WO2001094946A3 - Microarrays for performing proteomic analyses - Google Patents

Microarrays for performing proteomic analyses Download PDF

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Publication number
WO2001094946A3
WO2001094946A3 PCT/US2001/018066 US0118066W WO0194946A3 WO 2001094946 A3 WO2001094946 A3 WO 2001094946A3 US 0118066 W US0118066 W US 0118066W WO 0194946 A3 WO0194946 A3 WO 0194946A3
Authority
WO
WIPO (PCT)
Prior art keywords
array
protein
peptidomimetic
binding
microarrays
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/018066
Other languages
French (fr)
Other versions
WO2001094946A9 (en
WO2001094946A2 (en
Inventor
Deborah Charych
Eric Beausoleil
Ronald N Zuckermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Priority to DE60127958T priority Critical patent/DE60127958D1/en
Priority to JP2002502444A priority patent/JP2003536073A/en
Priority to AU2001268173A priority patent/AU2001268173A1/en
Priority to EP01946078A priority patent/EP1297338B1/en
Priority to DK01946078T priority patent/DK1297338T3/en
Publication of WO2001094946A2 publication Critical patent/WO2001094946A2/en
Publication of WO2001094946A9 publication Critical patent/WO2001094946A9/en
Anticipated expiration legal-status Critical
Publication of WO2001094946A3 publication Critical patent/WO2001094946A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nanotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

Provided are peptidomimetic protein-binding arrays, their manufacture, use, and application. The protein-binding array elements of the invention include a peptidomimetic segment linked to a solid support via a stable anchor. The invention contemplates peptidomimetic array element library synthesis, distribution, and spotting of array elements onto solid planar substrates, labeling of complex protein mixtures, and the analysis of differential protein binding to the array. The invention also enables the enrichment or purification, and subsequent sequencing or structural analysis of proteins that are identified as differential by the array screen. Kits including proteomic microarrays in accordance with the present invention are also provided.
PCT/US2001/018066 2000-06-05 2001-06-04 Microarrays for performing proteomic analyses Ceased WO2001094946A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE60127958T DE60127958D1 (en) 2000-06-05 2001-06-04 MICROARRAYS FOR PERFORMING PROTEOMAL ANALYSIS
JP2002502444A JP2003536073A (en) 2000-06-05 2001-06-04 Microarrays for performing proteomics analysis
AU2001268173A AU2001268173A1 (en) 2000-06-05 2001-06-04 Microarrays for performing proteomic analyses
EP01946078A EP1297338B1 (en) 2000-06-05 2001-06-04 Microarrays for performing proteomic analyses
DK01946078T DK1297338T3 (en) 2000-06-05 2001-06-04 Microarrays for performing proteomics analyzes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20971100P 2000-06-05 2000-06-05
US60/209,711 2000-06-05

Publications (3)

Publication Number Publication Date
WO2001094946A2 WO2001094946A2 (en) 2001-12-13
WO2001094946A9 WO2001094946A9 (en) 2002-04-11
WO2001094946A3 true WO2001094946A3 (en) 2003-01-30

Family

ID=22779937

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/018066 Ceased WO2001094946A2 (en) 2000-06-05 2001-06-04 Microarrays for performing proteomic analyses

Country Status (10)

Country Link
US (1) US20020055125A1 (en)
EP (1) EP1297338B1 (en)
JP (1) JP2003536073A (en)
AT (1) ATE360207T1 (en)
AU (1) AU2001268173A1 (en)
DE (1) DE60127958D1 (en)
DK (1) DK1297338T3 (en)
ES (1) ES2281424T3 (en)
PT (1) PT1297338E (en)
WO (1) WO2001094946A2 (en)

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Also Published As

Publication number Publication date
WO2001094946A9 (en) 2002-04-11
ATE360207T1 (en) 2007-05-15
DK1297338T3 (en) 2007-06-11
AU2001268173A1 (en) 2001-12-17
EP1297338B1 (en) 2007-04-18
JP2003536073A (en) 2003-12-02
ES2281424T3 (en) 2007-10-01
DE60127958D1 (en) 2007-05-31
WO2001094946A2 (en) 2001-12-13
EP1297338A2 (en) 2003-04-02
PT1297338E (en) 2007-05-31
US20020055125A1 (en) 2002-05-09

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