WO2002014558A3 - New hydrazide building blocks and hydrazide modified biomolecules - Google Patents

New hydrazide building blocks and hydrazide modified biomolecules Download PDF

Info

Publication number
WO2002014558A3
WO2002014558A3 PCT/US2001/041663 US0141663W WO0214558A3 WO 2002014558 A3 WO2002014558 A3 WO 2002014558A3 US 0141663 W US0141663 W US 0141663W WO 0214558 A3 WO0214558 A3 WO 0214558A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrazide
building blocks
new
modified biomolecules
attachment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/041663
Other languages
French (fr)
Other versions
WO2002014558A2 (en
Inventor
Stefan Raddatz
Jochen Mueller-Ibeler
Markus Schweitzer
Christoph Bruecher
Norbert Windhab
John R Havens
Thomas J Onofrey
Charles H Greef
Daguang Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanogen Inc
Original Assignee
Nanogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2000/022205 external-priority patent/WO2001051689A1/en
Application filed by Nanogen Inc filed Critical Nanogen Inc
Priority to AU2001295005A priority Critical patent/AU2001295005A1/en
Priority to DE60136715T priority patent/DE60136715D1/en
Priority to JP2002519683A priority patent/JP4880182B2/en
Priority to EP01975711A priority patent/EP1309730B1/en
Priority to US10/344,092 priority patent/US7129229B2/en
Publication of WO2002014558A2 publication Critical patent/WO2002014558A2/en
Publication of WO2002014558A3 publication Critical patent/WO2002014558A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2429—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of arylalkanols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

This invention relates to attachment chemistries for binding macromolecules to a substrate surface or to other conjugation targets. More particularly, this invention relates to attachment chemistries involving branched or linear structures having one or more hydrazide attachment moieties for binding the macromolecules to a substrate surface, or for other conjugation reactions. Novel modifying reagents are provided for the introduction of protected hydrazide attachment moieties or precursor forms of such hydrazides to the macromolecule, either as a single hydrazide or as multiple hydrazides.
PCT/US2001/041663 2000-08-11 2001-08-10 New hydrazide building blocks and hydrazide modified biomolecules Ceased WO2002014558A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2001295005A AU2001295005A1 (en) 2000-08-11 2001-08-10 Macromolecules having hydrazide attachment moieties and reagents for their production
DE60136715T DE60136715D1 (en) 2000-08-11 2001-08-10 HYDRAZINE COMPONENTS AND HYDRATINE-MODIFIED BIOMOLECULES
JP2002519683A JP4880182B2 (en) 2000-08-11 2001-08-10 Macromolecules with hydrazide binding moieties and reagents for their production
EP01975711A EP1309730B1 (en) 2000-08-11 2001-08-10 New hydrazide building blocks and hydrazide modified biomolecules
US10/344,092 US7129229B2 (en) 2000-08-11 2001-08-10 Hydrazide building blocks and hydrazide modified biomolecules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IBPCT/US00/22205 2000-08-11
PCT/US2000/022205 WO2001051689A1 (en) 2000-01-11 2000-08-11 Biomolecules having multiple attachment moieties for binding to a substrate surface

Publications (2)

Publication Number Publication Date
WO2002014558A2 WO2002014558A2 (en) 2002-02-21
WO2002014558A3 true WO2002014558A3 (en) 2002-05-02

Family

ID=21741678

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/041663 Ceased WO2002014558A2 (en) 2000-08-11 2001-08-10 New hydrazide building blocks and hydrazide modified biomolecules

Country Status (6)

Country Link
EP (1) EP1309730B1 (en)
JP (1) JP4880182B2 (en)
AT (1) ATE415489T1 (en)
AU (1) AU2001295005A1 (en)
DE (1) DE60136715D1 (en)
WO (1) WO2002014558A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5083788B2 (en) * 2004-04-20 2012-11-28 独立行政法人産業技術総合研究所 Oligonucleotide probe
US7772439B2 (en) 2004-10-25 2010-08-10 Operon Biotechnologies, Inc. Amino or thiol linker building block for the synthesis of amino- or thiol-functionalized nucleic acids and methods of making and use thereof
US10022454B2 (en) 2008-09-23 2018-07-17 Liposciences, Llc Functionalized phosphorodiamites for therapeutic oligonucleotide synthesis
WO2010039543A2 (en) * 2008-09-23 2010-04-08 Traversa Therapeutics, Inc. Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating rna interference

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0816368A1 (en) * 1996-07-02 1998-01-07 Glen Research Corporation Chemical phoshorylation of oligonucleotides and reactants used therefor
WO2000029373A2 (en) * 1998-11-18 2000-05-25 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Derivatisation of support surfaces
WO2001007657A1 (en) * 1999-07-27 2001-02-01 Phylos, Inc. Peptide acceptor ligation methods
WO2001009385A2 (en) * 1999-07-29 2001-02-08 Epoch Biosciences, Inc. Attachment of oligonucleotides to solid supports through schiff base type linkages for capture and detection of nucleic acids
WO2001051689A1 (en) * 2000-01-11 2001-07-19 Nanogen Recognomics Gmbh Biomolecules having multiple attachment moieties for binding to a substrate surface

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965349A (en) * 1987-12-24 1990-10-23 Applied Biosystems, Inc. Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports
CA2350417C (en) * 1998-12-02 2010-02-09 Bristol-Myers Squibb Company Dna-protein fusions and uses thereof
DE10013600A1 (en) * 2000-03-18 2002-01-10 Aventis Res & Tech Gmbh & Co Reactive monomers for oligonucleotide and polynucleotide synthesis, modified oligonucleotides and polynucleotides and a process for their preparation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0816368A1 (en) * 1996-07-02 1998-01-07 Glen Research Corporation Chemical phoshorylation of oligonucleotides and reactants used therefor
WO2000029373A2 (en) * 1998-11-18 2000-05-25 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Derivatisation of support surfaces
WO2001007657A1 (en) * 1999-07-27 2001-02-01 Phylos, Inc. Peptide acceptor ligation methods
WO2001009385A2 (en) * 1999-07-29 2001-02-08 Epoch Biosciences, Inc. Attachment of oligonucleotides to solid supports through schiff base type linkages for capture and detection of nucleic acids
WO2001051689A1 (en) * 2000-01-11 2001-07-19 Nanogen Recognomics Gmbh Biomolecules having multiple attachment moieties for binding to a substrate surface

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BEIER M ET AL: "Versatile derivatisation of solid support media for covalent bonding on DNA-microchips", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 27, no. 9, 1999, pages 1970 - 1977, XP002145887, ISSN: 0305-1048 *

Also Published As

Publication number Publication date
JP4880182B2 (en) 2012-02-22
DE60136715D1 (en) 2009-01-08
ATE415489T1 (en) 2008-12-15
WO2002014558A2 (en) 2002-02-21
EP1309730B1 (en) 2008-11-26
EP1309730A2 (en) 2003-05-14
AU2001295005A1 (en) 2002-02-25
JP2004517043A (en) 2004-06-10

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