WO2001098779A3 - Methods of identifying gabab receptor subtype-specific agonists - Google Patents

Methods of identifying gabab receptor subtype-specific agonists Download PDF

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Publication number
WO2001098779A3
WO2001098779A3 PCT/CA2001/000909 CA0100909W WO0198779A3 WO 2001098779 A3 WO2001098779 A3 WO 2001098779A3 CA 0100909 W CA0100909 W CA 0100909W WO 0198779 A3 WO0198779 A3 WO 0198779A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
identifying
receptor subtype
gabab receptor
specific agonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2001/000909
Other languages
French (fr)
Other versions
WO2001098779A2 (en
Inventor
Gordon Ng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Priority to JP2002504488A priority Critical patent/JP2004501375A/en
Priority to EP01949137A priority patent/EP1297341A2/en
Priority to CA002413451A priority patent/CA2413451A1/en
Publication of WO2001098779A2 publication Critical patent/WO2001098779A2/en
Publication of WO2001098779A3 publication Critical patent/WO2001098779A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/9426—GABA, i.e. gamma-amino-butyrate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Methods for identifying substances that are agonists of GABAB receptors that are heteromers of gb1a and gb2 subunits where the substances are not agonists of GABAB receptors that are heteromers of gb1b and gb2 subunits or gb1c and gb2 subunits are provided. The substances are useful for the treatment of a variety of conditions, e.g., epilepsy and certain pain syndromes.
PCT/CA2001/000909 2000-06-19 2001-06-19 Methods of identifying gabab receptor subtype-specific agonists Ceased WO2001098779A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2002504488A JP2004501375A (en) 2000-06-19 2001-06-19 Method for identifying GABAB receptor subtype-specific agonist
EP01949137A EP1297341A2 (en) 2000-06-19 2001-06-19 Methods of identifying gaba b? receptor subtype-specific agonists
CA002413451A CA2413451A1 (en) 2000-06-19 2001-06-19 Methods of identifying gabab receptor subtype-specific agonists

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21242600P 2000-06-19 2000-06-19
US60/212,426 2000-06-19
US28596901P 2001-04-24 2001-04-24
US60/285,969 2001-04-24

Publications (2)

Publication Number Publication Date
WO2001098779A2 WO2001098779A2 (en) 2001-12-27
WO2001098779A3 true WO2001098779A3 (en) 2002-12-12

Family

ID=26907127

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2001/000909 Ceased WO2001098779A2 (en) 2000-06-19 2001-06-19 Methods of identifying gabab receptor subtype-specific agonists

Country Status (4)

Country Link
EP (1) EP1297341A2 (en)
JP (1) JP2004501375A (en)
CA (1) CA2413451A1 (en)
WO (1) WO2001098779A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL160523A0 (en) 2001-09-03 2004-07-25 Newron Pharm Spa PHARMACEUTICAL COMPOSITION COMPRISING GABAPENTIN OR AN ANALOGUE THEREOF AND AN alpha-AMINOAMIDE AND ITS ANALGESIC USE
US7473548B2 (en) 2003-04-25 2009-01-06 Medtronic, Inc. Optical detector for enzyme activation
WO2005026208A2 (en) * 2003-09-12 2005-03-24 Janssen Pharmaceutica N.V. Chimeric gabab receptor
EP1963280B1 (en) 2005-12-22 2015-10-28 Newron Pharmaceuticals S.p.A. 2-phenylethylamino derivatives as calcium and/or sodium channel modulators

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000014222A2 (en) * 1998-09-07 2000-03-16 Glaxo Group Limited GABAB RECEPTOR SUBTYPES GABAB-R1c AND GABAB-R2 AND HETERODIMERS THEREOF
WO2000073788A1 (en) * 1999-06-01 2000-12-07 Merck Frosst Canada & Co. Use of gabapentin in assays to identify gabab receptor modulators

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000014222A2 (en) * 1998-09-07 2000-03-16 Glaxo Group Limited GABAB RECEPTOR SUBTYPES GABAB-R1c AND GABAB-R2 AND HETERODIMERS THEREOF
WO2000073788A1 (en) * 1999-06-01 2000-12-07 Merck Frosst Canada & Co. Use of gabapentin in assays to identify gabab receptor modulators

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BILLINTON ANDREW ET AL: "Advances in the molecular understanding of GABAB receptors.", TRENDS IN NEUROSCIENCES, vol. 24, no. 5, May 2001 (2001-05-01), pages 277 - 282, XP004234402, ISSN: 0166-2236 *
MALITSCHEK B ET AL: "Developmental changes of agonist affinity at GABABR1 receptor variants in rat brain.", MOLECULAR AND CELLULAR NEUROSCIENCES. UNITED STATES SEP 1998, vol. 12, no. 1-2, September 1998 (1998-09-01), pages 56 - 64, XP002213217, ISSN: 1044-7431 *
NG, GORDON ET AL, MOLECULAR PHARMACOLOGY, vol. 59, no. 1, January 2001 (2001-01-01), pages 144 - 152, XP002213218 *
PFAFF T ET AL: "Alternative splicing generates a novel isoform of the rat metabotropic GABA(B)R1 receptor.", THE EUROPEAN JOURNAL OF NEUROSCIENCE. FRANCE AUG 1999, vol. 11, no. 8, August 1999 (1999-08-01), pages 2874 - 2882, XP000884866, ISSN: 0953-816X *

Also Published As

Publication number Publication date
JP2004501375A (en) 2004-01-15
WO2001098779A2 (en) 2001-12-27
CA2413451A1 (en) 2001-12-27
EP1297341A2 (en) 2003-04-02

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