WO2002014499A3 - Claudin polypeptides - Google Patents

Claudin polypeptides Download PDF

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Publication number
WO2002014499A3
WO2002014499A3 PCT/US2001/025662 US0125662W WO0214499A3 WO 2002014499 A3 WO2002014499 A3 WO 2002014499A3 US 0125662 W US0125662 W US 0125662W WO 0214499 A3 WO0214499 A3 WO 0214499A3
Authority
WO
WIPO (PCT)
Prior art keywords
claudin
methods
claudin polypeptides
polypeptides
treat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/025662
Other languages
French (fr)
Other versions
WO2002014499A9 (en
WO2002014499A2 (en
Inventor
Adel Youakim
Robert F Dubose
Steven R Wiley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunex Corp
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/344,487 priority Critical patent/US7186802B2/en
Priority to DE60128701T priority patent/DE60128701T2/en
Priority to AU8497701A priority patent/AU8497701A/en
Priority to MXPA03001468A priority patent/MXPA03001468A/en
Priority to EP01964084A priority patent/EP1311663B1/en
Priority to CA002418725A priority patent/CA2418725A1/en
Priority to AU2001284977A priority patent/AU2001284977B2/en
Priority to JP2002519627A priority patent/JP2004519215A/en
Application filed by Immunex Corp filed Critical Immunex Corp
Publication of WO2002014499A2 publication Critical patent/WO2002014499A2/en
Publication of WO2002014499A9 publication Critical patent/WO2002014499A9/en
Publication of WO2002014499A3 publication Critical patent/WO2002014499A3/en
Anticipated expiration legal-status Critical
Priority to US11/701,883 priority patent/US20080254506A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

This invention relates to new members of the human Claudin polypeptide family, to methods of making such polypeptides, and to methods of using them to treat Claudin-associated conditions and to identify compounds that alter Claudin polypeptide activities.
PCT/US2001/025662 2000-08-15 2001-08-15 Claudin polypeptides Ceased WO2002014499A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2001284977A AU2001284977B2 (en) 2000-08-15 2001-08-15 Claudin polypeptides
AU8497701A AU8497701A (en) 2000-08-15 2001-08-15 Claudin polypeptides
MXPA03001468A MXPA03001468A (en) 2000-08-15 2001-08-15 Claudin polypeptides.
EP01964084A EP1311663B1 (en) 2000-08-15 2001-08-15 Claudin polypeptides
CA002418725A CA2418725A1 (en) 2000-08-15 2001-08-15 Claudin polypeptides
US10/344,487 US7186802B2 (en) 2000-08-15 2001-08-15 Claudin polypeptides
DE60128701T DE60128701T2 (en) 2000-08-15 2001-08-15 CLAUDIN POLYPEPTIDE
JP2002519627A JP2004519215A (en) 2000-08-15 2001-08-15 Claudin polypeptide
US11/701,883 US20080254506A1 (en) 2000-08-15 2007-02-01 Claudin polypeptides

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22579400P 2000-08-15 2000-08-15
US22551300P 2000-08-15 2000-08-15
US60/225,794 2000-08-15
US60/225,513 2000-08-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/701,883 Division US20080254506A1 (en) 2000-08-15 2007-02-01 Claudin polypeptides

Publications (3)

Publication Number Publication Date
WO2002014499A2 WO2002014499A2 (en) 2002-02-21
WO2002014499A9 WO2002014499A9 (en) 2002-04-18
WO2002014499A3 true WO2002014499A3 (en) 2002-10-31

Family

ID=26919667

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/025662 Ceased WO2002014499A2 (en) 2000-08-15 2001-08-15 Claudin polypeptides

Country Status (10)

Country Link
US (1) US20080254506A1 (en)
EP (1) EP1311663B1 (en)
JP (1) JP2004519215A (en)
AT (1) ATE363531T1 (en)
AU (2) AU8497701A (en)
CA (1) CA2418725A1 (en)
DE (1) DE60128701T2 (en)
ES (1) ES2284678T3 (en)
MX (1) MXPA03001468A (en)
WO (1) WO2002014499A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2833840B1 (en) * 2001-12-21 2010-06-18 Rytek METHODS AND COMPOSITIONS FOR THE TREATMENT OF RESPIRATORY PATHOLOGIES
FR2833839A1 (en) * 2001-12-21 2003-06-27 Rytek Use of pulmonary epithelial cell myosin contraction inhibitors for the treatment or prevention of respiratory disorders such as asthma, allergies, and chronic obstructive lung diseases.
JP2005526772A (en) * 2002-03-15 2005-09-08 リテック Composition for treating digestive function pathology
FR2844201A1 (en) * 2002-09-06 2004-03-12 Rytek Use of compound that controls the opening of intestinal epithelium tight junctions for prevention and cure of hyperalgesic intestinal disorders
FR2837103B1 (en) * 2002-03-15 2004-07-09 Rytek COMPOSITIONS FOR THE TREATMENT OF DIGESTIVE FUNCTIONAL CONDITIONS
WO2003100001A2 (en) 2002-05-20 2003-12-04 Immunex Corporation Claudin polypeptides, polynucleotides, and methods of making and use thereof
FR2844713A1 (en) * 2002-09-25 2004-03-26 Exonhit Therapeutics Sa Use of inhibitor of FLJ protein, for treatment and prevention of e.g. cancer, diabetic retinopathy or arthritis, also new protein, nucleic acid and their inhibitors
DE10254601A1 (en) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Gene products differentially expressed in tumors and their use
DE102004023187A1 (en) * 2004-05-11 2005-12-01 Ganymed Pharmaceuticals Ag Identification of surface-associated antigens for tumor diagnosis and therapy
DE102004024617A1 (en) 2004-05-18 2005-12-29 Ganymed Pharmaceuticals Ag Differentially expressed in tumors gene products and their use
FR2879100B1 (en) 2004-12-09 2007-07-06 Lionel Bueno COMPOSITIONS FOR THE TREATMENT OF OCULAR SURFACE PATHOLOGIES AND RETINA
EP1790664A1 (en) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
JP2011501662A (en) 2007-10-12 2011-01-13 ザ・プロウボウスト・フェロウズ・アンド・スカラーズ・オブ・ザ・カレッジ・オブ・ザ・ホリー・アンド・アンデバイデッド・トリニティ・オブ・クイーン・エリザベス・ニア・ダブリン Method for releasing tight bonds
JP5234666B2 (en) * 2009-12-11 2013-07-10 国立大学法人大阪大学 Measurement method for the determination of psoriasis
WO2013174404A1 (en) 2012-05-23 2013-11-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
IL282953B2 (en) 2012-11-13 2026-02-01 Tron Translationale Onkologie An Der Johannes Gutenberg Univ Mainz Gemeinnutzige Gmbh Agents for treatment of claudin expressing cancer diseases
WO2014127785A1 (en) 2013-02-20 2014-08-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
WO2014146672A1 (en) 2013-03-18 2014-09-25 Ganymed Pharmaceuticals Ag Therapy involving antibodies against claudin 18.2 for treatment of cancer
WO2016138245A2 (en) 2015-02-27 2016-09-01 The Regents Of The University Of Michigan Claudin-1 peptide reagents and methods
US10738079B2 (en) 2017-04-14 2020-08-11 Emory University Compositions and methods for managing respiratory conditions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000020447A2 (en) * 1998-10-06 2000-04-13 Curagen Corporation Polynucleotides coding for secreted polypeptides, some having similarity to syncollin or claudin or cytokine, their therapeutic uses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6416974B1 (en) * 1997-08-06 2002-07-09 Millennium Pharmaceuticals, Inc. Tango 71 nucleic acids
JP2003524384A (en) * 1998-11-03 2003-08-19 アドヘレックス テクノロジーズ インコーポレイテッド Compounds and methods for modulating claudin-mediated function
US20040033493A1 (en) * 2001-01-31 2004-02-19 Tchernev Velizar T. Proteins and nucleic acids encoding same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000020447A2 (en) * 1998-10-06 2000-04-13 Curagen Corporation Polynucleotides coding for secreted polypeptides, some having similarity to syncollin or claudin or cytokine, their therapeutic uses

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 21 June 1999 (1999-06-21), XP002196122 *
DATABASE EMBL 28 September 1998 (1998-09-28), XP002196123 *
KAZUMASA MORITA ET AL.: "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 96, no. 2, 19 January 1999 (1999-01-19), pages 511 - 516, XP002181049, ISSN: 0027-8424 *
MIKIO FURUSE ET AL: "Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to Occludin", JOURNAL OF CELL BIOLOGY, vol. 141, no. 7, 29 June 1998 (1998-06-29), pages 1539 - 1550, XP001008152, ISSN: 0021-9525 *

Also Published As

Publication number Publication date
DE60128701T2 (en) 2008-02-07
WO2002014499A9 (en) 2002-04-18
AU2001284977B2 (en) 2005-11-24
WO2002014499A2 (en) 2002-02-21
EP1311663B1 (en) 2007-05-30
AU8497701A (en) 2002-02-25
EP1311663A2 (en) 2003-05-21
CA2418725A1 (en) 2002-02-21
US20080254506A1 (en) 2008-10-16
MXPA03001468A (en) 2004-05-04
ATE363531T1 (en) 2007-06-15
DE60128701D1 (en) 2007-07-12
ES2284678T3 (en) 2007-11-16
JP2004519215A (en) 2004-07-02

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