WO2002029014A3 - Stem cell differentiation-inducing promoter - Google Patents

Stem cell differentiation-inducing promoter Download PDF

Info

Publication number
WO2002029014A3
WO2002029014A3 PCT/JP2001/008136 JP0108136W WO0229014A3 WO 2002029014 A3 WO2002029014 A3 WO 2002029014A3 JP 0108136 W JP0108136 W JP 0108136W WO 0229014 A3 WO0229014 A3 WO 0229014A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
cell differentiation
cells
stem cell
stem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2001/008136
Other languages
French (fr)
Other versions
WO2002029014A2 (en
Inventor
Bang Luu
Eliane Mohier
Masashi Yamada
Yukie Suma
Hiroto Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Dairies Corp
Original Assignee
Meiji Dairies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2000304746A external-priority patent/JP2002068973A/en
Application filed by Meiji Dairies Corp filed Critical Meiji Dairies Corp
Priority to AT01972471T priority Critical patent/ATE450602T1/en
Priority to EP01972471A priority patent/EP1322748B1/en
Priority to CA2424207A priority patent/CA2424207C/en
Priority to US10/381,586 priority patent/US20040115810A1/en
Priority to DE60140685T priority patent/DE60140685D1/en
Publication of WO2002029014A2 publication Critical patent/WO2002029014A2/en
Publication of WO2002029014A3 publication Critical patent/WO2002029014A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Provided is a stem-cell differentiation and induction promoter, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic derivative represented by the formula (1):[wherein, R?1, R2 and R3¿ each independently represents a hydrogen atom or a methyl group and X represents a linear or branched C10-28 alkylene or alkenylene group]. Since the cyclohexenone long-chain alcoholic derivative according to the present invention promotes differentiation-induction of stem cells into cells expressing a specific biological function, a medicament comprising the derivative is useful as a preventive or remedial drug for diseases such as nervous diseases, bone diseases, circulatory diseases and myopathy, caused by the degeneration of tissues or cells or cell death.
PCT/JP2001/008136 2000-10-04 2001-09-19 Stem cell differentiation-inducing promoter Ceased WO2002029014A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AT01972471T ATE450602T1 (en) 2000-10-04 2001-09-19 STEM CELL DIFFERENTIATION-INDUCING PROMOTERS
EP01972471A EP1322748B1 (en) 2000-10-04 2001-09-19 Stem cell differentiation-inducing promoter
CA2424207A CA2424207C (en) 2000-10-04 2001-09-19 Stem cell differentiation-inducing promoter
US10/381,586 US20040115810A1 (en) 2000-10-04 2001-09-19 Stem cell differentiation-inducing promoter
DE60140685T DE60140685D1 (en) 2000-10-04 2001-09-19 STEM CELL DIFFERENTIATION INDUCING PROMOTER

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000-304746 2000-10-04
JP2000304746A JP2002068973A (en) 2000-06-16 2000-10-04 Stem cell differentiation inducer

Publications (2)

Publication Number Publication Date
WO2002029014A2 WO2002029014A2 (en) 2002-04-11
WO2002029014A3 true WO2002029014A3 (en) 2002-12-19

Family

ID=18785739

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/008136 Ceased WO2002029014A2 (en) 2000-10-04 2001-09-19 Stem cell differentiation-inducing promoter

Country Status (6)

Country Link
US (1) US20040115810A1 (en)
EP (1) EP1322748B1 (en)
AT (1) ATE450602T1 (en)
CA (1) CA2424207C (en)
DE (1) DE60140685D1 (en)
WO (1) WO2002029014A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4861560B2 (en) * 2001-02-19 2012-01-25 株式会社明治 Treatment for diabetic complications
EP1608612B1 (en) * 2003-03-28 2008-02-27 Meiji Dairies Corporation Process for producing cyclohexenone long-chain alcohols
ATE503471T1 (en) * 2004-11-25 2011-04-15 Meiji Dairies Corp AGENTS FOR RELIEVING RENAL INSUFFICIENCY
WO2011085225A1 (en) * 2010-01-08 2011-07-14 Wake Forest University Health Sciences Delivery system
KR101983402B1 (en) 2011-03-07 2019-05-28 웨이크 포리스트 유니버시티 헬스 사이언시즈 Delivery system
ES2849425T3 (en) 2016-01-22 2021-08-18 Taiho Pharmaceutical Co Ltd High Purity Cyclohexenone Long Chain Alcohol Manufacturing Method
CN107032975B (en) * 2016-02-03 2022-06-28 大鹏药品工业株式会社 Preparation method of high-purity cyclohexenone long-chain alcohol

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999008987A1 (en) * 1997-08-13 1999-02-25 Meiji Milk Products Co., Ltd. Cyclohexenone long-chain alcohol and medicament containing same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999008987A1 (en) * 1997-08-13 1999-02-25 Meiji Milk Products Co., Ltd. Cyclohexenone long-chain alcohol and medicament containing same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GIRLANDA-JUNGES C ET AL: "Effect of Cyclohexenonic Long Chain Fatty Alcohols on Neurite Outgrowth. Study on Structure-Activity Relationship", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 54, no. 27, 2 July 1998 (1998-07-02), pages 7735 - 7748, XP004122484, ISSN: 0040-4020 *

Also Published As

Publication number Publication date
DE60140685D1 (en) 2010-01-14
CA2424207C (en) 2013-03-26
EP1322748B1 (en) 2009-12-02
CA2424207A1 (en) 2002-04-11
WO2002029014A2 (en) 2002-04-11
EP1322748A2 (en) 2003-07-02
US20040115810A1 (en) 2004-06-17
ATE450602T1 (en) 2009-12-15

Similar Documents

Publication Publication Date Title
CA1126158A (en) Cosmetic composition containing kojic acid ester
Zabetakis et al. Elicitation of tropane alkaloid biosynthesis in transformed root cultures of Datura stramonium
WO2003013497A1 (en) Compositions having effects of preventing or ameliorating conditions or diseases caused by brain hypofunction
EP1281398A4 (en) DERMAL COMPOSITIONS HAVING COENZYME Q AS ACTIVE INGREDIENT
BR0209320A (en) pharmaceutically active uridine esters
WO1999027924A3 (en) Fatty acid uninterrupted by a methylene as anti-inflammatory agents in superficial tissues of mammals
WO2002029014A3 (en) Stem cell differentiation-inducing promoter
EP1725536B8 (en) Imidazoline derivatives having cb1-antagonistic activity
TWI256292B (en) Reduction inhibitory agent for active oxygen eliminating activity
US9463338B2 (en) Derivatives of the sinapinic acid
DE60216239T8 (en) Use of cyclohexenone derivatives for the manufacture of a medicament for the treatment of dysuria
DE50211978D1 (en) STABILIZATION OF OXIDATIVE AND / OR UV-SENSITIVE ACTIVE SUBSTANCES
MA32146B1 (en) Stable microcapsule formulations of malathion
KR20160021371A (en) Anti-inflammation and Anti-aging composition for skin external application comprising Narcissus tazetta Cell Culture Extract and Methods for preparing the Same
DE69935597T2 (en) METHOD FOR THE PRODUCTION OF SELF-INDUCING SYNTHASE
KR101693923B1 (en) Anti-inflammation and Anti-aging composition for skin external application comprising Zostera marina Cell Culture Extract and Methods for preparing the Same
KR20250152146A (en) Cosmetic composition for antioxidant, whitening and skin wrinkle improvement containing N-benzyl-N-methyldecane-1-amine or a derivative thereof as an active ingredient
EP2178372A2 (en) Natural bioactive compounds
DE60238666D1 (en) CYCLOHEXENONE DERIVATIVES FOR THE TREATMENT OF DIABETIC NEUROPATHY
AU656855B2 (en) Octahydronaphthalene oxime derivatives for cholesterol biosynthesis inhibition, their preparation and use
KR20090052096A (en) Anti-aging skin external preparation composition containing moss extract or its active ingredient depsidone or depsidone derivative
US5618545A (en) Skin-cosmetic composition
AU2003200465A1 (en) Compositions for Skin Lightening and Toning Down Pigment Disorders, Comprising Creatinine and/or Creatinine Derivatives as Active Substances
AU2001260695A1 (en) Malto-oligosaccharide derivatives and use thereof
WO2002044403A3 (en) Markers for testing analogs of vitamin d and therapeutical uses

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): CA US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): CA US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

WWE Wipo information: entry into national phase

Ref document number: 2424207

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2001972471

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001972471

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10381586

Country of ref document: US