is disclosed.
However, none of the above disclosures discloses the compounds according to the present invention, or their use for the treatment of diabetes, obesity, glaucoma, osteoporosis, cognitive disorders, immune disorders, and depression.
Consequently, there is a need of new compounds that are useful in the treatment of diabetes, obesity, glaucoma, osteoporosis, cognitive disorders, immune disorders, and depression.
DISCLOSURE OF THE INVENTION
The compounds according to the present invention solve the above problems and embraces a novel class of compounds which has been developed and which inhibit the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme (11-β-HSD , and may therefore be of use in the treating disorders such as diabetes, obesity, glaucoma, osteoporosis, cognitive disorders, immune disorders, and depression.
One object of the present invention is compound of formula (I)
Figure imgf000008_0001
wherein
T is
I) thienyl, which optionally is substituted with at least one halogen, or
II) phenyl substituted with a) at least one C2.6-alkyl; or b) at least one Cι_6-alkyl and at least one halogen; or c) at least three halogens;
E is a bond, -CH2- or -CO-;
L is a bond, -CH2-, -CHR4- or -NR3-;
R3 is H, Cμe-alkyl, Cι.6-acyl or -COR4;
R4 is morpholinyl or C1-6 amido;
R6 and R7 are independently hydrogen or C1-6-alkyl; and
R8 and R9 are independently hydrogen or Cι-6-alkyl, as well as pharmaceutically acceptable salts, hydrates and solvates thereof.
It is preferred that:
T is I) thienyl, which is substituted with at least one halogen selected from chloro and bromo, or
II) phenyl substituted with a) at least one n-propyl; or b) at least one methyl and at least one halogen selected from chloro and bromo; or c) at least three halogens selected from fluoro, bromo and chloro;
E is a bond, -CH2- or -CO-; L is a bond, -CH2-, -CHR4- or -NR3-; R3 is methyl, acetyl or -COR4;
R4 is morpholinyl or propionamido;
R6 and R7 are both hydrogen; and
R8 and R9 are independently hydrogen or methyl.
Specific examples of compounds according to the present invention are:
N-(5-Acetyl-4,5,6,7-tetrahydro[l,3]tMazolo[5,4-c]pyridin-2-yl)-3-chloro-2- methylbenzenesulfonamide;
2,4-dcHoro-6-methyl-N-(5,6,6-trimethyl-4,5,6,7-tetrahydro[l,3]thiazolo[5,4- c]pyridin-2-yl)benzenesulfonamide; 2,4-ώchloro-6-methyl-N-[5-(4-morpholinylcarbonyl)-4,5,6,7- tetiahy(ko[l,3]tMazolo[5,4-c]pyrio^-2-yl]benzenesulfonamide;
2,4-DicWoro-6-memyl-N-(4,5,6,7-te1xahydro-l,3-benzothiazol-2- yl)benzenesulfonamide;
4-Bromo-N-(5,6-dihydro-4H-cyclopenta[d][l,3]thiazol-2-yl)-2,5- difluorobenzenesulfonamide;
2,3,4-Trichloro-N-(5,6-dihydro-4H-cycloρenta[d][l,3]thiazol-2- yl)benzenesulfonamide;
N-(2-{[(2,4-dicMoro-6-memylphenyl)sulfonyl]amino}-4,5,6,7-tetrahydro-l,3- benzothiazol-6-yl)propanamide; 2,4-Dic oro-N-(5,5-dimemyl-7-oxo-4,5,6,7-tetrahyα^o-l,3-beιιzothiazol-2-yl)-6- methylbenzenesulfonamide; 2,3,4-TricWoro-N-(5,5-α ιethyl-7-oxo-4,5,6,7-tetrahydro-l,3-benzothiazol-2- yl)benzenesulfonamide; .
4,5-DicWoro-N-(5,5-άmethyl-7-oxo-4,5,6,7-tefrahydro-l,3-benzothiazol-2-yl)-2- thiophenesulfonamide; 4-Bromo-5-cMoro-N-(5,5-ά^memyl-7-oxo-4,5,6,7-tetiahyά^o-l,3-benzothiazol-2-yl)-2- thiophenesulfonamide;
3-Bromo-5-cMoro-N-(5,5-mmemyl-7-oxo-4,5,6,7-tetrahy(ko-l,3-benzot_ιiazol-2-yl)-2- thiophenesulfonamide;
N-(5-Methyl-7-oxo-4,5,6,7-tetrahydro-l,3-benzothiazol-2-yl)-4- propylbenzenesulfonamide;
4,5-DicUoro-N-(5-memyl-7-oxo-4,5,6,7-tetiahy(ko-l,3-benzothiazol-2-yl)-2- thiophenesulfonamide;
2,4-Diclιloro-6-memyl-N-(5-methyl-7-oxo-4,5,6,7-tetiahydro-l,3-berizothiazol-2- yl)benzenesulfonamide; and 4-Bromo-2-methyl-N-(5-memyl-7-oxo-4,5,6,7-tetiahydro-l,3-benzothiazol-2- yl)benzenesulfonamide.
Another object of the present invention is compound as described above for medical use.
The compounds as described above can be prepared by methods comprising at least one of the following steps: a) sulfonamide coupling by reacting a 2-aminothiazole with a sulfonylchloride in the presence of a base, b) sulfonamide coupling by reacting a 2-aminothiazole derivative with a sulfonylchloride in the presence of a base.
Another object of the present invention is a method for the treatment or prevention of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, dementia, depression, virus diseases and inflammatory disorders, said method comprising administering to a mammal, including man, in need of such treatment, an effective amount of a compound having the formula (I)
Figure imgf000011_0001
wherein
T is I) thienyl, which optionally is substituted with halogen, or
II) phenyl optionally substituted with halogen and/or -6-alkyl; E is a bond, -CH2- or -CO-; L is a bond, -CH2-, -CHR4- or -NR3-; R3 is H, Cj-e-alkyl, Cι.6-acyl or -COR4; R4 is morpholino or Cι_6-amido; R and R are independently hydrogen or -6-alkyl; and R8 and R9 are independently hydrogen or
Figure imgf000011_0002
as well as pharmaceutically acceptable salts, hydrates and solvates thereof.
These compounds may also be used in the manufacture of a medicament for the treatment or prevention of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, dementia, depression, virus diseases and inflammatory disorders.
It is preferred that:
T is
I) thienyl, which is substituted with at least one halogen selected from chloro and bromo, or II) phenyl, which is substituted with at least one of methyl, n-propyl, fluoro, chloro and bromo;
E is a bond, -CH - or -CO-;
L is a bond, -CH2-, -CHR4- or -NR3-;
R3 is methyl, acetyl or -COR4;
R4 is morpholinyl or propionamido;
R and R are both hydrogen; and
R8 and R9 are independently hydrogen or methyl.
Specific examples of compounds according to the present invention are given above.
Another object of the present invention is a pharmaceutical composition comprising at least one compound of the formula (I) as defined above, and a pharmaceutically acceptable carrier.
The compounds according to the present invention may be used in several indications which involve 11-β-hydroxysteroid dehydrogenase type 1 enzyme. Thus the compounds according to the present invention may be used against dement a (see WO97/07789), osteoporosis (see Canalis E 1996, Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis, Journal of Clinical Endocrinology and Metabolism, 81, 3441-3447) and may also be used disorders in the immune system (see Franchimont et al, "Inhibition of Thl immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat 4 phosphorylation in T lymphocytes", The journal of Immunology 2000, Feb 15, vol 164 (4), pages 1768-74) and also in the above listed indications.
The various terms used, separately and in combinations, in the above definition of the compounds having the formula (I) will be explained. O 01/90094 12
The term "aryl" in the present description is intended to include aromatic rings (monocyclic or bicyclic) having from 6 to 10 ring carbon atoms, such as phenyl (Ph) and naphthyl, which optionally may be substituted by Cι.6-alkyl. Examples of substituted aryl groups are benzyl, and 2-methylphenyl.
The term "heteroaryl" means in the present description a monocyclic, bi- or tricyclic aromatic ring system (only one ring need to be aromatic) having from 5 to 14, preferably 5 to 10 ring atoms such as 5, 6, 7, 8, 9 or 10 ring atoms (mono- or bicyclic), in which one or more of the ring atoms are other than carbon, such as nitrogen, sulfur, oxygen and selenium. Examples of such heteroaryl rings are pyrrole, imidazole, thiophene, furan, thiazole, isothiazole, thiadiazole, oxazole, isoxazole, oxadiazole, pyridine, pyrazine, pyrimidine, pyridazine, pyrazole, triazole, tetrazole, chroman, isochroman, quinoline, quinoxaline, isoquinoline, phthalazine, cinnoline, quinazoline, indole, isoindole, indoline, isoindoline, benzothiophene, benzofuran, isobenzofuran, benzoxazole, 2,1,3-benzoxadiazole, benzothiazole, 2,1,3-benzothiazole, 2,1,3- benzoselenadiazole, benzimidazole, indazole, benzodioxane, indane, 1,2,3,4- tetrahydroquinoline, 3,4-dihydro-2H-l,4-benzoxazine, 1,5-naρhthyridine, 1,8- naphthyridine, acridine, fenazine and xanthene.
The term "heterocyclic" in the present description is intended to include unsaturated as well as partially and fully saturated mono-, bi- and tricyclic rings having from 4 to 14, preferably 4 to 10 ring atoms, such as, for example, the heteroaryl groups mentioned above as well as the corresponding partially saturated or fully saturated heterocyclic rings. Exemplary saturated heterocyclic rings are azetidine, pyrrolidine, piperidine, piperazine, morpholine, thiomorpholine and 1,4-oxazepane.
Cj.g-alkyl in the compound of formula (I) according to the present application, which may be straight, branched or cyclic, is preferably Cι_4-alkyl. Exemplary alkyl groups include methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, pentyl, isopentyl, hexyl, isohexyl, and cyclohexyl. C2-6-alkyl in the compound of formula (I) according to the present application, which may be straight, branched or cyclic, is preferably C2-4-alkyl. Exemplary alkyl groups include ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, pentyl, isopentyl, hexyl, isohexyl, and cyclohexyl.
Cj.g-acyl, in the compound of formula (I) according to the present application may be saturated or unsaturated and is preferably C]_„4-acyl. Exemplary acyl groups include formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, butenoyl (e.g. 3- butenoyl), hexenoyl (e.g. 5-hexenoyl).
Ci.g-amido, in the compound of formula (I) according to the present application may be saturated or unsaturated and is preferably Cι_4-amido. Exemplary amido groups include formamido, acetamido, propionamido, butyramido, isobutyramido, valeramido, isovaleramido, butenamido (e.g. 3-butenamido), hexenamido (e.g. 5- hexenamido).
The term "halogen" in the present description is intended to include fluorine, chlorine, bromine and iodine.
With the expression mono- or di-substituted is meant in the present description that the functionalities in question may be substituted with independently H, C1-6-acyl, Cι-6- alkenyl, Cι-6-(cyclo)alkyl, aryl, pyridylmethyl, or heterocyclic rings e.g. azetidine, pyrrolidine, piperidine, piperazine, morpholine and thiomorpholine, which heterocyclic rings optionally may be substituted with Cι-6-alkyl.
The term "prodrug forms" in the present description means a pharmacologically acceptable derivative, such as an ester or an amide, which derivative is biotransformed in the body to form the active drug (see Goodman and Gilman's, The Pharmacological basis of Therapeutics, 8th ed., McGraw-Hill, Int. Ed. 1992, "Biotransformation of Drugs, p. 13-15). "Pharmaceutically acceptable" means in the present description being useful in preparing a pharmaceutical composition that is generally safe, non-toxic and neither biologically nor otherwise undesirable and includes being useful for veterinary use as well as human pharmaceutical use.
"Pharmaceutically acceptable salts" mean in the present description salts which are pharmaceutically acceptable, as defined above, and which possess the desired pharmacological activity. Such salts include acid addition salts formed with organic and inorganic acids, such as hydrogen chloride, hydrogen bromide, hydrogen iodide, sulfuric acid, phosphoric acid, acetic acid, glycolic acid, maleic acid, malonic acid, oxalic acid, methanesulfonic acid, trifluoroacetic acid, fumaric acid, succinic acid, tartaric acid, citric acid, benzoic acid, ascorbic acid and the like. Base addition salts may be formed with organic and inorganic bases, such as sodium, ammonia, potassium, calcium, ethanolamine, diethanolamine, N-methylglucamine, choline and the like.
Pharmaceutical compositions according to the present invention contain a pharmaceutically acceptable carrier together with at least one of the compounds comprising the formula (I) as described herein above, dissolved or dispersed therein as an active, antimicrobial, ingredient. In a preferred embodiment, the therapeutic composition is not immunogenic when administered to a human patient for therapeutic purposes, unless that purpose is to induce an immune response.
The preparation of a pharmacological composition that contains active ingredients dissolved or dispersed therein is well understood in the art. Typically such compositions are prepared as sterile injectables either as liquid solutions or suspensions, aqueous or non-aqueous, however, solid forms suitable for solution, or suspensions, in liquid prior to use can also be prepared. The preparation can also be emulsified. The active ingredient may be mixed with excipients, which are pharmaceutically acceptable and compatible with the active ingredient and in amounts suitable for use in the therapeutic methods described herein. Suitable excipients are, for example, water, saline, dextrose, glycerol, ethanol or the like and combinations thereof. In addition, if desired, the composition may contain minor amounts of auxiliary substances such as wetting or emulsifying agents, pH buffering agents and the like which enhance the effectiveness of the active ingredient. Adjuvants may also be present in the composition.
Pharmaceutically acceptable carriers are well known in the art. Exemplary of liquid carriers are sterile aqueous solutions that contain no materials in addition to the active ingredients and water, or contain a buffer such as sodium phosphate at physiological pH value, physiological saline or both, such as phosphate-buffered saline. Still further, aqueous carriers can contain more than one buffer salt, as well as salts such as sodium and potassium chlorides, dextrose, propylene glycol, polyethylene glycol and other solutes.
Liquid compositions can also contain liquid phases in addition to and to the exclusion of water. Exemplary of such additional liquid phases are glycerine, vegetable oils such as cottonseed oil, organic esters such as ethyl oleate, and water-oil emulsions.
The pharmaceutical composition according to one of the preferred embodiments of the present invention comprising compounds comprising the formula (I), may include pharmaceutically acceptable salts of that component therein as set out above. Pharmaceutically acceptable salts include the acid addition salts (formed with the free amino groups of the polypeptide) that are formed with inorganic acids such as, for example, hydrochloric or phosphoric acids, or such organic acids as acetic acid, tartaric acid, mandelic acid and the like. Salts formed with the free carboxyl groups can also be derived from inorganic bases such as, for example, sodium, potassium, ammonium, calcium or ferric hydroxides, and such organic bases as isopropylamine, nimemylamine, 2-ethylamino ethanol, histidine, procaine and the like. The preparations according to the preferred embodiments may be administered orally, topically, intraperitoneally, intraarticularly, intracranially, intradermally, intramuscularly, intraocularly, intrathecally, intravenously, subcutaneously. Other routes which are known for the skilled person in the art are thinkable.
The orally aα ninistrable compositions according to the present invention may be in the form of tablets, capsules, powders, granules, lozenges, liquid or gel preparations, such as oral, topical or sterile parenteral solutions or suspensions. Tablets and capsules for oral administration may be in unit dose presentation form and may contain conventional excipients such as binding agents, for example syrup, acacia, gelatin, sorbitol, traganath or polyvinyl-pyrrolidone; fillers e.g. lactose, sugar, maize-starch, calcium phosphate, sorbitol or glycine; tabletting lubricant e.g. magnesium stearate, talc, polyethylene glycol or silica; disintegrants e.g. potato starch, or acceptable wetting agents such as sodium lauryl sulfate. The tablets may be coated according to methods well known in normal pharmaceutical practice. Oral liquid preparations may be in the form of e.g. aqueous or oily suspensions, solutions, emulsions, syrups or elixirs or may be presented as a dry product for reconstitution with water or other suitable vehicle before use. Such liquid preparations may contain conventional additives such as suspending agents, e.g. sorbitol, syrup, methyl cellulose, glucose syrup, gelatin hydrogenated edible fats; emulsifying agents e.g. lecithin, sorbitan monooleate or acacia, non-aqueous vehicles (which may include edible oils), e.g. almond oil, fractionated coconut oil, oily esters such as glycerine, propylene glycol, or ethyl alcohol; preservatives e.g. methyl or propyl p-hydroxybenzoate or sorbic acid, and if desired conventional flavouring or colouring agents.
A pharmaceutical composition according to the present invention, may comprise typically an amount of at least 0.1 weight percent of compound comprising the formula (I) per weight of total therapeutic composition. A weight percent is a ratio by weight of total composition. Thus, for example, 0.1 weight percent is 0.1 grams of compound comprising the formula (I) per 100 grams of total composition. A suitable daily oral dose for a mammal, preferably a human being, may vary widely depending on the condition of the patient. However a dose of compound comprising the formula (I) of about 0.1 to 300 mg/kg body weight may be appropriate.
The compositions according to the present invention may also be used veterinarily and thus they may comprise a veterinarily acceptable excipient or carrier.
The compounds of the present invention in labelled form, e.g. isotopically labelled, may be used as a diagnostic agent.
The compounds of the formula (I) above may be prepared by, or in analogy with, conventional methods, and especially according to or in analogy with the following methods. Further, the pharmacology in-vitro was studied using the following reagents and methods.
.All publications mentioned herein are hereby incorporated by reference. By the expression "comprising" we understand including but not limited to. Thus, other non- mentioned substances, additives or carriers may be present.
The invention will now be described in reference to the following Figures and
Examples. These Figures and Examples are not to be regarded as limiting the scope of the present invention, but shall only serve in an illustrative manner.
EXPERIMENTAL METHODS
Scintillation Proximity Assay
[1, 2(n) - 3H]-cortisone was purchased from Amersham Pharmacia Biotech. Anti- cortisol monoclonal mouse antibody, clone 6D6.7 was obtained from Immunotech and Scintillation proximity assay (SPA) beads coated with monoclonal antimouse antibodies were from Amersham Pharmacia Biotech. NADPH, tetrasodium salt was from Calbiochem and glucose-6-phosphate (G-6-P) was supplied by Sigma. The human 11-β-hydroxysteroid dehydrogenase type-1 enzyme (11-β-HSDι) was expressed in Pichiapastoris. 18-β-glycyrrhetinic acid (GA) was obtained from Sigma. The serial dilutions of the compounds were performed on a Tecan Genesis RSP 150. Compounds to be tested were dissolved in DMSO (1 mM) and diluted in 50 mM Tris- HC1, pH 7.2 containing 1 mM EDTA.
The multiplication of plates was done on a WallacQuadra. The amount of the product [3H]-cortisol, bound to the beads was determined in a Packard, Top Count microplate liquid scintillation counter.
The 11-β-HSDι enzyme assay was carried out in 96 well microtiter plates (Packard, Optiplate) in a total well volume of 220 μL and contained 30 mM Tris-HCl, pH 7.2 with 1 mM EDTA, a substrate mixture tritiated Cortisone/NADPH (175 nM / 181 μM), G-6-P (1 mM) and inhibitors in serial dilutions (9 to 0.15 μM). Reactions were initiated by the addition of human 11-β-HSDι, either as Pichiapastoris cell homogenate or microsomes prepared from Pichiapastoris (the final amount of enzyme used was varied between 0.057 to 0.11 mg/mL). Following mixing, the plates were shaken for 30 to 45 minutes at room temperature. The reactions were terminated with 10 μL 1 mM GA stop solution. Monoclonal mouse antibody was then added (10 μL of 4 μM) followed by 100 μL of SPA beads (suspended according to the manufacturers instructions). Appropriate controls were set up by omitting the 11-β- HSDi to obtain the non-specific binding (NSB) value.
The plates were covered with plastic fihn and incubated on a shaker for 30 minutes, at room temperature, before counting. The amount of [3H]-cortisol, bound to the beads was determined in a microplate liquid scintillation counter.
The calculation of the K; values for the inhibitors was performed by use of Activity Base. The K; value is calculated from IC50 and the Km value is calculated using the Cheng Prushoff equation (with reversible inhibition that follows the Michaelis-Menten equation): Ki = IC50(l+[S]/Km) [Cheng, Y.C; Prushoff, W.H. Biochem. Pharmacol. 1973, 22, 3099-3108]. The IC50 is measured experimentally in an assay wherein the decrease of the turnover of cortisone to cortisol is dependent on the inhibition potential of each substance. The Ki values of the compounds of the present invention for the 11- β-HSDl enzyme lie typically between about 10 nM and about 10 μM. Illustrative of the invention, the following Ki values have been determined in the human 11-β-HSDl enzyme assay (see Table 1):
Table 1: Ki values determined in the human 11-β-HSDl enzyme assay.
Figure imgf000020_0001
COMPOUND PREPARATION
General:
For preparative straight phase HPLC purification a Phenomenex column (250 x 21.1 mm, 10 μm) was used on a Gilson system eluting with ethanol in chloroform (gradient from 0 - 10% in 10 min) with a flow of 20 mL/min. Column chromatography was performed on silica using Silica gel 60 (230-400 mesh), Merck. Melting points were determined on a Gallenkamp apparatus. Elemental analyses were recorded using a Vario EL instrument. HPLC analyses were performed using a Hypersil Elite column (150 x 4.6 mm, 3μ) with a flow of 3 mL / min on a Waters 600E system with monitoring at 254 nm. Reverse phase preparative HPLC was carried out on a 100 x 21.2 mm, 5μ Hypersil Elite column eluting with a gradient of 5% ACN in 95% water to 95% ACN in 5% water (0.2% TFA buffer) over 10 mins at a flow rate of 20 mL / min with the UV detector set at 254 nm. Thin layer chromatography was carried out using pre-coated silica gel F-254 plates (thickness 0.25 mm). Electrospray MS spectra were obtained on a Micromass platform LCMS spectrometer. Crude, worked up compounds were purified by flash column chromatography using pre packed silica SPE columns (10 g silica) on an Isco Foxy 200 Combiflash system, and a gradient of 16.67% ethyl acetate in hexane increasing incrementally to 100% ethyl acetate.
List of Abbreviations
DCM = dichloromethane DMAP = 4-dimethylaminopyridine DMF = dimethylformamide DMSO = dimethyl sulfoxide
EDTA = ethylenectiaminetetraacetic acid
SULFONAMIDE COUPLINGS:
METHOD A:
1 Eq of the 2-aminothiazole was dissolved in pyridine (0.5 M solution). The sulfonyl chloride (1.2 eq) was added and the reaction mixture was stirred at ambient temperature under nitrogen atmosphere for 15 h. The reaction mixture was poured into aqueous HCl (1 M). If the product precipitated it was collected on a filter and washed with aqueous HCl (1 M) and recrystallised from ethanol. In case an oil was obtained, the crude was extracted with DCM and worked up and purified using standard procedures.
METHOD B: A solution of the 2-aminothiazole derivative (1 eq), triethylamine (2 eq) and DMAP (1 eq) in DMF (1 M) and DCM (0.225 M) was dispensed into a reaction vial. The sulfonyl chloride (1.2 eq) was dissolved in DCM (0.33 M) and added. The reaction mixtures were kept at room temperature over night. The mixture was then added to petroleum ether (10 times reaction volume). After some hours in refrigerator the supematants were decanted and (a portion of) the residual materials were dissolved in DMSO-methanol-acetic acid (300 μL + 500 μL + 50 μL) and purified by preparative LCMS (acetonitrile-water gradients). The purest fractions were collected and lyophilized. Alternatively, the crude was isolated using extractive work-up and purified using standard procedures.
EXAMPLES
The following specific compounds were synthesized. The commercially available compounds thus only form embodiments, as indicated earlier in the description, as pharmaceutical compositions and use of said compounds as set out in the appended set of claims.
EXAMPLE 1 [210P]
N-(5-Acetyl-4,5,6,7-tetrahydro[l,3]thiazolo[5,4-c]pyridin-2-yl)-3-chIoro-2- methylbenzenesulfonamide N-Acetyl-4-piperidone (7.05 g, 0.05 mol) in acetic acid (35 mL) was treated dropwise with bromine (8.0 g, 0.05 mol) in acetic acid (10 mL) at room temperature. After 4 h, the formed precipitate was collected on a filter, washed with diethyl ether and air- dried. This crude intermediate (3.01 g) was dissolved in ethanol (20 mL) and after the addition of thiourea (0.76 g, 10.0 mmol) the reaction mixture was refluxed for 4 h. The solvent was removed in vacuo. Water (20 mL) was added and the pH was adjusted to 9. Extraction with DCM, drying (sodium sulfate) and removal of the organic phase gave 1.1 g of a crude product. Purification by flash chromatography on silica gel gave 202 mg (10 %) of 5-acefyl-4,5,6,7-tetiahy(ko[l,3]tWazolo[5,4-c]pyridin-2-ylamine. This compound was sulfonylated with 3-chloro-2-methylbenzene sulfonyl chloride (234 mg, 1.02 mmol) in pyridine according to METHOD A. After workup, the final product was crystallised from methanol to afford 75 mg (%) of white crystals: 1H NMR (DMSO-dδ, 70 °C) δ 2.05 (s, 3H), 2.66 (s, 3H), 3.09 (m, 2H), 3.69 (m, 2H), 4.38 (m, 2H), 7.37 (t, 1H), 7.64 (d, 1H), 7.91 (d, 1H), 12.53 (br s, NH). EXAMPLE 2 [211A]
2,4-dichloro-6-methyl-N-(5,6,6-trimethyI-4,5,6,7-tetrahydro[l,3]thiazolo[5,4- c]pyridin-2-yl)benzenesulfonamide
The title compound was prepared from 5,6,6-trimethyl-4,5,6,7- tetrahyάi,o[l,3]tMazolo[5,4-c]pyridin-2-amine (45 mg, 0.23 mmol) as described in the synthetic METHOD B to give a white solid (13.0 mg) with purity >90%. MS (pos) m/z 420.1, 422.1.
EXAMPLE 3 [212A] 2,4-dichloro-6-methyl-N-[5-(4-morphoIinylcarbonyl)-4,5,6,7- tetrahydro[l,3]thiazolo[5,4-c]pyridin-2-yIJbenzenesulfonamide
The title compound was prepared from 5-(4-morpholinylcarbonyl)-4,5,6,7- tetiahydro[l,3]thiazolo[5,4-c]pyridin-2-amine (39 mg, 0.15 mmol) as described in the synthetic METHOD B to give a yellow solid (15.4 mg) with purity >90%. MS (pos) m/z 491.1, 493.1.
EXAMPLE 4 [234A]
2,4-Dichloro-6-methyl-N-(4,5,6,7-tetrahydro-l,3-benzothiazol-2- yl)benzenesu!fonamide The title compound was prepared from 4,5,6, 7-tetrahydro- l,3-benzotMazol-2-amine as described in the synthetic METHOD B to give a white solid (10.8 mg) with purity >90%. MS (pos) m/z 377.1, 379.1.
EXAMPLE 5 [234B] 4-Bromo-N-(5,6-dihydro-4H-cyclopenta[d][l,3]thiazoI-2-yl)-2,5- difluorobenzenesulfonamide
The title compound was prepared from 2-ammo-5,6-dihydro-4H-cyclopentathiazole hydrochloride (48 mg) and 4-bromo-2,5-difluorobenzenesulfonyl chloride (79 mg) as described in the synthetic METHOD B to give a yellow solid (2.5 mg) with purity >80%. MS (pos) m/z 395.2, 397.2; MS (neg) m/z 393.4, 395.4. EXAMPLE 6 [234C]
2,3,4-Trichloro-N-(5,6-dihydro-4H-cyclopenta[d][l,3]thiazol-2- yl)benzenesulfonamide
The title compound was prepared from 2-amino-5,6-dihydro-4H-cyclopentathiazole hydrochloride (48 mg) and 2,3,4-trichlorobenzenesulfonyl chloride (76 mg) as described in the synthetic METHOD B to give a yellow solid (4.5 mg): MS (pos) m/z 383.3, 385.3, 387.3; MS (neg) m/z 381.4, 383.4, 385.4.
EXAMPLE 7 [235A] N-(2-{[(2,4-dichloro-6-methyIphenyl)sulfonyI]amino}-4,5,6,7-tetrahydro-l,3- benzothiazol-6-yl)propanamide
The title compound was prepared from N-(2-amino-4,5,6, 7-tetrahydro- 1,3- benzothiazol-6-yl)propanamide (47 mg, 0.21 mmol) and 2,4-dichloro-6- methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (20.3 mg) with purity >90%. MS (pos) m/z 448.1, 450.1.
EXAMPLE 8 [236A]
2,4-Dichloro-N-(5,5-dimethyl-7-oxo-4,5,6,7-tetrahydro-l,3-benzothiazol-2-yl)-6- methylbenzenesulfonamide The title compound was prepared from 2-amino-5,5-dimethyl-5,6-dihydro- 1,3- benzothiazol-7(4H)-one hydrobromide and 2,4-dichloro-6-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white-yellow solid (26 mg) with purity >90%: MS (pos) m/z 419.1, 421.1; HRMS m/z 417.9979 (calc. of monoisotopic mass for Ci6Hι6Cl2N203S2 gives 417.9979).
EXAMPLE 9 [236B]
2,3,4-Trichloro-N-(5,5-dimethyI-7-oxo-4,5,6,7-tetrahydro-l,3-benzothiazol-2- yl)benzenesuIfonamide
The title compound was prepared from 2-amino-5,5-dimethyl-5,6-dihydro-l,3- benzothiazol-7(4H)-one (53 mg) and 2,3,4-trichlorobenzenesulfonyl chloride (76 mg) as described in the synthetic METHOD B to give a white solid (47.2 mg) with purity >90%: MS (pos) m/z 439.3, 441.3; HRMS m/z 437.9451 (calc. of monoisotopic mass for Ci5 Hj3 Cl3 N2 03 S2 gives 437.9433).
EXAMPLE 10 [236C] 4,5-Dichloro-N-(5,5-dimethyI-7-oxo-4,5,6,7-tetrahydro-l,3-benzothiazol-2-yl)-2- thiophenesulfonamide
The title compound was prepared from 2-amino-5,5-dimemyl-5,6-dihydro-l,3- benzothiazol-7(4H)-one (53 mg) and 2,3-ώ^Uorothiophene-5-sulfonyl chloride (68 mg) as described in the synthetic METHOD B to give a white-yellow solid (36.8 mg) with purity >90%: MS (pos) m/z 411.3, 413.3.
EXAMPLE 11 [236D]
4-Bromo-5-chloro-N-(5,5-dimethyl-7-oxo-4,5,6,7-tetrahydro-l,3-benzothiazol-2- yl)-2-thiophenesulfonamide The title compound was prepared from 2-amino-5,5-dimethyl-5,6-dihydro-l,3- benzothiazol-7(4H)-one (53 mg) and 4-bromo-5-chlorothiophene-2-sulfonyl chloride (80 mg) as described in the synthetic METHOD B to give a white-yellow solid (47.1 mg) with purity >90%: MS (pos) m/z 455.2, 457.2.
EXAMPLE 12 [236E]
3-Bromo-5-chloro-N-(5,5-dimethyl-7-oxo-4,5,6,7-tetrahydro-l,3-benzothiazol-2- yl)-2-thiophenes ulfonamide
The title compound was prepared from 2-amino-5,5-dimethyl-5,6-dihydro-l,3- benzothiazol-7(4H)-one (53 mg) and 3-bromo-5-c orothiophene-2-sulfonyl chloride (80 mg) as described in the synthetic method to give a white solid (62.2 mg) with purity >90%: MS (pos) m/z 455.2, 457.2. EXAMPLE 13 [236F]
N-(5-Methyl-7-oxo-4,5,6,7-tetrahydro-l,3-benzothiazol-2-yl)-4- propylbenzenesulfonamide
The title compound was prepared from 2-aιmiιo-5-memyl-5,6-dihydro-l,3- benzothiazol-7(4H)-one (49 mg) and 4-n-propylbenzenesulfonyl chloride (59 mg) as described in the synthetic METHOD B to give a white solid (51.2 mg) with purity >90%: MS (neg) m/z 363.6; HRMS m/z 364.0911 (calc. of monoisotopic mass for C H20 Cl5 N2 03 S2 gives 364.0915).
EXAMPLE 14 [236G]
4,5-Dichloro-N-(5-methyl-7-oxo-4,5,6,7-tetrahydro-l,3-benzothiazol-2-yl)-2- thiophenesulfonamide
The title compound was 2-amino-5-methyl-5,6-dihydro-l,3-benzothiazol-7(4H)-one (49 mg) and 2,3-dichlorothiophene-5-sulfonyl chloride (68 mg) as described in the synthetic METHOD B to give a white solid (34.2 mg) with purity >90%: MS (pos) m/z 397.2, 399.2; MS (neg) m/z 395.2, 397.2.
EXAMPLE 15 [236H]
2,4-Dichloro-6-methyl-N-(5-methyl-7-oxo-4,5,6,7-tetrahydro-l,3-benzothiazol-2- yl)benzenesulfonamide
The title compound was 2-anιino-5-methyl-5,6-dihyά^o-l,3-benzotlιiazol-7(4H)-one
(49 mg) and 2,4-dichloro-6-methylbenzenesulfonyl chloride (70 mg) as described in the synthetic METHOD B to give a white solid (39.3 mg) with purity >90%: MS (pos) m/z 405.4, 407.4; MS (neg) m/z 403.4, 405.3.
EXAMPLE 16 [2361]
4-Bromo-2-methyl-N-(5-methyl-7-oxo-4,5,6,7-tetrahydro-l,3-benzothiazol-2- yl)benzenesulfonamide
The title compound was 2-ammo-5-methyl-5,6-άihydro-l,3-ber_zothiazol-7(4H)-one (49 mg) and 4-bromo-2-methylbenzenesulfonyl chloride (73 mg) as described in the synthetic METHOD B to give a white solid (34.4 mg) with purity >90%: MS (pos) m/z 415.4, 417.4; MS (neg) m z 413.4, 415.4.
Various embodiments of the present invention have been described above but a person skilled in the art realizes further minor alterations which would fall into the scope of the present invention. The breadth and scope of the present invention should not be limited by any of the above-described exemplary embodiments, but should be defined only in accordance with the following claims and their equivalents.

Claims

Claims
1. A compound according to the formula (I)
Figure imgf000028_0001
wherein
T is
I) thienyl, which optionally is substituted with at least one halogen, or
II) phenyl substituted with a) at least one C2-6-alkyl; or b) at least one C1-6-alkyl and at least one halogen; or c) at least three halogens;
E is a bond, -CH2- or -CO-;
L is a bond, -CH2-, -CHR4- or -NR3-;
R3 is H, C1-6-alkyl, Cι„6-acyl or -COR4;
R4 is morpholinyl or Cι-6 amido;
R and R are independently hydrogen or d_6~alkyl; and
R8 and R9 are independently hydrogen or Cι_6-alkyl, as well as pharmaceutically acceptable salts, hydrates and solvates thereof.
2. A compound according to claim 1, wherein
T is I) thienyl, which is substituted with at least one halogen selected from chloro and bromo, or
II) phenyl substituted with a) at least one n-propyl; or b) at least one methyl and at least one halogen selected from chloro and bromo; or c) at least three halogens selected from fluoro, bromo and chloro;
E is a bond, -CH2- or -CO-; , L is a bond, -CH2-, -CHR4- or -NR3-; R3 is methyl, acetyl or -COR4;
R4 is morpholinyl or propionamido;
R6 and R7 are both hydrogen; and
R8 and R9 are independently hydrogen or methyl.
3. A compound according to claim 1-2, selected from the group of:
N-(5-Acetyl-4,5,6,7-tetiahydro[l,3]tltiazolo[5,4-c]pyridin-2-yl)-3-chloro-2- methylbenzenesulfonamide;
2,4-άicHoro-6-memyl-N-(5,6,6-trimemyl-4,5,6,7-tetiahydro[l,3]tIιiazolo[5,4- c]pyridin-2-yl)benzenesulfonamide; 2,4-dichloro-6-methyl-N-[5-(4-morpholinylcarbonyl)-4,5,6,7- tefrahyα^o[l,3]tMazolo[5,4-c]pyridin-2-yl]benzenesulfonamide;
2,4-Dichloro-6-methyl-N-(4,5,6,7-tetrahydro-l,3-benzothiazol-2- yl)benzenesulfonamide;
4-Bromo-N-(5,6-dihydro-4H-cyclopenta[d][l,3]thiazol-2-yl)-2,5- difluorobenzienesulfonamide;
2,3,4-TricWoro-N-(5,6-dihydro-4H-cyclopenta[d][l,3]thiazol-2- yl)benzenesulfonamide;
N-(2-{[(2,4-dicl oro-6-methylρhenyl)s fonyl]ammo}-4,5,6,7-tetrahydro-l,3- benzothiazol-6-yl)propanamide; 2,4-DicUoro-N-(5,5-o iethyl-7-oxo-4,5,6,7-tetrahydro-l,3-benzothiazol-2-yl)-6- methylbenzenesulfonamide; 2,3,4-Triclιloro-N-(5,5-dimemyl-7-oxo-4,5,6,7-tetiahydro-l,3-benzothiazol-2- yl)benzenesulfonamide;
4,5-Dicldoro-N-(5,5-dimemyl-7-oxo-4,5,6,7-tetiahyά^o-l,3-benzothiazol-2-yl)-2- thiophenesulfonamide; 4-Bromo-5-chloro-N-(5,5-άimethyl-7-oxo-4,5,6,7-tetiahydro-l,3-benzothiazol-2-yl)-2- thiophenesulfonamide;
3-Bromo-5-cMoro-N-(5,5-dimethyl-7-oxo-4,5,6,7-tetiahyα^o-l,3-benzothiazol-2-yl)-2- thiophenesulfonamide;
N-(5-Methyl-7-oxo-4,5,6,7-tetrahydro-l,3-benzothiazol-2-yl)-4- propylbenzenesulfonamide;
4,5-DicMoro-N-(5-methyl-7-oxo-4,5,6,7-tetiahydro-l,3-benzothiazol-2-yl)-2- thiophenesulfonamide;
2,4-DicWoro-6-methyl-N-(5-memyl-7-oxo-4,5,6,7-tetiahyαi'θ-l,3-benzothiazol-2- yl)benzenesulfonamide; and 4-Bromo-2-methyl-N-(5-methyl-7-oxo-4,5,6,7-tetiahydro-l,3-benzothiazol-2- yl)benzenesulfonamide.
4. A compound according to anyone of claims 1-3, for medical use.
5. A process for the preparation of a compound according to claim 1-3 comprising at least one of the following steps: a) sulfonamide coupling by reacting a 2-aminothiazole with a sulfonylchloride in the presence of a base, b) sulfonamide coupling by reacting a 2-aminothiazole derivative with a sulfonylchloride in the presence of a base.
6. A method for the treatment or prevention of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, dementia, depression, virus diseases and inflammatory disorders, said method comprising administering to a mammal, including man, in need of such treatment, an effective amount of a compound having the formula (I)
Figure imgf000031_0001
wherein
T is I) thienyl, which optionally is substituted with halogen, or
II) phenyl optionally substituted with halogen and/or C^-alkyl; E is a bond, -CH2- or -CO-; L is a bond, -CH2-, -CHR4- or -NR3-; R3 is H, Ci-6-alkyl, Cι-6-acyl or -COR4; R4 is morpholino or Cι.6-amido; R6 and R7 are independently hydrogen or Cι.6-alkyl; and R8 and R9 are independently hydrogen or Cι-6-alkyl, as well as pharmaceutically acceptable salts, hydrates and solvates thereof.
7. A method according to claim 6, wherein
T is
I) thienyl, which is substituted with at least one halogen selected from chloro and bromo, or
II) phenyl, which is substituted with at least one of methyl, n-propyl, fluoro, chloro and bromo;
E is a bond, -CH2- or -CO-; L is a bond, -CH2-, -CHR4- or -NR3-; R3 is methyl, acetyl or -COR4; R4 is morpholinyl or propionamido; R and R are both hydrogen; and R8 and R9 are independently hydrogen or methyl.
8. A method according to claim 6-7, wherein the compound is selected from the group of: N-(5-Acefyl-4,5,6,7-tetiahy(ko[l,3]tiύazolo[5,4-c]pyridin-2-yl)-3-chloro-2- methylbenzenesulfonamide;
2,4-(hchloro-6-methyl-N-(5,6,6-tιimemyl-4,5,6,7-tetiahydro[l,3]thiazolo[5,4- c]pyridin-2-yl)benzenesulfonamide;
2,4-dichloro-6-methyl-N-[5-(4-morpholinylcarbonyl)-4,5,6,7- tetiahyάro[l,3]tMazolo[5,4-c]pyridm-2-yl]benzenesuffonamide;
2,4-DicMoro-6rmethyl-N-(4,5,6,7-tetrahydro-l,3-benzothiazol-2- yl)benzenesulfonamide;
4-Bromo-N-(5,6-dihydro-4H-cyclopenta[d][l,3]thiazol-2-yl)-2,5- difluorobenzenesulfonamide; 2,3,4-Trichloro-N-(5,6-dihydro-4H-cyclopenta[d][l,3]thiazol-2- yl)benzenesulfonamide;
N-(2-{[(2,4-ώcUoro-6-methylphenyl)suffonyl]amino}-4,5,6,7-tetrahydro-l,3- beιιzothiazol-6-yl)proρanamide;
2,4-Dichloro-N-(5,5-dimemyl-7-oxo-4,5,6,7-tetrahy(ko-l,3-benzothiazol-2-yl)-6- methylbenzenesulfonamide;
2,3,4-TricMoro-N-(5,5-dimethyl-7-oxo-4,5,6,7-tetiahyά_ro-l,3-benzothiazol-2- yl)benzenesulfonamide;
4,5-Dichloro-N-(5,5-dimemyl-7-oxo-4,5,6,7-tetiahyα^o-l,3-benzothiazol-2-yl)-2- thiophenesulfonamide; 4-Bromo-5-clύoro-N-(5,5-α methyl-7-oxo-4,5,6,7-tettahydro-l,3-benzotιιiazol-2-yl)-2- thiophenesulfonamide; 3-Bromo-5-c oro-N-(5,5-dimemyl-7-oxo-4,5,6,7-teti-ihyάro-l,3-benzot_ιiazol-2-yl)-2- thiophenesulfonamide;
N-(5-Methyl-7-oxo-4,5,6,7-tetrahydro-l,3-benzothiazol-2-yl)-4- propylbenzenesulfonamide; 4,5-Dichloro-N-(5-methyl-7-oxo-4,5,6,7-tetrahydro-l,3-benzothiazol-2-yl)-2- thiophenesulfonamide;
2,4-DicWoro-6-memyl-N-(5-memyl-7-oxo-4,5,6,7-tetiahydro-l,3-benzothiazol-2- yl)benzenesulfonamide; and
4-Bromo-2-methyl-N-(5-memyl-7-oxo-4,5,6,7-tetiahydro-l,3-berιzothiazol-2- yl)benzenesulfonamide.
9. The use of a compound having the formula (I)
Figure imgf000033_0001
wherein
T is I) thienyl, which optionally is substituted with halogen, or
II) phenyl optionally substituted with halogen and/or Cι-6-alkyl; E is a bond, -CH2- or -CO-;
L is a bond, -CH2-, -CHR4- or -NR3-;
R3 is H, d-β-alkyl, Cι-6-acyl or -COR4;
R4 is morpholino or Cι_6-amido;
R6 and R7 are independently hydrogen or Cι.6-alkyl; and R8 and R9 are independently hydrogen or C1-6-alkyl, as well as pharmaceutically acceptable salts, hydrates and solvates thereof, in the manufacture of a medicament for the treatment or prevention of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, dementia, depression, virus diseases and inflammator disorders.
10. A method according to claim 9, wherein
T is
I) thienyl, which is substituted with at least one halogen selected from chloro and bromo, or
II) phenyl, which is substituted with at least one of methyl, n-propyl, fluoro, chloro and bromo;
E is a bond, -CH2- or -CO-; L is a bond, -CH2-, -CHR4- or -NR3-; R3 is methyl, acetyl or -COR4; R4 is morpholinyl or propionamido; R6 and R7 are both hydrogen; and
R8 and R9 are independently hydrogen or methyl.
11. A method according to claim 9-10, wherein the compound is selected from the group of:
N-(5-Acetyl-4,5,6,7-tetrahydro[l,3]tMazolo[5,4-c]pyridin-2-yl)-3-chloro-2- methylbenzenesulfonamide; 2,4-dicMoro-6-methyl-N-(5,6,6-1rimethyl-4,5,6,7-tettahydro[l,3]tl_iazolo[5,4- c]pyridin-2-yl)benzenesulfonamide;
2,4-dichloro-6-methyl-N-[5-(4-morpholinylcarbonyl)-4,5,6,7- tetrahydro[l,3]tMazolo[5,4-c]pyridin-2-yl]benzenesulfonamide;
2,4-DicUoro-6-methyl-N-(4,5,6,7-tetiahydro-l,3-benzothiazol-2- yl)benzenesulfonamide;
4-Bromo-N-(5,6-dihydro-4H-cycloρenta[d][ l,3]thiazol-2-yl)-2,5- difluorobenzenesiilfonamide;
2,3,4-Tricmoro-N-(5,6-dihydro-4H-cycloρenta[d][l,3]thiazol-2- yl)benzenesulfonamide; N-(2-{[(2,4-ώcMoro-6-memylphenyl)sulfonyl]ammo}-4,5,6,7-tetrahydro-l,3- benzothiazol-6-yl)propanamide; 2,4-Dic oro-N-(5,5-άimemyl-7-oxo-4,5,6,7-tetrahyά^o-l,3-benzo1hiazol-2-yl)-6- methylbenzenesulfonamide;
2,3,4-TricMoro-N-(5,5-dimethyl-7-oxo-4,5,6,7-tetrahyά^o-l,3-benzothiazol-2- yl)benzenesulfonamide; 4,5-DicMoro-N-(5,5-ό_imethyl-7-oxo-4,5,6,7-tetrahy ^ thiophenesulfonamide;
4-Bromo-5-cMoro-N-(5,5-αime yl-7-oxo-4,5,6,7-tetrahydro-l,3-benzothiazol-2-yl)-2- thiophenesulfonamide;
3-Bromo-5-cWoro-N-(5,5-dimemyl-7-oxo-4,5,6,7-tetiahydro-l,3-berιzo1hiazol-2-yl)-2- thiophenesulfonamide;
N-(5-Methyl-7-oxo-4,5,6,7-tetrahydro-l,3-benzothiazol-2-yl)-4- propylbenzenesulfonamide;
4,5-DicUoro-N-(5-methyl-7-oxo-4,5,6,7-tetiahydro-l,3-benzothiazol-2-yl)-2- thiophenesulfonamide; 2,4-Dichloro-6-methyl-N-(5-methyl-7-oxo-4,5,6, 7-tetrahydro- l,3-benzothiazol-2- yl)benzenesulfonamide; and
4-Bromo-2-methyl-N-(5-methyl-7-oxo-4,5,6,7-tetiahydι,o-l,3-benzothiazol-2- yl)benzenesulfonamide.
12. A pharmaceutical composition comprising at least one compound according to anyone of claims 1-3, and a pharmaceutically acceptable carrier.
PCT/SE2001/001157 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 Ceased WO2001090094A1 (en)

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AU6283101A AU6283101A (en) 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
AU2001262831A AU2001262831B9 (en) 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
CA002408144A CA2408144C (en) 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
EP01937063A EP1283834B1 (en) 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
JP2001586282A JP2003534339A (en) 2000-05-22 2001-05-22 Inhibitors of 11-beta hydroxysteroid dehydrogenase type 1
HK03109254.9A HK1056878B (en) 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
DE60139931T DE60139931D1 (en) 2000-05-22 2001-05-22 INHIBITORS OF TYPE 1 11-BETA HYDROXY-STEROID DEHYDROGENASE
US10/296,132 US7030135B2 (en) 2000-05-22 2001-05-22 Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
AT01937063T ATE443055T1 (en) 2000-05-22 2001-05-22 TYPE 1 11-BETA-HYDROXY-STEROID DEHYDROGENASE INHIBITORS
NZ522538A NZ522538A (en) 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 their use and preparation
IL15275301A IL152753A0 (en) 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
NO20025586A NO323832B1 (en) 2000-05-22 2002-11-21 Inhibitors for 11-beta-hydroxy steroid dehydrogenase type 1
US11/289,634 US20060160797A1 (en) 2000-05-22 2005-11-30 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1

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PCT/SE2001/001154 Ceased WO2001090093A1 (en) 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
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CA2408142C (en) 2009-10-20
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NO20025585D0 (en) 2002-11-21
NZ522507A (en) 2004-11-26
JP2003534338A (en) 2003-11-18
CN1430615A (en) 2003-07-16
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EP1283832A1 (en) 2003-02-19
WO2001090091A1 (en) 2001-11-29
US20060160797A1 (en) 2006-07-20
EP1283832B1 (en) 2010-10-20
CN1188403C (en) 2005-02-09
KR20030016269A (en) 2003-02-26
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AU2001262831B9 (en) 2007-08-09
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KR20030016271A (en) 2003-02-26
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WO2001090093A1 (en) 2001-11-29
EP1283834A1 (en) 2003-02-19
BR0111099A (en) 2003-04-15
EA005274B1 (en) 2004-12-30
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EP1283833A1 (en) 2003-02-19
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