WO2001090326A3 - Novel matrix metalloproteinases - Google Patents

Novel matrix metalloproteinases Download PDF

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Publication number
WO2001090326A3
WO2001090326A3 PCT/US2001/016563 US0116563W WO0190326A3 WO 2001090326 A3 WO2001090326 A3 WO 2001090326A3 US 0116563 W US0116563 W US 0116563W WO 0190326 A3 WO0190326 A3 WO 0190326A3
Authority
WO
WIPO (PCT)
Prior art keywords
matrix metalloproteinases
novel matrix
genes
mmp
constructs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/016563
Other languages
French (fr)
Other versions
WO2001090326A2 (en
Inventor
Erik Holmgren
Mats Kihlen
Tim Wood
Jonas Ekblom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Priority to AU2001274894A priority Critical patent/AU2001274894A1/en
Priority to EP01941549A priority patent/EP1297112A2/en
Publication of WO2001090326A2 publication Critical patent/WO2001090326A2/en
Anticipated expiration legal-status Critical
Publication of WO2001090326A3 publication Critical patent/WO2001090326A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides genes encoding novel matrix metalloproteinases termed MMP; constructs and recombinant host cells incorporating the genes; the MMP polypeptides encoded by the genes; antibodies to the MMP polypeptides; and methods of making and using all of the foregoing.
PCT/US2001/016563 2000-05-22 2001-05-22 Novel matrix metalloproteinases Ceased WO2001090326A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001274894A AU2001274894A1 (en) 2000-05-22 2001-05-22 Novel matrix metalloproteinases
EP01941549A EP1297112A2 (en) 2000-05-22 2001-05-22 Novel matrix metalloproteinases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20611900P 2000-05-22 2000-05-22
US60/206,119 2000-05-22

Publications (2)

Publication Number Publication Date
WO2001090326A2 WO2001090326A2 (en) 2001-11-29
WO2001090326A3 true WO2001090326A3 (en) 2003-01-16

Family

ID=22765058

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/016563 Ceased WO2001090326A2 (en) 2000-05-22 2001-05-22 Novel matrix metalloproteinases

Country Status (4)

Country Link
US (3) US6734005B2 (en)
EP (1) EP1297112A2 (en)
AU (1) AU2001274894A1 (en)
WO (1) WO2001090326A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020137890A1 (en) * 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU6063900A (en) * 1999-09-10 2001-04-10 Millennium Pharmaceuticals, Inc. Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
WO2002020739A2 (en) * 2000-09-08 2002-03-14 Millennium Pharmaceuticals, Inc. Human matrix metalloproteinase
GB0209893D0 (en) * 2002-04-30 2002-06-05 Molmed Spa Conjugate
GB0209896D0 (en) * 2002-04-30 2002-06-05 Molmed Spa Conjugate
EP2231186A4 (en) 2007-12-17 2012-08-08 Dyax Corp Compositions and methods for treating osteolytic disorders comprising mmp-14 binding proteins
EP2262529A4 (en) 2008-03-03 2013-05-08 Dyax Corp Metalloproteinase 9 binding proteins
AU2009221916A1 (en) * 2008-03-03 2009-09-11 Dyax Corp. Metalloproteinase 9 and metalloproteinase 2 binding proteins
WO2010079340A2 (en) * 2009-01-08 2010-07-15 Eisai R & D Management Co., Ltd. Assay
US20110229451A2 (en) * 2009-03-06 2011-09-22 Halozyme, Inc. Temperature sensitive mutants of matrix metalloproteases and uses thereof
US10314909B2 (en) 2011-10-21 2019-06-11 Dyax Corp. Combination therapy comprising an MMP-14 binding protein
JP6188390B2 (en) * 2013-04-10 2017-08-30 積水メディカル株式会社 Method for measuring MMP-3
ES2620702B2 (en) * 2017-03-29 2017-12-18 Universidad De Cantabria Gene construction and its use in the treatment of cardiac fibrosis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018900A1 (en) * 1998-09-29 2000-04-06 Motoji Seiki Dnas encoding novel polypeptides
WO2001016335A2 (en) * 1999-08-31 2001-03-08 Pierre Fabre Medicament Stromelysin-homologous novel mmp-27 matrix metalloproteinase

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US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4879236A (en) 1984-05-16 1989-11-07 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US5242794A (en) 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
WO1990005183A1 (en) 1988-10-31 1990-05-17 Immunex Corporation Interleukin-4 receptors
HU217212B (en) 1989-12-22 1999-12-28 Applied Research Systems, ARS Holding M.V. Modifying the expression of endogenous genes with a regulatory element
WO1991018982A1 (en) 1990-06-05 1991-12-12 Immunex Corporation Type ii interleukin-1 receptors
AU664847B2 (en) 1991-05-15 1995-12-07 Cell Genesys, Inc. Genomic modifications with homologous DNA targeting
PT1696031E (en) 1991-12-02 2010-06-25 Medical Res Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
TW402639B (en) 1992-12-03 2000-08-21 Transkaryotic Therapies Inc Protein production and protein delivery
US5585277A (en) 1993-06-21 1996-12-17 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
AU1662595A (en) 1994-01-28 1995-08-15 Herbert Altmann Method of determining the activity of a regulatory factor, and use of the method
GB9501567D0 (en) 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
GB9518220D0 (en) 1995-09-06 1995-11-08 Medical Res Council Checkpoint gene
US6017757A (en) 1997-02-20 2000-01-25 Mississippi State University Isolated viable nematode intestinal cells
WO1998040475A1 (en) * 1997-03-11 1998-09-17 Abbott Laboratories Human matrix metalloprotease gene, proteins encoded therefrom and methods of using same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018900A1 (en) * 1998-09-29 2000-04-06 Motoji Seiki Dnas encoding novel polypeptides
WO2001016335A2 (en) * 1999-08-31 2001-03-08 Pierre Fabre Medicament Stromelysin-homologous novel mmp-27 matrix metalloproteinase

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 21 December 1993 (1993-12-21), SHAPIRO ET AL.: "Metalloproteinase (HME) mRNA, complete cds.", XP002203714, Database accession no. L23808 *
DATABASE EMBL [online] 7 March 2000 (2000-03-07), STRAUSBERG, R.: "Matrix metallopteinase-14", XP002203713, Database accession no. AW519125 *
SHAPIRO ET AL.: "Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolarmacrophages", J. BIOLOGICAL CHEMISTRY, vol. 28, no. 32, 15 November 1993 (1993-11-15), pages 23824 - 23829, XP000564634 *
YANG & KURKINEN: "Cloning and chacterization of a novel matrix metalloproteinase (MMP), CMMP, from chicken embryo fibroblasts", J. BIOL. CHEMISTRY, vol. 273, no. 28, 10 July 1998 (1998-07-10), pages 17893 - 17900, XP002191238 *
YOSHIYAMA ET AL.: "Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer's disease brain", ACTA NEUROPATHOL., vol. 99, February 2000 (2000-02-01), pages 91 - 95, XP001055983 *

Also Published As

Publication number Publication date
EP1297112A2 (en) 2003-04-02
US20060275869A1 (en) 2006-12-07
US20030032164A1 (en) 2003-02-13
WO2001090326A2 (en) 2001-11-29
US6734005B2 (en) 2004-05-11
AU2001274894A1 (en) 2001-12-03
US7070976B2 (en) 2006-07-04
US20040146499A1 (en) 2004-07-29

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