WO2002011695A3 - Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation - Google Patents

Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation Download PDF

Info

Publication number
WO2002011695A3
WO2002011695A3 PCT/US2001/024632 US0124632W WO0211695A3 WO 2002011695 A3 WO2002011695 A3 WO 2002011695A3 US 0124632 W US0124632 W US 0124632W WO 0211695 A3 WO0211695 A3 WO 0211695A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhaleable
spray dried
helix bundle
protein powders
bundle protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/024632
Other languages
French (fr)
Other versions
WO2002011695A2 (en
Inventor
Cynthia Stevenson
Jayne E Hastedt
S Russ Lehrman
Hi-Shi Chiang
David B Bennett
David Lesikar
Bing Yang
David Gong
Kirsten Cabot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nektar Therapeutics
Original Assignee
Inhale Therapeutics Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhale Therapeutics Systems Inc filed Critical Inhale Therapeutics Systems Inc
Priority to JP2002517033A priority Critical patent/JP2004515467A/en
Priority to MXPA03001092A priority patent/MXPA03001092A/en
Priority to CA002418960A priority patent/CA2418960A1/en
Priority to EP01959572A priority patent/EP1309312A2/en
Priority to AU8111301A priority patent/AU8111301A/en
Priority to KR10-2003-7001831A priority patent/KR20030038690A/en
Priority to AU2001281113A priority patent/AU2001281113B2/en
Publication of WO2002011695A2 publication Critical patent/WO2002011695A2/en
Publication of WO2002011695A3 publication Critical patent/WO2002011695A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41J—TYPEWRITERS; SELECTIVE PRINTING MECHANISMS, i.e. MECHANISMS PRINTING OTHERWISE THAN FROM A FORME; CORRECTION OF TYPOGRAPHICAL ERRORS
    • B41J29/00—Details of, or accessories for, typewriters or selective printing mechanisms not otherwise provided for
    • B41J29/12—Guards, shields or dust excluders
    • B41J29/13—Cases or covers
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/30—Inkjet printing inks

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PCT/US2001/024632 2000-08-07 2001-08-06 Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation Ceased WO2002011695A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2002517033A JP2004515467A (en) 2000-08-07 2001-08-06 Inhalable, spray-dried, 4-helix bundle protein powder with minimal aggregates
MXPA03001092A MXPA03001092A (en) 2000-08-07 2001-08-06 Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation.
CA002418960A CA2418960A1 (en) 2000-08-07 2001-08-06 Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
EP01959572A EP1309312A2 (en) 2000-08-07 2001-08-06 Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
AU8111301A AU8111301A (en) 2000-08-07 2001-08-06 Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
KR10-2003-7001831A KR20030038690A (en) 2000-08-07 2001-08-06 Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
AU2001281113A AU2001281113B2 (en) 2000-08-07 2001-08-06 Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US22314400P 2000-08-07 2000-08-07
US60/223,144 2000-08-07
US22863400P 2000-08-29 2000-08-29
US60/228,634 2000-08-29
US24047800P 2000-10-13 2000-10-13
US60/240,478 2000-10-13

Publications (2)

Publication Number Publication Date
WO2002011695A2 WO2002011695A2 (en) 2002-02-14
WO2002011695A3 true WO2002011695A3 (en) 2002-04-25

Family

ID=27397184

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024632 Ceased WO2002011695A2 (en) 2000-08-07 2001-08-06 Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation

Country Status (10)

Country Link
US (3) US6569406B2 (en)
EP (1) EP1309312A2 (en)
JP (1) JP2004515467A (en)
KR (1) KR20030038690A (en)
CN (1) CN1446077A (en)
AU (2) AU2001281113B2 (en)
CA (1) CA2418960A1 (en)
MX (1) MXPA03001092A (en)
TW (1) TWI283182B (en)
WO (1) WO2002011695A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US7182961B2 (en) 2001-11-20 2007-02-27 Advanced Inhalation Research, Inc. Particulate compositions for pulmonary delivery

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0679088T3 (en) * 1992-09-29 2002-10-28 Inhale Therapeutic Syst Pulmonary delivery of active fragments of parathyroid hormone
US20030113273A1 (en) * 1996-06-17 2003-06-19 Patton John S. Methods and compositions for pulmonary delivery of insulin
DE69535897D1 (en) 1994-03-07 2009-01-22 Nektar Therapeutics Method and composition for the pulmonary delivery of insulin
AU696387B2 (en) * 1994-05-18 1998-09-10 Inhale Therapeutic Systems, Inc. Methods and compositions for the dry powder formulation of interferons
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US20030035778A1 (en) * 1997-07-14 2003-02-20 Robert Platz Methods and compositions for the dry powder formulation of interferon
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
PT1280520E (en) 2000-05-10 2014-12-16 Novartis Ag Phospholipid-based powders for drug delivery
JP4147234B2 (en) * 2004-09-27 2008-09-10 キヤノン株式会社 Discharge liquid, discharge method, cartridge, and discharge device
BR0214280A (en) * 2001-11-19 2005-01-11 Becton Dickinson Co Pharmaceutical composition in particulate form
TWI324518B (en) 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
WO2003079993A2 (en) * 2002-03-20 2003-10-02 Advanced Inhalation Research, Inc. hGH (HUMAN GROWTH HORMONE) FORMULATIONS FOR PULMONARY ADMINISTRATION
JP4681231B2 (en) 2002-03-20 2011-05-11 マンカインド コーポレイション Inhaler
US7008644B2 (en) * 2002-03-20 2006-03-07 Advanced Inhalation Research, Inc. Method and apparatus for producing dry particles
US20050163725A1 (en) * 2002-03-20 2005-07-28 Blizzard Charles D. Method for administration of growth hormone via pulmonary delivery
US20050037047A1 (en) * 2003-08-11 2005-02-17 Young-Ho Song Medical devices comprising spray dried microparticles
JP2006199589A (en) * 2003-09-03 2006-08-03 Ltt Bio-Pharma Co Ltd Nanoparticle containing physiologically active protein or peptide, method for producing the same and external preparation comprising the nanoparticle
US7024866B2 (en) * 2003-12-11 2006-04-11 Helix Technology Corporation Axial loaded seal system with a static L-seal
US20050191246A1 (en) * 2003-12-13 2005-09-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powders comprising low molecular dextran and methods of producing those powders
CA2555841A1 (en) * 2004-02-12 2005-09-01 Nektar Therapeutics Interleukin-13 antagonist powders, spray-dried particles, and methods
JO3102B1 (en) * 2004-03-17 2017-09-20 Chiesi Framaceutici S P A Pharmaceutical formulations for dry powder inhalers comprising a low- dosage strength active ingredient
ES2383994T3 (en) * 2004-04-07 2012-06-28 Ares Trading S.A. Liquid growth hormone formulation
DE102004022927A1 (en) * 2004-05-10 2005-12-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg 1,4 O-linked sucrose derivatives for the stabilization of antibodies or antibody derivatives
ATE486064T1 (en) 2004-08-20 2010-11-15 Mannkind Corp CATALYSIS OF DIKETOPIPERAZINE SYNTHESIS
HUE025151T2 (en) 2004-08-23 2016-01-28 Mannkind Corp Diketopiperazine salts for drug delivery
JP4147235B2 (en) * 2004-09-27 2008-09-10 キヤノン株式会社 Discharge liquid, discharge method, droplet forming method, liquid discharge cartridge, and discharge apparatus
WO2006071102A1 (en) * 2004-12-30 2006-07-06 Dobeel Co., Ltd. Spray-dried composition containing collectin family proteins or variants therof and process for preparing the same
MX373000B (en) 2005-09-14 2020-05-21 Mannkind Corp METHOD FOR FORMULATING A DRUG BASED ON INCREASING THE AFFINITY OF ACTIVE AGENTS TOWARDS THE SURFACES OF CRYSTALLINE MICROPARTICLES.
CN104383546B (en) 2006-02-22 2021-03-02 曼金德公司 Method for improving the pharmaceutical properties of microparticles comprising diketopiperazines and an active agent
TW200806317A (en) * 2006-03-20 2008-02-01 Wyeth Corp Methods for reducing protein aggregation
US20080035141A1 (en) * 2006-06-16 2008-02-14 Warner W R Aerosolized therapy kit
DE102006030164A1 (en) * 2006-06-29 2008-01-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalative powders
KR20080038224A (en) * 2006-07-20 2008-05-02 시코르, 인크. Method for preparing solid sterile active pharmacological ingredient
US7746769B2 (en) * 2007-03-26 2010-06-29 Alcatel Lucent Management of redundant and multi-segment pseudo-wire
CA2681752A1 (en) 2007-03-29 2008-10-09 Abbott Laboratories Crystalline anti-human 1l-12 antibodies
EP2050437A1 (en) * 2007-10-15 2009-04-22 Laboratoires SMB Improved pharmaceutical dry powder compositions for inhalation.
US20090145433A1 (en) * 2007-12-08 2009-06-11 Michael James Apparatus for dispensing a powdered composition into the aerodigestive tract
SG2013054218A (en) * 2008-01-15 2014-10-30 Abbott Gmbh & Co Kg Powdered protein compositions and methods of making same
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
MY155524A (en) 2008-06-13 2015-10-30 Mannkind Corp A dry powder inhaler and system for drug delivery
EP2609954B1 (en) 2008-06-20 2021-12-29 MannKind Corporation An interactive apparatus for real-time profiling of inhalation efforts
TWI494123B (en) 2008-08-11 2015-08-01 Mannkind Corp Ultra-fast use of insulin
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
CA2748490C (en) 2008-12-29 2016-10-04 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
AU2010259943C1 (en) 2009-06-12 2016-03-03 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
JP5784622B2 (en) 2009-11-03 2015-09-24 マンカインド コーポレ−ション Apparatus and method for simulating inhalation activity
RU2531455C2 (en) 2010-06-21 2014-10-20 Маннкайнд Корпорейшн Systems and methods for dry powder drugs delivery
WO2012051426A2 (en) * 2010-10-15 2012-04-19 Glaxo Group Limited Aggregate nanoparticulate medicament formulations, manufacture and use thereof
MX353285B (en) 2011-04-01 2018-01-05 Mannkind Corp Blister package for pharmaceutical cartridges.
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CN103649105A (en) * 2011-06-28 2014-03-19 白血球保健股份有限公司 Method for preventing the unfolding of a (poly) peptide and/or inducing the (re- ) folding of a (poly) peptide
HK1201475A1 (en) 2011-10-24 2015-09-04 Mannkind Corporation Methods and compositions for treating pain
AU2012340107B2 (en) 2011-11-18 2017-06-15 Regeneron Pharmaceuticals, Inc. Polymer protein microparticles
KR20140147891A (en) 2012-04-13 2014-12-30 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Aggregate particles
AU2013289957B2 (en) 2012-07-12 2017-02-23 Mannkind Corporation Dry powder drug delivery systems and methods
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
BR112015023168B1 (en) 2013-03-15 2021-08-10 Mannkind Corporation COMPOSITION OF 3,6-BIS(N-FUMARYL-4-AMINOBUTYL)-2,5-CRYSTALLINE DICETOPIPERAZINE, METHOD OF PRODUCTION OF 3,6-BIS(N-FUMARYL-4-AMINOBUTYL)-2,5-DICETOPIPERAZINE PARTICLES AND USE OF A CRYSTALLINE DICETOPIPERAZINE COMPOSITION
CN105473133A (en) 2013-04-30 2016-04-06 欧缇托匹克公司 Dry powder formulations and methods of use
BR122019026637B1 (en) 2013-07-18 2023-09-26 Mannkind Corporation PHARMACEUTICAL DRY POWDER FORMULATIONS AND METHOD FOR MANUFACTURING A DRY POWDER FORMULATION
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
AR097762A1 (en) * 2013-09-27 2016-04-13 Intervet Int Bv DRY FORMULATIONS OF VACCINES THAT ARE STABLE AT ENVIRONMENTAL TEMPERATURE
EP3107548B8 (en) 2014-02-20 2022-07-20 Otitopic Inc. Dry powder formulations for inhalation
JP2017506106A (en) * 2014-02-21 2017-03-02 ブラウン、デイビッド Inhalation device and method for inhaling powder
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
GB201419900D0 (en) * 2014-11-07 2014-12-24 Dupont Nutrition Biosci Aps Method
US9585835B1 (en) * 2015-09-16 2017-03-07 Sansa Corporation (Barbados) Inc. Inhalable nicotine formulations and methods of making and using the same
US11224594B2 (en) 2015-09-16 2022-01-18 Philip Morris Products S.A. Nicotine formulations and methods of making and using the same
MX385972B (en) * 2016-06-30 2025-03-18 Philip Morris Products Sa NICOTINE PARTICLES AND COMPOSITIONS.
JP7680823B2 (en) * 2017-03-07 2025-05-21 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム Inhalable nicotine formulations and methods of making and using same
EA202191403A1 (en) * 2018-11-21 2021-08-09 Ридженерон Фармасьютикалз, Инк. COMPOSITION WITH HIGH PROTEIN CONCENTRATION
CN111598399B (en) * 2020-04-17 2023-04-28 西安理工大学 Expansion Planning Method of Ultra-large-scale Transmission Network Based on Distributed Computing Platform
KR20230125383A (en) 2022-02-21 2023-08-29 주식회사 홀블렌딩 Plant-based protein powder and the method for producing the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000000176A1 (en) * 1998-06-30 2000-01-06 Quadrant Healthcare (Uk) Limited Microparticle formulation for inhalation
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
WO2001032144A1 (en) * 1999-10-29 2001-05-10 Inhale Therapeutic Systems, Inc. Dry powder compositions having improved dispersivity

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR890002631B1 (en) 1984-10-04 1989-07-21 몬산토 캄파니 Composition of prolonged release of biologically active somatotropin
IL79681A (en) 1985-08-12 1991-06-10 Int Minerals & Chem Corp Transition metal complexes of growth hormones and their prolonged release compositions
US4917685A (en) 1986-05-16 1990-04-17 International Minerals & Chem. Corp. Delivery device for the administration of stabilized growth promoting hormones
ES2032831T5 (en) 1986-08-19 2001-02-16 Genentech Inc DEVICE AND DISPERSION FOR INTRAPULMONARY SUPPLY OF POLYPEPTIDE AND CYTOKIN GROWTH FACTORS.
EP0303746B2 (en) 1987-08-21 1998-12-02 Mallinckrodt Group Inc. Stabilization of growth promoting hormones
CA1331133C (en) 1988-03-01 1994-08-02 Michael Jon Pikal Pharmaceutical growth hormone formulations
US5763394A (en) 1988-04-15 1998-06-09 Genentech, Inc. Human growth hormone aqueous formulation
US5182258A (en) * 1989-03-20 1993-01-26 Orbon Corporation Systemic delivery of polypeptides through the eye
DK168790D0 (en) 1990-07-13 1990-07-13 Novo Nordisk As
US5780599A (en) 1990-07-13 1998-07-14 Novo Nordisk A/S Growth hormone crystals and a process for production of growth hormone crystals
SE467525B (en) 1990-10-09 1992-08-03 Nemo Ivarson Ab PROCEDURE SHOULD TRANSFER SOLID PARTS IN POWDER FORM WITH A ROOM TEMPERATURE OR HIGH MATERIAL IN ROOM TEMPERATURE
DE69129154T2 (en) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. METHOD FOR ENRICHING PROTEIN VARIANTS WITH CHANGED BINDING PROPERTIES
WO1992014449A1 (en) * 1991-02-20 1992-09-03 Nova Pharmaceutical Corporation Controlled release microparticulate delivery system for proteins
WO1992017200A2 (en) 1991-03-28 1992-10-15 Genentech, Inc. Stable growth hormone metal ion formulations
DE59201645D1 (en) 1991-07-11 1995-04-20 Glatt Gmbh Method and device for coating particles.
US5849700A (en) 1991-12-20 1998-12-15 Novo Nordisk A/S Pharmaceutical formulation
DK204791D0 (en) 1991-12-20 1991-12-20 Novo Nordisk As UNKNOWN PHARMACEUTICAL PREPARATION
US5849704A (en) 1991-12-20 1998-12-15 Novo Nordisk A/S Pharmaceutical formulation
US6022858A (en) 1991-12-20 2000-02-08 Novo Nordisk A/S Pharmaceutical formulation of human-growth hormone pretreated with zinc salt
DE10399015I1 (en) 1991-12-20 2012-05-03 Novo Nordisk As Stabilized pharmaceutical formulation containing growth hormone and histidine
AU3582893A (en) 1992-01-13 1993-08-03 Pitman-Moore, Inc. Delayed release device for transition metal/protein complexes
SE9201073D0 (en) 1992-04-03 1992-04-03 Kabi Pharmacia Ab PROTEIN FORMULATION
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
JPH08503950A (en) 1992-12-02 1996-04-30 アルカーメス・コントロールド・セラピユーテイクス・インコーポレーテツド Microspheres containing sustained release growth hormone
DK0686045T3 (en) 1993-02-23 2001-03-05 Genentech Inc Stabilization of organic solvent-treated polypeptides with an adjuvant
JP3349540B2 (en) 1993-03-10 2002-11-25 フロイント産業株式会社 Granulation method and apparatus
IS1796B (en) 1993-06-24 2001-12-31 Ab Astra Inhaled polypeptide formulation composition which also contains an enhancer compound
CA2163860A1 (en) 1993-06-30 1995-01-12 Chung C. Hsu Method for preparing liposomes
JPH07232049A (en) 1994-02-25 1995-09-05 Freunt Ind Co Ltd Centrifugal rolling granulation coating apparatus, centrifugal rolling granulation coating method for powder and granular material, and granulation method and coating method for granular material using the method
JP2886446B2 (en) 1994-03-03 1999-04-26 関西ペイント株式会社 Sheet for coating protection
DE69420872T2 (en) 1994-06-17 2000-01-13 Applied Research Systems Ars Holding N.V., Curacao PHARMACEUTICAL PREPARATIONS CONTAINING HGH
US5641510A (en) 1994-07-01 1997-06-24 Genentech, Inc. Method for treating capsules used for drug storage
US5547696A (en) 1994-10-13 1996-08-20 Novo Nordisk A/S Pharmaceutical formulation
US5631225A (en) 1994-10-13 1997-05-20 Novo Nordisk A/S Pharmaceutical formulation
US5654278A (en) * 1994-10-13 1997-08-05 Novo Nordisk A/S Composition and method comprising growth hormone and leucine
IL115592A (en) 1994-10-13 2000-07-26 Novo Nordisk As Stabilized pharmaceutical formulation comprising a growth hormone and leucine
SE9404468D0 (en) 1994-12-22 1994-12-22 Astra Ab Powder formulations
US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
JPH10511964A (en) 1995-01-13 1998-11-17 ノボ ノルディスク アクティーゼルスカブ Stabilized pharmaceutical preparation containing growth hormone and X-Lys
US5705482A (en) 1995-01-13 1998-01-06 Novo Nordisk A/S Pharmaceutical formulation
ZA96122B (en) 1995-01-13 1996-07-24 Novo Nordisk As A pharmaceutical formulation
US6004583A (en) 1995-03-22 1999-12-21 Orex Pharmaceutical Development Corp. Protein-containing polymer composition for oral administration
US5552385A (en) 1995-06-05 1996-09-03 Novo Nordisk A/S Pharmaceutical formulation
ZA965367B (en) 1995-07-12 1997-01-23 Novo Nordisk As A pharmaceutical formulation
ZA965368B (en) 1995-07-14 1997-01-14 Novo Nordisk As A pharmaceutical formulation
ATE455171T1 (en) 1995-09-21 2010-01-15 Genentech Inc VARIANTS OF HUMAN GROWTH HORMONE
US20020077461A1 (en) 1996-04-24 2002-06-20 Soren Bjorn Pharmaceutical formulation
JP3839531B2 (en) 1996-11-05 2006-11-01 フロイント産業株式会社 Centrifugal rolling granulation coating apparatus, granulation method and coating method of granular material using the same
US6191107B1 (en) 1997-09-26 2001-02-20 Takeda Chemical Industries, Ltd. Complex of human growth hormone and zinc
CA2341624C (en) 1998-08-25 2008-12-02 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US6197369B1 (en) 1999-09-30 2001-03-06 New Jersey Institute Of Technology Method of particle coating
US6555660B2 (en) * 2000-01-10 2003-04-29 Maxygen Holdings Ltd. G-CSF conjugates

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
WO2000000176A1 (en) * 1998-06-30 2000-01-06 Quadrant Healthcare (Uk) Limited Microparticle formulation for inhalation
WO2001032144A1 (en) * 1999-10-29 2001-05-10 Inhale Therapeutic Systems, Inc. Dry powder compositions having improved dispersivity

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US7182961B2 (en) 2001-11-20 2007-02-27 Advanced Inhalation Research, Inc. Particulate compositions for pulmonary delivery
US7384649B2 (en) 2001-11-20 2008-06-10 Advanced Inhalation Research, Inc. Particulate compositions for pulmonary delivery

Also Published As

Publication number Publication date
KR20030038690A (en) 2003-05-16
US6838075B2 (en) 2005-01-04
US20050186143A1 (en) 2005-08-25
CN1446077A (en) 2003-10-01
US20030190291A1 (en) 2003-10-09
AU2001281113B2 (en) 2006-07-20
JP2004515467A (en) 2004-05-27
MXPA03001092A (en) 2003-09-25
TWI283182B (en) 2007-07-01
US6569406B2 (en) 2003-05-27
WO2002011695A2 (en) 2002-02-14
US20020065399A1 (en) 2002-05-30
AU8111301A (en) 2002-02-18
CA2418960A1 (en) 2002-02-14
EP1309312A2 (en) 2003-05-14

Similar Documents

Publication Publication Date Title
AU8111301A (en) Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
EP1307256A4 (en) Dry powder inhaler
SI1294421T1 (en) Dry Powder Inhaler
ZA200105453B (en) Potentiation of Anti-CD38-immunotoxin cytotoxicity.
GB0009592D0 (en) Respiratory combinations
AU1331802A (en) Cd38 modulated chemotaxis
AU2188402A (en) Delta 1-pyrrolines used as pesticides
AU2002225664A1 (en) A sprayer container comprising a fabric treatment composition
GB2373455B (en) Dynamic collapsible revolving toy
GB2352736B (en) Sparkle linen spray
TW543764U (en) Rotary dryer
HRPK20000355B1 (en) Electro-compressor knapsack sprayer
IL153556A0 (en) Novispirins: antimicrobial peptides
HUP0302964A3 (en) Delta 1-pyrrolines, intermediates, preparation thereof and their use as pesticides
AU142299S (en) Hair dryer
GB2365335B (en) Hairdryer
GB0113028D0 (en) Powder applicator
GB0000482D0 (en) Enteric coated pharmaceutical formulation
GB2397305B (en) Sparkle linen spray
GB0017444D0 (en) Dry sprayer
TW416265U (en) Improved sprayer
AU145498S (en) Lotion sprayer
AU145494S (en) Lotion sprayer
GB0021759D0 (en) Full body dryer
AUPR131800A0 (en) Body dryer

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2001281113

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 018137962

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: PA/a/2003/001092

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2418960

Country of ref document: CA

Ref document number: 2002517033

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 1020037001831

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 2001959572

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001959572

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1020037001831

Country of ref document: KR

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642