WO2002006343A3 - Composition for treatment of and method of monitoring hepatitis c virus using interferon-tau - Google Patents

Composition for treatment of and method of monitoring hepatitis c virus using interferon-tau Download PDF

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Publication number
WO2002006343A3
WO2002006343A3 PCT/US2001/022976 US0122976W WO0206343A3 WO 2002006343 A3 WO2002006343 A3 WO 2002006343A3 US 0122976 W US0122976 W US 0122976W WO 0206343 A3 WO0206343 A3 WO 0206343A3
Authority
WO
WIPO (PCT)
Prior art keywords
hcv
treatment
tau
interferon
virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/022976
Other languages
French (fr)
Other versions
WO2002006343A2 (en
Inventor
Yoshihiro Sokawa
Chih-Ping Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pepgen Corp
Original Assignee
Pepgen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2000317160A external-priority patent/JP2006213597A/en
Application filed by Pepgen Corp filed Critical Pepgen Corp
Priority to AU2001277055A priority Critical patent/AU2001277055A1/en
Priority to EP01954835A priority patent/EP1355938A2/en
Publication of WO2002006343A2 publication Critical patent/WO2002006343A2/en
Anticipated expiration legal-status Critical
Publication of WO2002006343A3 publication Critical patent/WO2002006343A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A method of monitoring treatment of HCV by oral administration of ovine IFN-τ is disclosed. The method includes measuring the blood levels of 2', 5'-oligoadenylate synthetase prior to and after such oral administration, and if necessary, adjusting the dose of IFN-τ until a measurable increase in blood 2', 5'-oligoadenylate synthetase level, relative to the level observed prior to administration, is observed. Also disclosed are oral-delivery compositions for use in treating HCV in an HCV-infected patient comprising ovine IFN-τ, in a dosage effective to stimulate bloodstream levels of 2', 5'-oligoadenylate synthetase.
PCT/US2001/022976 2000-07-19 2001-07-19 Composition for treatment of and method of monitoring hepatitis c virus using interferon-tau Ceased WO2002006343A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001277055A AU2001277055A1 (en) 2000-07-19 2001-07-19 Composition for treatment of and method of monitoring hepatitis c virus using interferon-tau
EP01954835A EP1355938A2 (en) 2000-07-19 2001-07-19 Composition for treatment of and method of monitoring hepatitis c virus using interferon-tau

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21912800P 2000-07-19 2000-07-19
US60/219,128 2000-07-19
JP2000317160A JP2006213597A (en) 2000-07-19 2000-10-17 Compositions and methods of monitoring for the treatment of hepatitis C virus using interferon-tau
JP2000-317160 2000-10-17

Publications (2)

Publication Number Publication Date
WO2002006343A2 WO2002006343A2 (en) 2002-01-24
WO2002006343A3 true WO2002006343A3 (en) 2003-08-21

Family

ID=26602264

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/022976 Ceased WO2002006343A2 (en) 2000-07-19 2001-07-19 Composition for treatment of and method of monitoring hepatitis c virus using interferon-tau

Country Status (3)

Country Link
EP (1) EP1355938A2 (en)
AU (1) AU2001277055A1 (en)
WO (1) WO2002006343A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105154B2 (en) * 2000-07-19 2006-09-12 Pepgen Corporation Method of treatment using interferon-tau
US20050226845A1 (en) * 2004-03-10 2005-10-13 Chih-Ping Liu Method of treatment using interferon-tau
US7431920B2 (en) 2000-07-19 2008-10-07 Pepgen Corporation Method of treating IL-10 deficiency
GB0208928D0 (en) * 2002-04-19 2002-05-29 Imp College Innovations Ltd Methods
CA2484251C (en) 2002-04-30 2015-06-23 University Of South Florida Materials and methods for inhibition of respiratory syncytial virus infection
US7595303B1 (en) 2002-09-05 2009-09-29 University Of South Florida Genetic adjuvants for immunotherapy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010313A2 (en) * 1992-10-30 1994-05-11 University Of Florida Interferon tau compositions and methods of use
WO1996035789A1 (en) * 1995-05-10 1996-11-14 The Women's Research Institute Human interferon tau compositions and methods of use
WO2000078266A2 (en) * 1999-06-22 2000-12-28 University Of Maryland College Park Interferon tau mutants and methods for making them

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010313A2 (en) * 1992-10-30 1994-05-11 University Of Florida Interferon tau compositions and methods of use
WO1996035789A1 (en) * 1995-05-10 1996-11-14 The Women's Research Institute Human interferon tau compositions and methods of use
WO2000078266A2 (en) * 1999-06-22 2000-12-28 University Of Maryland College Park Interferon tau mutants and methods for making them

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLAYETTE P ET AL: "[ IFN - tau, a new interferon type I with antiretroviral activity]. Un nouvel interferon de type I dote d'une activite antiretrovirale, L' IFN - tau.", PATHOLOGIE BIOLOGIE, (1999 MAY) 47 (5) 553-9., XP008009463 *
SAEZ-ROYUELA F ET AL: "TREATMENT OF CHRONIC NON-A NON-B HEPATITIS WITH HIGH DOSES OF RECOMBINANT IFN-ALPHA OR RECOMBINANT IFN - TAU.", 40TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES, CHICAGO, ILLINOIS, USA, OCTOBER 28-31, 1989. HEPATOLOGY (BALTIMORE). (1989) 10 (4), 646., XP008009464 *

Also Published As

Publication number Publication date
EP1355938A2 (en) 2003-10-29
WO2002006343A2 (en) 2002-01-24
AU2001277055A1 (en) 2002-01-30

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