WO2002024742A3 - Atp-binding cassette protein - Google Patents

Atp-binding cassette protein Download PDF

Info

Publication number
WO2002024742A3
WO2002024742A3 PCT/US2001/029455 US0129455W WO0224742A3 WO 2002024742 A3 WO2002024742 A3 WO 2002024742A3 US 0129455 W US0129455 W US 0129455W WO 0224742 A3 WO0224742 A3 WO 0224742A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
atp
binding cassette
breast
provides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/029455
Other languages
French (fr)
Other versions
WO2002024742A2 (en
Inventor
Randi E Krasnow
Mariah R Baughn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc filed Critical Incyte Genomics Inc
Priority to EP01973276A priority Critical patent/EP1319021A2/en
Priority to AU2001292873A priority patent/AU2001292873A1/en
Priority to CA002422508A priority patent/CA2422508A1/en
Publication of WO2002024742A2 publication Critical patent/WO2002024742A2/en
Anticipated expiration legal-status Critical
Publication of WO2002024742A3 publication Critical patent/WO2002024742A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention provides a mammalian cDNA which encodes a mammalian ATP-binding cassette protein. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of breast disorders, particularly breast proliferative fibrocystic disease, breast adenocarcinoma, and drug resistance. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
PCT/US2001/029455 2000-09-22 2001-09-20 Atp-binding cassette protein Ceased WO2002024742A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01973276A EP1319021A2 (en) 2000-09-22 2001-09-20 Atp-binding cassette protein
AU2001292873A AU2001292873A1 (en) 2000-09-22 2001-09-20 Atp-binding cassette protein
CA002422508A CA2422508A1 (en) 2000-09-22 2001-09-20 Atp-binding cassette protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66862800A 2000-09-22 2000-09-22
US09/668,628 2000-09-22

Publications (2)

Publication Number Publication Date
WO2002024742A2 WO2002024742A2 (en) 2002-03-28
WO2002024742A3 true WO2002024742A3 (en) 2003-04-03

Family

ID=24683122

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/029455 Ceased WO2002024742A2 (en) 2000-09-22 2001-09-20 Atp-binding cassette protein

Country Status (4)

Country Link
EP (1) EP1319021A2 (en)
AU (1) AU2001292873A1 (en)
CA (1) CA2422508A1 (en)
WO (1) WO2002024742A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1244698A2 (en) * 1999-11-02 2002-10-02 Lexicon Genetics Incorporated Novel human transporter proteins and polynucleotides encoding the same
US20040001840A1 (en) * 2002-03-04 2004-01-01 Young Paul E. Cancer-linked gene as target for chemotherapy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000036101A2 (en) * 1998-11-30 2000-06-22 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services An atp-binding cassette protein responsible for cytotoxin resistance
WO2001032706A2 (en) * 1999-11-02 2001-05-10 Lexicon Genetics Incorporated Novel human transporter proteins and polynucleotides encoding the same
WO2001057214A2 (en) * 2000-02-03 2001-08-09 Lexicon Genetics Incorporated Human transporter proteins and polynucleotides encoding the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000036101A2 (en) * 1998-11-30 2000-06-22 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services An atp-binding cassette protein responsible for cytotoxin resistance
WO2001032706A2 (en) * 1999-11-02 2001-05-10 Lexicon Genetics Incorporated Novel human transporter proteins and polynucleotides encoding the same
WO2001057214A2 (en) * 2000-02-03 2001-08-09 Lexicon Genetics Incorporated Human transporter proteins and polynucleotides encoding the same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALLIKMETS R ET AL: "CHARACTERIZATION OF THE HUMAN ABC SUPERFAMILY: ISOLATION AND MAPPING OF 21 NEW GENES USING THE EXPRESSED SEQUENCE TAGS DATABASE", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 5, no. 10, 1996, pages 1649 - 1655, XP002074412, ISSN: 0964-6906 *
DOYLE L A ET AL: "A MULTIDRUG RESISTANCE TRANSPORTER FROM HUMAN MCF-7 BREAST CANCER CELLS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, December 1998 (1998-12-01), pages 15665 - 15670, XP001055044, ISSN: 0027-8424 *
YANG D L A ET AL: "CLONING AND CHARACTERIZATION OF BREAST CANCER RESISTANCE PROTEIN (BCRP), A NOVEL ATP-BINDING CASSETTE (ABC) TRANSPORTER THAT MAY CONTRIBUTE TO THE MULTIDRUG-RESISTANCE PHENOTYPE OF MCF-7/ADRVP BREAST CANCER CELLS", PROCEEDINGS OF THE 89TH. ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. NEW ORLEANS, LA, MARCH 28 - APRIL 1, 1998, PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, PHILADELPHIA, PA: AACR, US, vol. 39, 28 March 1998 (1998-03-28), pages 657, XP000891682 *

Also Published As

Publication number Publication date
WO2002024742A2 (en) 2002-03-28
EP1319021A2 (en) 2003-06-18
CA2422508A1 (en) 2002-03-28
AU2001292873A1 (en) 2002-04-02

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