WO2001092503A3 - Regulation of human calcium-independent alpha-latro-toxin-like g protein-coupled receptor - Google Patents

Regulation of human calcium-independent alpha-latro-toxin-like g protein-coupled receptor Download PDF

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Publication number
WO2001092503A3
WO2001092503A3 PCT/EP2001/006088 EP0106088W WO0192503A3 WO 2001092503 A3 WO2001092503 A3 WO 2001092503A3 EP 0106088 W EP0106088 W EP 0106088W WO 0192503 A3 WO0192503 A3 WO 0192503A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
coupled receptor
latro
toxin
regulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/006088
Other languages
French (fr)
Other versions
WO2001092503A2 (en
Inventor
Shyam Ramakrishnan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU70541/01A priority Critical patent/AU7054101A/en
Priority to US10/276,338 priority patent/US20030148338A1/en
Priority to EP01949365A priority patent/EP1307487A2/en
Publication of WO2001092503A2 publication Critical patent/WO2001092503A2/en
Publication of WO2001092503A3 publication Critical patent/WO2001092503A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Reagents which regulate human calcium-independent alpha-latrotoxin-like G protein-coupled receptor (CIRL) and reagents which bind to human CIRL gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases associated with aberrant exocytosis in both the endocrine system and the nervous system.
PCT/EP2001/006088 2000-05-30 2001-05-29 Regulation of human calcium-independent alpha-latro-toxin-like g protein-coupled receptor Ceased WO2001092503A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU70541/01A AU7054101A (en) 2000-05-30 2001-05-29 Regulation of human calcium-independent alpha-latro-toxin-like g protein-coupledreceptor
US10/276,338 US20030148338A1 (en) 2000-05-30 2001-05-29 Regulation of human calcium-independent alpha-latro-toxin-like g protein-coupled receptor
EP01949365A EP1307487A2 (en) 2000-05-30 2001-05-29 Regulation of human calcium-independent alpha-latro-toxin-like g protein-coupled receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20734800P 2000-05-30 2000-05-30
US60/207,348 2000-05-30

Publications (2)

Publication Number Publication Date
WO2001092503A2 WO2001092503A2 (en) 2001-12-06
WO2001092503A3 true WO2001092503A3 (en) 2002-06-13

Family

ID=22770158

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/006088 Ceased WO2001092503A2 (en) 2000-05-30 2001-05-29 Regulation of human calcium-independent alpha-latro-toxin-like g protein-coupled receptor

Country Status (3)

Country Link
EP (1) EP1307487A2 (en)
AU (1) AU7054101A (en)
WO (1) WO2001092503A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030143668A1 (en) * 2001-06-18 2003-07-31 National Institute Of Advanced Industrial Guanosine triphosphate-binding protein coupled receptors
WO2004018516A1 (en) * 2002-08-19 2004-03-04 Bayer Healthcare Ag Regulation of human secretin-type gpcr (latrophilin)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998039440A2 (en) * 1997-03-04 1998-09-11 New York University CALCIUM INDEPENDENT RECEPTOR OF α-LATROTOXIN, CHARACTERIZATION AND USES THEREOF

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998039440A2 (en) * 1997-03-04 1998-09-11 New York University CALCIUM INDEPENDENT RECEPTOR OF α-LATROTOXIN, CHARACTERIZATION AND USES THEREOF

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A.J.W. ZENDMANN ET AL.: "TM7XN1 a novel human EGF-TM7 like cDNA detected with mRNA differential display using human melanoma cell lines with different metastasic potential.", FEBS LETTERS, vol. 446, 1999, pages 292 - 298, XP002192948 *
K. ICHTCHENKO ET AL.: "a novel ubiquitously expressed alfa-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 9, pages 5491 - 5496, XP000828192 *
S. SUGITA ET AL.: "alfa-latrotoxin receptor CIRL/latrophilin 1 (CL1) defines a unusual family of ubiquitous G-protein linked receptors", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 49, December 1998 (1998-12-01), pages 32715 - 32724, XP000946649 *

Also Published As

Publication number Publication date
AU7054101A (en) 2001-12-11
WO2001092503A2 (en) 2001-12-06
EP1307487A2 (en) 2003-05-07

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