WO2002002760A3 - 25869, a human carboxylesterase and uses thereof - Google Patents

25869, a human carboxylesterase and uses thereof Download PDF

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Publication number
WO2002002760A3
WO2002002760A3 PCT/US2001/020968 US0120968W WO0202760A3 WO 2002002760 A3 WO2002002760 A3 WO 2002002760A3 US 0120968 W US0120968 W US 0120968W WO 0202760 A3 WO0202760 A3 WO 0202760A3
Authority
WO
WIPO (PCT)
Prior art keywords
coe
nucleic acid
acid molecules
expression vectors
provides isolated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/020968
Other languages
French (fr)
Other versions
WO2002002760A2 (en
Inventor
Rory A J Curtis
Thomas Joseph Logan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Priority to AU2001271732A priority Critical patent/AU2001271732A1/en
Priority to EP01950769A priority patent/EP1297155A2/en
Publication of WO2002002760A2 publication Critical patent/WO2002002760A2/en
Publication of WO2002002760A3 publication Critical patent/WO2002002760A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides isolated nucleic acid molecules, designated COE-1 nucleic acid molecules, which encode novel carboxylesterase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing COE-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a COE-1 gene has been introduced or disrupted. The invention still further provides isolated COE-1 proteins, fusion proteins, antigenic peptides and anti-COE-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
PCT/US2001/020968 2000-06-29 2001-06-29 25869, a human carboxylesterase and uses thereof Ceased WO2002002760A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001271732A AU2001271732A1 (en) 2000-06-29 2001-06-29 25869, a human carboxylesterase and uses thereof
EP01950769A EP1297155A2 (en) 2000-06-29 2001-06-29 25869, a human carboxylesterase and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21537000P 2000-06-29 2000-06-29
US60/215,370 2000-06-29

Publications (2)

Publication Number Publication Date
WO2002002760A2 WO2002002760A2 (en) 2002-01-10
WO2002002760A3 true WO2002002760A3 (en) 2002-08-15

Family

ID=22802723

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/020968 Ceased WO2002002760A2 (en) 2000-06-29 2001-06-29 25869, a human carboxylesterase and uses thereof

Country Status (4)

Country Link
US (1) US20020076786A1 (en)
EP (1) EP1297155A2 (en)
AU (1) AU2001271732A1 (en)
WO (1) WO2002002760A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2357244A3 (en) 2004-04-22 2011-11-23 Commonwealth Scientific and Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells.
CN103451246B (en) 2004-04-22 2018-02-16 联邦科学技术研究组织 With recombinant cell synthesis of long-chain polyunsaturated fatty acids
RU2009111266A (en) 2006-08-29 2010-10-10 Коммонвелт Сайентифик энд Индастриал Рисерч Организейшн (AU) FATTY ACID SYNTHESIS
KR100975852B1 (en) * 2008-03-14 2010-08-13 연세대학교 산학협력단 Liver cancer diagnostic composition comprising an antibody that specifically binds to liver-carboxyesterase 1 protein
BRPI0921467B1 (en) 2008-11-18 2021-12-14 Commonwealth Scientific And Industrial Research Organisation PROCESS FOR THE PRODUCTION OF OIL COMPRISING EICOSAPENTAENOIC ACID (EPA), DOCOSAPENTAENOIC ACID (DPA) AND DOCOSAHEXAENOIC ACID (DHA)
US20120245201A1 (en) * 2009-07-23 2012-09-27 Markowitz John S Isopropylphenidate for Treatment of Attention-Deficit/Hyperactivity Disorder and Fatigue-Related Disorders and Conditions
US20140162896A1 (en) * 2011-04-20 2014-06-12 University Of Florida Research Foundation Compositions and methods for genotyping ces1 genetic variants and use thereof
WO2013185184A2 (en) 2012-06-15 2013-12-19 Commonwealth Scientific And Industrial Research Organisation Production of long chain polyunsaturated fatty acids in plant cells
EP3082405A4 (en) 2013-12-18 2017-12-13 Commonwealth Scientific and Industrial Research Organisation Lipid comprising long chain polyunsaturated fatty acids
SG11201610596PA (en) 2014-06-27 2017-01-27 Commw Scient Ind Res Org Lipid comprising docosapentaenoic acid
KR20210044216A (en) * 2018-08-10 2021-04-22 에프. 호프만-라 로슈 아게 CES-2 (carboxylesterase-2) for evaluation of atrial fibrillation-related stroke

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042593A1 (en) * 1998-02-19 1999-08-26 St. Jude Children's Research Hospital Compositions and methods for sensitizing and inhibiting growth of human tumor cells
WO2000028045A2 (en) * 1998-11-12 2000-05-18 Incyte Pharmaceuticals, Inc. Human hydrolase proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042593A1 (en) * 1998-02-19 1999-08-26 St. Jude Children's Research Hospital Compositions and methods for sensitizing and inhibiting growth of human tumor cells
WO2000028045A2 (en) * 1998-11-12 2000-05-18 Incyte Pharmaceuticals, Inc. Human hydrolase proteins

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] EBI; 22 February 2000 (2000-02-22), SUGANO S ET AL.: "Homo sapiens cDNA FLJ20098 fis, clone COL04537, highly similar to ESTM_MOUSE LIVER CARBOXYLESTERASE PRECURSOR", XP002198768, Database accession no. AK000105 *
DATABASE EMBL [online] EBI; 4 October 1993 (1993-10-04), AIDA K ET AL.: "carboxylesterase [mice, liver, Balb/cj X DBA/2J, mRNA, 2007 nt]", XP002198769, Database accession no. S64130 *
SATOH T ET AL.: "Molecular aspects of carboxylesterase isoforms in comparison with other esterases", TOXICOLOGY LETTERS, vol. 82/83, 1995, pages 439 - 445, XP001053079, ISSN: 0378-4274 *

Also Published As

Publication number Publication date
US20020076786A1 (en) 2002-06-20
AU2001271732A1 (en) 2002-01-14
EP1297155A2 (en) 2003-04-02
WO2002002760A2 (en) 2002-01-10

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