WO2002008227A3 - Bicyclic hydantoin derivatives and combinatorial libraries thereof - Google Patents

Bicyclic hydantoin derivatives and combinatorial libraries thereof Download PDF

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Publication number
WO2002008227A3
WO2002008227A3 PCT/EP2001/008322 EP0108322W WO0208227A3 WO 2002008227 A3 WO2002008227 A3 WO 2002008227A3 EP 0108322 W EP0108322 W EP 0108322W WO 0208227 A3 WO0208227 A3 WO 0208227A3
Authority
WO
WIPO (PCT)
Prior art keywords
combinatorial libraries
bicyclic hydantoin
hydantoin derivatives
bicyclic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/008322
Other languages
French (fr)
Other versions
WO2002008227A2 (en
Inventor
Shao-Po Lu
R Normand Hebert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sygnis Pharma AG
Original Assignee
Lion Bioscience AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Bioscience AG filed Critical Lion Bioscience AG
Priority to CA002416654A priority Critical patent/CA2416654A1/en
Priority to AU2001281995A priority patent/AU2001281995A1/en
Priority to EP01960516A priority patent/EP1301512A2/en
Publication of WO2002008227A2 publication Critical patent/WO2002008227A2/en
Publication of WO2002008227A3 publication Critical patent/WO2002008227A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel bicyclic hydantoin derivative compounds of the following formula (I): wherein R1 to R5 and n have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing bicyclic hydantoin derivative compounds.
PCT/EP2001/008322 2000-07-21 2001-07-18 Bicyclic hydantoin derivatives and combinatorial libraries thereof Ceased WO2002008227A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002416654A CA2416654A1 (en) 2000-07-21 2001-07-18 Bicyclic hydantoin derivatives and combinatorial libraries thereof
AU2001281995A AU2001281995A1 (en) 2000-07-21 2001-07-18 Bicyclic hydantoin derivatives and combinatorial libraries thereof
EP01960516A EP1301512A2 (en) 2000-07-21 2001-07-18 Bicyclic hydantoin derivatives and combinatorial libraries thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62117700A 2000-07-21 2000-07-21
US09/621,177 2000-07-21

Publications (2)

Publication Number Publication Date
WO2002008227A2 WO2002008227A2 (en) 2002-01-31
WO2002008227A3 true WO2002008227A3 (en) 2002-08-29

Family

ID=24489060

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/008322 Ceased WO2002008227A2 (en) 2000-07-21 2001-07-18 Bicyclic hydantoin derivatives and combinatorial libraries thereof

Country Status (4)

Country Link
EP (1) EP1301512A2 (en)
AU (1) AU2001281995A1 (en)
CA (1) CA2416654A1 (en)
WO (1) WO2002008227A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044181A1 (en) * 2000-12-01 2002-06-06 Bristol-Myers Squibb Company Hydantoin compounds useful as anti-inflammatory agents
US7199149B2 (en) 2003-10-01 2007-04-03 Bristol Myers Squibb Company Monocyclic and bicyclic lactams as factor Xa inhibitors
EP1939184B1 (en) * 2005-09-02 2013-06-05 Nippoh Chemicals Co., Ltd 1,3-diiodohydantoin compound and process for production thereof
ES2618315T3 (en) 2007-05-25 2017-06-21 Ipsen Pharma S.A.S. Hydantoin-modified melanocortin receptor ligands
EP2937338B1 (en) 2012-12-19 2019-07-10 Nippoh Chemicals Co., Ltd Production method and production device for halo-hydantoin compound, reuse system, and halo-hydantoin compound
JP6470045B2 (en) 2012-12-19 2019-02-13 日宝化学株式会社 Method for producing halohydantoin compound

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198423A (en) * 1979-03-20 1980-04-15 Basf Aktiengesellschaft 1,3-Bis-(trihalomethylsulfenyl)-imidazoline-2,4-diones
EP0493323A1 (en) * 1990-12-18 1992-07-01 Sandoz Ltd. Novel hydantoin compounds
WO1995023509A1 (en) * 1994-03-01 1995-09-08 E.I. Du Pont De Nemours And Company Herbicidal bicyclic hydantoins
WO1997047626A1 (en) * 1996-06-14 1997-12-18 Sagami Chemical Research Center Bicyclic hydantoin derivatives, intermediates for the preparation thereof, process for the preparation of them, and herbicides containing the same as active ingredient
WO1998008813A1 (en) * 1996-08-26 1998-03-05 Eli Lilly And Company Combinatorial process for preparing substituted pyrrolidine libraries
WO1998011107A1 (en) * 1996-09-12 1998-03-19 Sagami Chemical Research Center Bicyclic hydantoin derivatives, process for producing the same, and herbicides containing the same as active ingredient
WO1998033776A1 (en) * 1997-02-04 1998-08-06 Trega Biosciences, Inc. Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein
WO2000077519A1 (en) * 1999-06-15 2000-12-21 Aventis Pharmaceuticals Products Inc. Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
WO2001030781A2 (en) * 1999-10-20 2001-05-03 Tanabe Seiyaku Co., Ltd. INHIBITORS OF αLβ2 MEDIATED CELL ADHESION

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198423A (en) * 1979-03-20 1980-04-15 Basf Aktiengesellschaft 1,3-Bis-(trihalomethylsulfenyl)-imidazoline-2,4-diones
EP0493323A1 (en) * 1990-12-18 1992-07-01 Sandoz Ltd. Novel hydantoin compounds
WO1995023509A1 (en) * 1994-03-01 1995-09-08 E.I. Du Pont De Nemours And Company Herbicidal bicyclic hydantoins
WO1997047626A1 (en) * 1996-06-14 1997-12-18 Sagami Chemical Research Center Bicyclic hydantoin derivatives, intermediates for the preparation thereof, process for the preparation of them, and herbicides containing the same as active ingredient
WO1998008813A1 (en) * 1996-08-26 1998-03-05 Eli Lilly And Company Combinatorial process for preparing substituted pyrrolidine libraries
WO1998011107A1 (en) * 1996-09-12 1998-03-19 Sagami Chemical Research Center Bicyclic hydantoin derivatives, process for producing the same, and herbicides containing the same as active ingredient
WO1998033776A1 (en) * 1997-02-04 1998-08-06 Trega Biosciences, Inc. Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein
US5859190A (en) * 1997-02-04 1999-01-12 Trega Biosciences, Inc. Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein
WO2000077519A1 (en) * 1999-06-15 2000-12-21 Aventis Pharmaceuticals Products Inc. Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
WO2001030781A2 (en) * 1999-10-20 2001-05-03 Tanabe Seiyaku Co., Ltd. INHIBITORS OF αLβ2 MEDIATED CELL ADHESION

Also Published As

Publication number Publication date
CA2416654A1 (en) 2002-01-31
AU2001281995A1 (en) 2002-02-05
WO2002008227A2 (en) 2002-01-31
EP1301512A2 (en) 2003-04-16

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