WO2001090286A1

WO2001090286A1 - A microemulsion containing a branched alkyl glycoside

Info

Publication number: WO2001090286A1
Application number: PCT/SE2001/001109
Authority: WO
Inventors: Ingegärd Johansson; Christine Strandberg
Original assignee: Akzo Nobel NV
Current assignee: Akzo Nobel NV
Priority date: 2000-05-25
Filing date: 2001-05-18
Publication date: 2001-11-29
Anticipated expiration: 2002-11-25
Also published as: SE523226C2; AU2001260910A1; MXPA02011596A; SE0001973D0; US20030181347A1; JP2003534446A; DE60107424D1; BR0111047A; EP1292660A1; CA2407926A1; SE0001973L; DE60107424T2; KR20030001534A; EP1292660B1; ATE283338T1; BR0111047B1; ES2233637T3

Abstract

The present invention relates to a one-phase microemulsion that contains an emulsifier system containing a branched alkyl glycoside of the formula (I): R1OGn, where R1 is a branched alkyl group containing 8-16 carbon atoms, G is a saccharide residue and n, the degree of polymerisation, is between 1-5, and optionally a linear alkyl glycoside with the formula (II): R2OGn, where R2 is a linear alkyl group containing 6-18 carbon atoms, G is a saccharide residue and n is between 1-5, a water insoluble oil component, water and, if needed, minor amounts of a cosurfactant/cosolvent. This microemulsion may be used e.g. in a cleaning process for removal of hydrophobic substances from hard surfaces or textile, and in personal care of pharmaceutical formulations.

Description

A MICROEMULSION CONTAINING A BRANCHED ALKYL GLYCOSIDE

The present invention relates to a one-phase microemulsion that contains an emulsifier system containing a branched alkyl glycoside and optionally a linear alkyl glycoside, a water insoluble oil component, water and, if needed, minor amounts of a cosurfactant/cosolvent. This microemulsion may be used e.g. in a cleaning process for removal of hydrophobic substances from hard surfaces or textile, and in personal care or pharmaceutical formulations.

A microemulsion is defined as a thermodynamically stable, macroscopically homogeneous mixture of oil, water and surfactant. It contains, on a microscopical level, individual domains of oil and water separated by a surfactant layer. The visual appearance may be very similar to a true solution but also somewhat opaque or bluish depending on the microscopic structure. This structure has a high degree of dynamics thus making it irrelevant to talk about droplet size and to refer to a microemulsion as an emulsion with micro-droplets. The decisive property is the thermodynamic stability. For a general description of microemulsions and their properties see "Surfactants and polymers in aqueous solution", Jδnsson

B., Lindman B., Holmberg K., Kronberg B., iley&Sons Ltd,

1998, 365-399. Microemulsions can be used technically in different ways

1. To solubilize hydrophobic components from a surface, i.e. cleaning of oily dirt from hard surfaces, from textile, from skin, from rocks, from soil etc. 2. To carry water insoluble ingredients in a practical form i.e. in personal care formulations, pharmaceutical formulations, for agrochemical additives etc.

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between 1.2-2.5, although the degree of polymerisation for certain types of alkyl glycosides included in the system may be outside this range.

Another problem with alkyl glycosides based on longer linear alkyl chains, such as C12, is the high Krafft point, giving rise to unstable microemulsions where the alkyl glycoside separates as crystals at lower temperatures. Using a branched C12 -glycoside, the Krafft point is essentially reduced. For example, the Krafft point for n-dodecyl glycoside is 36°C as compared to < 0°C for 2-butyloctyl glycoside. In both cases the degree of polymerization was 1.8.

Since one of the application areas for this type of microemulsions is cleaning of hard surfaces, especially when it comes to very difficult, greasy dirt, the efficiency is dependent on the wetting ability against such a contaminated surface. Also in this aspect it was astonishingly found that the branched alkyl glycosides increase the efficiency, showing much better wetting as such, but also in mixture with linear alkyl glycosides.

Thus, the microemulsion composition of the invention all in all solves the problems described above concerning stability and viscosity. It also exhibits an increased wetting of hydrophobic surfaces as compared to a microemulsion based on only a linear alkyl glycoside as emulsifier.

The oil component in the microemulsion composition according to the invention is water insoluble. Suitable oils may be of the hydrocarbon type, for example cyclohexane, octane, decane, dodecane and different paraffinic cuts like

Halpasol 190/240, as well as more polar oils such as long chain alcohols, triglycerides or fatty acid esters and mixtures thereof .

Suitable branched alcohols that could be used to make the branched alkyl glycosides according to the invention may be of the Guerbet type, such as 2-ethylhexanol, 2- propylheptanol, 2-butyloctanol, 2-pentylnonanol, 2-hexyl- decanol, 2-ethyloctanol, 2-butylhexanol , 2-butyldecanol and 2-hexyloctanol. Another suitable type is the highly methyl branched (with two or more methyl branches) primary alcohols that are sold under for instance the trade name Exxal, such as Exxal 8, Exxal 9, Exxal 10, Exxal 11, Exxal 12 and Exxal 13. One further type of suitable branched alcohols is represented by the formula

CH₃ (CH₂) _x-CH(CH₂)_yCH₃ (III)

I CH₂OH where x and y are at least one and the sum of x+y+4 is the number of carbon atoms in the alcohol. Alcohols of this type are present in the mixtures of linear and monobranched alcohols that are traded as Lials, containing approximately equal amounts of the branched and the linear alcohols. Preferred branched alkyl glycosides are 2-ethylhexyl glucoside, 2-propylheptyl glucoside, 2-butyloctyl glucoside, Lial 111 glucoside, Exxal 10 glucoside, Exxal 11 glucoside and Exxal 12 glucoside. In suitable embodiments of the invention the branched alkyl glycosides are derived from alcohols consisting of at least 50%, preferably at least 65%, of an alcohol of the Guerbet type, a primary alcohol containing at least two methyl branches in the alkyl chain or alcohols of the formula (III) or a mixture thereof. The linear alkyl glycosides can be made from conventional straight chain alcohols, like hexanol, octanol, decanol and dodecanol .

General production descriptions for alkyl glycosides, and further details concerning the types of possible structures for branched alkyl glycosides can be found for instance in EP-B-690 868 and EP-B-690 905.

In addition, cosurfactants/cosolvents may be present in the microemulsion composition according to the present invention. Typically, these are fatty alcohols or diols with C8-C14 chain length, as well as other hydrophobic straight chain nonionic surfactants with a small hydrophilic head e.g. alkyl glyceryl ethers. The microemulsion composition may also contain short chain glycols like propylene glycol, dipropylenglycol, dipropylenglycol monomethyl ether (DPM) and similar well-known formulation stabilisers.

The microemulsion according to the invention can be obtained with no addition of cosolvent/cosurfactant . When present, the cosurfactant/cosolvent normally amounts to less than 50% by weight of the alkyl glycoside system, preferably less than 35%, and often less than 15%. Nevertheless, higher amounts may be desirable for certain applications. To the microemulsion could also be added e.g. complexing agents, such as NTA, EDTA, phoshates and citrates, and pH regulating additives, such as alkali hydroxides and silicates, as well as perfumes, pearlescing agents, opacifiers, colors, color stabilisers, preservatives, defoamers and foam boosters .

The choice of oil and additives determines the application area where the invention may be used. With esters, triglycerides and other skin compatible oils it can be used as a mild cleaning agent or as a carrier of active ingredients in the personal care area. The latter functional use can also be found within pharmaceutical applications with edible or non-toxic oils. With good degreasing oils like paraffinic solvents or methyl laurate a hard surface cleaner can be formulated. Other suitable areas are for example agrochemical formulations including active compounds not soluble in water, but in the microemulsion of the invention. Examples of such active compounds are plant growth regulators, herbicides and pesticides, for example insecticides, fungicides or acaricides . The following embodiments illustrate the invention, and they should not be construed as limiting the scope thereof .

Example 1

The microemulsions in Table 1 were prepared in the following way. All the components were weighed and mixed in a test tube, left to equilibrate at 50°C approximately half an hour^' and then shaken thoroughly to ensure that all the components were dissolved properly.

Table 1

vo

1) A paraffinic fraction, boiling point 190-240°C, average chain length C10-C13

2) Dipropylene glycol monomethyl ether

3) Nitrilotriacetic acid trisodium salt

4) Straight chain C10-C12 (average 10.4) glucosides with a degree of polymerization equal to 1.6 '

5) 2-Propylheptyl glucoside with a degree of polymerization equal to 1.2

6) 2-Butyloctyl glucoside with a degree of polymerization equal to 1.8

7) ϋndecyl glucoside, 45% branched/55% straight chain, with a degree of polymerization equal to 1.6

The amounts of the components are given as weight percentages.

All the microemulsions were clear to opaque. All the compositions according to the invention were one-phase microemulsions, which did not show any optical activity. Sample 1, 10 and 11 showed optical activity, which indicates that lamellar structures are present. Sample 10 and 11 contained liquid crystalline phases and tended to separate with time in two clear microemulsion phases . The pourpoint for sample 1 is 5°C and for sample 2, 3 and 4 it is below -1°C. From the compositions and appearance of the microemulsions the following conclusions can be drawn.

- The need for relative amounts of cosolvent/cosurfactant (here 1-dodecanol) ranges from 0 to 0.13 (ratio dodecanol/glucoside) when the branched alkyl glucoside is dominating the emulsifier mixture. The more straight chain glucoside that is present, the higher the ratio gets. With only straight chain glucoside the ratio varies between 0.36 (sample 1) and 0.54 (sample 10).

- It is obvious that the appearance of lamellar structures ^' or liquid crystals is only seen with the straight chain glucoside, compare sample 1, 10 and 11 with the others.

- The stability is also good when diluted. Compare samples 3 and 3b as well as 8 and 8b.

Sample 8 and 9 show that it is easy to include a sequestering agent like nitrilotriacetic acid trisodium salt (Na₃NTA) . Example 2

The viscosity was measured at room temperature with the following equipment : Brookfield LVDV-11+ apparatus

Cylindrical sample chamber (19 mm with volumes 2-16 ml) Spindle 18 range 3 - 10000 cP Table 2

Composition 1, which contains only straight chain alkyl glucosides as emulsifiers, is approximately 15 times more viscous than the corresponding branched alkyl glucoside compositions .

Example 3

To investigate the wetting ability of the microemulsions, the following procedure was used: A lacquered white metal plate is painted with asphalt. The drying time is 24 hours at room temperature. 15 ml of the test sample is poured from one side of the plate, which is placed in an inclined position, and after 1 minute the plate is rinsed with water. The result is evaluated by measuring the wetting capacity, i.e. the width of the cleaned surface, which is measured with a ruler.

Table 3

When comparing the results obtained with the compositions containing the same amount of oil, it is obvious that the microemulsion compositions containing branched chain glucosides give rise to a better wetting than the reference compositions.

Claims

C L A I ' M S

1. A one-phase microemulsion composition having an oil/water ratio of 1:99 to 60:40 characterised in that it contains an alkyl glycoside emulsifier system which contains a branched alkyl glycoside with the formula

RιOG_n (I) where R is a branched alkyl group containing 8-16 carbon atoms, G is a saccharide residue and n, the degree of polymerisation, is between 1-5, the weight ratio between the emulsifier system and the oil being less than 4:1.

2. A microemulsion composition according to claim 1 characterised in that it contains a linear alkyl glycoside with the formula R₂θG_n (II) where R₂ is a linear alkyl group containing 6-18 carbon atoms, G is a saccharide residue and n is between 1-5; where the linear alkyl glycoside is present in an amount of up to 70%(w/w) of the total amount of the alkyl glycoside emulsifier system.

3. A microemulsion composition according to claim 2 characterised in that the alkyl glycoside emulsifier system contains 5-60% of the linear alkyl glycoside.

4. A microemulsion composition according to claims 1-3, where the branched alkyl glycoside is derived from an alcohol consisting of at least 50% of an alcohol of the Guerbet type; a primary alcohol containing at least two methyl branches in the carbon chain; or alcohols of the formula CH₃ (CH₂)_x-CH(CH₂)_yCH₃ (III) I

CH₂OH where x and y are at least one and the sum of x+y+4 is the number of carbon atoms in the alcohol ; or a mixture thereof .

5. A microemulsion composition according to claims 1-4 where the weight ratio between the emulsifier system and the oil is less than 2:1.

6. A microemulsion according to claims 1-5 where Ri contains 8-14 carbon atoms.

7. A microemulsion according to claims 1-6 where R contains 8-12 carbon atoms.

8. A microemulsion according to claims 1-7 where R₂ contains 6-12 carbon atoms.

9. A microemulsion according to claims 1-8 where the oil is a water insoluble hydrocarbon or polar oil or a mixture thereof .

10. Use of a microemulsion according to claims 1-9 in a cleaning process for removal of hydrophobic substances.

11. Use of a microemulsion according to claims 1-9 in a personal care formulation.

12. Use of a microemulsion according to claim 10 for cleaning of hard surfaces.