WO2002020754A3 - Molecules for diagnostics and therapeutics - Google Patents

Molecules for diagnostics and therapeutics Download PDF

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Publication number
WO2002020754A3
WO2002020754A3 PCT/US2001/027127 US0127127W WO0220754A3 WO 2002020754 A3 WO2002020754 A3 WO 2002020754A3 US 0127127 W US0127127 W US 0127127W WO 0220754 A3 WO0220754 A3 WO 0220754A3
Authority
WO
WIPO (PCT)
Prior art keywords
dithp
provides
therapeutics
diagnostics
diagnostic assays
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/027127
Other languages
French (fr)
Other versions
WO2002020754A2 (en
Inventor
Jackson Stuart
Stephen E Lincoln
Christina M Altus
Gerard E Dufour
Michael S Chalup
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc filed Critical Incyte Genomics Inc
Priority to EP01966454A priority Critical patent/EP1364015A2/en
Priority to CA002421265A priority patent/CA2421265A1/en
Priority to AU8696401A priority patent/AU8696401A/en
Publication of WO2002020754A2 publication Critical patent/WO2002020754A2/en
Anticipated expiration legal-status Critical
Publication of WO2002020754A3 publication Critical patent/WO2002020754A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides purified human polynucleotides for diagnostics and therapeutics (dithp). Also encompassed are the polypeptides (DITHP) encoded by dithp. The invention also provides for the use of dithp, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing dithp for the expression of DITHP. The invention additionally provides for the use of isolated and purified DITHP to induce antibodies and to screen libraries of compounds and the use of anti-DITHP antibodies in diagnostic assays. Also provided are microarrays containing dithp and methods of use.
PCT/US2001/027127 2000-09-05 2001-08-29 Molecules for diagnostics and therapeutics Ceased WO2002020754A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01966454A EP1364015A2 (en) 2000-09-05 2001-08-29 Molecules for diagnostics and therapeutics
CA002421265A CA2421265A1 (en) 2000-09-05 2001-08-29 Molecules for diagnostics and therapeutics
AU8696401A AU8696401A (en) 2000-09-05 2001-09-02 Molecules for diagnostics and therapeutics

Applications Claiming Priority (44)

Application Number Priority Date Filing Date Title
US22974700P 2000-09-05 2000-09-05
US23058300P 2000-09-05 2000-09-05
US22974800P 2000-09-05 2000-09-05
US22974900P 2000-09-05 2000-09-05
US22975100P 2000-09-05 2000-09-05
US22975000P 2000-09-05 2000-09-05
US60/229,749 2000-09-05
US60/229,748 2000-09-05
US60/229,750 2000-09-05
US60/230,583 2000-09-05
US60/229,751 2000-09-05
US60/229,747 2000-09-05
US23059700P 2000-09-06 2000-09-06
US23086500P 2000-09-06 2000-09-06
US23051900P 2000-09-06 2000-09-06
US23050500P 2000-09-06 2000-09-06
US23061000P 2000-09-06 2000-09-06
US23051400P 2000-09-06 2000-09-06
US23051700P 2000-09-06 2000-09-06
US23059500P 2000-09-06 2000-09-06
US23051800P 2000-09-06 2000-09-06
US23051500P 2000-09-06 2000-09-06
US23098800P 2000-09-06 2000-09-06
US23059800P 2000-09-06 2000-09-06
US23059900P 2000-09-06 2000-09-06
US60/230,514 2000-09-06
US60/230,599 2000-09-06
US60/230,518 2000-09-06
US60/230,519 2000-09-06
US60/230,865 2000-09-06
US60/230,988 2000-09-06
US60/230,595 2000-09-06
US60/230,597 2000-09-06
US60/230,610 2000-09-06
US60/230,517 2000-09-06
US60/230,505 2000-09-06
US60/230,515 2000-09-06
US60/230,598 2000-09-06
US23116700P 2000-09-07 2000-09-07
US23095100P 2000-09-07 2000-09-07
US23116300P 2000-09-07 2000-09-07
US60/231,163 2000-09-07
US60/230,951 2000-09-07
US60/231,167 2000-09-07

Publications (2)

Publication Number Publication Date
WO2002020754A2 WO2002020754A2 (en) 2002-03-14
WO2002020754A3 true WO2002020754A3 (en) 2003-09-25

Family

ID=27586647

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/027127 Ceased WO2002020754A2 (en) 2000-09-05 2001-08-29 Molecules for diagnostics and therapeutics

Country Status (3)

Country Link
EP (1) EP1364015A2 (en)
CA (1) CA2421265A1 (en)
WO (1) WO2002020754A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020102637A1 (en) * 2000-12-21 2002-08-01 Chunhua Yan Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
WO2002074906A2 (en) * 2001-03-16 2002-09-26 Eli Lilly And Company Lp mammalian proteins; related reagents
US8163892B2 (en) 2002-07-08 2012-04-24 Oncolys Biopharma, Inc. Oncolytic virus replicating selectively in tumor cells
WO2005019258A2 (en) * 2003-08-11 2005-03-03 Genentech, Inc. Compositions and methods for the treatment of immune related diseases

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045712A2 (en) * 1997-04-08 1998-10-15 Human Genome Sciences, Inc. 20 human secreted proteins
WO1998048274A1 (en) * 1997-04-22 1998-10-29 Smithkline Beecham Corporation Homogeneous fluorescence assay for measuring the effect of compounds on gene expression
WO1999025825A2 (en) * 1997-11-13 1999-05-27 Genset EXTENDED cDNAs FOR SECRETED PROTEINS
WO2001055301A2 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2001090325A2 (en) * 2000-05-19 2001-11-29 Millennium Pharmaceuticals, Inc. 50365, a hexokinase family member and uses thereof
WO2002008399A2 (en) * 2000-07-21 2002-01-31 Incyte Genomics, Inc. Human kinases

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045712A2 (en) * 1997-04-08 1998-10-15 Human Genome Sciences, Inc. 20 human secreted proteins
WO1998048274A1 (en) * 1997-04-22 1998-10-29 Smithkline Beecham Corporation Homogeneous fluorescence assay for measuring the effect of compounds on gene expression
WO1999025825A2 (en) * 1997-11-13 1999-05-27 Genset EXTENDED cDNAs FOR SECRETED PROTEINS
WO2001055301A2 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2001090325A2 (en) * 2000-05-19 2001-11-29 Millennium Pharmaceuticals, Inc. 50365, a hexokinase family member and uses thereof
WO2002008399A2 (en) * 2000-07-21 2002-01-31 Incyte Genomics, Inc. Human kinases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] EBI Hinxton, UK; 30 November 1999 (1999-11-30), NCI.CGAP: "National Cancer Institute, Cancer Genome Anatomy Project (CGAP)", XP002218725, Database accession no. AW194769 *
NISHI S ET AL: "HUMAN HEXOKINASE SEQUENCES OF AMINO AND CARBOXYL-TERMINAL HALVES ARE HOMOLOGOUS", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 157, no. 3, 1988, pages 937 - 943, XP002218724, ISSN: 0006-291X *

Also Published As

Publication number Publication date
EP1364015A2 (en) 2003-11-26
CA2421265A1 (en) 2002-03-14
WO2002020754A2 (en) 2002-03-14

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